Page last updated: 2024-10-23

berberine and Diarrhea

berberine has been researched along with Diarrhea in 25 studies

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS-D) receiving berberine hydrochloride in a randomized double-blind placebo-controlled clinical trial."9.20A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. ( Chen, C; Fichna, J; Li, Q; Liu, Z; Lu, M; Pan, Q; Song, Z; Tao, C; Zheng, L, 2015)
"To evaluate the antisecretory activity of berberine sulfate (BS), we studied 165 adult patients with acute diarrhea due to enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae in randomized controlled trials."9.06Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. ( Alam, K; Butler, T; Knight, J; Rabbani, GH; Sanyal, SC, 1987)
"Despite the highly pragmatic scheme of our study, our findings strongly confirm the antidiarrheal properties of berberine and recommend its use in some gut functional diseases characterized by frequent evacuation of mushy and/or watery stools."7.96Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. ( Bertuccioli, A; Di Pierro, F; Giuberti, R; Ivaldi, L; Saponara, M, 2020)
" The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed."7.91Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019)
"Berberine (BBR) is a non-prescription drug to treat various bacteria-associated diarrheas."7.91Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. ( Guan, HS; Liu, J; Wang, AT; Wang, CY; Wang, WX; Yan, D; Yang, XY; Yue, SJ, 2019)
"In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain."7.81Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015)
"To investigate the underlying mechanisms of Berberine-mediated antidiarrheal effects in thyroid hormone-induced diarrhea in rats, gastrointestinal peptides, such as motilin, gastrin, vasoactive intestinal peptide, and somatostatin from plasma and tissue of hyperthyroid diarrheic rats were measured using radioimmunoassay in healthy control, model, and treated model groups."7.75Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. ( Cheng, ZF; Liu, FC; Zhang, YQ, 2009)
"We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS-D) receiving berberine hydrochloride in a randomized double-blind placebo-controlled clinical trial."5.20A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. ( Chen, C; Fichna, J; Li, Q; Liu, Z; Lu, M; Pan, Q; Song, Z; Tao, C; Zheng, L, 2015)
"To evaluate the antisecretory activity of berberine sulfate (BS), we studied 165 adult patients with acute diarrhea due to enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae in randomized controlled trials."5.06Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. ( Alam, K; Butler, T; Knight, J; Rabbani, GH; Sanyal, SC, 1987)
"Berberine (BR) shows promise as a candidate for treating irritable bowel syndrome with diarrhea (IBS-D)."4.31Cannabidiol-Decorated Berberine-Loaded Microemulsions Improve IBS-D Therapy Through Ketogenic Diet-Induced Cannabidiol Receptors Overexpression. ( Fan, X; Liu, Y; Lu, M; Qu, D; Shi, J; Zhang, M, 2023)
"Despite the highly pragmatic scheme of our study, our findings strongly confirm the antidiarrheal properties of berberine and recommend its use in some gut functional diseases characterized by frequent evacuation of mushy and/or watery stools."3.96Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. ( Bertuccioli, A; Di Pierro, F; Giuberti, R; Ivaldi, L; Saponara, M, 2020)
" The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed."3.91Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019)
