berberine has been researched along with Inflammation in 154 studies
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this one-group pretest-post-test explanatory study was to evaluate, in normal-overweight PCOS women with normal menses, the effectiveness of berberine on: Insulin resistance (IR) by Homeostasis Model Assessment (HOMA); Inflammation by C-Reactive Protein (CRP), Tumor Necrosis Factor α (TNF-α); Lipid metabolism; Sex hormone profile and symptoms correlated to hyperandrogenism, such as acne, by Global Acne Grading System (GAGS) and Cardiff Acne Disability Index (CADI); Body composition by DXA." | 9.41 | Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study. ( Allegrini, P; Bernardinelli, L; Fazia, T; Gasparri, C; Giacosa, A; Perna, S; Peroni, G; Petrangolini, G; Riva, A; Rondanelli, M, 2021) |
| "A meta-analysis of randomized controlled trials (RCTs) was conducted to systematically evaluate the effects of berberine on the inflammatory markers of metabolic syndrome (MetS) and related disorders." | 9.22 | The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials. ( Chang, F; Dai, Z; He, J; Lu, Y; Shi, P; Zhang, X, 2022) |
| " Berberine is the main alkaloid of Coptis Chinensis, and, recent researches showed that berberine had the effect of anti-atherosclerosis." | 8.86 | Advance of studies on anti-atherosclerosis mechanism of berberine. ( Liu, LT; Wang, J; Wu, M, 2010) |
| "To determine the effects of berberine (BBR) on the activation of toll-like receptor 4 (TLR4), nuclear factor (NF)κB (NF-κB) signaling and NLRP3 inflammasome in patients with gout." | 8.31 | Effect of Berberine on Activation of TLR4-NFκB Signaling Pathway and NLRP3 Inflammasome in Patients with Gout. ( Dang, WT; Xu, D; Zhou, JG, 2023) |
| "Our previous studies have shown that berberine can improve the nerve function deficits in ischemic stroke by inhibiting inflammation." | 8.31 | Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway. ( Ding, W; Gu, Q; Liu, M; Sun, J; Zhu, J; Zou, J, 2023) |
| " Berberine hydrochloride (BBR), a natural product, has shown effective inflammation inhibitory activity." | 8.31 | Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine. ( Fan, J; Jia, R; Li, L; Liu, L; Lv, C; Song, X; Wan, H; Xing, R; Xue, J; Yin, Z; Zhao, X; Zhou, X; Zou, J; Zou, Y, 2023) |
| "The CUMS model and behavioral evaluation were utilized in this study to evaluate the efficacy of berberine in the treatment of depression." | 8.31 | Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. ( Chen, F; Huang, Y; Liu, W; Su, K; Tao, W; Wang, Y; Yang, L; Zhao, M, 2023) |
| "Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects." | 8.31 | Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction. ( Gao, Z; Han, B; Hou, Y; Shi, H; Tan, E; Wang, L; Wang, Q; Zhu, G, 2023) |
| "Our findings suggest that Berberine plays an important neuroprotective role against ICH-induced neurological impairments and BBB injury, probably by inhibition of inflammation and activation of AMPK/PGC1α signaling." | 8.12 | Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage. ( Liu, X; Wang, Y; Wu, X; Yang, L, 2022) |
| "Berberine-loaded gum nanocomplexes were prepared by the ionic complexation between the negative charges of the gums (tragacanth and acacia gum) using a cross-linker for loading cationic berberine and their anti-inflammatory activity was evaluated against carrageenan-induced paw edema in rats." | 8.12 | Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats. ( Bakshi, J; Dhingra, D; Grewal, S; Kumari, S; Lathar, P; Mehra, M, 2022) |
| " In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model." | 8.12 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota. ( Deng, J; Han, L; Li, Y; Shi, J; Wang, H; Yan, Y; Yuan, X; Zhang, H; Zhao, H; Zhao, L; Zhao, Y; Zou, F, 2022) |
| "The present study explored the synergetic effects of berberine and 6-shogaol, the primary components of Coptidis Rhizoma and Zingiberis Rhizoma, respectively, on intestinal inflammation and intestinal flora in mice with ulcerative colitis to reveal the effect and mechanism of cold-heat combination in the treatment of ulcerative colitis." | 8.12 | [Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis]. ( Chen, ZG; Li, JT; Wei, HL; Yan, SG, 2022) |
| "The role of berberine in low shear stress-induced vascular endothelial inflammation was investigated in human umbilical vein endothelial cells (HUVECs) using a plate flow chamber in vitro and in mice with an established LSS model by partial ligation of the carotid artery in vivo." | 8.12 | Berberine inhibits low shear stress-induced vascular endothelial inflammation via decreasing phosphorylation of Akt and IRF3. ( Chen, S; Gu, Y; Kong, C; Lv, Y; Qian, Z; Wang, D; Yang, H; Ye, P; Zhou, W; Zhu, L, 2022) |
| "This study focuses on constructing of an anti-inflammatory drug delivery system by encapsulation of berberine in the β-glucan nanoparticles and evaluates its effect on treating ulcerative colitis." | 8.12 | Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis. ( Chen, Q; Fan, Y; Huang, J; Liang, M; Long, H; Wang, Y; Wang, Z; Wu, C; Xu, Y, 2022) |
| " It is widely reported that berberine (BBR) has an anti-inflammatory effect and can reduce glucose and lipid accumulation, whereas ginsenoside Rb1 (Rb1) has been shown to have a significant inhibitory effect on insulin resistance and lipid peroxidation." | 8.02 | Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. ( Cai, Z; Chen, Y, 2021) |
| "This study aimed to explore the protective actions of berberine on inflammation, and alveolar bone loss in ligature-induced periodontitis, as well as its mechanism of action METHODS: Micro-computed tomography was conducted to analyze the alveolar bone loss, and hematoxylin and eosin staining was carried out to observe the histopathological changes and inflammation status." | 8.02 | Berberine suppresses bone loss and inflammation in ligature-induced periodontitis through promotion of the G protein-coupled estrogen receptor-mediated inactivation of the p38MAPK/NF-κB pathway. ( Gan, J; Gu, L; Ke, Y; Li, X, 2021) |
| "Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD)." | 8.02 | Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats. ( Chen, HB; Chen, JN; Dou, YX; Huang, XQ; Huang, ZW; Li, QP; Li, YC; Liu, YH; Su, ZR; Xie, JH; Yang, XB; Zeng, HF, 2021) |
| "The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)." | 7.96 | Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020) |
| " Although berberine, an isoquinoline alkaloid, has been revealed to exert protective effects on experimental colitis, the underlying molecular mechanism in chronic intestinal inflammation remains ill-defined." | 7.96 | Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis. ( Fan, C; Feng, C; He, P; Li, H; Lu, H; Lu, Q; Tang, W; Xiang, C; Yang, X; Yang, Y; Zhang, Z; Zhu, F; Zuo, J, 2020) |
| "Berberine has been established as a potential drug for inflammation and metabolic disorder." | 7.96 | Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu. ( Fan, DH; Han, YB; Li, WZ; Liu, L; Tian, M; Wang, XX; Wu, F, 2020) |
| "This study was designed to investigate the molecular mechanisms underlying the anti-inflammatory and anti-fibrosis effects of Berberine hydrochloride (BBR) following canalicular laceration (CL) surgical repair." | 7.96 | Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits. ( Bai, F; Huang, Y; Liu, C; Tao, H; Wang, F; Wang, L; Wang, P; Zhou, X, 2020) |
| "This study aimed to investigate the protective effects of berberine (BBR) against D-galactose (D-gal)-induced renal aging in rats, pointing to its ability to modulate phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt signalling, and to attenuate oxidative stress, inflammation and apoptosis." | 7.96 | Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. ( El-Horany, HE; Gaballah, HH; Helal, DS, 2020) |
| "Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease (COPD), its underlying mechanisms were not clear until now." | 7.91 | Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway. ( Li, CN; Wang, W; Wang, X; Wu, XJ; Zha, G; Zou, JJ, 2019) |
| "The present study was performed to show the ameliorative effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, against experimental varicocele (VCL)-induced molecular and histological damages." | 7.91 | Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation. ( Hassani-Bafrani, H; Najaran, H; Rashtbari, H; Razi, M, 2019) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 7.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| "This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility." | 7.88 | The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress. ( Attia, R; Ghareeb, DA; Saleh, SR, 2018) |
| "Berberine is a natural product that shows benefits for metabolic syndrome (MS)." | 7.81 | Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome. ( Gao, HQ; Ji, XP; Li, CB; Li, XX; Wang, HW; Xiao, J; Zhang, C; Zhang, XY, 2015) |
| " Berberine (BBR), a compound long used in traditional Chinese medicines, has been reported to have therapeutic effects in treating experimental colitis." | 7.81 | Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation. ( Chen, G; Cheng, W; Li, C; Li, S; Niu, X; Wang, Z; Xi, Y; Zhao, Q; Zhong, J, 2015) |
