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berberine and Hyperglycemia, Postprandial

berberine has been researched along with Hyperglycemia, Postprandial in 24 studies

Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.

Research Excerpts

ExcerptRelevanceReference
"Berberine and Bifidobacterium have been reported to improve glucose tolerance in people with hyperglycemia or other metabolic disorders."9.41Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ( Ding, C; Du, Y; Fang, Y; Gao, X; He, Q; Ji, Q; Li, C; Li, S; Luo, S; Ma, K; Ming, J; Tian, Z; Wang, L; Wang, X; Wang, Z; Xie, X; Xu, X; Yang, W; Yu, X; Zhao, J, 2021)
"Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main cause of persistent hyperglycemia in type 2 diabetes."7.96Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice. ( Jiang, B; Jin, J; Liu, P; Sheng, L; Song, Y; Zhang, H; Zhong, Y; Zhou, H, 2020)
"This study investigated the effects of berberine on amelioration of hyperglycemia and hyperlipidemia and the mechanism involved in high glucose and high fat diet-induced diabetic hamsters."7.81Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo. ( Jin, J; Li, L; Li, P; Liu, C; Song, Y; Wang, Z; Wu, D; Xu, N; Zheng, X, 2015)
" The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction."7.75Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. ( Huang, Y; Lam, KS; Lau, CW; Li, Y; Vanhoutte, PM; Wang, Y; Wong, WT; Xu, A; Ye, H, 2009)
"Berberine (BBR) is a widely used anti-diabetic agent, and liver glucokinase (GK) has been reported to be involved."5.51Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. ( Dang, Y; Ji, G; Li, M; Li, Q; Yao, Z; Zhang, L; Zhou, W; Zuo, J, 2019)
"Berberine and Bifidobacterium have been reported to improve glucose tolerance in people with hyperglycemia or other metabolic disorders."5.41Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ( Ding, C; Du, Y; Fang, Y; Gao, X; He, Q; Ji, Q; Li, C; Li, S; Luo, S; Ma, K; Ming, J; Tian, Z; Wang, L; Wang, X; Wang, Z; Xie, X; Xu, X; Yang, W; Yu, X; Zhao, J, 2021)
"Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main cause of persistent hyperglycemia in type 2 diabetes."3.96Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice. ( Jiang, B; Jin, J; Liu, P; Sheng, L; Song, Y; Zhang, H; Zhong, Y; Zhou, H, 2020)
"This study investigated the effects of berberine on amelioration of hyperglycemia and hyperlipidemia and the mechanism involved in high glucose and high fat diet-induced diabetic hamsters."3.81Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo. ( Jin, J; Li, L; Li, P; Liu, C; Song, Y; Wang, Z; Wu, D; Xu, N; Zheng, X, 2015)
"Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance."3.78Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. ( Duarte, FV; Gomes, AP; Hubbard, BP; Jones, JG; Nunes, P; Palmeira, CM; Rolo, AP; Sinclair, DA; Teodoro, JS; Varela, AT, 2012)
" Berberine (BBR) has recently been shown to lower blood glucose levels and to improve insulin resistance in db/db mice partly through the activation of AMP-activated protein kinase (AMPK) signaling and induction of phosphorylation of insulin receptor (IR)."3.76Berberine inhibits PTP1B activity and mimics insulin action. ( Chen, C; Huang, C; Zhang, Y, 2010)
" The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction."3.75Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. ( Huang, Y; Lam, KS; Lau, CW; Li, Y; Vanhoutte, PM; Wang, Y; Wong, WT; Xu, A; Ye, H, 2009)
"A berberine pretreatment attenuated paliperidone-induced increases in blood concentrations of glucose, adrenaline, and insulin and phosphorylated AMPK concentrations in the hypothalamus."1.72Paliperidone-Induced Acute Hyperglycemia Is Caused by Adrenaline Secretion via the Activation of Hypothalamic AMP-Activated Protein Kinase. ( Aoyama, T; Ishiwata, Y; Kawano, Y; Nagata, M; Negishi, K; Takahashi, H; Xue, B, 2022)
"Postprandial hyperglycemia is an important causative factor of type 2 diabetes mellitus, and permanent localization of intestinal GLUT2 in the brush border membrane is an important reason of postprandial hyperglycemia."1.62Berberine Decreases Intestinal GLUT2 Translocation and Reduces Intestinal Glucose Absorption in Mice. ( Dong, L; Li, J; Yang, E; Yang, H; Zhang, M, 2021)
"Berberine (BBR) is a widely used anti-diabetic agent, and liver glucokinase (GK) has been reported to be involved."1.51Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. ( Dang, Y; Ji, G; Li, M; Li, Q; Yao, Z; Zhang, L; Zhou, W; Zuo, J, 2019)
" This work intended to develop selenium-coated nanostructured lipid carriers (SeNLCs) for enhancing the oral bioavailability and the curative effect of berberine, an antidiabetic phytomedicine."1.46Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect. ( Hou, Y; Song, X; Yin, J; Yin, Y, 2017)
"Berberine is an isoquinoline alkaloid widely used in Asian countries as a traditional medicine."1.38Possible therapeutic potential of berberine in diabetic osteopathy. ( Bhutada, PS; Kaulaskar, SV; Rahigude, AB, 2012)
"Berberine treatment reduced the plasma sugar and lipid levels by 24-69% in the rat model of hyperglycemia and hypercholesterolemia."1.37Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats. ( Dong, SF; Hao, YZ; Hong, Y; Liu, M; Liu, Y; Sun, JN; Yu, HS, 2011)
"Berberine was found to effectively inhibit the activity of disaccharidases in Caco-2 cells."1.32The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. ( Fawcett, JP; Huang, ZJ; Liu, XD; Pan, GY; Sun, JG; Wang, GJ; Xie, YY; Zhao, XC, 2003)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (8.33)29.6817
2010's13 (54.17)24.3611
2020's9 (37.50)2.80

