berberine has been researched along with Disease Models, Animal in 239 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To elucidate the underly molecular mechanisms of berberine in colorectal cancer from a perspective of epigenetics, and tried to explore the role of lincROR-Wnt/β-catenin molecular axis in the berberine induced the anti-tumour activity in colorectal cancer." | 8.31 | Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer. ( Fu, WM; Li, SY; Shi, CJ; Zhang, JF, 2023) |
| "Our findings suggest that Berberine plays an important neuroprotective role against ICH-induced neurological impairments and BBB injury, probably by inhibition of inflammation and activation of AMPK/PGC1α signaling." | 8.12 | Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage. ( Liu, X; Wang, Y; Wu, X; Yang, L, 2022) |
| " In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model." | 8.12 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota. ( Deng, J; Han, L; Li, Y; Shi, J; Wang, H; Yan, Y; Yuan, X; Zhang, H; Zhao, H; Zhao, L; Zhao, Y; Zou, F, 2022) |
| "Berberine reduced the uterine weight, suppressed the myometrial infiltration of ectopic endometrium, improved the hotplate and tail-flick latency of the adenomyosis mice." | 8.12 | Berberine attenuates hyperalgesia in mice with adenomyosis. ( Chen, Y; Guo, M; Huang, L; Lin, T; Lu, Y; Pan, Q; Shen, X; Zhang, C; Zhang, H; Zhu, B, 2022) |
| " Berberine can reduce colorectal adenoma recurrence and inhibit colorectal carcinogenesis." | 8.12 | Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora. ( Chang, J; Geng, Z; Hao, X; Liu, J; Tan, X; Wang, Z; Yan, S, 2022) |
| "The present study explored the synergetic effects of berberine and 6-shogaol, the primary components of Coptidis Rhizoma and Zingiberis Rhizoma, respectively, on intestinal inflammation and intestinal flora in mice with ulcerative colitis to reveal the effect and mechanism of cold-heat combination in the treatment of ulcerative colitis." | 8.12 | [Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis]. ( Chen, ZG; Li, JT; Wei, HL; Yan, SG, 2022) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 8.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years." | 8.02 | Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model. ( Chen, J; Huang, Z; Li, Q; Li, Y; Liu, D; Su, Z; Xie, J; Zeng, H; Zheng, J, 2021) |
| "Berberine (BBR) is an effective component of Huanglian and has shown to attenuate atherosclerosis (AS); however, the detailed mechanism of BBR-mediated protective actions against AS remains elusive." | 7.96 | Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy. ( Huang, Y; Ke, X; Li, L; Lin, F; Song, Y; Xin, F; Xu, L; Zeng, Z; Zhang, Y, 2020) |
| "Berberine has been established as a potential drug for inflammation and metabolic disorder." | 7.96 | Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu. ( Fan, DH; Han, YB; Li, WZ; Liu, L; Tian, M; Wang, XX; Wu, F, 2020) |
| "This study aimed to explore the therapeutic effects and underlying mechanism of berberine (BBR) on the non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD)." | 7.96 | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway. ( Jia, Z; Wang, B; Wang, L; Zhang, B, 2020) |
| "Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease (COPD), its underlying mechanisms were not clear until now." | 7.91 | Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway. ( Li, CN; Wang, W; Wang, X; Wu, XJ; Zha, G; Zou, JJ, 2019) |
| "This study aimed to verify the effects of berberine (BBR) on the fat metabolism proteins involved in the sirtuin 3 (SIRT3)/adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway in the liver tissues of rats with high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD)." | 7.91 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. ( Chen, RS; Chen, YN; Deng, YJ; Han, L; Jin, L; Liang, S; Liang, YJ; Liang, ZE; Tang, KR; Yang, QH; Zhang, YP, 2019) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 7.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| " Berberine is used to treat obesity, diabetes and atherosclerosis." | 7.88 | Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe ( Dong, L; Hu, Y; Liu, T; Shen, X; Weng, S; Zhang, D; Zhu, H; Zhu, J; Zhu, L, 2018) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 7.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| "Berberine, a natural compound extracted from several Chinese herbs including Coptis chinensis, has been shown to have anti-obesity effects and prevents insulin resistance in high-fat diet (HFD)-fed obese rats by modulating the gut microbiota; however, the molecular mechanisms underlying these activities remain unknown." | 7.88 | Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. ( Hou, L; Li, S; Liu, D; Liu, Y; Tian, H; Zhang, Y; Zhao, T, 2018) |
| "Berberine has been reported to have protective effects in colitis treatment." | 7.88 | Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis. ( Chen, C; Fang, X; Ge, C; Hua, W; Liu, C; Liu, X; Liu, Y; Tao, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 7.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "The rat cecal ligation and puncture (CLP) sepsis model was employed to evaluate the effect of berberine on serum endotoxin level and intestinal vascular permeability to Evans blue in vivo." | 7.88 | Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis. ( Feng, A; He, Y; Sun, Y; Yuan, X; Zuo, H, 2018) |
| " This study aimed at investigating the effects of Berberine nanoparticles (BBR-NP) on the ischemia-reperfusion injury of renal tubular epithelial cells and underlying the mechanisms." | 7.85 | Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury. ( Hailun, L; Jing, W; Juxiang, Z; Lin, YT; Xie, D; Xu, Y; Yu, H; Zheng, DH, 2017) |
| " Berberine dose-dependently reversed the alterations induced by OVA in the asthmatic rats." | 7.83 | Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma. ( Li, C; Li, Z; Zhang, N; Zheng, J, 2016) |
| " Berberine has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties, but its mechanisms for treating nonbacterial prostatitis (NBP) remain unclear completely." | 7.81 | Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation. ( An, N; Sun, H; Wang, H; Wang, X; Yan, G; Zhang, A; Zhang, Y, 2015) |
| " The present investigation was deliberated to scrutinize the renoprotective potential of berberine in animal model of renal ischemia reperfusion (RIR) induced dent via assessment of various biochemical and molecular biomarkers." | 7.81 | Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. ( Bodhankar, SL; Kandhare, AD; Visnagri, A, 2015) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 7.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| "Berberine is a natural product that shows benefits for metabolic syndrome (MS)." | 7.81 | Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome. ( Gao, HQ; Ji, XP; Li, CB; Li, XX; Wang, HW; Xiao, J; Zhang, C; Zhang, XY, 2015) |
| "In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain." | 7.81 | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015) |
| "To investigate the potential effects of berberine on renal interstitial fibrosis (RIF) of obstructed kidneys in a unilateral ureteral obstruction (UUO) rat model." | 7.80 | Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. ( He, YQ; Ma, LL; Tian, XJ; Wang, FM; Yang, YJ, 2014) |
| "Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway." | 7.79 | Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. ( Du, GH; Fang, LH; Gong, LL; Guo, J; Li, L; Qin, HL; Wang, SB; Wu, YJ; Xu, XN; Yan, Y; Yuan, TY, 2013) |
| "In this study, we have examined the effects of berberine on tumorigenicity and growth of nasopharyngeal carcinoma (NPC) cells and their relationship to STAT3 signaling using both in vivo and in vitro models." | 7.79 | Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. ( Cheung, KC; Cheung, YC; Feng, Y; Lin, VW; Lui, VW; Tsang, CM; Tsao, SW; Yip, YL; Zhang, G, 2013) |
| "Eighty-seven SD rats were randomly divided into normal group, sham-operated group and acetic acid-induced gastric ulcer group, omeprazole group as a positive control, five active components (glycyrrhetic acid, beta-sitosterol, berberine, baicalin and ginsenoside) of Banxia Xiexin Decoction were divided into groups by L16 orthogonal design." | 7.78 | [Effect of banxia xiexin decoction on leptin and endothelin-1 of gastric ulcer rat and the optimal combination screening of active components]. ( Liang, XB; Sun, J; Zhao, GP, 2012) |
| "The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS)." | 7.78 | Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis. ( Hong, T; Lv, CF; Yang, Z; Zhang, Y, 2012) |
| "The purpose of this study was to explore the anti-arrhythmic mechanisms of berberine in diabetic rats with myocardial infarction." | 7.77 | Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model. ( Fu, Y; Li, Q; Sun, YQ; Wang, LH; Yu, CH, 2011) |
| "Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs." | 7.77 | Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. ( O, K; Sarna, LK; Siow, YL; Wu, N, 2011) |
| "To observe the effect of berberine on uncoupling protein-2 (UCP2) mRNA and protein expressions in the hepatic tissue of non-alcoholic fatty liver disease (NAFLD) in rats, and to explore the molecular mechanism." | 7.77 | Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. ( Chen, TY; Hu, SP; Ji, GY; Li, N; Lin, XF; Liu, HT; Qiao, NL; Xie, WN; Yang, QH; Zhang, YP, 2011) |
| "The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia." | 7.77 | Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. ( Feng, AW; Li, JS; Li, N; Li, QR; Mao, Q; Yu, C, 2011) |
| "To study the effects of total saponins of Panax ginseng combined with berberine on hemodynamics, Plasma brain natriuretic peptide and Ca2+ concentration in cardiac cells of chronic congestive heart failure rats." | 7.75 | [Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure]. ( Chen, X; Li, G; Li, Y; Liu, H; Luo, F, 2009) |
| "We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer." | 7.71 | Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001) |
| "A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0." | 6.80 | Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. ( Chang, XX; Deng, W; Feng, R; Gao, X; Jia, WP; Jiang, JD; Liu, J; Rao, SX; Tu, YF; Wang, Y; Xia, MF; Yan, HM; Yao, XZ; Zeng, MS, 2015) |
| "Berberine (BRB) is a compound belonging to the group of isoquinoline alkaloids of plant origin that has long been used in traditional chinese medicine (TMC)." | 6.61 | Berberine as a potential therapeutic agent in the treatment of acute pancreatitis ( Fichna, J; Pawlik, L; Tarasiuk, A, 2019) |
| "Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine." | 6.52 | Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015) |
| "Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota." | 5.91 | Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. ( Ge, PY; Guo, R; Ni, SJ; Qi, YY; Qu, SY; Yang, NY; Yao, ZY; Zhang, QC; Zhao, X; Zhu, HX, 2023) |
| "Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability." | 5.62 | Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model. ( Azadi, R; Jaafari, MR; Kazemi, NM; Mousavi, SE; Rezayat, SM; Yousefi-Manesh, H, 2021) |
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 5.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| "Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis." | 5.56 | Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020) |