| "Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway." | 7.79 | Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. ( Du, GH; Fang, LH; Gong, LL; Guo, J; Li, L; Qin, HL; Wang, SB; Wu, YJ; Xu, XN; Yan, Y; Yuan, TY, 2013) |
| "The present results suggest that berberine inhibits dyslipidemia in C57BL/6 mice with LPS induced inflammation through regulating PCSK9-LDLR pathway." | 7.78 | Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. ( Sun, ZL; Xiao, HB; Zhang, DS; Zhang, HB, 2012) |
| "Berberine, a major isoquinoline alkaloid present in Chinese herb Rhizoma coptidis, is a potent inhibitor of inflammation and has anti-diabetic activity." | 7.77 | Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. ( Huang, F; Li, L; Liu, B; Liu, K; Lou, T; Xi, Z; Zhang, Z, 2011) |
| "Berberine, which is a major constituent of the rhizome of Coptidis japonica (CJ), inhibits IL-8 production in colonic epithelial cells and improves 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice." | 7.76 | Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation. ( Hyun, YJ; Kim, DH; Lee, IA, 2010) |
| "Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation." | 6.82 | Effects of Berberine against Pancreatitis and Pancreatic Cancer. ( Gagacev, F; O'Neill, EJ; Tsiani, E; Vlavcheski, F, 2022) |
| "1." | 6.77 | Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. ( Cao, JT; Huang, ZQ; Li, YG; Meng, S; Sun, YG; Wang, CQ; Wang, LS; Zhou, Q, 2012) |
| "Berberine (BBR) has shown efficacy in treating inflammatory diseases." | 5.91 | Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye. ( Guo, S; Han, Y; Hu, J; Huang, C; Li, C; Li, J; Li, Y; Liu, Y; Liu, Z; Lv, Y; Yu, D; Zheng, L; Zhu, L, 2023) |
| "Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties." | 5.72 | Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation. ( Celik, H; Comakli, S; Gur, C; Kandemir, FM; Kucukler, S; Ozdemir, S; Yardim, A, 2022) |
| "Berberine (Ber) is an isoquinoline alkaloid that has shown therapeutic potential in mice with chronic obstructive pulmonary disease (COPD)." | 5.72 | Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats. ( Li, D; Li, Y; Liu, H; Shi, M; Wang, Y; Zhang, X, 2022) |
| " Moreover, the thick colonic mucus layer obstructs the penetration of the drug, resulting in low bioavailability to the inflammatory site of the colon." | 5.72 | Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis. ( Chen, S; Fang, W; Gao, S; Hu, R; Lu, W; Nie, X; Sun, L; Zhang, Q, 2022) |
| "Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia." | 5.72 | Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE ( Hu, C; Ma, C; Man, B; Xiang, J; Yang, G; Yang, S, 2022) |
| "Berberine (BBR) has many pharmacological properties and is used as an insulin sensitizer." | 5.62 | Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis. ( Li, XL; Shen, HR; Xu, X, 2021) |
| "Berberine is a well-known quaternary ammonium salt that is usually found in the roots of such plants as Phellodendron amurense and Coptis chinensis." | 5.62 | Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway. ( Kim, HJ; Kim, YJ; Park, W, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide." | 5.56 | Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway. ( Chen, Z; He, B; Lu, Z; Wu, L; Yan, M, 2020) |
| " In summary, BB exerted similar effect to its analogue BBR and positive control in attenuating DSS-induced UC with much lower dosage and similar mechanism." | 5.48 | Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. ( Chen, JP; Huang, YF; Li, HL; Qu, C; Su, ZR; Xu, LQ; Xu, YF; Yi, TG; Yu, XT; Zeng, HF; Zhang, XJ; Zheng, L, 2018) |
| "Berberine was orally administrated in normal or CUMS mice for successive four weeks." | 5.46 | Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. ( Bai, L; Fang, XY; Li, YC; Liu, YM; Niu, L; Wang, LL; Yi, LT, 2017) |
| "Berberine chloride (BC) has been widely used as an unprescribed oral drug in China for the treatment of various diseases, and it is an active ingredient in many traditionally used medicinal plants." | 5.46 | Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. ( Chandirasegaran, G; Elanchezhiyan, C; Ghosh, K; Sethupathy, S, 2017) |
| "Chronic inflammation is a major contributing factor in the pathogenesis of many diseases." | 5.46 | Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells. ( Shan, Y; Shang, W; Wu, Y; Xu, C; Yan, J; Yu, X; Zhang, H; Zhao, J, 2017) |
| "Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)." | 5.46 | Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017) |
| "Berberine (BBR) is a natural compound derived from some medicinal plants, and accumulating evidence has shown its potent anti-tumor activity with diverse action on tumor cells, including inducing cancer cell death and blocking cell cycle and migration." | 5.43 | Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. ( Cao, F; Feng, Y; Li, H; Liu, M; Tan, Y; Wang, N; Wang, X; Xiang, L; Yu, X; Zhang, J, 2016) |
| " The aim of this one-group pretest-post-test explanatory study was to evaluate, in normal-overweight PCOS women with normal menses, the effectiveness of berberine on: Insulin resistance (IR) by Homeostasis Model Assessment (HOMA); Inflammation by C-Reactive Protein (CRP), Tumor Necrosis Factor α (TNF-α); Lipid metabolism; Sex hormone profile and symptoms correlated to hyperandrogenism, such as acne, by Global Acne Grading System (GAGS) and Cardiff Acne Disability Index (CADI); Body composition by DXA." | 5.41 | Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study. ( Allegrini, P; Bernardinelli, L; Fazia, T; Gasparri, C; Giacosa, A; Perna, S; Peroni, G; Petrangolini, G; Riva, A; Rondanelli, M, 2021) |
| "Berberine, with the skeleton of quaternary ammonium, has been considered as the well-defined natural product in treating multiple diseases, including inflammation, acute and chronic infection, autoimmune diseases, and diabetes." | 5.22 | Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders. ( Fu, Y; Li, H; Lu, Q, 2022) |
| "A meta-analysis of randomized controlled trials (RCTs) was conducted to systematically evaluate the effects of berberine on the inflammatory markers of metabolic syndrome (MetS) and related disorders." | 5.22 | The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials. ( Chang, F; Dai, Z; He, J; Lu, Y; Shi, P; Zhang, X, 2022) |
| " Various in vitro and in vivo studies have reported the anti-inflammatory role of berberine (BRB), an organic heteropentacyclic phytochemical and natural isoquinoline, in inhibiting NLRP3 inflammasome-dependent inflammation against many disorders." | 5.12 | Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases. ( Abrahamse, H; George, BP; Sarbadhikary, P, 2021) |
| " Berberine is the main alkaloid of Coptis Chinensis, and, recent researches showed that berberine had the effect of anti-atherosclerosis." | 4.86 | Advance of studies on anti-atherosclerosis mechanism of berberine. ( Liu, LT; Wang, J; Wu, M, 2010) |
| "To determine the effects of berberine (BBR) on the activation of toll-like receptor 4 (TLR4), nuclear factor (NF)κB (NF-κB) signaling and NLRP3 inflammasome in patients with gout." | 4.31 | Effect of Berberine on Activation of TLR4-NFκB Signaling Pathway and NLRP3 Inflammasome in Patients with Gout. ( Dang, WT; Xu, D; Zhou, JG, 2023) |
| "Our previous studies have shown that berberine can improve the nerve function deficits in ischemic stroke by inhibiting inflammation." | 4.31 | Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway. ( Ding, W; Gu, Q; Liu, M; Sun, J; Zhu, J; Zou, J, 2023) |
| " Berberine hydrochloride (BBR), a natural product, has shown effective inflammation inhibitory activity." | 4.31 | Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine. ( Fan, J; Jia, R; Li, L; Liu, L; Lv, C; Song, X; Wan, H; Xing, R; Xue, J; Yin, Z; Zhao, X; Zhou, X; Zou, J; Zou, Y, 2023) |
| "The CUMS model and behavioral evaluation were utilized in this study to evaluate the efficacy of berberine in the treatment of depression." | 4.31 | Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. ( Chen, F; Huang, Y; Liu, W; Su, K; Tao, W; Wang, Y; Yang, L; Zhao, M, 2023) |
| "Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects." | 4.31 | Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction. ( Gao, Z; Han, B; Hou, Y; Shi, H; Tan, E; Wang, L; Wang, Q; Zhu, G, 2023) |
| "Our findings suggest that Berberine plays an important neuroprotective role against ICH-induced neurological impairments and BBB injury, probably by inhibition of inflammation and activation of AMPK/PGC1α signaling." | 4.12 | Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage. ( Liu, X; Wang, Y; Wu, X; Yang, L, 2022) |
| "Berberine-loaded gum nanocomplexes were prepared by the ionic complexation between the negative charges of the gums (tragacanth and acacia gum) using a cross-linker for loading cationic berberine and their anti-inflammatory activity was evaluated against carrageenan-induced paw edema in rats." | 4.12 | Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats. ( Bakshi, J; Dhingra, D; Grewal, S; Kumari, S; Lathar, P; Mehra, M, 2022) |