"Berberine (BBR) is a non-prescription drug to treat various bacteria-associated diarrheas."3.91Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. ( Guan, HS; Liu, J; Wang, AT; Wang, CY; Wang, WX; Yan, D; Yang, XY; Yue, SJ, 2019)
"To investigate effects of berberine exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)."3.91Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice. ( Chen, X; Guo, Y; Han, Q; Hou, Q; Huang, Y; Li, P; Liu, F; Wen, Y; Zhang, C; Zhu, S, 2019)
"In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain."3.81Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015)
"Berberine is a natural quaternary ammonium alkaloid used clinically in the chloride salt form for the treatment of diarrhea in many Asian countries."3.76Process-induced phase transformation of berberine chloride hydrates. ( Chan, CK; Chan, HM; Chow, AH; Chow, AS; Shek, FL; Tong, HH; Wan, YK; Williams, ID, 2010)
"To investigate the underlying mechanisms of Berberine-mediated antidiarrheal effects in thyroid hormone-induced diarrhea in rats, gastrointestinal peptides, such as motilin, gastrin, vasoactive intestinal peptide, and somatostatin from plasma and tissue of hyperthyroid diarrheic rats were measured using radioimmunoassay in healthy control, model, and treated model groups."3.75Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. ( Cheng, ZF; Liu, FC; Zhang, YQ, 2009)
"The frequency of diarrhea was higher in LPS group than in LPS + Lianshu group and LPS + berberine group (36."3.75Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats. ( Guo, CY; Liu, H; Liu, J; Wan, R; Wang, XP; Xia, YJ; Xu, XF; Yan, DX; Yan, QL; Yang, WJ, 2009)
"Berberine did not produce an antisecretory effect."2.66Clinical trial of berberine in acute watery diarrhoea. ( , 1985)
"Diarrhea is a big problem in piglets."1.40Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid. ( Liu, S; Liu, Y; Liu, Z; Niu, X; Qi, Z; Wang, H; Wang, S; Xia, X, 2014)
"Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp."1.40Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications. ( Chen, C; Fichna, J; Li, Y; Storr, M; Yu, Z, 2014)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19907 (28.00)18.7374
1990's1 (4.00)18.2507
2000's3 (12.00)29.6817
2010's12 (48.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Fan, X1
Shi, J1
Liu, Y2
Zhang, M1
Lu, M3
Qu, D1
Di Pierro, F1
Bertuccioli, A1
Giuberti, R1
Saponara, M1
Ivaldi, L1
Liu, CS1
Liang, X1
Wei, XH1
Chen, FL1
Tang, QF1
Tan, XM1
Jia, Q1
Zhang, L1
Zhang, J1
Pei, F1
Zhu, S2
Sun, Q1
Duan, L1
Yue, SJ1
Liu, J2
Wang, WX1
Wang, AT1
Yang, XY1
Guan, HS1
Wang, CY1
Yan, D1
Hou, Q1
Zhang, C1
Huang, Y1
Guo, Y1
Li, P1
Chen, X1
Wen, Y1
Han, Q1
Liu, F1
Bandyopadhyay, S2
Patra, PH1
Mahanti, A1
Mondal, DK1
Dandapat, P1
Samanta, I1
Lodh, C1
Bera, AK1
Bhattacharyya, D1
Sarkar, M1
Baruah, KK1
Xia, X1
Wang, H3
Niu, X1
Liu, Z3
Qi, Z1
Wang, S1
Liu, S2
Chen, C3
Yu, Z2
Li, Y2
Fichna, J3
Storr, M1
Tao, C1
Pan, Q2
Zheng, L2
Li, Q1
Song, Z2
Wang, K1
Li, K1
Song, A1
Kreis, M1
Cheng, ZF1
Zhang, YQ1
Liu, FC1
Wan, R1
Xu, XF1
Wang, XP1
Yang, WJ1
Xia, YJ1
Liu, H1
Yan, QL1
Yan, DX1
Guo, CY1
Tong, HH1
Chow, AS1
Chan, HM1
Chow, AH1
Wan, YK1
Williams, ID1
Shek, FL1
Chan, CK1
Joshi, PV1
Shirkhedkar, AA1
Prakash, K1
Maheshwari, VL1
Zhang, Y1
Wang, X1
Sha, S1
Liang, S1
Zhao, L1
Liu, L1
Chai, N1
Wu, K1
Donowitz, M1
Wicks, J1
Cusolito, S1
Sharp, GW1
Zhu, B1
Ahrens, FA1
Schiller, LR1
Yeşilada, E1
Küpeli, E1
Akhter, MH2
Sabir, M2
Bhide, NK2
Zhang, MF1
Shen, YQ1
Rabbani, GH1
Butler, T1
Knight, J1
Sanyal, SC1
Alam, K1