| "Sepsis is a deadly complication raised by bacterial pathogens-induced dysregulated innate inflammatory response." | 5.56 | Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation. ( Du, P; Jiang, D; Wang, Y, 2020) |
| "Berberine (BBR) is a bioactive constituent that displays effects on blood glucose; however, the mechanism underlying the role of BBR during the development of DR is not completely understood." | 5.56 | Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway. ( Li, M; Li, X; Li, Z; Ma, L; Ma, Z; Wang, X; Zhai, J; Zhang, H; Zhang, Y; Zou, J, 2020) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 5.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Berberine (BBR) is a herbal alkaloid, which shows many neuroprotective properties in neurodegenerative diseases." | 5.51 | Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia. ( Bashiri, H; Ghotbi Ravandi, S; Khodamoradi, M; Nozari, M; Saeedi Goraghani, M; Shabani, M, 2019) |
| " In summary, BB exerted similar effect to its analogue BBR and positive control in attenuating DSS-induced UC with much lower dosage and similar mechanism." | 5.48 | Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. ( Chen, JP; Huang, YF; Li, HL; Qu, C; Su, ZR; Xu, LQ; Xu, YF; Yi, TG; Yu, XT; Zeng, HF; Zhang, XJ; Zheng, L, 2018) |
| "Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR." | 5.48 | Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model. ( Cheng, W; Li, J; Li, W; Sun, B; Wu, J; Xie, J; Zhang, Q, 2018) |
| "Berberine (BBR) has been shown to relieve several metabolic disorders, including obesity and type 2 diabetes." | 5.48 | Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice. ( Hua, Y; Song, Y; Wang, L; Ye, X, 2018) |
| "Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, which exhibits numerous biological effects on gastrointestinal disorders." | 5.48 | Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. ( Gong, C; Hua, Y; Kang, Y; Liao, X; Ou, X, 2018) |
| "Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents." | 5.46 | Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017) |
| "Berberine was orally administrated in normal or CUMS mice for successive four weeks." | 5.46 | Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. ( Bai, L; Fang, XY; Li, YC; Liu, YM; Niu, L; Wang, LL; Yi, LT, 2017) |
| " It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters." | 5.46 | Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE ( Feng, M; Hu, Y; Li, X; Ma, H; Xiao, Y; Ye, X; Zhou, X; Zou, Z, 2017) |
| "Colitis was induced by two cycles of 2." | 5.43 | Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses. ( Bian, ZX; Fatima, S; Hu, DD; Lee, NP; Li, YH; Lin, CY; Mu, HX; Xiao, HT, 2016) |
| " In the present study, we investigated the effects of berberine in combination with yohimbine (BY) on neutrophil tissue infiltration and multiple organ damage during sepsis, and further elucidated the involved mechanisms." | 5.43 | Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils. ( Li, H; Lu, D; Lv, X; Tang, X; Wang, F; Wang, H; Wang, Y; Yang, D, 2016) |
| " Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software." | 5.42 | Pharmacokinetic difference of berberine between normal and chronic visceral hypersensitivity irritable bowel syndrome rats and its mechanism. ( Chen, Y; Dong, Y; Gong, Z; Guo, Y; Li, Y; Liu, X; Wang, Y; Weng, X; Yang, Q; Zhang, R; Zhou, B; Zhu, X, 2015) |
| "Berberine was found to inhibit these signaling components in OASFs in vitro and prevent cartilage degradation in vivo." | 5.42 | Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis. ( Hung, CY; Lee, HP; Li, TM; Liu, SC; Tang, CH; Tsai, CH, 2015) |
| "Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects." | 5.42 | Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses. ( Kaneko, A; Kawano, M; Matsushita, S; Takagi, R, 2015) |
| "Berberine (BBR) has been reported in several studies in cell and animal models." | 5.42 | Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity. ( Cha, Y; Chen, Z; Ding, H; Huang, X; Liu, J; Sheng, L; Wang, F; Wu, U; Xu, J, 2015) |
| " Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software." | 5.40 | Pharmacokinetic comparison of berberine in rat plasma after oral administration of berberine hydrochloride in normal and post inflammation irritable bowel syndrome rats. ( Chen, Y; Dong, Y; Gao, S; Gong, Z; Guo, Y; Wang, Y; Weng, X; Yang, Q; Zhang, H; Zhang, R; Zhu, X, 2014) |
| "Cardiac hypertrophy is a maladaptive change in response to pressure overload, and is also an important risk for developing heart failure." | 5.40 | Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. ( Chen, SL; Iqbal, J; Li, B; Li, MH; Mao, WX; Mi, QY; Wang, ZM; Xie, HG; Yang, SH; Yu, YH; Zhang, YJ, 2014) |
| "Berberine is an alkaloid derived from herb the Berberis sp." | 5.40 | Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014) |
| "Berberine treatment was found to have no significant effect on the histological changes in the pancreas, but was observed to ameliorate the intestinal mucosal barrier damage and membrane permeability associated with SAP." | 5.40 | Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway. ( Chen, T; Huang, Z; Liang, HY; Tang, LJ; Yan, HT, 2014) |
| "Berberine was administered through gavage to mice with established DSS-induced intestinal injury and colitis." | 5.38 | Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. ( Cao, H; Chaturvedi, R; Israel, DA; Liu, L; Peek, RM; Polk, DB; Shi, Y; Wang, B; Wang, L; Washington, MK; Wilson, KT; Yan, F, 2012) |
| "To elucidate the underly molecular mechanisms of berberine in colorectal cancer from a perspective of epigenetics, and tried to explore the role of lincROR-Wnt/β-catenin molecular axis in the berberine induced the anti-tumour activity in colorectal cancer." | 4.31 | Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer. ( Fu, WM; Li, SY; Shi, CJ; Zhang, JF, 2023) |
| "Our findings suggest that Berberine plays an important neuroprotective role against ICH-induced neurological impairments and BBB injury, probably by inhibition of inflammation and activation of AMPK/PGC1α signaling." | 4.12 | Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage. ( Liu, X; Wang, Y; Wu, X; Yang, L, 2022) |
| " Berberine has demonstrated good neuroprotective effects in models of acute cerebral ischemia; however, whether it can alleviate cognitive impairment caused by chronic cerebral hypoperfusion has rarely been investigated." | 4.12 | Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats. ( Du, Y; Huang, Y; Li, F; Luo, Y; Tao, Z; Tian, Y; Wang, N; Wang, Q; Wang, Y; Yan, F; Zhao, F; Zheng, Y, 2022) |
| " In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model." | 4.12 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota. ( Deng, J; Han, L; Li, Y; Shi, J; Wang, H; Yan, Y; Yuan, X; Zhang, H; Zhao, H; Zhao, L; Zhao, Y; Zou, F, 2022) |
| "Berberine reduced the uterine weight, suppressed the myometrial infiltration of ectopic endometrium, improved the hotplate and tail-flick latency of the adenomyosis mice." | 4.12 | Berberine attenuates hyperalgesia in mice with adenomyosis. ( Chen, Y; Guo, M; Huang, L; Lin, T; Lu, Y; Pan, Q; Shen, X; Zhang, C; Zhang, H; Zhu, B, 2022) |
| " Berberine can reduce colorectal adenoma recurrence and inhibit colorectal carcinogenesis." | 4.12 | Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora. ( Chang, J; Geng, Z; Hao, X; Liu, J; Tan, X; Wang, Z; Yan, S, 2022) |
| "The present study explored the synergetic effects of berberine and 6-shogaol, the primary components of Coptidis Rhizoma and Zingiberis Rhizoma, respectively, on intestinal inflammation and intestinal flora in mice with ulcerative colitis to reveal the effect and mechanism of cold-heat combination in the treatment of ulcerative colitis." | 4.12 | [Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis]. ( Chen, ZG; Li, JT; Wei, HL; Yan, SG, 2022) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 4.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years." | 4.02 | Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model. ( Chen, J; Huang, Z; Li, Q; Li, Y; Liu, D; Su, Z; Xie, J; Zeng, H; Zheng, J, 2021) |
| "Compared with the sham group, rats of the TAC group showed significantly increased cardiac hypertrophy and fibrosis, which could be ameliorated by treatment with berberine." | 3.96 | Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway. ( Chen, J; Chen, X; Cheng, C; Huang, S; Jiang, X; Liu, S; Xu, M, 2020) |
| "Berberine (BBR) is an effective component of Huanglian and has shown to attenuate atherosclerosis (AS); however, the detailed mechanism of BBR-mediated protective actions against AS remains elusive." | 3.96 | Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy. ( Huang, Y; Ke, X; Li, L; Lin, F; Song, Y; Xin, F; Xu, L; Zeng, Z; Zhang, Y, 2020) |
| "Berberine has been established as a potential drug for inflammation and metabolic disorder." | 3.96 | Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu. ( Fan, DH; Han, YB; Li, WZ; Liu, L; Tian, M; Wang, XX; Wu, F, 2020) |
| "This study aimed to explore the therapeutic effects and underlying mechanism of berberine (BBR) on the non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD)." | 3.96 | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway. ( Jia, Z; Wang, B; Wang, L; Zhang, B, 2020) |
| "Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease (COPD), its underlying mechanisms were not clear until now." | 3.91 | Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway. ( Li, CN; Wang, W; Wang, X; Wu, XJ; Zha, G; Zou, JJ, 2019) |
| "Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity." | 3.91 | Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation. ( Du, LJ; Feng, YL; Gao, HW; Gong, Q; He, LL; Lei, F; Li, J; Luo, YY; Wang, ML; Yan, XJ; Yang, SL, 2019) |
| "This study aimed to verify the effects of berberine (BBR) on the fat metabolism proteins involved in the sirtuin 3 (SIRT3)/adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway in the liver tissues of rats with high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD)." | 3.91 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. ( Chen, RS; Chen, YN; Deng, YJ; Han, L; Jin, L; Liang, S; Liang, YJ; Liang, ZE; Tang, KR; Yang, QH; Zhang, YP, 2019) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 3.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| "To investigate effects of berberine exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)." | 3.91 | Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice. ( Chen, X; Guo, Y; Han, Q; Hou, Q; Huang, Y; Li, P; Liu, F; Wen, Y; Zhang, C; Zhu, S, 2019) |
| " Berberine is used to treat obesity, diabetes and atherosclerosis." | 3.88 | Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe ( Dong, L; Hu, Y; Liu, T; Shen, X; Weng, S; Zhang, D; Zhu, H; Zhu, J; Zhu, L, 2018) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 3.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| "Berberine, a natural compound extracted from several Chinese herbs including Coptis chinensis, has been shown to have anti-obesity effects and prevents insulin resistance in high-fat diet (HFD)-fed obese rats by modulating the gut microbiota; however, the molecular mechanisms underlying these activities remain unknown." | 3.88 | Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. ( Hou, L; Li, S; Liu, D; Liu, Y; Tian, H; Zhang, Y; Zhao, T, 2018) |