| " In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model." | 4.12 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota. ( Deng, J; Han, L; Li, Y; Shi, J; Wang, H; Yan, Y; Yuan, X; Zhang, H; Zhao, H; Zhao, L; Zhao, Y; Zou, F, 2022) |
| "Berberine exerts therapeutic effects in inflammation-associated diseases." | 4.12 | Berberine Suppresses Leukocyte Adherence by Downregulating CX3CL1 Expression and Shedding and ADAM10 in Lipopolysaccharide-Stimulated Vascular Endothelial Cells. ( Hong, WC; Pang, JS; Wei, CY; Wu, YH, 2022) |
| "The aim of this study was to evaluate the efficacy of solid lipid nanoparticles of berberine against doxorubicin-induced cardiotoxicity." | 4.12 | Solid Lipid Nanoformulation of Berberine Attenuates Doxorubicin Triggered ( Bhatnagar, P; Dinda, AK; Gupta, P; Rawal, S; Yadav, HN, 2022) |
| "The present study explored the synergetic effects of berberine and 6-shogaol, the primary components of Coptidis Rhizoma and Zingiberis Rhizoma, respectively, on intestinal inflammation and intestinal flora in mice with ulcerative colitis to reveal the effect and mechanism of cold-heat combination in the treatment of ulcerative colitis." | 4.12 | [Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis]. ( Chen, ZG; Li, JT; Wei, HL; Yan, SG, 2022) |
| "Berberine (BBR), an alkaloid produced by a traditional Chinese plant, was recently attributed multiple effects on lipometabolism, inflammation, and fibrosis." | 4.12 | Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts. ( Chen, X; Diao, J; Ma, X; Mou, P; Wei, R, 2022) |
| "The role of berberine in low shear stress-induced vascular endothelial inflammation was investigated in human umbilical vein endothelial cells (HUVECs) using a plate flow chamber in vitro and in mice with an established LSS model by partial ligation of the carotid artery in vivo." | 4.12 | Berberine inhibits low shear stress-induced vascular endothelial inflammation via decreasing phosphorylation of Akt and IRF3. ( Chen, S; Gu, Y; Kong, C; Lv, Y; Qian, Z; Wang, D; Yang, H; Ye, P; Zhou, W; Zhu, L, 2022) |
| "This study focuses on constructing of an anti-inflammatory drug delivery system by encapsulation of berberine in the β-glucan nanoparticles and evaluates its effect on treating ulcerative colitis." | 4.12 | Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis. ( Chen, Q; Fan, Y; Huang, J; Liang, M; Long, H; Wang, Y; Wang, Z; Wu, C; Xu, Y, 2022) |
| " It is widely reported that berberine (BBR) has an anti-inflammatory effect and can reduce glucose and lipid accumulation, whereas ginsenoside Rb1 (Rb1) has been shown to have a significant inhibitory effect on insulin resistance and lipid peroxidation." | 4.02 | Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. ( Cai, Z; Chen, Y, 2021) |
| "This study aimed to explore the protective actions of berberine on inflammation, and alveolar bone loss in ligature-induced periodontitis, as well as its mechanism of action METHODS: Micro-computed tomography was conducted to analyze the alveolar bone loss, and hematoxylin and eosin staining was carried out to observe the histopathological changes and inflammation status." | 4.02 | Berberine suppresses bone loss and inflammation in ligature-induced periodontitis through promotion of the G protein-coupled estrogen receptor-mediated inactivation of the p38MAPK/NF-κB pathway. ( Gan, J; Gu, L; Ke, Y; Li, X, 2021) |
| "Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats. ( Chen, HB; Chen, JN; Dou, YX; Huang, XQ; Huang, ZW; Li, QP; Li, YC; Liu, YH; Su, ZR; Xie, JH; Yang, XB; Zeng, HF, 2021) |
| "The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)." | 3.96 | Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020) |
| " Berberine is an isoquinoline plant alkaloid with remarkable antioxidant and anti-inflammation roles, which is used in ethnic medicines, including traditional Chinese and North American medicine." | 3.96 | Berberine Inhibits MDA-MB-231 Cells by Attenuating Their Inflammatory Responses. ( Zhang, C; Zhao, L, 2020) |
| " Although berberine, an isoquinoline alkaloid, has been revealed to exert protective effects on experimental colitis, the underlying molecular mechanism in chronic intestinal inflammation remains ill-defined." | 3.96 | Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis. ( Fan, C; Feng, C; He, P; Li, H; Lu, H; Lu, Q; Tang, W; Xiang, C; Yang, X; Yang, Y; Zhang, Z; Zhu, F; Zuo, J, 2020) |
| "Berberine has been established as a potential drug for inflammation and metabolic disorder." | 3.96 | Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu. ( Fan, DH; Han, YB; Li, WZ; Liu, L; Tian, M; Wang, XX; Wu, F, 2020) |
| "This study was designed to investigate the molecular mechanisms underlying the anti-inflammatory and anti-fibrosis effects of Berberine hydrochloride (BBR) following canalicular laceration (CL) surgical repair." | 3.96 | Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits. ( Bai, F; Huang, Y; Liu, C; Tao, H; Wang, F; Wang, L; Wang, P; Zhou, X, 2020) |
| "This study aimed to investigate the protective effects of berberine (BBR) against D-galactose (D-gal)-induced renal aging in rats, pointing to its ability to modulate phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt signalling, and to attenuate oxidative stress, inflammation and apoptosis." | 3.96 | Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. ( El-Horany, HE; Gaballah, HH; Helal, DS, 2020) |
| "Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease (COPD), its underlying mechanisms were not clear until now." | 3.91 | Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway. ( Li, CN; Wang, W; Wang, X; Wu, XJ; Zha, G; Zou, JJ, 2019) |
| "The present study was performed to show the ameliorative effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, against experimental varicocele (VCL)-induced molecular and histological damages." | 3.91 | Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation. ( Hassani-Bafrani, H; Najaran, H; Rashtbari, H; Razi, M, 2019) |
| "Berberine (BBR) possesses many pharmacological characteristics including anti-inflammation, anti-allergy, anti-angiogenesis and anti-tumor." | 3.91 | Berberine suppresses IL-33-induced inflammatory responses in mast cells by inactivating NF-κB and p38 signaling. ( Fan, H; Li, W; Tao, W; Wang, Q; Wang, Z; Yin, N, 2019) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 3.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| "Berberine has multiple clinical applications, including the treatment of tumors, diabetes, cardiovascular diseases, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemic injuries, mental diseases, Alzheimer's disease and osteoporosis." | 3.88 | Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression. ( Wang, J; Zhang, Y, 2018) |
| "This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility." | 3.88 | The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress. ( Attia, R; Ghareeb, DA; Saleh, SR, 2018) |
| "Berberine is a natural product that shows benefits for metabolic syndrome (MS)." | 3.81 | Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome. ( Gao, HQ; Ji, XP; Li, CB; Li, XX; Wang, HW; Xiao, J; Zhang, C; Zhang, XY, 2015) |
| " Berberine (BBR), a compound long used in traditional Chinese medicines, has been reported to have therapeutic effects in treating experimental colitis." | 3.81 | Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation. ( Chen, G; Cheng, W; Li, C; Li, S; Niu, X; Wang, Z; Xi, Y; Zhao, Q; Zhong, J, 2015) |
| "Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway." | 3.79 | Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. ( Du, GH; Fang, LH; Gong, LL; Guo, J; Li, L; Qin, HL; Wang, SB; Wu, YJ; Xu, XN; Yan, Y; Yuan, TY, 2013) |
| "Our data indicated berberine is a potent suppressor of neuroflammation, presumably through inhibition of NF-κB activation, and suggested berberine has therapeutic potential for the treatment of neuroinflammation that is involved in neurological diseases such as AD." | 3.78 | Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. ( Chen, L; Cui, X; Jia, L; Liu, J; Pan, X; Song, Z; Wang, M, 2012) |
| "The present results suggest that berberine inhibits dyslipidemia in C57BL/6 mice with LPS induced inflammation through regulating PCSK9-LDLR pathway." | 3.78 | Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. ( Sun, ZL; Xiao, HB; Zhang, DS; Zhang, HB, 2012) |
| " 2) Mice with xylene-induced acute exudative edema and acetic acid-induced writhing." | 3.77 | Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid. ( Guo, Z; Li, C; Li, Q; Li, Y; Liu, L; Long, Y; Mei, Q; Niu, Y; Sun, Y; Wang, Y; Wu, H; Zhang, M, 2011) |
| "Berberine, a major isoquinoline alkaloid present in Chinese herb Rhizoma coptidis, is a potent inhibitor of inflammation and has anti-diabetic activity." | 3.77 | Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. ( Huang, F; Li, L; Liu, B; Liu, K; Lou, T; Xi, Z; Zhang, Z, 2011) |
