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berberine and Hypoxia

berberine has been researched along with Hypoxia in 18 studies

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"In this study, hypoxia-reoxygenation (H/R)-treated L02 cells were pretreated with berberine to study the role and mechanism of berberine in resisting hepatic ischemia-reperfusion injury."8.31Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2. ( Li, C; Li, J; Liu, H; Ming, Y; Peng, B; Zhang, P; Zhu, Y, 2023)
" Ischemia-related damage was induced by OGD (5, 15, 45 min) or NMDA (10 microM) treatment, and was evaluated by measuring propidium iodide (PI) uptake."7.75Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. ( Cui, HS; Hori, H; Matsumoto, K; Murakami, Y; Obi, R; Zhao, Q, 2009)
"Berberine is an alkaloid derived from herb the Berberis sp."5.40Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014)
"In this study, hypoxia-reoxygenation (H/R)-treated L02 cells were pretreated with berberine to study the role and mechanism of berberine in resisting hepatic ischemia-reperfusion injury."4.31Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2. ( Li, C; Li, J; Liu, H; Ming, Y; Peng, B; Zhang, P; Zhu, Y, 2023)
"Male ICR mice were divided into 5 groups: control group, hypoxia group, hypoxia group treated with nifedipine (10 mg/kg), hypoxia groups treated with CPU86017-RS (60 or 80 mg/kg)."3.78CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines. ( Cheng, YS; Dai, DZ; Dai, Y; Yu, F; Zhang, C; Zhang, GL, 2012)
"To investigate the protection of pulmonary arterial rings and cardiac myocytes of rats by raisanberine (RS), a derivative of berberine, against hypoxia injury and to elucidate the action mechanisms."3.78Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx. ( Cheng, YS; Dai, DZ; Dai, Y; Gao, J; Tang, YQ; Zhang, C; Zhang, GL, 2012)
" Ischemia-related damage was induced by OGD (5, 15, 45 min) or NMDA (10 microM) treatment, and was evaluated by measuring propidium iodide (PI) uptake."3.75Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. ( Cui, HS; Hori, H; Matsumoto, K; Murakami, Y; Obi, R; Zhao, Q, 2009)
"Remodeling of the pulmonary artery is a major feature of pulmonary artery hypertension, and CPU86017, a derivative of berberine, is known to effectively alleviate hypoxic pulmonary hypertension (HPH)."3.74CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. ( Dai, DZ; Dai, Y; Li, N, 2008)
"To investigate the protective mechanism of geniposide, baicalin and berberine on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells."3.74[Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells]. ( Gao, YH; Niu, FL; Pang, H; Shan, ZS; Wang, SR; Yuan, ZZ; Zhu, LQ, 2008)
" The present study was conducted to examine the effects of a novel compound p-chlorobenzyltetrahydroberberine (CPU 86017) on endothelin-1 system of hypoxia-induced pulmonary hypertension in rats."3.73Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. ( Cui, B; Dai, DZ; Tang, XY; Zhang, TT, 2005)
"Berberine is an alkaloid derived from herb the Berberis sp."1.40Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's1 (5.56)18.2507
2000's4 (22.22)29.6817
2010's8 (44.44)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Zhang, Z1
Dong, Q1
Guan, R1
Sun, Y2
Liu, X1
Zou, Y1
Xia, QS1
Wu, F1
Wu, WB1
Dong, H1
Huang, ZY1
Xu, L1
Lu, FE1
Gong, J1
Zhou, Q1
Chen, F1
Gao, X1
Yang, L1
Jin, X1
Wink, M1
Sharopov, FS1
Sethi, G1
Zhu, Y1
Li, J1
Zhang, P1
Peng, B1
Li, C1
Ming, Y1
Liu, H1
Yue, M1
Tao, Y1
Fang, Y1
Lian, X1
Zhang, Q1
Xia, Y1
Wei, Z1
Dai, Y5
Wang, Y1
Wang, Q1
Zhang, L1
Ke, Z1
Zhao, Y1
Wang, D1
Chen, H1
Jiang, X1
Gu, M1
Fan, S1
Huang, C1
Sreeja, S1
Krishnan Nair, CK1
Chen, M1
Shen, H1
Zhu, L1
Yang, H1
Ye, P1
Liu, P1
Gu, Y1
Chen, S1
Simões Pires, EN1
Frozza, RL1
Hoppe, JB1
Menezes, Bde M1
Salbego, CG1
Li, N1
Dai, DZ5
Cui, HS1
Matsumoto, K1
Murakami, Y1
Hori, H1
Zhao, Q1
Obi, R1
Yuan, ZZ1
Zhu, LQ1
Pang, H1
Shan, ZS1
Wang, SR1
Gao, YH1
Niu, FL1
Liu, GL1
Yu, F2
Zhang, GL3
Zhang, C3
Cheng, YS2
Gao, J1
Tang, YQ1
Zhang, TT1
Cui, B1
Tang, XY1
Wang, YX1
Yao, XJ1
Tan, YH1
Xu, LY1
Li, YK1
Cai, ZZ1
Zhou, H1
Feng, Y1