| "Berberine has been reported to have protective effects in colitis treatment." | 3.88 | Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis. ( Chen, C; Fang, X; Ge, C; Hua, W; Liu, C; Liu, X; Liu, Y; Tao, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 3.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "The rat cecal ligation and puncture (CLP) sepsis model was employed to evaluate the effect of berberine on serum endotoxin level and intestinal vascular permeability to Evans blue in vivo." | 3.88 | Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis. ( Feng, A; He, Y; Sun, Y; Yuan, X; Zuo, H, 2018) |
| " This study aimed at investigating the effects of Berberine nanoparticles (BBR-NP) on the ischemia-reperfusion injury of renal tubular epithelial cells and underlying the mechanisms." | 3.85 | Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury. ( Hailun, L; Jing, W; Juxiang, Z; Lin, YT; Xie, D; Xu, Y; Yu, H; Zheng, DH, 2017) |
| " The animals were grouped in to solvent control; hypothyroid; hyperthyroid; prophylactic with two different doses of berberine chloride (50 and 100 mg/kg); treatment groups similar to that of the prophylactic and therapeutic group." | 3.83 | Pharmacological Effect of Berberine Chloride in Propyl Thiouracil Induced Thyroidal Dysfunction - A Time Bound Study in Female Rats. ( Dhiman, S; Dua, K; Gupta, G; Maurya, H, 2016) |
| " Berberine dose-dependently reversed the alterations induced by OVA in the asthmatic rats." | 3.83 | Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma. ( Li, C; Li, Z; Zhang, N; Zheng, J, 2016) |
| "Berberine increases atherosclerotic plaque stability in hyperhomocysteinemia mice, which is related to the activation of peroxisome proliferator-activated receptor-γ and subsequent suppression of oxidative stress in endothelial cells." | 3.83 | Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe ( Fang, L; He, C; Li, H; Li, X; Liu, N; Sun, X; Wang, J; Yang, Z, 2016) |
| "The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia." | 3.83 | Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. ( Abdalla, FH; Adefegha, SA; Baldissarelli, J; da Silva Bernardi, J; de Andrade, CM; de Oliveira, JS; Dornelles, GL; Lenz, LS; Magni, LP; Palma, TV; Pillat, MM; Rubin, MA; Signor, C, 2016) |
| " Berberine has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties, but its mechanisms for treating nonbacterial prostatitis (NBP) remain unclear completely." | 3.81 | Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation. ( An, N; Sun, H; Wang, H; Wang, X; Yan, G; Zhang, A; Zhang, Y, 2015) |
| " The present investigation was deliberated to scrutinize the renoprotective potential of berberine in animal model of renal ischemia reperfusion (RIR) induced dent via assessment of various biochemical and molecular biomarkers." | 3.81 | Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. ( Bodhankar, SL; Kandhare, AD; Visnagri, A, 2015) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 3.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| "Berberine could delay the onset and attenuate the severity of hypertension, as well as ameliorate hypertension-induced renal damage in SHR rats." | 3.81 | Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats. ( Guo, Z; Sun, H; Zhang, H; Zhang, Y, 2015) |
| "Berberine is a natural product that shows benefits for metabolic syndrome (MS)." | 3.81 | Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome. ( Gao, HQ; Ji, XP; Li, CB; Li, XX; Wang, HW; Xiao, J; Zhang, C; Zhang, XY, 2015) |
| "In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain." | 3.81 | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015) |
| "To investigate the potential effects of berberine on renal interstitial fibrosis (RIF) of obstructed kidneys in a unilateral ureteral obstruction (UUO) rat model." | 3.80 | Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. ( He, YQ; Ma, LL; Tian, XJ; Wang, FM; Yang, YJ, 2014) |
| "More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| "Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway." | 3.79 | Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. ( Du, GH; Fang, LH; Gong, LL; Guo, J; Li, L; Qin, HL; Wang, SB; Wu, YJ; Xu, XN; Yan, Y; Yuan, TY, 2013) |
| "In this study, we have examined the effects of berberine on tumorigenicity and growth of nasopharyngeal carcinoma (NPC) cells and their relationship to STAT3 signaling using both in vivo and in vitro models." | 3.79 | Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. ( Cheung, KC; Cheung, YC; Feng, Y; Lin, VW; Lui, VW; Tsang, CM; Tsao, SW; Yip, YL; Zhang, G, 2013) |
| "Eighty-seven SD rats were randomly divided into normal group, sham-operated group and acetic acid-induced gastric ulcer group, omeprazole group as a positive control, five active components (glycyrrhetic acid, beta-sitosterol, berberine, baicalin and ginsenoside) of Banxia Xiexin Decoction were divided into groups by L16 orthogonal design." | 3.78 | [Effect of banxia xiexin decoction on leptin and endothelin-1 of gastric ulcer rat and the optimal combination screening of active components]. ( Liang, XB; Sun, J; Zhao, GP, 2012) |
| "To investigate the protection of pulmonary arterial rings and cardiac myocytes of rats by raisanberine (RS), a derivative of berberine, against hypoxia injury and to elucidate the action mechanisms." | 3.78 | Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx. ( Cheng, YS; Dai, DZ; Dai, Y; Gao, J; Tang, YQ; Zhang, C; Zhang, GL, 2012) |
| "The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS)." | 3.78 | Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis. ( Hong, T; Lv, CF; Yang, Z; Zhang, Y, 2012) |
| "The purpose of this study was to explore the anti-arrhythmic mechanisms of berberine in diabetic rats with myocardial infarction." | 3.77 | Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model. ( Fu, Y; Li, Q; Sun, YQ; Wang, LH; Yu, CH, 2011) |
| "Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs." | 3.77 | Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. ( O, K; Sarna, LK; Siow, YL; Wu, N, 2011) |
| "To observe the effect of berberine on uncoupling protein-2 (UCP2) mRNA and protein expressions in the hepatic tissue of non-alcoholic fatty liver disease (NAFLD) in rats, and to explore the molecular mechanism." | 3.77 | Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. ( Chen, TY; Hu, SP; Ji, GY; Li, N; Lin, XF; Liu, HT; Qiao, NL; Xie, WN; Yang, QH; Zhang, YP, 2011) |
| " In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model." | 3.77 | Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011) |
| "The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia." | 3.77 | Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. ( Feng, AW; Li, JS; Li, N; Li, QR; Mao, Q; Yu, C, 2011) |
| "To study the effects of total saponins of Panax ginseng combined with berberine on hemodynamics, Plasma brain natriuretic peptide and Ca2+ concentration in cardiac cells of chronic congestive heart failure rats." | 3.75 | [Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure]. ( Chen, X; Li, G; Li, Y; Liu, H; Luo, F, 2009) |
| " In the present study, we examined the potential antipsychotic effect of l-SPD-A in a phencyclidine (PCP)-induced rat model of schizophrenia." | 3.75 | Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. ( Cai, W; Chen, X; Cheng, J; Guo, Y; Jin, G; Yang, Y; Zhang, H; Zhen, X, 2009) |
| " We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)." | 3.74 | Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008) |
| "We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer." | 3.71 | Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001) |
| "A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0." | 2.80 | Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. ( Chang, XX; Deng, W; Feng, R; Gao, X; Jia, WP; Jiang, JD; Liu, J; Rao, SX; Tu, YF; Wang, Y; Xia, MF; Yan, HM; Yao, XZ; Zeng, MS, 2015) |
| "Berberine (BRB) is a compound belonging to the group of isoquinoline alkaloids of plant origin that has long been used in traditional chinese medicine (TMC)." | 2.61 | Berberine as a potential therapeutic agent in the treatment of acute pancreatitis ( Fichna, J; Pawlik, L; Tarasiuk, A, 2019) |
| "Berberine is an isoquinoline alkaloid extracted from various Berberis species which is widely used in East Asia for a wide range of symptoms." | 2.61 | Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies. ( Cai, CZ; Li, M; Lu, JH; Su, HX; Wu, MY; Yuan, NN, 2019) |
| "00001) in a linear The dose-response relationship (Pearson r = - 0." | 2.61 | Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis. ( Long, Y; Ni, L; Tao, J; Wu, R; Xu, J; Yu, N; Yuan, X; Zhang, Y, 2019) |
| "Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine." | 2.52 | Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015) |
| "Berberine (BBR) is an isoquinoline plant alkaloid endowed with several pharmacological activities, including anti-microbial, glucose- and cholesterol-lowering, anti-tumoral and immunomodulatory properties." | 2.52 | Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. ( Catapano, AL; Pirillo, A, 2015) |
| "Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota." | 1.91 | Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. ( Ge, PY; Guo, R; Ni, SJ; Qi, YY; Qu, SY; Yang, NY; Yao, ZY; Zhang, QC; Zhao, X; Zhu, HX, 2023) |
| "Berberine (BBR) is a plant-origin quaternary isoquinoline alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects." | 1.72 | Berberine-loaded liposomes for oral delivery: Preparation, physicochemical characterization and in-vivo evaluation in an endogenous hyperlipidemic animal model. ( Duong, TT; Heinämäki, J; Nghiem, TH; Nguyen, LT; Nguyen, TD; Nguyen, TQ; Pham, HT; Pham, TM; Raal, A; Yen, TTH, 2022) |
| "Berberine (BBR) is an effective drug for UC treatment." | 1.72 | Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway. ( Dong, Y; Fan, H; Fu, Y; Gui, Y; Guo, W; Hu, D; Jiang, F; Kang, Z; Li, J; Li, M; Luo, S; Sarapultsev, A; Shou, Z; Wang, H; Zhang, G; Zhang, Z; Zhou, H; Zhu, R, 2022) |
| " Despite having substantial therapeutic potential, it exhibits poor absorption, low oral bioavailability and limited penetration in the brain." | 1.62 | Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance. ( Auti, ST; Kulkarni, YA; Kunde, SS; Raju, M; Wairkar, S, 2021) |
| "Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability." | 1.62 | Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model. ( Azadi, R; Jaafari, MR; Kazemi, NM; Mousavi, SE; Rezayat, SM; Yousefi-Manesh, H, 2021) |
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 1.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| "The anti-diabetic nephropathy properties were systematically analyzed in the diabetic db/db mice treated with Met, BBR or with combination of Met and BBR." | 1.62 | Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation. ( Sun, G; Sun, X; Zhang, B; Zhang, C; Zhang, X, 2021) |
| "Berberine (BBR) is a natural ingredient that has antioxidant and anti-inflammatory properties." | 1.62 | Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats. ( Goudarzi, M; Kalantar, H; Kalantar, M; Kalantari, H; Mansouri, E; Shabani, E, 2021) |
| "As a chronic inflammatory disease, ulcerative colitis (UC) is relevant to a rising risk of colorectal cancer." | 1.62 | Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice. ( Dong, N; Li, C; Lu, Q; Mo, Z; Wu, B; Xie, J, 2021) |