| "The up-regulation of JAK3/STATs was closely correlated with acute arthritic inflammation and that inhibition of JAK3 activity by JAK3 antagonists, such as berberine chloride, alleviated the inflammation in vivo." | 3.77 | Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. ( Bach, EA; Baeg, GH; Hahm, DH; Jee, JG; Kim, BH; Kim, M; Lee, H; Sandoval, C; Yin, CH, 2011) |
| "Berberine, which is a major constituent of the rhizome of Coptidis japonica (CJ), inhibits IL-8 production in colonic epithelial cells and improves 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice." | 3.76 | Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation. ( Hyun, YJ; Kim, DH; Lee, IA, 2010) |
| "Berberine (BBR) is an alkaloid extracted from the family Berberidacea." | 2.82 | The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress. ( Hayes, AW; Karimi, G; Yarmohammadi, F, 2022) |
| "Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation." | 2.82 | Effects of Berberine against Pancreatitis and Pancreatic Cancer. ( Gagacev, F; O'Neill, EJ; Tsiani, E; Vlavcheski, F, 2022) |
| "1." | 2.77 | Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. ( Cao, JT; Huang, ZQ; Li, YG; Meng, S; Sun, YG; Wang, CQ; Wang, LS; Zhou, Q, 2012) |
| "Berberine (BBR) has shown efficacy in treating inflammatory diseases." | 1.91 | Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye. ( Guo, S; Han, Y; Hu, J; Huang, C; Li, C; Li, J; Li, Y; Liu, Y; Liu, Z; Lv, Y; Yu, D; Zheng, L; Zhu, L, 2023) |
| "Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties." | 1.72 | Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation. ( Celik, H; Comakli, S; Gur, C; Kandemir, FM; Kucukler, S; Ozdemir, S; Yardim, A, 2022) |
| "Berberine (BBR) is an effective drug for UC treatment." | 1.72 | Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway. ( Dong, Y; Fan, H; Fu, Y; Gui, Y; Guo, W; Hu, D; Jiang, F; Kang, Z; Li, J; Li, M; Luo, S; Sarapultsev, A; Shou, Z; Wang, H; Zhang, G; Zhang, Z; Zhou, H; Zhu, R, 2022) |
| "Berberine has myocardial protective effects." | 1.72 | Berberine alleviates myocardial ischemia-reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction. ( Jia, X; Shao, W; Tian, S, 2022) |
| "Berberine (Ber) is an isoquinoline alkaloid that has shown therapeutic potential in mice with chronic obstructive pulmonary disease (COPD)." | 1.72 | Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats. ( Li, D; Li, Y; Liu, H; Shi, M; Wang, Y; Zhang, X, 2022) |
| " Moreover, the thick colonic mucus layer obstructs the penetration of the drug, resulting in low bioavailability to the inflammatory site of the colon." | 1.72 | Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis. ( Chen, S; Fang, W; Gao, S; Hu, R; Lu, W; Nie, X; Sun, L; Zhang, Q, 2022) |
| "Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia." | 1.72 | Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE ( Hu, C; Ma, C; Man, B; Xiang, J; Yang, G; Yang, S, 2022) |
| "Berberine (BBR) has many pharmacological properties and is used as an insulin sensitizer." | 1.62 | Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis. ( Li, XL; Shen, HR; Xu, X, 2021) |
| "Berberine (BBR) has attracted much interest because of its anti-oxidative, anti-inflammatory and anti-apoptotic actions." | 1.62 | Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats. ( El-Demerdash, E; El-Derany, MO; El-Mesallamy, HO; Shaker, FH; Wahdan, SA, 2021) |
| "Berberine is a well-known quaternary ammonium salt that is usually found in the roots of such plants as Phellodendron amurense and Coptis chinensis." | 1.62 | Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway. ( Kim, HJ; Kim, YJ; Park, W, 2021) |
| "Berberine (BBR) is an alkaloid extracted from Coptidis Rhizoma, also known as Huang-Lian." | 1.62 | Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology. ( Chen, L; Ho, PC; Lian, XL; Lim, MEJ; Shen, W; Tan, EA; Wang, Y; Wong, LR, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide." | 1.56 | Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway. ( Chen, Z; He, B; Lu, Z; Wu, L; Yan, M, 2020) |
| "Chronic inflammation is known to promote carcinogenesis; Dicer heterozygous mice are more likely to develop colitis-associated tumors." | 1.56 | Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis. ( Chen, X; Gao, J; He, Q; He, ZW; Jin, Y; Lei, Y; Liu, H; Ou, R; Song, G; Tang, KF; Wang, WY; Wang, Z; Wei, LJ; Wu, X; Xu, Y; Yang, W; Zhang, Z; Zhong, S; Zhou, L, 2020) |
| "Berberine (BBR) is an isoquinoline alkaloid found in numerous types of medicinal plants, which has been clinically used in China to treat symptoms of gastrointestinal pathogenic bacterial infection, especially bacteria‑induced diarrhea and inflammation." | 1.56 | Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics. ( Ma, L; Qin, W; Xi, C; Xu, B; Xu, X; Yan, Y; Yin, B; Zhang, L; Zhao, Y, 2020) |
| "Berberine is an isoquinoline alkaloid in Berberis genus with antioxidant and anti-inflammatory property and protective effects in neurodegenerative disorders." | 1.51 | Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms. ( Afshin-Majd, S; Azimi, S; Baluchnejadmojarad, T; Kiasalari, Z; Razavian, M; Roghani, M; Sadraie, S; Sedighnejad, L, 2019) |
| "Berberine (BBR) has been reported to ameliorate diabetes and diabetic encephalopathy (DE)." | 1.48 | Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. ( Chen, YB; Cheng, SY; Fang, JS; Hao, XY; Li, HY; Luo, NC; Luo, S; Wang, Q; Wang, XC; Xu, YM; Zhang, SJ, 2018) |
| " NAFLD model was established by high fat food, and rats were administrated with lovastatin, berberine, curcumin, berberine + curcumin at the dosage of 100, 100, 100, 50 + 50 mg/kg bw, respectively." | 1.48 | Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin. ( Feng, WW; Kuang, SY; Liu, TS; Ma, ZJ; Pang, JY; Tu, C; Wang, JB; Wang, YH; Xiao, XH; Zang, QC; Zhao, YL, 2018) |
| " In summary, BB exerted similar effect to its analogue BBR and positive control in attenuating DSS-induced UC with much lower dosage and similar mechanism." | 1.48 | Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. ( Chen, JP; Huang, YF; Li, HL; Qu, C; Su, ZR; Xu, LQ; Xu, YF; Yi, TG; Yu, XT; Zeng, HF; Zhang, XJ; Zheng, L, 2018) |
| "Berberine (BBR) is a natural alkaloid derived from traditional medicine Rhizoma Coptidis and possesses various pharmacological properties." | 1.48 | Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice. ( Hua, W; Liu, X; Liu, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "Berberine is an isoquinoline derivative alkaloid with anti-inflammatory activity." | 1.48 | The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses. ( Barati, E; Fazel Nasab, N; Jalilvand, T; Mahdavi Siuki, M; Namdar Ahmadabad, H; Nezafat Firizi, M, 2018) |
| " Moreover, KRN2 and KRN5, the latter of which exhibits high oral bioavailability and metabolic stability, ameliorated experimentally induced arthritis in mice without serious adverse effects, decreasing pro-inflammatory cytokine production." | 1.46 | Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. ( Cho, CS; Cho, H; De, TQ; Han, EJ; Jeong, DY; Jue, DM; Kim, HY; Kim, NH; Kim, WU; Kwon, HM; Lee, GH; Lee, N; Lim, HJ; Park, WK; Park, YJ; Yoo, SA, 2017) |
| "Berberine was orally administrated in normal or CUMS mice for successive four weeks." | 1.46 | Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. ( Bai, L; Fang, XY; Li, YC; Liu, YM; Niu, L; Wang, LL; Yi, LT, 2017) |
| "Berberine chloride (BC) has been widely used as an unprescribed oral drug in China for the treatment of various diseases, and it is an active ingredient in many traditionally used medicinal plants." | 1.46 | Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. ( Chandirasegaran, G; Elanchezhiyan, C; Ghosh, K; Sethupathy, S, 2017) |
| "Chronic inflammation is a major contributing factor in the pathogenesis of many diseases." | 1.46 | Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells. ( Shan, Y; Shang, W; Wu, Y; Xu, C; Yan, J; Yu, X; Zhang, H; Zhao, J, 2017) |
| "Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)." | 1.46 | Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017) |
| "Berberine (BBR) is a natural compound derived from some medicinal plants, and accumulating evidence has shown its potent anti-tumor activity with diverse action on tumor cells, including inducing cancer cell death and blocking cell cycle and migration." | 1.43 | Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. ( Cao, F; Feng, Y; Li, H; Liu, M; Tan, Y; Wang, N; Wang, X; Xiang, L; Yu, X; Zhang, J, 2016) |
| "Berberine, which is a well‑known drug used in traditional medicine, has been demonstrated to exert diverse pharmacological effects, including anti‑inflammatory effects." | 1.42 | Berberine inhibits tumor necrosis factor-α-induced expression of inflammatory molecules and activation of nuclear factor-κB via the activation of AMPK in vascular endothelial cells. ( Ding, MC; Liu, SJ; Wang, H; Wang, YZ; Yin, CX, 2015) |
| "Rats with renal artery stenosis were randomly assigned to two groups (n = 6 each) - ARD, or ARD+BBR - according to diet alone or in combination with BBR." | 1.39 | Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats. ( Cao, CC; Chen, W; Chen, X; Huang, WJ; Liu, L; Miao, GG; Wan, X; Xie, HG; Zhang, Q; Zhao, Y, 2013) |