Authors

AuthorsStudies
Zhao, MM1
Lu, J1
Li, S2
Wang, H1
Cao, X1
Li, Q2
Shi, TT1
Matsunaga, K1
Chen, C2
Huang, H2
Izumi, T1
Yang, JK1
Wang, N1
Wang, L2
Zhang, C1
Tan, HY1
Zhang, Y2
Feng, Y1
Zhang, M1
Yang, H1
Yang, E1
Li, J1
Dong, L1
Xue, B1
Ishiwata, Y1
Kawano, Y1
Takahashi, H1
Negishi, K1
Aoyama, T1
Nagata, M1
Purwaningsih, I1
Maksum, IP1
Sumiarsa, D1
Sriwidodo, S1
Zhong, Y1
Jin, J2
Liu, P2
Song, Y2
Zhang, H2
Sheng, L1
Zhou, H1
Jiang, B1
Li, M2
Zhou, W2
Dang, Y2
Li, C2
Ji, G2
Zhang, L2
Yin, Z1
Tan, R1
Yuan, T1
Chen, S1
Quan, Y1
Hao, Q1
Zeng, J1
Zhao, J2
Li, L2
Ming, J1
Yu, X1
Xu, X1
Ding, C1
Wang, Z2
Xie, X2
Yang, W1
Luo, S1
He, Q1
Du, Y1
Tian, Z1
Gao, X1
Ma, K1
Fang, Y1
Wang, X1
Ji, Q1
Yin, J1
Hou, Y1
Yin, Y1
Song, X1
Yue, X1
Liang, J1
Gu, F1
Du, D1
Chen, F1
Zuo, J1
Yao, Z1
Liu, C1
Wu, D2
Zheng, X1
Li, P1
Xu, N1
Ma, YG1
Zhang, YB1
Bai, YG1
Dai, ZJ1
Liang, L1
Liu, M2
Xie, MJ1
Guan, HT1
Yang, N1
Sun, RB1
Chen, XL1
Zhen, L1
Ge, C1
Zhao, YQ1
He, J1
Geng, JL1
Guo, JH1
Yu, XY1
Fei, F1
Feng, SQ1
Zhu, XX1
Wang, HB1
Fu, FH1
Aa, JY1
Wang, GJ2
Wang, Y1
Huang, Y1
Lam, KS1
Li, Y1
Wong, WT1
Ye, H1
Lau, CW1
Vanhoutte, PM1
Xu, A1
Wei, J1
Xue, R1
Wu, JD1
Zhao, W1
Wang, ZZ1
Wang, SK1
Zhou, ZX1
Song, DQ1
Wang, YM1
Pan, HN1
Kong, WJ1
Jiang, JD1
Huang, C1
Dong, SF1
Hong, Y1
Hao, YZ1
Yu, HS1
Liu, Y1
Sun, JN1
Li, W1
Lan, T1
Liu, W1
Peng, J1
Huang, K1
Huang, J1
Shen, X1
Gomes, AP1
Duarte, FV1
Nunes, P1
Hubbard, BP1
Teodoro, JS1
Varela, AT1
Jones, JG1
Sinclair, DA1
Palmeira, CM1
Rolo, AP1
Wen, W1
Qi, CL1
Zhao, RX1
Lü, JH1
Zhong, CY1
Chen, YY1
Rahigude, AB1
Kaulaskar, SV1
Bhutada, PS1
Pan, GY1
Huang, ZJ1
Fawcett, JP1
Liu, XD1
Zhao, XC1
Sun, JG1
Xie, YY1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Berberine on Insulin Release at a High Blood Glucose Level in Normal Man[NCT03972215]Early Phase 115 participants (Actual)Interventional2019-10-01Completed
Effectiveness and Safety of Berberine Hydrochloride and Bifidobacterium in People With Abnormal Glucose Level: an Multicenter, Randomized, Double-blinded, Placebo-controlled Study.[NCT03330184]300 participants (Actual)Interventional2015-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for berberine and Hyperglycemia, Postprandial

ArticleYear
A Review of
    Molecules (Basel, Switzerland), 2023, Jan-29, Volume: 28, Issue:3

    Topics: Alkaloids; Antioxidants; Berberine; Humans; Hyperglycemia; Hypoglycemic Agents; Menispermaceae