| "Berberine is a famous alkaloid extracted from Berberis plants and has been widely used as medications and functional food additives." | 1.62 | Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments. ( Jin, M; Liu, K; Liu, X; Ren, Q; Shang, X; Sheng, W; Stoika, R; Tan, Z; Wang, L; Wang, R, 2021) |
| "Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis." | 1.56 | Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020) |
| "Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall." | 1.56 | Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway. ( Chen, Y; Ding, XS; Feng, N; Feng, XF; Liu, F; Yang, LC; Yang, XJ; Zhu, SX, 2020) |
| "Berberine is a naturally occurring isoquinoline alkaloid and has been used as an important functional food additive in China due to its various pharmacological activities." | 1.56 | Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology. ( Jin, M; Kong, H; Li, X; Lin, H; Liu, K; Stoika, R; Wang, L, 2020) |
| "BACKGROUND Depression is the 5th most prevalent disorder adversely affecting the health of humans worldwide." | 1.56 | Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. ( Chen, H; Liu, L; Wang, N; Wang, X; Yang, T, 2020) |
| "Berberine and diazepam were used to treat the established insomnia rats." | 1.56 | Therapeutic Effect of Berberine on Insomnia Rats by ErbB Signaling Pathway. ( Deng, N; Liu, T; Peng, Z; Ren, X; Wang, G; Wang, Q; Xu, H; Zhang, X, 2020) |
| "Sepsis is a deadly complication raised by bacterial pathogens-induced dysregulated innate inflammatory response." | 1.56 | Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation. ( Du, P; Jiang, D; Wang, Y, 2020) |
| "Berberine (BBR) is a bioactive constituent that displays effects on blood glucose; however, the mechanism underlying the role of BBR during the development of DR is not completely understood." | 1.56 | Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway. ( Li, M; Li, X; Li, Z; Ma, L; Ma, Z; Wang, X; Zhai, J; Zhang, H; Zhang, Y; Zou, J, 2020) |
| "Berberine is an alkaloid of the protoberberine type used in traditional oriental medicine." | 1.56 | In Vitro and In Vivo Biological Activity of Berberine Chloride against Uropathogenic ( Cutuli, MA; Di Marco, R; Magnifico, I; Pane, A; Petronio Petronio, G; Pietrangelo, L; Scapagnini, G; Venditti, N; Vergalito, F, 2020) |
| "Berberine could be a promising antidiabetic nephropathy drug through ameliorating renal impairment and inhibiting podocyte dysfunction in diabetic rats, and the underlying molecular mechanisms might be involved in the regulation of the PI3K-Akt signaling pathway." | 1.56 | Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3-kinase-protein kinase B pathway in diabetic rats. ( Ding, HH; Ni, WJ; Tang, LQ; Zhou, H, 2020) |
| "Berberine (BBR) has been used to treat patients with IBS, but the underlying therapeutic mechanism is little understood." | 1.51 | Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats. ( Cen, YX; Guo, LL; Li, DF; Li, YX; Liu, TT; Luo, MH; Wang, JY; Wang, LS; Wei, C; Wu, BH; Xiong, F; Yao, J; Yu, ZC, 2019) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 1.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Berberine hydrochloride has beneficial effects in UC." | 1.51 | Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats. ( Gu, P; Shen, H; Zhu, L, 2019) |
| "Pretreatment with berberine prevented morphological changes in IgE-stimulated RBL-2H3 cells such as the recovery of an elongated shape." | 1.51 | Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling. ( Fu, M; Fu, S; Hong, T; Ni, S; Wang, D, 2019) |
| "Psoriasis is a chronic skin disease characterized by hyperproliferation and impaired differentiation of epidermal keratinocytes accompanied by increased inflammation, suggesting that molecules with antiproliferation and anti-inflammatory abilities may be effective for its treatment." | 1.51 | Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes. ( Cui, J; Gong, Y; Liang, C; Liu, X; Shao, C; Sun, S; Tian, F; Wang, Q; Wei, H; Wu, G; Xia, Y; Xu, B; Xu, M; Yang, G; Zhang, F; Zhang, L; Zhang, X; Zhao, H; Zhou, S; Zou, Y, 2019) |
| "Berberine (BBR) is a herbal alkaloid, which shows many neuroprotective properties in neurodegenerative diseases." | 1.51 | Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia. ( Bashiri, H; Ghotbi Ravandi, S; Khodamoradi, M; Nozari, M; Saeedi Goraghani, M; Shabani, M, 2019) |
| "When treated with berberine, the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice." | 1.48 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis. ( Fu, G; Huang, W; Qin, C; Wang, H; Yan, H; Zeng, M; Zhang, H; Zhao, L; Zhou, W, 2018) |
| "Periodontitis is a highly prevalent infectious disease associated genetically with coronary heart disease (CHD)." | 1.48 | Role of PCSK9 in the Development of Mouse Periodontitis Before and After Treatment: A Double-Edged Sword. ( Gan, J; Huang, C; Huang, LY; Song, FF; Sun, HL; Wu, YR; Zhang, L, 2018) |
| "Berberine (BBR) is a pharmacological compound with a potential protective effect of the mitochondrial function in the context of I/R." | 1.48 | Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion. ( Caetano Oliveira, R; Furtado, E; Marques Palmeira, C; Martins, RM; Pinto Rolo, A; Soeiro Teodoro, J; Tralhão, JG, 2018) |
| " In summary, BB exerted similar effect to its analogue BBR and positive control in attenuating DSS-induced UC with much lower dosage and similar mechanism." | 1.48 | Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. ( Chen, JP; Huang, YF; Li, HL; Qu, C; Su, ZR; Xu, LQ; Xu, YF; Yi, TG; Yu, XT; Zeng, HF; Zhang, XJ; Zheng, L, 2018) |
| "Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR." | 1.48 | Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model. ( Cheng, W; Li, J; Li, W; Sun, B; Wu, J; Xie, J; Zhang, Q, 2018) |
| "Berberine (BBR) has been shown to relieve several metabolic disorders, including obesity and type 2 diabetes." | 1.48 | Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice. ( Hua, Y; Song, Y; Wang, L; Ye, X, 2018) |
| "Berberine (BBR) has neuroprotective effects on many brain diseases, including Alzheimer's disease (AD)." | 1.48 | Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases. ( Cai, Z; Chen, Y; He, W; Wang, C, 2018) |
| " This study aimed to investigate the effect of an interpenetrating polymer network (IPN) of a sodium hyaluronate and sodium alginate (HA/SA) scaffold combined with berberine (BER) on osteochondral repair." | 1.48 | Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration. ( Chen, P; Fan, S; Lin, X; Mei, S; Mo, J; Xia, C, 2018) |
| "Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, which exhibits numerous biological effects on gastrointestinal disorders." | 1.48 | Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. ( Gong, C; Hua, Y; Kang, Y; Liao, X; Ou, X, 2018) |
| "Berberine was administered p." | 1.48 | Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. ( Chen, J; Chen, Q; Feng, Z; Hang, W; He, B; Wang, S; Wang, X; Wu, N; Xia, L; Zhang, Q; Zhou, X, 2018) |
| "Non‑alcoholic fatty liver disease (NAFLD), which affects approximately one‑third of the general population, has become a global health problem." | 1.48 | Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling. ( Gao, S; Huang, D; Huang, J; Tong, P; Wang, Y; Wu, X; Yue, Y; Zhao, J, 2018) |
| "Berberine has many pharmacological effects, such as antidiabetic, antimicrobial, anti-inflammatory, and antioxidant, but the question remains on how its low oral bioavailability has greatly limited its clinical application." | 1.48 | Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability. ( Cui, HX; Guo, Y; Hu, YN; Li, JW; Yuan, K, 2018) |
| "Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents." | 1.46 | Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017) |
| " Moreover, KRN2 and KRN5, the latter of which exhibits high oral bioavailability and metabolic stability, ameliorated experimentally induced arthritis in mice without serious adverse effects, decreasing pro-inflammatory cytokine production." | 1.46 | Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. ( Cho, CS; Cho, H; De, TQ; Han, EJ; Jeong, DY; Jue, DM; Kim, HY; Kim, NH; Kim, WU; Kwon, HM; Lee, GH; Lee, N; Lim, HJ; Park, WK; Park, YJ; Yoo, SA, 2017) |
| "Pioglitazone treatment significantly increased urinary calcium, serum TRAP, mRNA expression of RANKL, PPAR-γ as well as significantly decreased Runx2, OPG, osteocalcin and AMPK levels in diabetic rats." | 1.46 | Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk. ( Adil, M; Kandhare, AD; Mansoori, MN; Sharma, M; Singh, D, 2017) |
| "Berberine was orally administrated in normal or CUMS mice for successive four weeks." | 1.46 | Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. ( Bai, L; Fang, XY; Li, YC; Liu, YM; Niu, L; Wang, LL; Yi, LT, 2017) |
| "Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities." | 1.46 | Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. ( Bao, J; Chen, M; Chen, S; He, C; Jia, X; Lee, SMY; Li, C; Li, P; Li, Z; Liang, Y; Liu, K; Su, H; Wan, JB; Wang, K; Wang, X; Zhang, C, 2017) |
| " It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters." | 1.46 | Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE ( Feng, M; Hu, Y; Li, X; Ma, H; Xiao, Y; Ye, X; Zhou, X; Zou, Z, 2017) |
| " Histological analysis using plastic sections showed dosing with BBR preserved photoreceptors." | 1.43 | Berberine protects against light-induced photoreceptor degeneration in the mouse retina. ( Dunaief, JL; Li, Y; Song, D; Song, J; Wang, C, 2016) |
| "Colitis was induced by two cycles of 2." | 1.43 | Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses. ( Bian, ZX; Fatima, S; Hu, DD; Lee, NP; Li, YH; Lin, CY; Mu, HX; Xiao, HT, 2016) |
| "Berberine (BBR) has been shown to exhibit protective effects against diabetes and dyslipidemia." | 1.43 | Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway. ( Chen, L; Hatch, GM; Lan, X; Wei, S; Yan, X; Yao, F; Yu, Y; Zhang, M, 2016) |
| " In the present study, we investigated the effects of berberine in combination with yohimbine (BY) on neutrophil tissue infiltration and multiple organ damage during sepsis, and further elucidated the involved mechanisms." | 1.43 | Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils. ( Li, H; Lu, D; Lv, X; Tang, X; Wang, F; Wang, H; Wang, Y; Yang, D, 2016) |
| "Gastric cancer is the second leading cause of cancer-associated mortality worldwide." | 1.43 | MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo. ( Li, HL; Shi, HL; Wu, H; Wu, XJ; Zhang, BB, 2016) |
| "Demethyleneberberine (DMB) is an essential metabolite of Berberine (BBR) in vivo." | 1.43 | Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling. ( Chen, H; Li, R; Qiang, X; Wang, Y; Yan, Y; Zhang, Y; Zhao, Z; Zhou, C, 2016) |
| "Berberine was found to inhibit growth in GC cell lines and to induce apoptosis." | 1.43 | Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer. ( Cai, X; Cao, H; Chen, Z; Dong, J; Fan, D; Hao, J; Jin, T; Lu, D; Nie, Y; Wang, J; Wang, R; Yang, S; Zhang, S, 2016) |
| " Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software." | 1.42 | Pharmacokinetic difference of berberine between normal and chronic visceral hypersensitivity irritable bowel syndrome rats and its mechanism. ( Chen, Y; Dong, Y; Gong, Z; Guo, Y; Li, Y; Liu, X; Wang, Y; Weng, X; Yang, Q; Zhang, R; Zhou, B; Zhu, X, 2015) |