| "Berberine has the protective effect in Abeta-induced inflammatory injury in SH-SY5Y cells." | 1.39 | [Intervention effect of berberine on expressions of TNF-alpha and receptor type I in Abeta25-35-induced inflammatory reaction in SH-SY5Y cell lines]. ( Xu, J; Yang, F; Yu, JX; Zhang, H, 2013) |
| "Berberine (BBR) has been shown to improve several metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia, by stimulating AMP-activated protein kinase (AMPK)." | 1.35 | Berberine suppresses proinflammatory responses through AMPK activation in macrophages. ( Ham, M; Hsu, KC; Huh, JY; Jeong, HW; Kim, JB; Kim, WS; Lee, JW; Shin, HJ, 2009) |
| "Pulmonary inflammation is a characteristic of many lung diseases." | 1.34 | Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells. ( Chen, JC; Ho, TY; Hsiang, CY; Lee, CH; Wu, HC; Wu, SL, 2007) |
| "Glycerol secretion was increased, whereas expression of lipolytic enzymes (hormone-sensitive lipase and perilipin) mRNA was slightly decreased." | 1.33 | Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. ( Ahn, IS; Choi, BH; Do, MS; Hyun, CK; Kim, YH; Lee, SY; Park, JW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.65) | 18.7374 |
| 1990's | 2 (1.30) | 18.2507 |
| 2000's | 4 (2.60) | 29.6817 |
| 2010's | 67 (43.51) | 24.3611 |
| 2020's | 80 (51.95) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, H | 1 |
| Rengasamy, KRR | 1 |
| Pervaiz, A | 1 |
| Nabavi, SM | 1 |
| Atanasov, AG | 1 |
| Kamal, MA | 1 |
| Li, B | 3 |
| Niu, S | 1 |
| Geng, H | 1 |
| Yang, C | 2 |
| Zhao, C | 1 |
| Rondanelli, M | 1 |
| Riva, A | 1 |
| Petrangolini, G | 1 |
| Allegrini, P | 1 |
| Giacosa, A | 1 |
| Fazia, T | 1 |
| Bernardinelli, L | 1 |
| Gasparri, C | 1 |
| Peroni, G | 1 |
| Perna, S | 1 |
| Sarbadhikary, P | 1 |
| George, BP | 1 |
| Abrahamse, H | 1 |
| Cai, Z | 2 |
| Chen, Y | 4 |
| Liang, Y | 1 |
| Zhang, T | 2 |
| Zhao, J | 2 |
| Li, C | 5 |
| Zou, H | 1 |
| Li, F | 4 |
| Zhang, J | 4 |
| Ren, L | 1 |
| Guo, Q | 1 |
| Wang, C | 2 |
| Xue, X | 1 |
| Hu, B | 1 |
| Bao, H | 1 |
| Wu, X | 7 |
| Liu, X | 4 |
| Yang, L | 3 |
| Wang, Y | 11 |
| Bakshi, J | 1 |
| Lathar, P | 1 |
| Mehra, M | 1 |
| Grewal, S | 1 |
| Dhingra, D | 1 |
| Kumari, S | 1 |
| Lu, Q | 2 |
| Fu, Y | 2 |
| Li, H | 4 |
| Yardim, A | 1 |
| Gur, C | 1 |
| Comakli, S | 1 |
| Ozdemir, S | 1 |
| Kucukler, S | 1 |
| Celik, H | 1 |
| Kandemir, FM | 1 |
| Lee, CK | 1 |
| Zhang, S | 1 |
| Venkatesan, G | 1 |
| Chong, SY | 1 |
| Wang, JW | 1 |
| Goh, WJ | 1 |
| Panczyk, T | 1 |
| Tay, YZ | 1 |
| Hu, J | 2 |
| Ng, WK | 1 |
| Wacker, MG | 1 |
| Toh, WS | 1 |
| Pastorin, G | 1 |
| Deng, J | 1 |
| Zhao, L | 5 |
| Yuan, X | 1 |
| Li, Y | 5 |
| Shi, J | 1 |
| Zhang, H | 3 |
| Zhao, Y | 4 |
| Han, L | 1 |
| Wang, H | 6 |
| Yan, Y | 3 |
| Zhao, H | 1 |
| Zou, F | 1 |
| Sharma, A | 2 |
| Tirpude, NV | 1 |
| Bhardwaj, N | 1 |
| Kumar, D | 1 |
| Padwad, Y | 2 |
| Dong, Y | 1 |
| Fan, H | 3 |
| Zhang, Z | 6 |
| Jiang, F | 1 |
| Li, M | 2 |
| Zhou, H | 2 |
| Guo, W | 1 |
| Kang, Z | 1 |
| Gui, Y | 1 |
| Shou, Z | 1 |
| Li, J | 4 |
| Zhu, R | 1 |
| Sarapultsev, A | 1 |
| Luo, S | 2 |
| Zhang, G | 1 |
| Hu, D | 1 |
| Jia, X | 2 |
| Shao, W | 1 |
| Tian, S | 1 |
| Lu, Y | 2 |
| Zhang, X | 5 |
| He, J | 1 |
| Dai, Z | 1 |
| Shi, P | 1 |
| Chang, F | 1 |
| Ke, X | 1 |
| Zhang, R | 2 |
| Li, P | 1 |
| Zuo, L | 1 |
| Wang, M | 4 |
| Yang, J | 1 |
| Wang, J | 4 |
| Liu, H | 5 |
| Shi, M | 1 |
| Li, D | 2 |
| Wu, YH | 1 |
| Wei, CY | 1 |
| Hong, WC | 1 |
| Pang, JS | 1 |
| Alorabi, M | 1 |
| Cavalu, S | 1 |
| Al-Kuraishy, HM | 1 |
| Al-Gareeb, AI | 1 |
| Mostafa-Hedeab, G | 1 |
| Negm, WA | 1 |
| Youssef, A | 1 |
| El-Kadem, AH | 1 |
| Saad, HM | 1 |
| Batiha, GE | 1 |
| Rawal, S | 1 |
| Gupta, P | 1 |
| Bhatnagar, P | 1 |
| Yadav, HN | 1 |
| Dinda, AK | 2 |
| Sun, L | 1 |
| Nie, X | 1 |
| Lu, W | 1 |
| Zhang, Q | 3 |
| Fang, W | 1 |
| Gao, S | 1 |
| Chen, S | 3 |
| Hu, R | 1 |
| Yarmohammadi, F | 1 |
| Hayes, AW | 1 |
| Karimi, G | 1 |
| Man, B | 1 |
| Hu, C | 1 |
| Yang, G | 1 |
| Xiang, J | 2 |
| Yang, S | 1 |
| Ma, C | 1 |
| Wei, HL | 1 |
| Li, JT | 1 |
| Chen, ZG | 1 |
| Yan, SG | 1 |
| Diao, J | 1 |
| Chen, X | 3 |
| Mou, P | 1 |
| Ma, X | 4 |
| Wei, R | 1 |
| Liu, Q | 2 |
| Tang, J | 1 |
| Hu, S | 1 |
| Shen, C | 1 |
| Chen, N | 1 |
| Zhang, Y | 10 |
| Zeng, J | 1 |
| Naz, I | 1 |
| Masoud, MS | 1 |
| Chauhdary, Z | 1 |
| Shah, MA | 1 |
| Panichayupakaranant, P | 1 |
| Dang, WT | 1 |
| Xu, D | 1 |
| Zhou, JG | 1 |
| Lv, Y | 2 |
| Yang, H | 1 |
| Ye, P | 1 |
| Qian, Z | 1 |
| Wang, D | 3 |
| Kong, C | 1 |
| Gu, Y | 1 |
| Zhou, W | 1 |
| Zhu, L | 2 |
| Li, X | 8 |
| Xu, S | 2 |
| Li, K | 2 |
| Gao, XJ | 1 |
| Guo, MY | 1 |
| Xu, Y | 4 |
| Huang, J | 3 |
| Fan, Y | 3 |
| Long, H | 3 |
| Liang, M | 3 |
| Chen, Q | 3 |
| Wang, Z | 10 |
| Wu, C | 3 |
| Long, T | 3 |
| Pan, W | 3 |
| Sheikh, SA | 3 |
| Xie, Q | 3 |
| Zhang, C | 6 |
| Vlavcheski, F | 2 |
| O'Neill, EJ | 2 |
| Gagacev, F | 2 |
| Tsiani, E | 2 |
| Luo, Z | 2 |
| Li, Z | 2 |
| Liang, Z | 2 |
| Wang, L | 5 |
| He, G | 2 |
| Shen, L | 2 |
| Geng, F | 2 |
| Liu, W | 4 |
| Zhu, C | 1 |
| Peng, XX | 1 |
| Yao, TJ | 1 |
| Wang, ZY | 1 |
| Hu, P | 1 |
| Cai, D | 1 |
| Liu, HY | 1 |
| Dehau, T | 1 |
| Cherlet, M | 1 |
| Croubels, S | 1 |
| van Immerseel, F | 1 |
| Goossens, E | 1 |
| Ye, C | 1 |
| Lin, S | 1 |
| Feng, H | 1 |
| Fang, G | 1 |
| Quan, S | 1 |
| He, H | 1 |
| Chai, X | 1 |
| Ye, X | 2 |
| Ma, H | 3 |
| Ding, W | 1 |
| Gu, Q | 1 |
| Liu, M | 2 |
| Zou, J | 2 |
| Sun, J | 1 |
| Zhu, J | 2 |
| Bai, Y | 2 |
| Ma, Y | 1 |
| Liu, L | 5 |
| Xing, R | 1 |
| Xue, J | 1 |
| Fan, J | 1 |
| Song, X | 1 |
| Jia, R | 1 |
| Zou, Y | 1 |
| Li, L | 4 |
| Zhou, X | 3 |
| Lv, C | 1 |
| Wan, H | 1 |
| Zhao, X | 2 |
| Yin, Z | 1 |
| Xu, H | 2 |
| Sun, H | 1 |
| Han, J | 1 |
| Sun, X | 1 |
| Dong, X | 1 |
| Xu, R | 1 |
| Chen, Z | 6 |
| Du, M | 1 |
| Tang, P | 1 |
| Lin, Y | 1 |
| Han, W | 1 |
| Phogat, A | 1 |
| Singh, J | 1 |
| Kumar, V | 1 |
| Malik, V | 1 |
| Wu, H | 3 |
| Xie, X | 2 |
| Tang, Q | 1 |
| Huang, T | 1 |
| Tang, X | 1 |
| Jiao, B | 1 |
| Wang, R | 1 |
| Zhu, X | 2 |
| Huang, Y | 2 |
| Chen, F | 2 |
| Su, K | 1 |
| Zhao, M | 2 |
| Tao, W | 2 |
| Han, Y | 1 |
| Guo, S | 1 |
| Liu, Y | 3 |
| Yu, D | 1 |
| Zheng, L | 2 |
| Huang, C | 1 |
| Liu, Z | 1 |
| Tan, E | 1 |
| Gao, Z | 2 |
| Wang, Q | 3 |
| Han, B | 1 |
| Shi, H | 1 |
| Zhu, G | 1 |
| Hou, Y | 1 |
| Cao, DW | 1 |
| Liu, MM | 1 |
| Duan, R | 1 |
| Tao, YF | 1 |
| Zhou, JS | 1 |
| Fang, WR | 1 |
| Zhu, JR | 1 |
| Niu, L | 2 |
| Sun, JG | 1 |
| Beba, M | 1 |
| Djafarian, K | 1 |
| Shab-Bidar, S | 1 |
| Wu, Y | 2 |
| Huang, X | 1 |
| Yu, Z | 1 |
| Liu, J | 2 |
| Wang, W | 1 |
| Zha, G | 1 |
| Zou, JJ | 1 |
| Wang, X | 3 |
| Li, CN | 1 |
| Wu, XJ | 1 |
| Dai, X | 1 |
| Ding, M | 1 |
| Zhang, W | 1 |
| Xuan, Z | 1 |
| Liang, J | 1 |
| Yang, D | 1 |
| Su, B | 1 |
| Zhu, H | 1 |
| Wang, RH | 1 |
| Zhou, R | 1 |
| Ding, Y | 1 |
| Zhou, ZX | 1 |
| Kim, DG | 1 |
| Choi, JW | 1 |
| Jo, IJ | 1 |
| Kim, MJ | 1 |
| Lee, HS | 1 |
| Hong, SH | 1 |
| Song, HJ | 1 |
| Bae, GS | 1 |
| Park, SJ | 1 |
| Zhang, P | 1 |
| He, L | 1 |
| Mei, X | 1 |
| Tian, H | 1 |
| Song, J | 1 |
| Wu, Q | 1 |
| Jiang, J | 2 |
| Sun, D | 1 |
| Wang, F | 2 |
| Xin, B | 1 |
| Cui, Q | 1 |
| Tew, XN | 1 |
| Xin Lau, NJ | 1 |
| Chellappan, DK | 1 |
| Madheswaran, T | 1 |
| Zeeshan, F | 1 |
| Tambuwala, MM | 1 |
| Aljabali, AA | 1 |
| Balusamy, SR | 1 |
| Perumalsamy, H | 1 |
| Gupta, G | 1 |
| Oliver, BG | 1 |
| Hsu, A | 1 |
| Wark, P | 1 |
| Reddy, K | 1 |
| Wadhwa, R | 1 |
| Hansbro, PM | 1 |
| Dua, K | 1 |
| Kumar, R | 1 |
| Awasthi, M | 1 |
| Sharma, R | 1 |
| Verma, VK | 1 |
| Malik, S | 1 |
| Mutneja, E | 1 |
| Sahu, AK | 1 |
| Rupashi, K | 1 |
| Arya, DS | 1 |
| Bhatia, J | 1 |
| Feng, C | 1 |
| Fan, C | 1 |
| Yang, Y | 2 |
| Yang, X | 2 |
| Lu, H | 1 |
| Zhu, F | 1 |
| Xiang, C | 1 |
| He, P | 1 |
| Zuo, J | 1 |
| Tang, W | 1 |
| Zhao, D | 1 |
| Gurley, EC | 1 |
| Liu, R | 1 |
| Hylemon, PB | 1 |
| Chen, W | 2 |
| Lu, Z | 1 |
| He, B | 1 |
| Yan, M | 1 |
| Wu, L | 2 |
| He, ZW | 1 |
| Wei, LJ | 1 |
| Wang, WY | 1 |
| Zhong, S | 1 |
| He, Q | 1 |
| Ou, R | 1 |
| Gao, J | 1 |
| Lei, Y | 1 |
| Yang, W | 1 |
| Song, G | 1 |
| Jin, Y | 1 |
| Zhou, L | 1 |
| Tang, KF | 1 |
| Li, G | 1 |
| Wang, T | 1 |
| Zhao, S | 1 |
| Wu, J | 1 |
| Peng, S | 1 |
| Han, YB | 1 |
| Tian, M | 1 |
| Wang, XX | 1 |
| Fan, DH | 1 |
| Li, WZ | 1 |
| Wu, F | 1 |
| Asbaghi, O | 1 |
| Ghanbari, N | 1 |
| Shekari, M | 1 |
| Reiner, Ž | 1 |
| Amirani, E | 1 |
| Hallajzadeh, J | 1 |
| Mirsafaei, L | 1 |
| Asemi, Z | 1 |
| Bai, F | 1 |
| Tao, H | 1 |
| Wang, P | 2 |
| Liu, C | 1 |
| Ehteshamfar, SM | 1 |
| Akhbari, M | 1 |
| Afshari, JT | 1 |
| Seyedi, M | 1 |
| Nikfar, B | 1 |
| Shapouri-Moghaddam, A | 1 |
| Ghanbarzadeh, E | 1 |
| Momtazi-Borojeni, AA | 1 |
| Xu, X | 2 |
| Zhang, L | 2 |
| Xu, B | 1 |
| Qin, W | 1 |
| Yin, B | 1 |
| Xi, C | 1 |
| Ma, L | 1 |
| Dai, Q | 1 |
| He, X | 1 |
| Yu, H | 1 |
| Jiang, L | 1 |
| Sheng, H | 1 |
| Peng, J | 2 |
| Yu, J | 1 |
| Zhang, K | 1 |
| Gu, L | 1 |
