Page last updated: 2024-10-23

berberine and Heart Failure

berberine has been researched along with Heart Failure in 8 studies

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"This study was designed to assess the efficacy and safety of berberine for chronic congestive heart failure (CHF)."9.10Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Li, YY; Zeng, XH; Zeng, XJ, 2003)
"To investigate whether CPU86017, a berberine derivative, attenuates heart failure by blocking calcium influx and exerting its antioxidant activity."7.76CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity. ( Cheng, YS; Dai, DZ; Dai, Y; Feng, Y; Li, N; Qi, MY, 2010)
"To study the effects of total saponins of Panax ginseng combined with berberine on hemodynamics, Plasma brain natriuretic peptide and Ca2+ concentration in cardiac cells of chronic congestive heart failure rats."7.75[Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure]. ( Chen, X; Li, G; Li, Y; Liu, H; Luo, F, 2009)
"Emerging evidence indicates that leptin may be a potential new target in chronic heart failure (CHF) treatment."7.74Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017. ( Dai, DZ; Dai, Y; Na, T; Tang, XY, 2007)
"It has been reported that berberine is valuable for long-term treatment of ventricular premature beats (VPBs) and leads to a decrease in mortality for patients with congestive heart failure (CHF)."7.70Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC. ( Zeng, X, 1999)
"Berberine, an alkaloid of the protoberberine family, has been shown to have strong positive inotropic and peripheral resistance-lowering effects in dogs with and without heart failure."7.67Cardiovascular effects of berberine in patients with severe congestive heart failure. ( Gallo Júnior, L; Maciel, BC; Marin-Neto, JA; Secches, AL, 1988)
"This study was designed to assess the efficacy and safety of berberine for chronic congestive heart failure (CHF)."5.10Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Li, YY; Zeng, XH; Zeng, XJ, 2003)
"To investigate whether CPU86017, a berberine derivative, attenuates heart failure by blocking calcium influx and exerting its antioxidant activity."3.76CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity. ( Cheng, YS; Dai, DZ; Dai, Y; Feng, Y; Li, N; Qi, MY, 2010)
"To study the effects of total saponins of Panax ginseng combined with berberine on hemodynamics, Plasma brain natriuretic peptide and Ca2+ concentration in cardiac cells of chronic congestive heart failure rats."3.75[Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure]. ( Chen, X; Li, G; Li, Y; Liu, H; Luo, F, 2009)
"Emerging evidence indicates that leptin may be a potential new target in chronic heart failure (CHF) treatment."3.74Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017. ( Dai, DZ; Dai, Y; Na, T; Tang, XY, 2007)
"It has been reported that berberine is valuable for long-term treatment of ventricular premature beats (VPBs) and leads to a decrease in mortality for patients with congestive heart failure (CHF)."3.70Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC. ( Zeng, X, 1999)
"Berberine, an alkaloid of the protoberberine family, has been shown to have strong positive inotropic and peripheral resistance-lowering effects in dogs with and without heart failure."3.67Cardiovascular effects of berberine in patients with severe congestive heart failure. ( Gallo Júnior, L; Maciel, BC; Marin-Neto, JA; Secches, AL, 1988)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, YW1
Li, XD1
Sun, MJ1
Liu, ZP1
Liu, SW1
Li, Y1
Chen, X1
Liu, H1
Luo, F1
Li, G1
Qi, MY1
Feng, Y1
Dai, DZ2
Li, N1
Cheng, YS1
Dai, Y2
Zeng, XH1
Zeng, XJ1
Li, YY1
Na, T1
Tang, XY1
Yang, SY1
Zeng, X2
Marin-Neto, JA1
Maciel, BC1
Secches, AL1
Gallo Júnior, L1

Reviews

1 review available for berberine and Heart Failure

ArticleYear
[Study on inotropic action of berberine].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:9

    Topics: Animals; Berberine; Cyclic AMP; Heart Failure; Humans; Myocardial Contraction; Stimulation, Chemical

1994

Trials

1 trial available for berberine and Heart Failure

ArticleYear
Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
    The American journal of cardiology, 2003, Jul-15, Volume: 92, Issue:2

    Topics: Aged; Aged, 80 and over; Berberine; Cardiomyopathy, Dilated; Double-Blind Method; Exercise Test; Fem

2003

Other Studies

6 other studies available for berberine and Heart Failure

ArticleYear
[Protective effects of berberine against exhaustion exercise induced myocardial injury in rats].
    Zhonghua xin xue guan bing za zhi, 2019, Aug-24, Volume: 47, Issue:8

    Topics: Animals; Berberine; Heart Failure; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley

2019
[Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:3

    Topics: Animals; Berberine; Calcium; Disease Models, Animal; Heart Failure; Hemodynamics; Male; Natriuretic

2009
CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:2

    Topics: Animals; Antioxidants; Base Sequence; Berberine; Calcium; Calcium-Binding Proteins; DNA Primers; Dow

2010
Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptid

2007
Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC.
    Biomedical chromatography : BMC, 1999, Volume: 13, Issue:7

    Topics: Aged; Anticoagulants; Berberine; Blood Pressure; Chromatography, High Pressure Liquid; Chronic Disea

1999
Cardiovascular effects of berberine in patients with severe congestive heart failure.
    Clinical cardiology, 1988, Volume: 11, Issue:4

    Topics: Adult; Aged; Berberine; Berberine Alkaloids; Echocardiography; Electrocardiography; Female; Heart Fa

1988