| "Berberine was administered through gavage to C57BL/6 mice with established CDI-induced intestinal injury and colitis." | 1.42 | Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment. ( Liu, W; Lv, Z; Peng, G; Su, J; Xu, H, 2015) |
| "Berberine (BBR) is a natural isoquinoline alkaloid with proven antiangiogenic and anticancer activities." | 1.42 | Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma. ( Bartozzi, B; Damiani, E; Donati, A; Geroni, C; Lombardi, P; Lucarini, G; Orlando, F; Pierpaoli, E; Provinciali, M; Salvatore, C, 2015) |
| "Berberine was found to inhibit these signaling components in OASFs in vitro and prevent cartilage degradation in vivo." | 1.42 | Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis. ( Hung, CY; Lee, HP; Li, TM; Liu, SC; Tang, CH; Tsai, CH, 2015) |
| "Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects." | 1.42 | Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses. ( Kaneko, A; Kawano, M; Matsushita, S; Takagi, R, 2015) |
| "Berberine (BBR) has been reported in several studies in cell and animal models." | 1.42 | Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity. ( Cha, Y; Chen, Z; Ding, H; Huang, X; Liu, J; Sheng, L; Wang, F; Wu, U; Xu, J, 2015) |
| "The hyperlipidemia zebrafish model was successfully established by feeding with 4% cholesterol for 20 days." | 1.42 | [Efficient and rapid liquid reduction animal model]. ( Chen, B; Han, B; Han, YL; Kou, SM; Li, XG; Peng, YZ; Wang, Y; Ye, XL, 2015) |
| "CCl4-induced chronic liver fibrosis model in mice was established and activated rat hepatic stellate cell was treated with BBR." | 1.40 | Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase. ( Chen, L; Guan, F; Kan, M; Li, J; Pan, Y; Wang, Y; Xiao, X; Zhang, X, 2014) |
| " Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software." | 1.40 | Pharmacokinetic comparison of berberine in rat plasma after oral administration of berberine hydrochloride in normal and post inflammation irritable bowel syndrome rats. ( Chen, Y; Dong, Y; Gao, S; Gong, Z; Guo, Y; Wang, Y; Weng, X; Yang, Q; Zhang, H; Zhang, R; Zhu, X, 2014) |
| "Berberine (BBR) has preventive effects on diabetes and its complications." | 1.40 | Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy. ( Liu, S; Tang, LQ; Wang, FL; Zhang, ST; Zhu, LN, 2014) |
| "Cardiac hypertrophy is a maladaptive change in response to pressure overload, and is also an important risk for developing heart failure." | 1.40 | Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. ( Chen, SL; Iqbal, J; Li, B; Li, MH; Mao, WX; Mi, QY; Wang, ZM; Xie, HG; Yang, SH; Yu, YH; Zhang, YJ, 2014) |
| "Berberine is an alkaloid derived from herb the Berberis sp." | 1.40 | Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014) |
| "Berberine treatment was found to have no significant effect on the histological changes in the pancreas, but was observed to ameliorate the intestinal mucosal barrier damage and membrane permeability associated with SAP." | 1.40 | Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway. ( Chen, T; Huang, Z; Liang, HY; Tang, LJ; Yan, HT, 2014) |
| "Low oral bioavailability of berberine due to poor solubility and membrane permeability limits its clinical use for treatment of diabetes." | 1.40 | Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability. ( Hatch, GM; Jingkai, G; Li, C; Ming, Z; Shengnan, W; Xiaojia, B; Zhaojie, M, 2014) |
| "The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use." | 1.40 | Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. ( Doddapaneni, R; Godugu, C; Patel, AR; Singh, M; Somagoni, J, 2014) |
| "Various potential molecules with putative positive role in stroke pathology have failed to confer neuro-protection in animal models due to their insufficient bioavailability in brain." | 1.39 | Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. ( Chopra, K; Singh, DP, 2013) |
| "Berberine (BBR) has been shown to attenuate the deleterious effects of ischemia/reperfusion (I/R) injury in the brain." | 1.39 | Berberine reduces rat intestinal tight junction injury induced by ischemia-reperfusion associated with the suppression of inducible nitric oxide synthesis. ( Gong, J; Gu, L; Li, J; Li, N; Li, Q; Yu, W; Zhu, W, 2013) |
| "As our continuing efforts for treatment of herpes simplex virus (HSV), we studied the topical delivery and safety of HB-13 in a gel formulation (0." | 1.39 | Evaluation of a 13-hexyl-berberine hydrochloride topical gel formulation. ( Chen, Y; Wang, S; Wei, HL; Xu, F; Xu, LF; Zheng, JR, 2013) |
| " As apoE is a potent ligand for the LDL receptor, we next evaluated the effects of TOR in combination with the LDL-lowering drug berberine, which upregulates LDL receptor expression in dyslipidemic hamsters." | 1.39 | Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters. ( Briand, F; Muzotte, E; Sulpice, T; Thieblemont, Q, 2013) |
| "Berberine was administered through gavage to mice with established DSS-induced intestinal injury and colitis." | 1.38 | Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. ( Cao, H; Chaturvedi, R; Israel, DA; Liu, L; Peek, RM; Polk, DB; Shi, Y; Wang, B; Wang, L; Washington, MK; Wilson, KT; Yan, F, 2012) |
| "Berberine (BBR) has gained attention for its vast beneficial biological effects through immunomodulation, anti-inflammatory and anti-apoptosis properties." | 1.38 | Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability. ( Cao, X; Cui, L; Dong, L; Ji, Y; Li, Y; Liu, Z; Qiao, H; Wang, C; Wang, L; Xing, Y; Zhang, X; Zhao, K; Zhu, C, 2012) |
| "Treated with berberine for 4 weeks, elevated blood pressure and heightened levels of urine protein, blood urea nitrogen and serum creatinine in model rats were depressed significantly (P < 0." | 1.37 | [Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose diet]. ( Cai, Y; Li, HB; Lv, JH; Qi, CL, 2011) |
| "Similar effects from lovastatin on lipidemia were observed except the Ber effect on CPT I A gene expression." | 1.37 | [Study on effect of berberine on modulating lipid and CPT I A gene expression]. ( Shi, L; Wang, H; Yin, H; Zhou, Q, 2011) |
| "The latency for development of convulsions and mortality rate was recorded in these models using mice." | 1.36 | Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. ( Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S, 2010) |
| " Mice in BL and BH were administered berberine by gavage at the dosage of 50 mg x kg(-1) and 150 mg x kg(-1), respectively." | 1.36 | [Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet]. ( Liu, J; Shang, W; Yu, X; Zhao, J, 2010) |
| " It is, therefore, suggested that the use of long-term l-DOPA therapy with isoquinoline derivatives including berberine may need to be examined for the presence of adverse symptoms." | 1.36 | Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease. ( Choi, HS; Hwang, BY; Kwon, IH; Lee, BK; Lee, CK; Lee, MK; Lim, SC; Shin, KS, 2010) |
| "Berberine at lower dose did not affect the locomotor activity and barbiturate-induced sleep time." | 1.35 | On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008) |
| "Berberine is an alkaloid derived from herb medicine Coptidis Rhizom." | 1.35 | Neuroprotective effects of berberine on stroke models in vitro and in vivo. ( Kong, H; Sun, XL; Zeng, XN; Zhou, XQ, 2008) |
| "Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic." | 1.35 | Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. ( Chiang, JH; Chung, JG; Ho, YT; Lai, KC; Li, TC; Liao, CL; Lin, JG; Lin, JJ; Lu, CC; Yang, JS, 2009) |
| "Because type 1 diabetes is caused by T cell-mediated destruction of beta cells and severe islet inflammation, we hypothesized that berberine could ameliorate type 1 diabetes through its immune regulation properties." | 1.35 | Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. ( Cui, G; Ge, B; Gong, Z; Qin, X; Zang, YQ; Zhang, Y, 2009) |
| "Berberine was orally administered." | 1.34 | Effect of berberine on monocyte chemotactic protein-1 and cytokine-induced neutrophil chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis. ( Chi, ZL; Cui, HS; Hayasaka, S; Hayasaka, Y; Zhang, XY; Zheng, LS, 2007) |
| "Berberine is a major component of Coptis japonica extract, and it has been established that the adverse effects of morphine on the brain involve dopamine (DA) receptors." | 1.33 | Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. ( Cho, JH; Jang, CG; Jeong, SM; Kim, HC; Kim, KW; Kim, SH; Lee, JH; Lee, SY; Nah, SY; Yang, EM; Yoo, JH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.42) | 18.7374 |
| 1990's | 1 (0.42) | 18.2507 |
| 2000's | 20 (8.37) | 29.6817 |
| 2010's | 143 (59.83) | 24.3611 |
| 2020's | 74 (30.96) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, B | 5 |
| Niu, S | 1 |
| Geng, H | 1 |
| Yang, C | 1 |
| Zhao, C | 1 |
| Luo, S | 2 |
| Kan, J | 1 |
| Zhang, J | 10 |
| Ye, P | 3 |
| Wang, D | 5 |
| Jiang, X | 3 |
| Li, M | 7 |
| Zhu, L | 5 |
| Gu, Y | 4 |
| Raju, M | 1 |
| Kunde, SS | 1 |
| Auti, ST | 1 |
| Kulkarni, YA | 1 |
| Wairkar, S | 1 |
| Song, T | 1 |
| Chen, WD | 1 |
| Azadi, R | 1 |
| Mousavi, SE | 1 |
| Kazemi, NM | 1 |
| Yousefi-Manesh, H | 1 |
| Rezayat, SM | 1 |
| Jaafari, MR | 1 |
| Lin, G | 3 |
| Yu, Q | 1 |
| Xu, L | 2 |
| Huang, Z | 5 |
| Mai, L | 1 |
| Jiang, L | 2 |
| Su, Z | 4 |
| Xie, J | 6 |
| Li, Y | 14 |
| Liu, Y | 3 |
| Lin, Z | 1 |
| Chen, J | 5 |
| Liang, Y | 6 |
| Zhang, T | 3 |
| Zhao, J | 3 |
| Li, C | 8 |
| Zou, H | 1 |
| Li, F | 2 |
| Ren, L | 1 |
| Zhang, B | 3 |
| Zhang, X | 11 |
| Zhang, C | 10 |
| Sun, G | 1 |
| Sun, X | 2 |
| Wang, N | 3 |
| Wang, L | 12 |
| Tan, HY | 1 |
| Zhang, Y | 18 |
| Feng, Y | 2 |
| Pang, H | 1 |
| Zhou, Y | 2 |
| Wang, J | 6 |
| Wu, H | 3 |
| Liu, X | 9 |
| Gao, F | 2 |
| Xiao, Z | 1 |
| Shabani, E | 1 |
| Kalantari, H | 1 |
| Kalantar, M | 1 |
| Goudarzi, M | 1 |
| Mansouri, E | 1 |
| Kalantar, H | 1 |
| Gao, X | 3 |
| Liu, J | 6 |
| Fan, D | 2 |
| Li, X | 13 |
| Fang, Z | 1 |
| Yan, K | 1 |
| Fan, Y | 1 |
| Wu, X | 5 |
| Yang, L | 2 |
| Wang, Y | 19 |
| Duong, TT | 1 |
| Yen, TTH | 1 |
| Nguyen, LT | 1 |
| Nguyen, TD | 1 |
| Nguyen, TQ | 1 |
| Nghiem, TH | 1 |
| Pham, HT | 1 |
| Raal, A | 1 |
| Heinämäki, J | 1 |
| Pham, TM | 1 |
| Tian, Y | 1 |
| Zheng, Y | 1 |
| Wang, Q | 3 |
| Yan, F | 2 |
| Tao, Z | 1 |
| Zhao, F | 1 |
| Huang, Y | 5 |
| Du, Y | 2 |
| Luo, Y | 1 |
| Zhang, L | 6 |
| Han, L | 3 |
| Ma, J | 1 |
| Wu, T | 1 |
| Wei, Y | 2 |
| Zhao, L | 4 |
| Tong, X | 1 |
| Wang, X | 10 |
| Liu, P | 4 |
| Wu, Q | 1 |
| Zheng, Z | 1 |
| Xie, M | 1 |
| Chen, G | 2 |
| Yu, J | 2 |
| Li, G | 3 |
| Kaplan, D | 1 |
| Deng, J | 1 |
| Yuan, X | 3 |
| Shi, J | 1 |
| Zhang, H | 8 |
| Zhao, Y | 2 |
| Wang, H | 9 |
| Yan, Y | 4 |
| Zhao, H | 3 |
| Zou, F | 1 |
| Zhu, B | 1 |
| Chen, Y | 9 |
| Guo, M | 1 |
| Huang, L | 2 |
| Pan, Q | 3 |
| Lin, T | 1 |
| Lu, Y | 2 |
| Shen, X | 2 |
| Sharma, A | 1 |
| Tirpude, NV | 1 |
| Bhardwaj, N | 1 |
| Kumar, D | 1 |
| Padwad, Y | 1 |
| Dong, Y | 3 |
| Fan, H | 1 |
| Zhang, Z | 4 |
| Jiang, F | 1 |
| Zhou, H | 3 |
| Guo, W | 1 |
| Kang, Z | 1 |
| Gui, Y | 1 |
| Shou, Z | 1 |
| Li, J | 11 |
| Zhu, R | 1 |
| Fu, Y | 2 |
| Sarapultsev, A | 1 |
| Zhang, G | 4 |
| Hu, D | 1 |
| Chen, H | 8 |
| Ye, C | 2 |
| Cai, B | 1 |
| Zhang, F | 2 |
| Guo, Y | 6 |
| Yao, Q | 1 |
| Yan, S | 1 |
| Chang, J | 1 |
| Hao, X | 1 |
| Tan, X | 1 |
| Geng, Z | 1 |
| Wang, Z | 5 |
| Yang, M | 4 |
| Li, L | 6 |
| Wu, K | 2 |
| Peng, L | 1 |
| Han, Q | 2 |