| Ke, Y | 1 |
| Gan, J | 1 |
| Bhatia, E | 1 |
| Sharma, S | 1 |
| Jadhav, K | 1 |
| Banerjee, R | 1 |
| Shen, HR | 1 |
| Li, XL | 1 |
| Shaker, FH | 1 |
| El-Derany, MO | 1 |
| Wahdan, SA | 1 |
| El-Demerdash, E | 1 |
| El-Mesallamy, HO | 1 |
| Li, QP | 1 |
| Dou, YX | 1 |
| Huang, ZW | 1 |
| Chen, HB | 1 |
| Li, YC | 2 |
| Chen, JN | 1 |
| Liu, YH | 1 |
| Huang, XQ | 1 |
| Zeng, HF | 2 |
| Yang, XB | 1 |
| Su, ZR | 2 |
| Xie, JH | 1 |
| Kim, HJ | 1 |
| Kim, YJ | 1 |
| Park, W | 1 |
| Šudomová, M | 1 |
| Berchová-Bímová, K | 1 |
| Marzocco, S | 1 |
| Liskova, A | 1 |
| Kubatka, P | 1 |
| Hassan, STS | 1 |
| Hassanein, EHM | 1 |
| Kamel, EO | 1 |
| Ali, FEM | 1 |
| Ahmed, MA | 1 |
| Wong, LR | 1 |
| Tan, EA | 1 |
| Lim, MEJ | 1 |
| Shen, W | 1 |
| Lian, XL | 1 |
| Chen, L | 2 |
| Ho, PC | 1 |
| Tang, M | 1 |
| Yuan, D | 1 |
| Liao, P | 1 |
| Ibrahim Fouad, G | 1 |
| Ahmed, KA | 1 |
| Zhu, JZ | 1 |
| Lopez, E | 1 |
| Tong, Q | 1 |
| Peng, C | 1 |
| Lin, LG | 1 |
| Han, EJ | 1 |
| Kim, HY | 1 |
| Lee, N | 1 |
| Kim, NH | 1 |
| Yoo, SA | 1 |
| Kwon, HM | 1 |
| Jue, DM | 1 |
| Park, YJ | 1 |
| Cho, CS | 1 |
| De, TQ | 1 |
| Jeong, DY | 1 |
| Lim, HJ | 1 |
| Park, WK | 1 |
| Lee, GH | 1 |
| Cho, H | 1 |
| Kim, WU | 1 |
| McCubrey, JA | 1 |
| Lertpiriyapong, K | 1 |
| Steelman, LS | 1 |
| Abrams, SL | 1 |
| Cocco, L | 1 |
| Ratti, S | 1 |
| Martelli, AM | 1 |
| Candido, S | 1 |
| Libra, M | 1 |
| Montalto, G | 1 |
| Cervello, M | 1 |
| Gizak, A | 1 |
| Rakus, D | 1 |
| Brown, BI | 1 |
| Li, HY | 1 |
| Wang, XC | 1 |
| Xu, YM | 1 |
| Luo, NC | 1 |
| Hao, XY | 1 |
| Cheng, SY | 1 |
| Fang, JS | 1 |
| Zhang, SJ | 1 |
| Chen, YB | 1 |
| Liu, YM | 1 |
| Wang, LL | 1 |
| Bai, L | 1 |
| Fang, XY | 1 |
| Yi, LT | 1 |
| Chandirasegaran, G | 1 |
| Elanchezhiyan, C | 1 |
| Ghosh, K | 1 |
| Sethupathy, S | 1 |
| Shan, Y | 1 |
| Xu, C | 1 |
| Yu, X | 2 |
| Yan, J | 1 |
| Shang, W | 1 |
| Cao, H | 1 |
| Liao, S | 1 |
| Zhong, W | 1 |
| Xiao, X | 1 |
| Li, W | 2 |
| Feng, Y | 2 |
| He, W | 1 |
| He, Y | 2 |
| Li, Q | 3 |
| Tong, X | 1 |
| Hussien, HM | 1 |
| Abd-Elmegied, A | 1 |
| Ghareeb, DA | 2 |
| Hafez, HS | 1 |
| Ahmed, HEA | 1 |
| El-Moneam, NA | 1 |
| Xu, L | 1 |
| Zheng, X | 1 |
| Fan, Q | 1 |
| Zhang, M | 3 |
| Li, R | 1 |
| Ye, J | 1 |
| Zhao, W | 1 |
| Feng, WW | 1 |
| Kuang, SY | 1 |
| Tu, C | 1 |
| Ma, ZJ | 1 |
| Pang, JY | 1 |
| Wang, YH | 1 |
| Zang, QC | 1 |
| Liu, TS | 1 |
| Zhao, YL | 1 |
| Xiao, XH | 1 |
| Wang, JB | 1 |
| Yu, XT | 1 |
| Xu, YF | 1 |
| Huang, YF | 1 |
| Qu, C | 1 |
| Xu, LQ | 1 |
| Yi, TG | 1 |
| Li, HL | 1 |
| Chen, JP | 1 |
| Zhang, XJ | 1 |
| Dinesh, P | 2 |
| Rasool, M | 2 |
| Lee, JW | 2 |
| Kang, YJ | 1 |
| Choi, HK | 1 |
| Yoon, YG | 1 |
| Oshima, N | 1 |
| Shimizu, T | 1 |
| Narukawa, Y | 1 |
| Hada, N | 1 |
| Kiuchi, F | 1 |
| Saleh, SR | 1 |
| Attia, R | 1 |
| Zhao, Z | 1 |
| Wei, Q | 1 |
| Hua, W | 1 |
| Zhu, Y | 1 |
| Geng, C | 1 |
| Hidru, TH | 1 |
| Zhi, L | 1 |
| Tao, M | 1 |
| Zou, L | 1 |
| Chen, C | 1 |
| Mahdavi Siuki, M | 1 |
| Fazel Nasab, N | 1 |
| Barati, E | 1 |
| Nezafat Firizi, M | 1 |
| Jalilvand, T | 1 |
| Namdar Ahmadabad, H | 1 |
| El-Horany, HE | 1 |
| Gaballah, HH | 1 |
| Helal, DS | 1 |
| Hassani-Bafrani, H | 1 |
| Najaran, H | 1 |
| Razi, M | 1 |
| Rashtbari, H | 1 |
| Pei, C | 1 |
| Zhang, B | 1 |
| Fang, L | 1 |
| Liu, B | 2 |
| Meng, S | 2 |
| Yin, N | 1 |
| Sadraie, S | 1 |
| Kiasalari, Z | 1 |
| Razavian, M | 1 |
| Azimi, S | 1 |
| Sedighnejad, L | 1 |
| Afshin-Majd, S | 1 |
| Baluchnejadmojarad, T | 1 |
| Roghani, M | 1 |
| Lin, J | 1 |
| Cai, Q | 1 |
| Liang, B | 1 |
| Zhuang, Y | 1 |
| Lin, W | 1 |
| Poudel, A | 1 |
| Zhou, JY | 1 |
| Mekala, N | 1 |
| Welchko, R | 1 |
| Rosca, MG | 1 |
| Jia, Q | 1 |
| Pei, F | 1 |
| Zhu, S | 1 |
| Sun, Q | 1 |
| Duan, L | 1 |
| Liu, G | 1 |
| Liang, X | 1 |
| Luo, Y | 1 |
| Shang, Y | 1 |
| Yang, JQ | 1 |
| Zhou, P | 1 |
| Gu, XL | 1 |
| Wan, X | 1 |
| Huang, WJ | 1 |
| Miao, GG | 1 |
| Xie, HG | 1 |
| Cao, CC | 1 |
| Xu, J | 2 |
| Yang, F | 1 |
| Yu, JX | 1 |
| Yao, J | 1 |
| Kong, W | 1 |
| Pund, S | 1 |
| Borade, G | 1 |
| Rasve, G | 1 |
| Guo, J | 1 |
| Wang, SB | 1 |
| Yuan, TY | 1 |
| Wu, YJ | 1 |
| Xu, XN | 1 |
| Gong, LL | 1 |
| Qin, HL | 1 |
| Fang, LH | 1 |
| Du, GH | 1 |
| Chen, CC | 1 |
| Hung, TH | 1 |
| Lee, CY | 1 |
| Wang, LF | 1 |
| Wu, CH | 1 |
| Ke, CH | 1 |
| Chen, SF | 1 |
| Li, XX | 1 |
| Li, CB | 1 |
| Xiao, J | 1 |
| Gao, HQ | 1 |
| Wang, HW | 1 |
| Zhang, XY | 1 |
| Ji, XP | 1 |
| Zou, ZY | 1 |
| Hu, YR | 1 |
| Wang, YZ | 2 |
| He, K | 1 |
| Xia, S | 1 |
| Xue, DF | 1 |
| Li, XG | 1 |
| Ye, XL | 1 |
| Liu, SJ | 1 |
| Yin, CX | 1 |
| Ding, MC | 1 |
| Xi, Y | 1 |
| Li, S | 1 |
| Zhao, Q | 1 |
| Cheng, W | 1 |
| Zhong, J | 2 |
| Niu, X | 1 |
| Chen, G | 1 |
| Chang, RC | 1 |
| Yu, L | 1 |
| Yu, B | 1 |
| Jin, Z | 1 |
| Duan, W | 1 |
| Zhao, G | 1 |
| Zhai, M | 1 |
| Yi, D | 1 |
| Chen, M | 1 |
| Yu, S | 1 |
| Ye, L | 1 |
| Yuan, H | 1 |
| Wang, N | 1 |
| Cao, F | 1 |
| Tan, Y | 1 |
| Xiang, L | 1 |
| Chen, T | 1 |
| Yi, T | 1 |
| Zheng, Z | 1 |
| Pandey, MK | 1 |
| Sung, B | 1 |
| Kunnumakkara, AB | 1 |
| Sethi, G | 1 |
| Chaturvedi, MM | 1 |
| Aggarwal, BB | 1 |
| Jeong, HW | 1 |
| Hsu, KC | 1 |
| Ham, M | 1 |
| Huh, JY | 1 |
| Shin, HJ | 1 |
| Kim, WS | 1 |
| Kim, JB | 1 |
| Shen, YB | 1 |
| Piao, XS | 1 |
| Kim, SW | 1 |
| Liu, P | 2 |
| Wu, M | 1 |
| Liu, LT | 1 |
| Lu, DY | 1 |
| Tang, CH | 1 |
| Chen, YH | 1 |
| Wei, IH | 1 |
| Jiang, Q | 1 |
| Shen, X | 1 |
| Lan, T | 1 |
| Huang, H | 1 |
| Lee, IA | 1 |
| Hyun, YJ | 1 |
| Kim, DH | 1 |
| Long, Y | 1 |
| Sun, Y | 1 |
| Guo, Z | 1 |
| Niu, Y | 1 |
| Mei, Q | 1 |
| Lou, T | 1 |
| Xi, Z | 1 |
| Liu, K | 1 |
| Huang, F | 1 |
| Kim, BH | 1 |
| Kim, M | 1 |
| Yin, CH | 1 |
| Jee, JG | 1 |
| Sandoval, C | 1 |
| Lee, H | 1 |
| Bach, EA | 1 |
| Hahm, DH | 1 |
| Baeg, GH | 1 |
| Hao, X | 1 |
| Yao, A | 1 |
| Gong, J | 1 |
| Zhu, W | 1 |
| Li, N | 1 |
| Ma, BL | 1 |
| Yao, MK | 1 |
| Ma, YM | 1 |
| Gao, CL | 1 |
| Wu, JS | 1 |
| Qiu, FR | 1 |
| Wang, CH | 1 |
| Wang, XH | 1 |
| Wang, LS | 1 |
| Huang, ZQ | 1 |
| Zhou, Q | 1 |
| Sun, YG | 1 |
| Cao, JT | 1 |
| Li, YG | 1 |
| Wang, CQ | 1 |
| Pang, X | 1 |
| Kang, C | 1 |
| Ning, G | 1 |
| Jia, L | 1 |
| Song, Z | 1 |
| Pan, X | 1 |
| Cui, X | 1 |
| Xiao, HB | 1 |
| Sun, ZL | 1 |
| Zhang, HB | 1 |
| Zhang, DS | 1 |
| Lee, D | 1 |
| Bae, J | 1 |
| Kim, YK | 1 |
| Gil, M | 1 |
| Lee, JY | 1 |
| Park, CS | 1 |
| Lee, KJ | 1 |
| Choi, BH | 1 |
| Ahn, IS | 1 |
| Kim, YH | 1 |
| Park, JW | 1 |
| Lee, SY | 1 |
| Hyun, CK | 1 |
| Do, MS | 1 |
| Lee, CH | 1 |
| Chen, JC | 1 |
| Hsiang, CY | 1 |
| Wu, SL | 1 |
| Wu, HC | 1 |
| Ho, TY | 1 |
| Ivanovska, N | 1 |
| Philipov, S | 1 |
| Akhter, MH | 1 |
| Sabir, M | 1 |
| Bhide, NK | 1 |
| Yasukawa, K | 1 |
| Takido, M | 1 |
| Ikekawa, T | 1 |
| Shimada, F | 1 |
| Takeuchi, M | 1 |
| Nakagawa, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention[NCT03378934] | Phase 4 | 64 participants (Anticipated) | Interventional | 2018-09-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for berberine and Inflammation
| Article | Year |
|---|---|
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
Topics: Animals; Anti-Inflammatory Agents; Biological Products; Drug Discovery; Enzyme Inhibitors; Humans; I | 2018 |
Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Humans; Inflammasomes; Inflammation; Metabolic Disease | 2021 |
Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders.
Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Berberine; Humans; Inflammation | 2022 |
The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials.
Topics: Berberine; Biomarkers; C-Reactive Protein; China; Cytokines; Humans; Inflammation; Metabolic Syndrom | 2022 |
The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress.
Topics: Antioxidants; Apoptosis; Berberine; Endoplasmic Reticulum Stress; Humans; Inflammation | 2022 |
Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects.
Topics: Anti-Bacterial Agents; Berberine; Carcinogenesis; Cytokines; Gastritis; Gastritis, Atrophic; Helicob | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy.
Topics: Anti-Inflammatory Agents; Berberine; Colitis, Ulcerative; Drug Repositioning; Humans; Inflammation; | 2022 |
Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide: molecular mechanisms and preclinical evidence.
Topics: Acute Lung Injury; Anti-Inflammatory Agents; Berberine; Humans; Inflammation; Lipopolysaccharides; L | 2023 |
Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.
Topics: Berberine; Biomarkers; C-Reactive Protein; Dietary Supplements; Humans; Inflammation; Randomized Con | 2019 |
Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.
Topics: Anti-Inflammatory Agents; Berberine; Chronic Disease; Gene Expression Regulation; Humans; Inflammati | 2020 |
The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.
Topics: Berberine; Dietary Supplements; Humans; Inflammation; Liver; Obesity; Randomized Controlled Trials a | 2020 |
Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Autoimmune Diseases of the Nervous System; A | 2020 |
Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers.