Other Studies

18 other studies available for berberine and Hypoxia

ArticleYear
[Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-α/caspase-8/caspase-3 signaling pathway].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022, Volume: 38, Issue:1

    Topics: Animals; Berberine; Caspase 3; Caspase 8; Hypoxia; Liver; Mice; Mice, Inbred C57BL; Signal Transduct

2022
Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2α.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Berberine; Ceramides; Diabetes Mellitus, Type

2022
Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites.
    Pharmacological research, 2023, Volume: 193

    Topics: Animals; Berberine; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Gast

2023
Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2.
    PeerJ, 2023, Volume: 11

    Topics: Berberine; Cytokines; Hepatocytes; Humans; Hypoxia; Reperfusion Injury

2023
The gut microbiota modulator berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:11

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Berberine; Butyrates; Female; Gastrointesti

2019
Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy.
    Biochemical and biophysical research communications, 2017, 08-19, Volume: 490, Issue:2

    Topics: Animals; Apoptosis; Berberine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hyp

2017
Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle - Berberine complexes in a mouse model.
    Life sciences, 2018, Feb-15, Volume: 195

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Berberine; Biomarkers, Tumor; DNA, Neoplas

2018
Berberine attenuates hypoxia-induced pulmonary arterial hypertension via bone morphogenetic protein and transforming growth factor-β signaling.
    Journal of cellular physiology, 2019, Volume: 234, Issue:10

    Topics: Animals; Berberine; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell

2019
Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved.
    Brain research, 2014, Apr-04, Volume: 1557

    Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Caspase 3; Cell Survival; Disease Models, Animal; Dos

2014
CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:5

    Topics: Animals; Berberine; Extracellular Matrix; Gene Expression Regulation; Hypertension, Pulmonary; Hypox

2008
Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:1

    Topics: Animals; Berberine; Cell Death; Docosahexaenoic Acids; Excitatory Amino Acid Agonists; Glucose; Hipp

2009
[Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:23

    Topics: Animals; Berberine; Cell Hypoxia; Cells, Cultured; Cerebrum; Drugs, Chinese Herbal; Endothelium, Vas

2008
Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.
    Journal of biomedical science, 2012, Jan-08, Volume: 19

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Berberine; Calcium; Calcium Channel Blockers; Down-Regulat

2012
CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:4

    Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Animals; Berberine; Calcium Channel Blockers; Connexin 4

2012
Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:5

    Topics: Administration, Oral; Animals; Antioxidants; Arterioles; Berberine; Calcium Channel Blockers; Calciu

2012
Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:6

    Topics: Animals; Antioxidants; Berberine; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelin-1;

2005
Effects of berberine on delayed afterdepolarizations in ventricular muscles in vitro and in vivo.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Berberine; Calcium Gluconate; Electrophysiology; Female; Guinea Pig

1994
[Chemical components and pharmacological effects of Chinese herbal drugs after radio-sterilization].
    Zhong yao tong bao (Beijing, China : 1981), 1987, Volume: 12, Issue:9

    Topics: Animals; Berberine; Cobalt Radioisotopes; Drugs, Chinese Herbal; Female; Ginsenosides; Hypoxia; Mice

1987