| Deng, LR | 1 |
| Zou, M | 1 |
| Tang, HZ | 1 |
| Huang, CY | 1 |
| Chen, FJ | 1 |
| Tomlinson, B | 1 |
| Li, YH | 3 |
| Wei, HL | 2 |
| Li, JT | 1 |
| Chen, ZG | 1 |
| Yan, SG | 1 |
| Diddi, S | 1 |
| Lohidasan, S | 1 |
| Arulmozhi, S | 1 |
| Mahadik, KR | 1 |
| Ge, PY | 1 |
| Qu, SY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Pioglitazone and Berberine in Treatment of Non-alcoholic Fatty Liver Disease(NAFLD) Patients With Impaired Glucose Regulation or Type 2 Diabetes Mellitus[NCT00633282] | Phase 2 | 184 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial[NCT03198572] | Phase 4 | 120 participants (Anticipated) | Interventional | 2017-08-16 | Recruiting | ||
| Assess the Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals With Obesity and Non-alcoholic Fatty Liver Disease[NCT05647915] | Phase 4 | 326 participants (Anticipated) | Interventional | 2022-12-15 | Not yet recruiting | ||
| A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention[NCT03378934] | Phase 4 | 64 participants (Anticipated) | Interventional | 2018-09-26 | Recruiting | ||
| To Test the Efficacy of Novel Berberine Emulsification by TPGS or Quillaja Extract on the Absorption of Berberine Compared to Berberine Powder in Humans[NCT03438292] | 32 participants (Actual) | Interventional | 2018-09-25 | Completed | |||
| A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188] | Phase 2/Phase 3 | 113 participants (Actual) | Interventional | 2018-04-25 | Completed | ||
| The Study of Berberine Affecting Metabolism, Inflammation Status, Endothelial Function and Thrombotic Events in Patients With Coronary Artery Disease by Remodeling Gut Microbiota[NCT04434365] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2019-06-21 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for berberine and Disease Models, Animal
| Article | Year |
|---|---|
Berberine as a potential therapeutic agent in the treatment of acute pancreatitis
Topics: Acute Disease; Animals; Berberine; Disease Models, Animal; Humans; Lung; Pancreas; Pancreatitis | 2019 |
Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies.
Topics: Alzheimer Disease; Animals; Berberine; Disease Models, Animal; Mice; Neuroprotective Agents; Rats | 2019 |
Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Berberine; Berberis; Body Weight; Cricetina | 2019 |
Therapeutic potential of berberine against neurodegenerative diseases.
Topics: Alzheimer Disease; Animals; Berberine; Blood-Brain Barrier; Disease Models, Animal; Humans; Medicine | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.
Topics: Animals; Anticholesteremic Agents; Berberine; Biomarkers; Blood Glucose; Cholesterol; Diabetes Melli | 2015 |
1 trial available for berberine and Disease Models, Animal
| Article | Year |
|---|---|
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Adiposity; Administration, Oral; Animals; Berberine; Blood Glucose; Body Weight; Diet, High-Fat; Dis | 2015 |
233 other studies available for berberine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Berberine Attenuates Neonatal Sepsis in Mice By Inhibiting FOXA1 and NF-κB Signal Transduction Via the Induction of MiR-132-3p.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Cytokines; Disease | 2021 |
Bioactive Compounds From Coptidis Rhizoma Alleviate Pulmonary Arterial Hypertension by Inhibiting Pulmonary Artery Smooth Muscle Cells' Proliferation and Migration.
Topics: Animals; Antihypertensive Agents; Berberine; Cell Movement; Cell Proliferation; Cells, Cultured; Cop | 2021 |
Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Berberine; Biological Availability; Disease Models, | 2021 |
Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway.
Topics: Animals; Berberine; Carotid Artery Diseases; Diet, High-Fat; Disease Models, Animal; Lipids; Male; M | 2021 |
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Brain; Brain Ischemia; Carotid Artery Diseases; Diseas | 2021 |
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Ch | 2021 |
Glucocorticoid receptor-mediated alleviation of inflammation by berberine:
Topics: Animals; Anti-Inflammatory Agents; Berberine; Dermatitis, Contact; Disease Models, Animal; Female; H | 2021 |
Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation.
Topics: Animals; Berberine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Drug Synerg | 2021 |
Berberine suppresses advanced glycation end products-associated diabetic retinopathy in hyperglycemic mice.
Topics: Animals; Berberine; Diabetic Retinopathy; Disease Models, Animal; Glycation End Products, Advanced; | 2021 |
Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells.
Topics: Adipose Tissue; Animals; Apoptosis; Autophagy; Berberine; Cell Survival; Disease Models, Animal; Fem | 2021 |
Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Dihydrotestosterone; Disease Models, Ani | 2021 |
Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Berberine; Carrier Proteins; Cell Line, Tumor; | 2022 |
Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Blood-Brain Barrier; Cerebral Hemorrhage; Cytokin | 2022 |
Berberine-loaded liposomes for oral delivery: Preparation, physicochemical characterization and in-vivo evaluation in an endogenous hyperlipidemic animal model.
Topics: Animals; Berberine; Cholesterol; Cholesterol, LDL; Disease Models, Animal; Liposomes; Mice; Rats | 2022 |
Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Brain Ischemia; Carotid Artery, Common; Cognitive Dysf | 2022 |
Exploring the synergistic and complementary effects of berberine and paeoniflorin in the treatment of type 2 diabetes mellitus by network pharmacology.
Topics: Animals; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Drugs, Chinese | 2022 |
Sustainable Antibacterial and Anti-Inflammatory Silk Suture with Surface Modification of Combined-Therapy Drugs for Surgical Site Infection.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Artemisinins; Berberine; Cell Line; Cell S | 2022 |
Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Colitis; Colon; Dextran Sulfate; Disease Models, A | 2022 |
Berberine attenuates hyperalgesia in mice with adenomyosis.
Topics: Adenomyosis; Animals; Berberine; Disease Models, Animal; Endometrium; Female; Humans; Hyperalgesia; | 2022 |
Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3β/STAT/Akt/MAPKs/NF-κB signaling axis mediated oxi-inflammation and joint articular damage in murine model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Berberine; Berberis; Collagen; Disease M | 2022 |
Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway.
Topics: Animals; Berberine; beta Catenin; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mode | 2022 |
Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Colitis; Colon; Dextran Sulfate; Disease Models, A | 2022 |
Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorect | 2022 |
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice.
Topics: Alzheimer Disease; Animals; Berberine; Cognition; Cognitive Dysfunction; Cytokines; Disease Models, | 2022 |
A Combination of Baicalin and Berberine Hydrochloride Ameliorates Dextran Sulfate Sodium-Induced Colitis by Modulating Colon Gut Microbiota.
Topics: Animals; Berberine; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Topics: Animals; Berberine; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
[Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis].
Topics: Animals; Berberine; Catechols; Claudin-1; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dise | 2022 |
Standardization and Ameliorative effect of Kalyanaka ghrita in β-amyloid induced memory impairment in wistar rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Berberine; Br | 2023 |
Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.
Topics: Animals; Berberine; Chromatography, Liquid; Depression; Disease Models, Animal; Indoleamine-Pyrrole | 2023 |
Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Berberine; China; Colitis; Colitis, Ulcerative; Dextran | 2022 |
Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; beta Catenin; Cell Line, Tumor; Cell Prolifera | 2023 |
Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulcerative Colitis via Regulating Gut Microbiota.
Topics: Animals; Berberine; Chitosan; Claudin-2; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disea | 2022 |
A Composition of Phytonutrients for Glycemic and Weight Management.
Topics: Acrolein; Animals; Berberine; Blood Glucose; Curcumin; Diabetes Mellitus; Disease Models, Animal; Fa | 2022 |
Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota.
Topics: Animals; Berberine; Cats; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Anim | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Berberine increases stromal production of Wnt molecules and activates Lgr5
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucos | 2022 |
Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats.
Topics: Animals; Antidepressive Agents; Berberine; Brain-Derived Neurotrophic Factor; Depression; Disease Mo | 2023 |
LCN2 contributes to the improvement of nonalcoholic steatohepatitis by 8-Cetylberberine.
Topics: Animals; Berberine; Diet, High-Fat; Disease Models, Animal; Inflammation; Lipids; Lipocalin-2; Liver | 2023 |
[Therapeutic effect of ursodeoxycholic acid-berberine supramolecular nanoparticles on ulcerative colitis based on supramolecular system induced by weak bond].
Topics: Animals; Berberine; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Dr | 2023 |
Synergistic effect of berberine hydrochloride and dehydrocostus lactone in the treatment of ulcerative colitis: Take gut microbiota as the target.
Topics: Animals; Berberine; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Ga | 2023 |
Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats.
Topics: Animals; Berberine; Cytokines; Disease Models, Animal; Enteric Nervous System; Gastrointestinal Moti | 2019 |
Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Bronchoalveolar Lavage Fluid; Cigarette | 2019 |
Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy.
Topics: Animals; Autophagy; Berberine; Cardiomegaly; Disease Models, Animal; Down-Regulation; Male; Myocytes | 2019 |
Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats.
Topics: Animals; Berberine; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Coculture Techniqu | 2019 |
LC-MS-based metabolomics analysis of Berberine treatment in ulcerative colitis rats.
Topics: Amino Acids; Animals; Berberine; Chromatography, Liquid; Colitis, Ulcerative; Disease Models, Animal | 2019 |
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance.
Topics: Alzheimer Disease; Animals; Autophagy; Beclin-1; Berberine; Cathepsin D; Cells, Cultured; Cognitive | 2020 |
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
Topics: Animals; Behavior, Animal; Berberine; Cell Survival; Corticosterone; Depression; Disease Models, Ani | 2019 |
Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway.
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subf | 2020 |
Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Berberine; Bone Marrow Transplantation; Cyclospori | 2020 |
Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Line; Cell Proliferation; Cell Survival; Chemokin | 2020 |
Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects.
Topics: Administration, Intranasal; Animals; Antidepressive Agents; Berberine; Blood-Brain Barrier; Depressi | 2020 |
Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology.