Topics: Animals; Antiviral Agents; Berberine; Carcinogenesis; Clinical Trials as Topic; Herpesviridae; Herpe | 2021 |
Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases.
Topics: Berberine; Cardiovascular Diseases; Curcumin; Gene Expression Regulation; Glycogen Synthase Kinase 3 | 2017 |
Nutritional Management of Metabolic Endotoxemia: A Clinical Review.
Topics: Anti-Infective Agents; Berberine; Diet Therapy; Dysbiosis; Endotoxemia; Fermentation; Glutamine; Hum | 2017 |
New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the "Bacteria-Mucosal Immunity-Inflammation-Diabetes" Axis.
Topics: Animals; Berberine; Curcumin; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Gastrointestinal Mic | 2017 |
Sonodynamic therapy: A potential treatment for atherosclerosis.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chal | 2018 |
Learning from berberine: Treating chronic diseases through multiple targets.
Topics: Berberine; China; Chronic Disease; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hyperlipidemia | 2015 |
Advance of studies on anti-atherosclerosis mechanism of berberine.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Berberine; Blood Glucose; Blood Pressure; Humans | 2010 |
4 trials available for berberine and Inflammation
| Article | Year |
|---|---|
Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study.
Topics: Adult; Berberine; Body Composition; Endpoint Determination; Female; Hormones; Humans; Inflammation; | 2021 |
Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways.
Topics: Aged; Aged, 80 and over; AMP-Activated Protein Kinases; Berberine; Cells, Cultured; Down-Regulation; | 2019 |
The effects of berberine on the magnitude of the acute inflammatory response induced by Escherichia coli lipopolysaccharide in broiler chickens.
Topics: Animals; Berberine; Blood Cell Count; Body Weight; Cell Line; Chickens; Digestion; Hybridomas; Infla | 2010 |
Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroid | 2012 |
130 other studies available for berberine and Inflammation
| Article | Year |
|---|---|
Berberine Attenuates Neonatal Sepsis in Mice By Inhibiting FOXA1 and NF-κB Signal Transduction Via the Induction of MiR-132-3p.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Cytokines; Disease | 2021 |
Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Berberine; Cell Proliferation; Cell Survival; Drug | 2021 |
Glucocorticoid receptor-mediated alleviation of inflammation by berberine:
Topics: Animals; Anti-Inflammatory Agents; Berberine; Dermatitis, Contact; Disease Models, Animal; Female; H | 2021 |
SOCS1 Mediates Berberine-Induced Amelioration of Microglial Activated States in N9 Microglia Exposed to
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginase; Berberine; Cell Line; China; Cytokines; Humans; | 2021 |
Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Blood-Brain Barrier; Cerebral Hemorrhage; Cytokin | 2022 |
Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Carrageenan; Edema; Inflammation; Rats | 2022 |
Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation.
Topics: Animals; Berberine; Bortezomib; Inflammation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sciatic | 2022 |
Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis.
Topics: Animals; Berberine; Chondrocytes; Gels; Inflammation; Mice; Osteoarthritis; Pain; Skin Absorption | 2022 |
Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Colitis; Colon; Dextran Sulfate; Disease Models, A | 2022 |
Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3β/STAT/Akt/MAPKs/NF-κB signaling axis mediated oxi-inflammation and joint articular damage in murine model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Berberine; Berberis; Collagen; Disease M | 2022 |
Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway.
Topics: Animals; Berberine; beta Catenin; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mode | 2022 |
Berberine alleviates myocardial ischemia-reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction.
Topics: Animals; Apoptosis; Berberine; Cells, Cultured; Cyclooxygenase 2; Humans; Inflammation; Male; MAP Ki | 2022 |
Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Chemical and Drug Induced Liver Injury, Chronic; | 2022 |
Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats.
Topics: Animals; Berberine; Chitosan; Cigarette Smoking; Cytokines; Humans; Inflammation; Lipids; Liposomes; | 2022 |
Berberine Suppresses Leukocyte Adherence by Downregulating CX3CL1 Expression and Shedding and ADAM10 in Lipopolysaccharide-Stimulated Vascular Endothelial Cells.
Topics: Acute Lung Injury; ADAM10 Protein; Animals; Anti-Inflammatory Agents; Berberine; Chemokine CX3CL1; C | 2022 |
Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Diclofenac; D | 2022 |
Solid Lipid Nanoformulation of Berberine Attenuates Doxorubicin Triggered
Topics: Animals; Apoptosis; Berberine; Cardiotoxicity; Doxorubicin; Inflammation; Lipids; Liposomes; Myocyte | 2022 |
Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis.
Topics: Administration, Oral; Alginates; Berberine; Chitosan; Colitis, Ulcerative; Drug Carriers; Drug Deliv | 2022 |
Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE
Topics: Animals; Apolipoproteins E; Atherosclerosis; Berberine; Diabetes Mellitus; Glucose; Inflammation; Kr | 2022 |
[Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis].
Topics: Animals; Berberine; Catechols; Claudin-1; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dise | 2022 |
Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts.
Topics: Berberine; Fibroblasts; Fibrosis; Graves Ophthalmopathy; Humans; Hyaluronic Acid; Inflammation; Orbi | 2022 |
Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Carrageenan; Formaldehyde; Hypoglycemic | 2022 |
Effect of Berberine on Activation of TLR4-NFκB Signaling Pathway and NLRP3 Inflammasome in Patients with Gout.
Topics: Berberine; Gout; Humans; I-kappa B Kinase; Inflammasomes; Inflammation; Interleukin-18; Interleukin- | 2023 |
Berberine inhibits low shear stress-induced vascular endothelial inflammation via decreasing phosphorylation of Akt and IRF3.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Human Umbilical Vein Endothelial Cells; Humans; Inflam | 2022 |
Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota.
Topics: Animals; Berberine; Cats; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Anim | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; beta-Glucans; Colitis; Colitis, Ulcerative; Inflammati | 2022 |
Berberine up-regulates miR-340-5p to protect myocardial ischaemia/reperfusion from HMGB1-mediated inflammatory injury.
Topics: Animals; Berberine; Coronary Artery Disease; HMGB1 Protein; Inflammation; MicroRNAs; Myocardial Infa | 2023 |
Berberine up-regulates miR-340-5p to protect myocardial ischaemia/reperfusion from HMGB1-mediated inflammatory injury.
Topics: Animals; Berberine; Coronary Artery Disease; HMGB1 Protein; Inflammation; MicroRNAs; Myocardial Infa | 2023 |
Berberine up-regulates miR-340-5p to protect myocardial ischaemia/reperfusion from HMGB1-mediated inflammatory injury.
Topics: Animals; Berberine; Coronary Artery Disease; HMGB1 Protein; Inflammation; MicroRNAs; Myocardial Infa | 2023 |
Berberine up-regulates miR-340-5p to protect myocardial ischaemia/reperfusion from HMGB1-mediated inflammatory injury.
Topics: Animals; Berberine; Coronary Artery Disease; HMGB1 Protein; Inflammation; MicroRNAs; Myocardial Infa | 2023 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of
Topics: Animals; Berberine; Butyrates; Chickens; Enterobacteriaceae; Gastrointestinal Microbiome; Inflammati | 2023 |
Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions.
Topics: Animals; ARNTL Transcription Factors; Berberine; Glucosamine; Hep G2 Cells; Homeostasis; Humans; Hyd | 2023 |
LCN2 contributes to the improvement of nonalcoholic steatohepatitis by 8-Cetylberberine.
Topics: Animals; Berberine; Diet, High-Fat; Disease Models, Animal; Inflammation; Lipids; Lipocalin-2; Liver | 2023 |
Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway.
Topics: Animals; Apoptosis; Astrocytes; Berberine; Exosomes; Glucose; Inflammation; Ischemic Stroke; Mice; M | 2023 |
Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Berberine; Human Umbilical Vein Endothelia | 2023 |
Tetrahydroberberrubine prevents peritoneal adhesion by suppressing inflammation and extracellular matrix accumulation.
Topics: Animals; Berberine; Extracellular Matrix; Inflammation; Intercellular Adhesion Molecule-1; NF-kappa | 2023 |
Berberine mitigates acetamiprid-induced hepatotoxicity and inflammation via regulating endogenous antioxidants and NF-κB/TNF-α signaling in rats.
Topics: Animals; Antioxidants; Berberine; Chemical and Drug Induced Liver Injury; Inflammation; Mammals; Neo | 2023 |
Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression.
Topics: Animals; Berberine; Helicobacter Infections; Helicobacter pylori; Inflammation; Molecular Docking Si | 2024 |
Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65.
Topics: Animals; Berberine; Depression; Hippocampus; Inflammasomes; Inflammation; Interleukin-18; Mice; NLR | 2023 |
Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye.
Topics: Animals; Apoptosis; Berberine; Dry Eye Syndromes; Humans; Inflammation; Mice; Molecular Docking Simu | 2023 |
Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Fatty Acids; Fibrosis; Inflammasomes; Inflammatio | 2023 |
The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation.
Topics: Administration, Oral; Animals; Berberine; Cells, Cultured; HEK293 Cells; HMGB1 Protein; Humans; In S | 2020 |
Berberine (BBR) Attenuated Palmitic Acid (PA)-Induced Lipotoxicity in Human HK-2 Cells by Promoting Peroxisome Proliferator-Activated Receptor α (PPAR-α).
Topics: Apoptosis; Berberine; Cell Line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; | 2019 |
Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Bronchoalveolar Lavage Fluid; Cigarette | 2019 |
Anti-Inflammatory Effects of Different Elution Fractions of Er-Miao-San on Acute Inflammation Induced by Carrageenan in Rat Paw Tissue.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Carrageenan; Dinoprostone; Drugs, Chinese Herbal; Edem | 2019 |
[Effects of berberine on learning and memory ability in vascular cognitive impairment rats].
Topics: Animals; Berberine; Cognitive Dysfunction; Hippocampus; Inflammation; Maze Learning; Memory; Oxidati | 2019 |
Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway.
Topics: Animals; Berberine; Cell Line; Cyclooxygenase 2; Gene Expression Regulation; Humans; Inflammation; I | 2020 |
Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway.
Topics: Animals; Berberine; Cell Line; Cell Movement; Cell Proliferation; Colloids; Diabetes Mellitus, Exper | 2020 |
Berberine reduces inflammation of human dental pulp fibroblast via miR-21/KBTBD7 axis.
Topics: Berberine; Dental Pulp; Fibroblasts; Humans; Inflammation; Intracellular Signaling Peptides and Prot | 2020 |
Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway.
Topics: A549 Cells; Apoptosis; Berberine; Cell Proliferation; Cellular Senescence; Cyclins; Gene Expression | 2020 |
Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity.
Topics: Animals; Apoptosis; Beclin-1; Berberine; Biomarkers; Cisplatin; Heme Oxygenase-1; Inflammation; Kidn | 2020 |
Berberine Inhibits MDA-MB-231 Cells by Attenuating Their Inflammatory Responses.
Topics: Alkaloids; Antioxidants; Berberine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2020 |
Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis.
Topics: Animals; Berberine; Chronic Disease; Colitis, Ulcerative; Humans; Inflammation; Intestinal Mucosa; M | 2020 |
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
Topics: Animals; Berberine; Cytokines; Endoplasmic Reticulum Stress; Hepatocytes; Inflammation; Lipopolysacc | 2020 |
Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway.