2023

Trials

3 trials available for berberine and Hyperglycemia, Postprandial

ArticleYear
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
    Nature communications, 2021, 09-23, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Animals; Berberine; Cell Line, Tumor; Cross-Over Studies; Diet, High-Fat; Ether-A

2021
Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study.
    Genome medicine, 2021, 08-09, Volume: 13, Issue:1

    Topics: Aged; Berberine; Bifidobacterium; Blood Glucose; Combined Modality Therapy; Disease Management; Fece

2021
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:2

    Topics: Aged; Berberine; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Expression; Human

2010

Other Studies

20 other studies available for berberine and Hyperglycemia, Postprandial

ArticleYear
Berberine suppresses advanced glycation end products-associated diabetic retinopathy in hyperglycemic mice.
    Clinical and translational medicine, 2021, Volume: 11, Issue:11

    Topics: Animals; Berberine; Diabetic Retinopathy; Disease Models, Animal; Glycation End Products, Advanced;

2021
Berberine Decreases Intestinal GLUT2 Translocation and Reduces Intestinal Glucose Absorption in Mice.
    International journal of molecular sciences, 2021, Dec-28, Volume: 23, Issue:1

    Topics: Animals; Berberine; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Epitheli

2021
Paliperidone-Induced Acute Hyperglycemia Is Caused by Adrenaline Secretion via the Activation of Hypothalamic AMP-Activated Protein Kinase.
    Biological & pharmaceutical bulletin, 2022, Volume: 45, Issue:11

    Topics: AMP-Activated Protein Kinases; Animals; Berberine; Glucose; Hyperglycemia; Hypothalamus; Insulin; Pa

2022
Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Liver; Mice; Mice, Obe

2020
Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 132

    Topics: Animals; Berberine; Colon; Gastrointestinal Microbiome; Glucagon-Like Peptides; Hyperglycemia; Male;

2020
Berberine prevents diabetic retinopathy through inhibiting HIF-1α /VEGF/ NF-κ B pathway in db/db mice.
    Die Pharmazie, 2021, 04-01, Volume: 76, Issue:4

    Topics: Animals; Berberine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Hyperglyce

2021
Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Administration, Oral; Animals; Berberine; Biological Availability; Caco-2 Cells; Delayed-Action Prep

2017
Berberine activates bitter taste responses of enteroendocrine STC-1 cells.
    Molecular and cellular biochemistry, 2018, Volume: 447, Issue:1-2

    Topics: Berberine; Cell Line, Tumor; Enteroendocrine Cells; Estrenes; Glucagon-Like Peptide 1; Humans; Hyper

2018
Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.
    Scientific reports, 2019, 05-29, Volume: 9, Issue:1

    Topics: Animals; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Glucokinase; Glucose; Hepatocytes; Hum

2019
Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo.
    BioMed research international, 2015, Volume: 2015

    Topics: Animals; Berberine; Blood Glucose; Cardiovascular Diseases; Cricetinae; Diabetes Mellitus, Experimen

2015
Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells.
    Cardiovascular diabetology, 2016, Apr-12, Volume: 15

    Topics: Animals; Berberine; Blood Glucose; Calcium; Calcium Channels, L-Type; Diabetes Mellitus, Experimenta

2016
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine.
    Acta pharmacologica Sinica, 2017, Volume: 38, Issue:3

    Topics: Animals; Berberine; Glucuronides; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Mice, Inbred C57

2017
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase.
    Cardiovascular research, 2009, Jun-01, Volume: 82, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Aorta; Apoptosis; Berberine; Cell Adhesion; Cell Line; Endot

2009
Berberine inhibits PTP1B activity and mimics insulin action.
    Biochemical and biophysical research communications, 2010, Jul-02, Volume: 397, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Berberine; Diet; Female; Hyperglycemia; Hypoglycemic Agents; Insu

2010
Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats.
    European journal of pharmacology, 2011, Jun-25, Volume: 660, Issue:2-3

    Topics: Animals; Berberine; Biomarkers; Dietary Fats; Gene Expression Regulation; Glucose Transporter Type 4

2011
Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway.
    Endocrine journal, 2011, Volume: 58, Issue:9

    Topics: Animals; Berberine; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Glucokinase;

2011
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.
    Biochimica et biophysica acta, 2012, Volume: 1822, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cell Line; Diet, High-Fat; Glucose; Hormones; Hyp

2012
Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Jun-15, Volume: 19, Issue:8-9

    Topics: Animals; Berberine; Blood Glucose; Body Weight; Cholesterol; Creatinine; Diabetes Mellitus, Experime

2012
Possible therapeutic potential of berberine in diabetic osteopathy.
    Medical hypotheses, 2012, Volume: 79, Issue:4

    Topics: Berberine; Calcitonin; Diabetes Complications; Glucagon-Like Peptides; Glycation End Products, Advan

2012
The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption.
    Planta medica, 2003, Volume: 69, Issue:7

    Topics: alpha-Glucosidases; Berberine; Caco-2 Cells; Enzyme Activation; Enzyme Inhibitors; Gluconeogenesis;

2003