Topics: Animals; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Disaccharides; Disease Models, Animal; | 2020 |
Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway.
Topics: Animals; Atrial Natriuretic Factor; Berberine; Cell Line; Disease Models, Animal; Fibrosis; Hypertro | 2020 |
ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.
Topics: 3T3-L1 Cells; Adenosine Triphosphate; Animals; Berberine; Diet, High-Fat; Disease Models, Animal; Do | 2020 |
Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Berberine; Depression; Disease Models, Animal; Dop | 2020 |
Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Disease Models, Animal; Edema; Inflamma | 2020 |
Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy.
Topics: Administration, Oral; Animals; Atherosclerosis; Autophagy; Berberine; Disease Models, Animal; Dose-R | 2020 |
Therapeutic Effect of Berberine on Insomnia Rats by ErbB Signaling Pathway.
Topics: Animals; Berberine; Disease Models, Animal; Male; Medicine, Chinese Traditional; Memory; Metabolic N | 2020 |
Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Differentiation; Chronic Disease; Cytokines; Dise | 2020 |
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; | 2020 |
Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation.
Topics: Animals; Berberine; Disease Models, Animal; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; Se | 2020 |
Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis.
Topics: Animals; Apolipoproteins M; Berberine; Capillary Permeability; Disease Models, Animal; Gastrointesti | 2020 |
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Topics: Animals; Apoptosis; Berberine; Cells, Cultured; Diabetic Retinopathy; Disease Models, Animal; Ependy | 2020 |
In Vitro and In Vivo Biological Activity of Berberine Chloride against Uropathogenic
Topics: Animals; Anti-Bacterial Agents; Berberine; Disease Models, Animal; Escherichia coli Infections; Hemo | 2020 |
Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.
Topics: Animals; Antiviral Agents; Berberine; Coxsackievirus Infections; Disease Models, Animal; Enterovirus | 2021 |
Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Berberine; Colitis; Col | 2021 |
ROS-Responsive Nanoparticle as a Berberine Carrier for OHC-Targeted Therapy of Noise-Induced Hearing Loss.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Berberine; Disease Models, Animal; D | 2021 |
Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway.
Topics: Animals; Berberine; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Male; Myel | 2020 |
Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine.
Topics: Administration, Oral; Animals; Berberine; Colitis; Colon; Delayed-Action Preparations; Dextran Sulfa | 2021 |
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome.
Topics: Animals; Atherosclerosis; Berberine; Choline; Diet; Disease Models, Animal; Disease Susceptibility; | 2021 |
Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.
Topics: Animals; Berberine; Disease Models, Animal; Electron Transport Complex I; Intestines; Lipid Metaboli | 2021 |
Activity of Compound Agrimony Enteritis Capsules against invasive candidiasis: Exploring the differences between traditional Chinese medicine prescriptions and its main components in the treatment of diseases.
Topics: Animals; Antifungal Agents; Berberine; Candida albicans; Candidiasis, Invasive; Capsules; Disease Mo | 2021 |
Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ve | 2021 |
Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Berberine; Brain; Cerebrovascular Circ | 2021 |
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.
Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fa | 2021 |
Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice.
Topics: Animals; Berberine; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Isoquinolin | 2021 |
Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments.
Topics: Animals; Berberine; Blood-Brain Barrier; Brain; Disease Models, Animal; Dopaminergic Neurons; Dose-R | 2021 |
Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.
Topics: Animals; Berberine; Disease Models, Animal; Hyperuricemia; Kidney; Kidney Diseases; Male; Mice; Mole | 2021 |
Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays.
Topics: Animals; Behavior, Animal; Berberine; Bifidobacterium; Body Weight; Depression; Disease Models, Anim | 2017 |
Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors.
Topics: Animals; Arthritis; Berberine; Binding Sites; Cells, Cultured; Chromatin Immunoprecipitation; Collag | 2017 |
Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice.
Topics: Animals; Berberine; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diseas | 2017 |
Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Berberine; Disease Models, Animal; Epithelial Cells; Kidney Function Tests; Kidn | 2017 |
Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk.
Topics: Animals; Berberine; Biomarkers; Blood Glucose; Bone and Bones; Bone Density; Diabetes Mellitus, Expe | 2017 |
Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Berberine; Chronic Disease; | 2017 |
Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; | 2017 |
Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe
Topics: Animals; Anti-Inflammatory Agents; Aorta; Aortic Diseases; Atherosclerosis; Berberine; Cytokines; Di | 2018 |
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cyclooxygenase 1; Cyclooxygenase 2; Dise | 2018 |
Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis.
Topics: Animals; Berberine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dysbiosis; Fecal | 2018 |
Role of PCSK9 in the Development of Mouse Periodontitis Before and After Treatment: A Double-Edged Sword.
Topics: Adult; Aftercare; Animals; Bacteroidaceae Infections; Berberine; Bone Resorption; Cytokines; Disease | 2018 |
Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion.
Topics: Animals; Apoptosis; Berberine; Cold Ischemia; Disease Models, Animal; Humans; Liver; Liver Transplan | 2018 |
Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway.
Topics: Animals; Berberine; Blood Glucose; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Drugs, | 2018 |
Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Differentiation; Colitis; Cytokines; Dextran Sulf | 2018 |
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Berberine; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammation | 2018 |
Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model.
Topics: Achyranthes; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; ATP Binding Cassette Transporter, | 2018 |
Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Berberine; Diet, H | 2018 |
Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Caco-2 Cells; Colon; Di | 2018 |
Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2018 |
Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration.
Topics: Alginates; Animals; Berberine; Bone and Bones; Bone Regeneration; Cartilage, Articular; Disease Mode | 2018 |
Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats.
Topics: Acute Disease; Animals; Apoptosis; Berberine; Blood-Brain Barrier; Cognition; Cognitive Dysfunction; | 2018 |
Berberine attenuates pulmonary arterial hypertension via protein phosphatase 2A signaling pathway both in vivo and in vitro.
Topics: Animals; Apoptosis; Berberine; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expre | 2018 |
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Disease Models, Animal; Histamine H1 Ant | 2018 |
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway.
Topics: Animals; Axons; Berberine; Cells, Cultured; Chromones; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2018 |
Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis.
Topics: Animals; Antigens, CD; Berberine; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cadherins; | 2018 |
Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling.
Topics: Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Aspartate Aminotransferases; Be | 2018 |
Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Antio | 2019 |
Coptisine Suppresses Mast Cell Degranulation and Ovalbumin-Induced Allergic Rhinitis.
Topics: Animals; Berberine; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Line; Disease Models, Ani | 2018 |
Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability.
Topics: Administration, Oral; Animals; Berberine; Biological Availability; Chromatography, High Pressure Liq | 2018 |
Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disea | 2019 |
Berberine attenuates hypoxia-induced pulmonary arterial hypertension via bone morphogenetic protein and transforming growth factor-β signaling.
Topics: Animals; Berberine; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell | 2019 |
Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling.
Topics: Animals; Anti-Allergic Agents; Berberine; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Lin | 2019 |
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Animals; Berberine; Carnitine O-Palmitoyltransferase; Diet | 2019 |
Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice.
Topics: Alzheimer Disease; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Amyloid beta | 2019 |
Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Cycle Proteins; Cell Line; Cell Proliferation; Di | 2019 |
Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress.
Topics: Animals; Antioxidants; Berberine; Disease Models, Animal; Humans; Male; Malondialdehyde; Oxidative S | 2020 |
Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.
Topics: Animals; Berberine; Bifidobacterium; Diarrhea; Disease Models, Animal; Faecalibacterium; Fecal Micro | 2019 |
Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.
Topics: Animals; Animals, Newborn; Berberine; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Mal | 2019 |
Berberine coated mannosylated liposomes curtail RANKL stimulated osteoclastogenesis through the modulation of GSK3β pathway via upregulating miR-23a.
Topics: Aniline Compounds; Animals; Arthritis, Rheumatoid; Berberine; Cells, Cultured; Disease Models, Anima | 2019 |
Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice.
Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Irri | 2019 |
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase | 2019 |
Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3-kinase-protein kinase B pathway in diabetic rats.
Topics: Animals; Berberine; Blood Glucose; Diabetic Nephropathies; Disease Models, Animal; Male; Phosphatidy | 2020 |
[Effect of banxia xiexin decoction on leptin and endothelin-1 of gastric ulcer rat and the optimal combination screening of active components].
Topics: Acetates; Animals; Berberine; Disease Models, Animal; Drugs, Chinese Herbal; Endothelin-1; Flavonoid | 2012 |
Antinociceptive effect of berberine on visceral hypersensitivity in rats.
Topics: Acetic Acid; Analgesics; Animals; Berberine; Colon; Defecation; Disease Models, Animal; Disease Prog | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Berberine; Brain; Disease Models, Animal; Glutathio | 2013 |
Berberine reduces rat intestinal tight junction injury induced by ischemia-reperfusion associated with the suppression of inducible nitric oxide synthesis.
Topics: Animals; Berberine; Disease Models, Animal; Intestinal Diseases; Intestinal Mucosa; Male; Membrane M | 2013 |
Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation.
Topics: Animals; Apoptosis; Berberine; Cytokines; Disease Models, Animal; Electrocardiography; Enzyme-Linked | 2013 |
Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts.
Topics: Animals; Antineoplastic Agents; Berberine; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Tra | 2013 |
Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Blotting, Western; Body Weight; Cell Proliferatio | 2014 |
Pharmacokinetic comparison of berberine in rat plasma after oral administration of berberine hydrochloride in normal and post inflammation irritable bowel syndrome rats.
Topics: Administration, Oral; Animals; Berberine; Cell Count; Chromatography, High Pressure Liquid; Disease | 2014 |
Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dinoprostone; Disease M | 2014 |
Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-κB activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Cell Line; Colitis; Colon; Cytokines; D | 2014 |
Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy.
Topics: Animals; Arterial Pressure; Autophagy; Berberine; Blotting, Western; Body Weight; Cardiomegaly; Card | 2014 |
Establishment of an allo-transplantable hamster cholangiocarcinoma cell line and its application for in vivo screening of anti-cancer drugs.
Topics: Allografts; Animals; Antineoplastic Agents; Berberine; Cell Culture Techniques; Cell Line, Tumor; Ce | 2013 |
Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved.
Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Caspase 3; Cell Survival; Disease Models, Animal; Dos | 2014 |
Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway.
Topics: Animals; Berberine; Disease Models, Animal; Intestinal Diseases; Intestinal Mucosa; Myosin Light Cha | 2014 |
Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability.
Topics: Administration, Oral; Animals; Berberine; Biological Availability; Blood Glucose; Caco-2 Cells; Calo | 2014 |
Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Berberine; Betulinic Acid; Biological Availabi | 2014 |
Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Cell Survival; Disease Models | 2014 |
Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Disease Models, Animal; Intercellular Adhesion Molecul | 2014 |
Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats.
Topics: Actins; Animals; Berberine; Biomarkers; Catalase; Cytoprotection; Disease Models, Animal; Fibrosis; | 2014 |
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Brain; Cell Survival; Cogniti | 2015 |
Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Berberine; Cytochrome P-450 CYP2E1; Disease Mo | 2015 |
Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation.