Reviews

2 reviews available for berberine and Diarrhea

ArticleYear
Pharmacotherapy of diarrheal diseases: an approach based on physiologic principles.
    Kroc Foundation series, 1984, Volume: 17

    Topics: Administration, Oral; Anti-Inflammatory Agents; Berberine; Calcium Channel Blockers; Calmodulin; Chl

1984
Review article: anti-diarrhoeal pharmacology and therapeutics.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Animals; Antidiarrheals; Berberine; Biological T

1995

Trials

3 trials available for berberine and Diarrhea

ArticleYear
A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:11

    Topics: Abdominal Pain; Adult; Berberine; Diarrhea; Double-Blind Method; Female; Humans; Irritable Bowel Syn

2015
Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:5

    Topics: Adult; Bacterial Toxins; Berberine; Berberine Alkaloids; Cholera; Clinical Trials as Topic; Diarrhea

1987
Clinical trial of berberine in acute watery diarrhoea.
    British medical journal (Clinical research ed.), 1985, Dec-07, Volume: 291, Issue:6509

    Topics: Acute Disease; Adult; Berberine; Berberine Alkaloids; Cholera; Clinical Trials as Topic; Diarrhea; D

1985

Other Studies

20 other studies available for berberine and Diarrhea

ArticleYear
Cannabidiol-Decorated Berberine-Loaded Microemulsions Improve IBS-D Therapy Through Ketogenic Diet-Induced Cannabidiol Receptors Overexpression.
    International journal of nanomedicine, 2023, Volume: 18

    Topics: Animals; Berberine; Brain-Derived Neurotrophic Factor; Cannabidiol; Diarrhea; Diet, Ketogenic; Irrit

2023
Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.
    Minerva gastroenterologica e dietologica, 2020, Volume: 66, Issue:1

    Topics: Adult; Berberine; Diarrhea; Dietary Supplements; Female; Gastrointestinal Diseases; Humans; Male; Mi

2020
Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets.
    Biomedical chromatography : BMC, 2019, Volume: 33, Issue:3

    Topics: Animals; Bacteria; Berberine; Diarrhea; Drugs, Chinese Herbal; Flavonoids; Gastrointestinal Microbio

2019
Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Berberine; Bifidobacterium; Diarrhea; Disease Models, Animal; Faecalibacterium; Fecal Micro

2019
Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 116

    Topics: Animals; Berberine; Biodiversity; Cecum; Colon; Diarrhea; Dysbiosis; Fatty Acids; Feces; Gastrointes

2019
Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Irri

2019
Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks (Poephagus grunniens) with haemorrhagic diarrhoea.
    Asian Pacific journal of tropical medicine, 2013, Apr-13, Volume: 6, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Berberine; Cattle; Cattle Diseases; Diarrhea; DNA, Bacterial; Drug R

2013
Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014, Volume: 11, Issue:1

    Topics: Animals; Antidiarrheals; Berberine; Biphenyl Compounds; Coptis; Diarrhea; Dose-Response Relationship

2014
Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Antidiarrheals; Antineoplastic Agents; Berberine; Berberis; Cardi

2014
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Female; Gastrointestinal Motility; Irritable B

2015
Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats.
    Regulatory peptides, 2009, Jun-05, Volume: 155, Issue:1-3

    Topics: Animals; Antidiarrheals; Berberine; Colon; Diarrhea; Duodenum; Gastrins; Gastrointestinal Hormones;

2009
Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats.
    World journal of gastroenterology, 2009, Apr-28, Volume: 15, Issue:16

    Topics: Amine Oxidase (Copper-Containing); Animals; Berberine; Cholinesterase Inhibitors; Diarrhea; Drugs, C

2009
Process-induced phase transformation of berberine chloride hydrates.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:4

    Topics: Antidiarrheals; Berberine; Crystallography, X-Ray; Diarrhea; Drug Compounding; Drugs, Chinese Herbal

2010
Antidiarrheal activity, chemical and toxicity profile of Berberis aristata.
    Pharmaceutical biology, 2011, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antidiarrheals; Berberine; Berberis; Ciproflox

2011
Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model.
    Fitoterapia, 2012, Volume: 83, Issue:6

    Topics: Animals; Antidiarrheals; Aquaporin 4; Berberine; Cell Line; Coptis; Diarrhea; Drugs, Chinese Herbal;

2012
Effect of berberine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in jejunum of pigs.
    American journal of veterinary research, 1982, Volume: 43, Issue:9

    Topics: Animals; Animals, Suckling; Antidiarrheals; Berberine; Berberine Alkaloids; Body Water; Diarrhea; Do

1982
Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats.
    Journal of ethnopharmacology, 2002, Volume: 79, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

2002
Possible mechanism of antidiarrhoeal effect of berberine.
    The Indian journal of medical research, 1979, Volume: 70

    Topics: Administration, Oral; Animals; Antidiarrheals; Berberine; Berberine Alkaloids; Diarrhea; Dogs; Femal

1979
Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats.
    The Indian journal of medical research, 1977, Volume: 65, Issue:3

    Topics: Animals; Berberine; Berberine Alkaloids; Cholera Toxin; Diarrhea; Digestive System; Female; Male; Ra

1977
[Antidiarrheal and anti-inflammatory effects of berberine].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1989, Volume: 10, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Berberine Alkaloids; Capillary Permeabi

1989