Topics: Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Animals; Anti-Inflammatory Agents; Berberin | 2020 |
Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.
Topics: Anastrozole; Animals; Berberine; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; | 2020 |
Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Disease Models, Animal; Edema; Inflamma | 2020 |
Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Differentiation; Chronic Disease; Cytokines; Dise | 2020 |
Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Collagen; Cytokines; Fibrosis; Inflammation; Laceratio | 2020 |
Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Berberine; Cell Line; China; Computational Biology; Ep | 2020 |
Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.
Topics: Animals; Antiviral Agents; Berberine; Coxsackievirus Infections; Disease Models, Animal; Enterovirus | 2021 |
Berberine suppresses bone loss and inflammation in ligature-induced periodontitis through promotion of the G protein-coupled estrogen receptor-mediated inactivation of the p38MAPK/NF-κB pathway.
Topics: Alveolar Bone Loss; Animals; Berberine; Inflammation; MAP Kinase Signaling System; p38 Mitogen-Activ | 2021 |
Combinatorial liposomes of berberine and curcumin inhibit biofilm formation and intracellular methicillin resistant
Topics: Animals; Anti-Bacterial Agents; Berberine; Biofilms; Cells, Cultured; Curcumin; Humans; Inflammation | 2021 |
Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis.
Topics: Animals; Apoptosis; Berberine; Diet, High-Fat; Female; Gene Expression; Inflammation; Insulin Resist | 2021 |
Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats.
Topics: Animals; Antibiotics, Antineoplastic; Behavior, Animal; Berberine; Chemotherapy-Related Cognitive Im | 2021 |
Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinase Kinases; Animals; Berberine; Diet, High-Fat; Hom | 2021 |
Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Calcium; Cytokines; Inflammation; Macrophages; Mice; N | 2021 |
Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways.
Topics: Animals; Berberine; Forkhead Box Protein O3; Glycogen Synthase Kinase 3 beta; Inflammation; Intestin | 2021 |
Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; CHO Cells; Cricetulus; Inflammation; M | 2021 |
Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets.
Topics: Animals; Berberine; Immunosuppression Therapy; Inflammation; NF-kappa B; Oxidative Stress; Signal Tr | 2021 |
The protective impact of berberine against doxorubicin-induced nephrotoxicity in rats.
Topics: Animals; Apoptosis; Berberine; Biomarkers; Body Weight; Doxorubicin; Fibrillar Collagens; Inflammati | 2021 |
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Topics: Adipose Tissue; Animals; Berberine; Diet, High-Fat; Inflammation; Insulin Resistance; Mice; MicroRNA | 2022 |
Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors.
Topics: Animals; Arthritis; Berberine; Binding Sites; Cells, Cultured; Chromatin Immunoprecipitation; Collag | 2017 |
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice.
Topics: Animals; Berberine; Biomarkers; Blood Glucose; Brain Diseases; Cognition Disorders; Conditioning, Ps | 2018 |
Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Berberine; Chronic Disease; | 2017 |
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Blood Glucose; Diabetes Mellitus, Experimental; Inflamm | 2017 |
Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.
Topics: Animals; Berberine; Carbazoles; Chemokine CCL2; Inflammation; Interleukin-6; Lipopolysaccharides; Ma | 2017 |
Synthesis, Characterization, and Biological Evaluations of 1,3,5-Triazine Derivatives of Metformin Cyclization with Berberine and Magnolol in the Presence of Sodium Methylate.
Topics: Anti-Inflammatory Agents; Berberine; Biphenyl Compounds; Cyclization; Humans; Inflammation; Insulin | 2017 |
Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation.
Topics: Alzheimer Disease; Animals; Berberine; Biomarkers; Blotting, Western; Cognitive Dysfunction; Glutath | 2017 |
Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats.
Topics: Alzheimer Disease; Animals; Berberine; Biomarkers; Environmental Pollutants; Female; Hippocampus; In | 2018 |
Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis.
Topics: Animals; Apoptosis; Berberine; Cytoprotection; Galactosamine; Inflammation; Liver Failure, Acute; Ma | 2018 |
Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Berberine; Biologi | 2018 |
Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression.
Topics: Animals; Apoptosis; Berberine; Brain Injuries, Traumatic; Inflammation; Male; Maze Learning; Memory; | 2018 |
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Berberine; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammation | 2018 |
Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis.
Topics: Animals; Arthritis, Experimental; Berberine; Cell Proliferation; Cell Survival; Cytokines; Female; F | 2018 |
Fractionated
Topics: Anti-Inflammatory Agents; Berberine; Cell Line; Coptis; Gene Expression Profiling; Humans; Immunolog | 2018 |
Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Drugs, Chinese Herbal; Inflammation; Mice; Nitric Oxid | 2018 |
The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress.
Topics: Animals; Berberine; Gossypol; Infertility, Male; Inflammation; Male; Oxidative Stress; Rats; Rats, S | 2018 |
Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Inflam | 2018 |
The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses.
Topics: Abortion, Septic; Animals; Berberine; Female; Inflammation; Lipopolysaccharides; Male; Mice; Mice, I | 2018 |
Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Aging; Animals; Anti-Inflammatory Agents; Antioxi | 2020 |
Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation.
Topics: Animals; Antioxidants; Berberine; Cytokines; Inflammation; Male; Malondialdehyde; Oxidative Stress; | 2019 |
Berberine suppresses IL-33-induced inflammatory responses in mast cells by inactivating NF-κB and p38 signaling.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Cytokines; Humans; Hypersensitivity; | 2019 |
Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms.
Topics: Acetylcholinesterase; Animals; Antioxidants; Berberine; DNA Fragmentation; Hippocampus; Inflammation | 2019 |
Berberine, a Traditional Chinese Medicine, Reduces Inflammation in Adipose Tissue, Polarizes M2 Macrophages, and Increases Energy Expenditure in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Berberine; China; Diet, High- | 2019 |
Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cell Nuc | 2019 |
Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.
Topics: Animals; Berberine; Bifidobacterium; Diarrhea; Disease Models, Animal; Faecalibacterium; Fecal Micro | 2019 |
Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers.
Topics: Animals; Antioxidant Response Elements; Antioxidants; Berberine; Chickens; Diet; Dietary Supplements | 2019 |
Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats.
Topics: Animals; Antioxidants; Atherosclerosis; Berberine; Biomarkers; Fibrosis; Inflammation; Male; NF-kapp | 2013 |
[Intervention effect of berberine on expressions of TNF-alpha and receptor type I in Abeta25-35-induced inflammatory reaction in SH-SY5Y cell lines].
Topics: Amyloid beta-Peptides; Berberine; Cell Line; Humans; Inflammation; Peptide Fragments; Receptors, Int | 2013 |
Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Berberine; Biological Availability; Chic | 2014 |
Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation.
Topics: Animals; Apoptosis; Berberine; Cytokines; Disease Models, Animal; Electrocardiography; Enzyme-Linked | 2013 |
Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury.
Topics: Animals; Apoptosis; Berberine; Blood-Brain Barrier; Brain Injuries; Cells, Cultured; Chemokines; Ext | 2014 |
Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome.
Topics: Activating Transcription Factor 2; Animals; Aorta; Berberine; Disease Models, Animal; Inflammation; | 2015 |
Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters.
Topics: Animals; Berberine; Body Weight; Cholesterol; Cholesterol, LDL; Coptis; Diet, High-Fat; Disease Mode | 2015 |
Berberine inhibits tumor necrosis factor-α-induced expression of inflammatory molecules and activation of nuclear factor-κB via the activation of AMPK in vascular endothelial cells.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Cell Line; Chemok | 2015 |
Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation.
Topics: Animals; Berberine; Cell Differentiation; Colitis; Colon; Inflammation; Macrophages; Male; Mice, Inb | 2015 |
Editorial: Bioactive Small Molecules in Regulating Inflammation and Metabolic Disorder.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Humans; Inflammation; Metabol | 2016 |
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Berberine; Caspase 3; Cell Line; Cell Su | 2016 |
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Berberine; Body Weight; Cytokines; Disease Models, Ani | 2016 |
Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine.
Topics: Anti-Inflammatory Agents; Berberine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Dow | 2016 |
Berberine Attenuates Inflammation Associated with Delayed-Type Hypersensitivity via Suppressing Th1 Response and Inhibiting Apoptosis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Berberine; Cell Differentiation; Cytokines; Hypersensi | 2017 |
Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats.
Topics: Alkaloids; Animals; Arthritis, Gouty; Berberine; Carrier Proteins; Female; Inflammation; Isoquinolin | 2017 |
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Berberine; | 2008 |
Berberine suppresses proinflammatory responses through AMPK activation in macrophages.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipose Tissue, White; Animals; Anti-Inflammatory Agents; Berberine; | 2009 |
Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia.
Topics: Adenylate Kinase; Animals; Berberine; Blotting, Western; Cell Line; Cyclooxygenase 2; Cytokines; Enz | 2010 |
Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathway.
Topics: Animals; Berberine; Cell Nucleus; Cell Proliferation; Extracellular Matrix; Fibronectins; Fluorescen | 2011 |
Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation.
Topics: Animals; Berberine; Colitis; Enterobacteriaceae; Enzyme Activation; HEK293 Cells; Humans; Inflammati | 2010 |
Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid.
Topics: Acetic Acid; Aconitine; Alkaloids; Analgesics; Animals; Antidiarrheals; Behavior, Animal; Berberine; | 2011 |
Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.
Topics: Berberine; Cell Line; Hepatocytes; Humans; Inflammation; Insulin Receptor Substrate Proteins; Insuli | 2011 |
Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats.
Topics: Animals; Arthritis; Berberine; Cell Line; Cell Line, Tumor; Cell Survival; Inflammation; Interleukin | 2011 |
Berberine ameliorates pro-inflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitro.
Topics: Apoptosis; Berberine; Caco-2 Cells; Caspase 12; Caspase 3; Cell Line; Cell Survival; DNA-Binding Pro | 2012 |
Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Biological Availability; Cop | 2012 |
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats.
Topics: Adiposity; Animals; Berberine; Diet, High-Fat; Fatty Acids, Volatile; Feces; Feeding Behavior; Gastr | 2012 |
Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Blotting, Western; Cells, Cultured; En | 2012 |
Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation.
Topics: Animals; Berberine; Dinoprost; Dyslipidemias; Female; Inflammation; Interferon-gamma; Interleukin-1a | 2012 |
Inhibitory effects of berberine on lipopolysaccharide-induced inducible nitric oxide synthase and the high-mobility group box 1 release in macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Extracellular Signal-Regulated MAP Kina | 2013 |
Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Berberine; Cytokines; Gene Expression Regulation; G | 2006 |
Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.
Topics: Alkaloids; Anti-Inflammatory Agents; Benzophenanthridines; Berberine; Cell Survival; Ceramides; Dose | 2007 |
Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids.
Topics: Alkaloids; Animals; Anti-Infective Agents; Antibody Formation; Arthritis, Experimental; Berberine; C | 1996 |
Anti-inflammatory effect of berberine in rats injected locally with cholera toxin.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Toxins; Berberine; Berberine Alkaloids; Cholera; Diseas | 1977 |
Relative inhibitory activity of berberine-type alkaloids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Female; Inflammation; Mice; | 1991 |