Topics: Animals; Berberine; Biomarkers; Biopsy; Blood Proteins; Cytokines; Disease Models, Animal; Humans; I | 2015 |
Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Berberine; Biomarkers; Caspase 3; Creatinine; Disease Model | 2015 |
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
Topics: Amitriptyline; Analgesics; Animals; Berberine; Cold Temperature; Constriction; Disease Models, Anima | 2015 |
Pharmacokinetic difference of berberine between normal and chronic visceral hypersensitivity irritable bowel syndrome rats and its mechanism.
Topics: Animals; Area Under Curve; Berberine; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2015 |
Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Base Sequence; Berberine; Clos | 2015 |
Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats.
Topics: Animals; Berberine; Blood Pressure; Disease Models, Animal; Glomerular Filtration Rate; Hypertension | 2015 |
Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome.
Topics: Activating Transcription Factor 2; Animals; Aorta; Berberine; Disease Models, Animal; Inflammation; | 2015 |
Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters.
Topics: Animals; Berberine; Body Weight; Cholesterol; Cholesterol, LDL; Coptis; Diet, High-Fat; Disease Mode | 2015 |
Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Berberine; Berberine Alkaloids; beta-Galactosidase; Bre | 2015 |
Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory | 2015 |
Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model.
Topics: Animals; Autophagy; Behavior, Animal; Berberine; Disease Models, Animal; HEK293 Cells; Humans; Hunti | 2015 |
Screening β1AR inhibitors by cell membrane chromatography and offline UPLC/MS method for protecting myocardial ischemia.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Apoptosis; Berberine; Binding, Competitive; Cell Me | 2015 |
Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model.
Topics: Animals; Berberine; Blotting, Western; Cytokines; Dermatophagoides farinae; Disease Models, Animal; | 2015 |
Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Berberine; Cartilage; Cells, Cultured; Connective | 2015 |
Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Body Weight; Carnitine O-Palm | 2015 |
Berberine protects against light-induced photoreceptor degeneration in the mouse retina.
Topics: Animals; Berberine; Cell Death; Disease Models, Animal; Electroretinography; In Situ Nick-End Labeli | 2016 |
Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.
Topics: Adaptive Immunity; Animals; Benzazepines; Berberine; Bone Marrow; Colitis; Cytokines; Dendritic Cell | 2015 |
Addition of Berberine to 5-Aminosalicylic Acid for Treatment of Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Cells, Cultured; Colitis, Ulcerative; C | 2015 |
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Female; Gastrointestinal Motility; Irritable B | 2015 |
Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Berberine; Blood Glucose; C-Reactive Protein; C | 2015 |
Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats.
Topics: Animals; Berberine; Blood Glucose; Body Weight; Diabetic Neuropathies; Diet, High-Fat; Dietary Carbo | 2016 |
Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.
Topics: Animals; Berberine; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Gastrointestinal | 2016 |
Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.
Topics: Animals; Berberine; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Gastrointestinal | 2016 |
Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.
Topics: Animals; Berberine; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Gastrointestinal | 2016 |
Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.
Topics: Animals; Berberine; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Gastrointestinal | 2016 |
Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses.
Topics: Animals; Berberine; Cells, Cultured; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Model | 2016 |
Pharmacological Effect of Berberine Chloride in Propyl Thiouracil Induced Thyroidal Dysfunction - A Time Bound Study in Female Rats.
Topics: Animals; Antithyroid Agents; Berberine; Biomarkers; Chlorides; Disease Models, Animal; Dose-Response | 2016 |
Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway.
Topics: Acetyl-CoA Carboxylase; Animals; Berberine; Blood Glucose; Carnitine O-Palmitoyltransferase; Cell Su | 2016 |
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Berberine; Body Weight; Cytokines; Disease Models, Ani | 2016 |
Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils.
Topics: Animals; Antibodies, Blocking; Berberine; Cecum; Cell Movement; Cells, Cultured; Disease Models, Ani | 2016 |
[Efficient and rapid liquid reduction animal model].
Topics: Animals; Berberine; Cholesterol; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Hype | 2015 |
Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Chemokines; Chlorogenic Acid; Cocultu | 2016 |
Berberine inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of JNK signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Blotting, Western; Disease Models, Animal; Enzyme Inhi | 2016 |
Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Berberine; Bronchoalveolar Lavage Fluid; Cell Count; Cyto | 2016 |
Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe
Topics: Animals; Apolipoproteins E; Berberine; Carotid Arteries; Cell Survival; Cells, Cultured; Disease Mod | 2016 |
MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Berberine; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2016 |
Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling.
Topics: Actins; Animals; Apoptosis; Berberine; Cell Line; Collagen; Disease Models, Animal; Hepatic Stellate | 2016 |
ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis.
Topics: Animals; Autophagy; Berberine; Body Weight; Cell Line; Diet, High-Fat; Disease Models, Animal; Extra | 2016 |
Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; Cell Cycle Checkpoints; Cell Line, Tumor; Cell | 2016 |
Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Anxiety; Berberine; B | 2016 |
The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model.
Topics: Animals; Berberine; Brain; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Flavonoids | 2016 |
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Cell Survival; Disease Models, Animal; Dopaminergic Neu | 2017 |
Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Apolipoproteins E; Atherosclerosis; Berberin | 2017 |
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Araceae; Berberine; Cell Proliferation; Colore | 2017 |
On the mechanism of antidepressant-like action of berberine chloride.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De | 2008 |
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly | 2008 |
Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Berberis; Cyclooxygenase 2; Dinoprostone; Disease Mode | 2008 |
L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antiparkinson Agents; Antipsy | 2010 |
Neuroprotective effects of berberine on stroke models in vitro and in vivo.
Topics: Animals; Apoptosis Inducing Factor; Berberine; Brain Infarction; Cell Hypoxia; Cell Survival; Cytoch | 2008 |
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.
Topics: Animals; Antibiotics, Antineoplastic; Berberine; Diabetes Mellitus; Disease Models, Animal; Gene Exp | 2009 |
The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model.
Topics: Alkaloids; Animals; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Disease Model | 2008 |
[Study on drug-guide effect of Achyranthes bidentata in Sanmiao pill in arthritic rats].
Topics: Achyranthes; Animals; Arthritis; Berberine; Disease Models, Animal; Drugs, Chinese Herbal; Female; H | 2008 |
Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Berberis; Carcinoma, Squamous Cell; Cell Line | 2009 |
[Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure].
Topics: Animals; Berberine; Calcium; Disease Models, Animal; Heart Failure; Hemodynamics; Male; Natriuretic | 2009 |
Berberine reduces the hypoxic-ischemic insult in rat pup brain.
Topics: Age Factors; Analysis of Variance; Animals; Anti-Inflammatory Agents; Berberine; Brain; Disease Mode | 2009 |
Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease.
Topics: Aluminum; Animals; Berberine; Brain Injuries; Disease Models, Animal; Drugs, Chinese Herbal; Male; N | 2009 |
Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.
Topics: Animals; Berberine; Cell Differentiation; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Anim | 2009 |
Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Berbe | 2009 |
Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
Topics: 3T3-L1 Cells; Adipogenesis; Animals; Berberine; Blood Glucose; Cholesterol; Diet, Atherogenic; Dieta | 2010 |
Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model.
Topics: Animals; Anti-Arrhythmia Agents; Berberine; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; | 2011 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Antidiarrheal activity, chemical and toxicity profile of Berberis aristata.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antidiarrheals; Berberine; Berberis; Ciproflox | 2011 |
[Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet].
Topics: Animals; Berberine; Dietary Fats; Disease Models, Animal; Glucose Tolerance Test; Humans; Inflammati | 2010 |
Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease.
Topics: Animals; Berberine; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rel | 2010 |
Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; Berberine; Cell Differentiation; | 2011 |
Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia.
Topics: Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Aminotransferases; Berberine | 2011 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |
Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats.
Topics: Animals; Berberine; Cholesterol; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Io | 2011 |
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C | 2011 |
Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia.
Topics: Animals; Berberine; Disease Models, Animal; Down-Regulation; Endotoxemia; Immunohistochemistry; Inte | 2011 |
Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.
Topics: Acute Disease; Anilides; Animals; Anti-Inflammatory Agents; Berberine; Coptis; Cyclooxygenase 2; Cyc | 2011 |
Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice.
Topics: Animals; Berberine; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 1; Disease Models, A | 2011 |
[Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose diet].
Topics: Animals; Berberine; Blood Pressure; Body Weight; Creatinine; Diet; Diet, High-Fat; Disease Models, A | 2011 |
Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia.
Topics: Anilides; Animals; Berberine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; | 2012 |
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice.
Topics: Animals; Apoptosis; Berberine; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; E | 2012 |
[Study on effect of berberine on modulating lipid and CPT I A gene expression].
Topics: Animals; Berberine; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Drugs, Chinese Herbal; | 2011 |
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precur | 2012 |
Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx.
Topics: Administration, Oral; Animals; Antioxidants; Arterioles; Berberine; Calcium Channel Blockers; Calciu | 2012 |
Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability.
Topics: Animals; Berberine; Blood-Brain Barrier; Brain Edema; Cerebral Infarction; CREB-Binding Protein; Dis | 2012 |
Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Berberine; Colitis; Cytokines; Dextran Sulf | 2012 |
Evaluation of a 13-hexyl-berberine hydrochloride topical gel formulation.
Topics: Administration, Topical; Animals; Antiviral Agents; Berberine; Chromatography, High Pressure Liquid; | 2013 |
Increased serotonergic neurotransmission is not responsible for the anticompulsive effect of berberine in a murine model of obsessive-compulsive disorder.
Topics: Aniline Compounds; Animals; Behavior, Animal; Berberine; Disease Models, Animal; Dose-Response Relat | 2012 |
Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.
Topics: Animals; Berberine; Biological Transport; Cholesterol; Cholesterol Ester Transfer Proteins; Choleste | 2013 |
Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats.
Topics: Animals; Berberine; Blood Glucose; Body Weight; Cyclic AMP; Diabetes Mellitus, Experimental; Diabeti | 2013 |
Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.
Topics: 3-Hydroxysteroid Dehydrogenases; Acetophenones; Animals; Berberine; Biomarkers; Calcium Channel Bloc | 2013 |
Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model.
Topics: Aging; Animals; Berberine; Bone Density; Disease Models, Animal; Female; Hydrastis; Male; Mice; Mice | 2003 |
Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model.
Topics: Angioplasty, Balloon; Angiotensin II; Animals; Aorta, Thoracic; Berberine; Blotting, Western; Caroti | 2006 |
[Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers].
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Berberine; Cimetidine; Coptis; Disease Models, Animal; Drugs, | 2005 |
Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice.
Topics: Animals; Berberine; Brain; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Glutamic Acid; | 2006 |
Effect of berberine on monocyte chemotactic protein-1 and cytokine-induced neutrophil chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis.
Topics: Animals; Berberine; Chemokine CCL2; Chemokine CXCL1; Chemokines, CXC; Ciliary Body; Disease Models, | 2007 |
Effects of 8-oxoberberine on sodium current in rat ventricular and human atrial myocytes.
Topics: Animals; Berberine; Cardiotonic Agents; Disease Models, Animal; Heart Atria; Heart Ventricles; Human | 1997 |
Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Berberin | 2000 |
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis L | 2001 |
Anti-inflammatory effect of berberine in rats injected locally with cholera toxin.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Toxins; Berberine; Berberine Alkaloids; Cholera; Diseas | 1977 |