berberine has been researched along with Diarrhea in 25 studies
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS-D) receiving berberine hydrochloride in a randomized double-blind placebo-controlled clinical trial." | 9.20 | A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. ( Chen, C; Fichna, J; Li, Q; Liu, Z; Lu, M; Pan, Q; Song, Z; Tao, C; Zheng, L, 2015) |
| "To evaluate the antisecretory activity of berberine sulfate (BS), we studied 165 adult patients with acute diarrhea due to enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae in randomized controlled trials." | 9.06 | Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. ( Alam, K; Butler, T; Knight, J; Rabbani, GH; Sanyal, SC, 1987) |
| "Despite the highly pragmatic scheme of our study, our findings strongly confirm the antidiarrheal properties of berberine and recommend its use in some gut functional diseases characterized by frequent evacuation of mushy and/or watery stools." | 7.96 | Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. ( Bertuccioli, A; Di Pierro, F; Giuberti, R; Ivaldi, L; Saponara, M, 2020) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 7.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| "Berberine (BBR) is a non-prescription drug to treat various bacteria-associated diarrheas." | 7.91 | Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. ( Guan, HS; Liu, J; Wang, AT; Wang, CY; Wang, WX; Yan, D; Yang, XY; Yue, SJ, 2019) |
| "In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain." | 7.81 | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015) |
| "To investigate the underlying mechanisms of Berberine-mediated antidiarrheal effects in thyroid hormone-induced diarrhea in rats, gastrointestinal peptides, such as motilin, gastrin, vasoactive intestinal peptide, and somatostatin from plasma and tissue of hyperthyroid diarrheic rats were measured using radioimmunoassay in healthy control, model, and treated model groups." | 7.75 | Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. ( Cheng, ZF; Liu, FC; Zhang, YQ, 2009) |
| "We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS-D) receiving berberine hydrochloride in a randomized double-blind placebo-controlled clinical trial." | 5.20 | A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. ( Chen, C; Fichna, J; Li, Q; Liu, Z; Lu, M; Pan, Q; Song, Z; Tao, C; Zheng, L, 2015) |
| "To evaluate the antisecretory activity of berberine sulfate (BS), we studied 165 adult patients with acute diarrhea due to enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae in randomized controlled trials." | 5.06 | Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. ( Alam, K; Butler, T; Knight, J; Rabbani, GH; Sanyal, SC, 1987) |
| "Berberine (BR) shows promise as a candidate for treating irritable bowel syndrome with diarrhea (IBS-D)." | 4.31 | Cannabidiol-Decorated Berberine-Loaded Microemulsions Improve IBS-D Therapy Through Ketogenic Diet-Induced Cannabidiol Receptors Overexpression. ( Fan, X; Liu, Y; Lu, M; Qu, D; Shi, J; Zhang, M, 2023) |
| "Despite the highly pragmatic scheme of our study, our findings strongly confirm the antidiarrheal properties of berberine and recommend its use in some gut functional diseases characterized by frequent evacuation of mushy and/or watery stools." | 3.96 | Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. ( Bertuccioli, A; Di Pierro, F; Giuberti, R; Ivaldi, L; Saponara, M, 2020) |
| " The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed." | 3.91 | Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially. ( Duan, L; Jia, Q; Pei, F; Sun, Q; Zhang, J; Zhang, L; Zhu, S, 2019) |
| "Berberine (BBR) is a non-prescription drug to treat various bacteria-associated diarrheas." | 3.91 | Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. ( Guan, HS; Liu, J; Wang, AT; Wang, CY; Wang, WX; Yan, D; Yang, XY; Yue, SJ, 2019) |
| "To investigate effects of berberine exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)." | 3.91 | Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice. ( Chen, X; Guo, Y; Han, Q; Hou, Q; Huang, Y; Li, P; Liu, F; Wen, Y; Zhang, C; Zhu, S, 2019) |
| "In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain." | 3.81 | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. ( Chen, C; Fichna, J; Kreis, M; Li, K; Li, Y; Liu, Z; Lu, M; Pan, Q; Song, A; Song, Z; Wang, K; Yu, Z; Zheng, L, 2015) |
| "Berberine is a natural quaternary ammonium alkaloid used clinically in the chloride salt form for the treatment of diarrhea in many Asian countries." | 3.76 | Process-induced phase transformation of berberine chloride hydrates. ( Chan, CK; Chan, HM; Chow, AH; Chow, AS; Shek, FL; Tong, HH; Wan, YK; Williams, ID, 2010) |
| "To investigate the underlying mechanisms of Berberine-mediated antidiarrheal effects in thyroid hormone-induced diarrhea in rats, gastrointestinal peptides, such as motilin, gastrin, vasoactive intestinal peptide, and somatostatin from plasma and tissue of hyperthyroid diarrheic rats were measured using radioimmunoassay in healthy control, model, and treated model groups." | 3.75 | Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. ( Cheng, ZF; Liu, FC; Zhang, YQ, 2009) |
| "The frequency of diarrhea was higher in LPS group than in LPS + Lianshu group and LPS + berberine group (36." | 3.75 | Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats. ( Guo, CY; Liu, H; Liu, J; Wan, R; Wang, XP; Xia, YJ; Xu, XF; Yan, DX; Yan, QL; Yang, WJ, 2009) |
| "Berberine did not produce an antisecretory effect." | 2.66 | Clinical trial of berberine in acute watery diarrhoea. ( , 1985) |
| "Diarrhea is a big problem in piglets." | 1.40 | Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid. ( Liu, S; Liu, Y; Liu, Z; Niu, X; Qi, Z; Wang, H; Wang, S; Xia, X, 2014) |
| "Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp." | 1.40 | Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications. ( Chen, C; Fichna, J; Li, Y; Storr, M; Yu, Z, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (28.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 12 (48.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, X | 1 |
| Shi, J | 1 |
| Liu, Y | 2 |
| Zhang, M | 1 |
| Lu, M | 3 |
| Qu, D | 1 |
| Di Pierro, F | 1 |
| Bertuccioli, A | 1 |
| Giuberti, R | 1 |
| Saponara, M | 1 |
| Ivaldi, L | 1 |
| Liu, CS | 1 |
| Liang, X | 1 |
| Wei, XH | 1 |
| Chen, FL | 1 |
| Tang, QF | 1 |
| Tan, XM | 1 |
| Jia, Q | 1 |
| Zhang, L | 1 |
| Zhang, J | 1 |
| Pei, F | 1 |
| Zhu, S | 2 |
| Sun, Q | 1 |
| Duan, L | 1 |
| Yue, SJ | 1 |
| Liu, J | 2 |
| Wang, WX | 1 |
| Wang, AT | 1 |
| Yang, XY | 1 |
| Guan, HS | 1 |
| Wang, CY | 1 |
| Yan, D | 1 |
| Hou, Q | 1 |
| Zhang, C | 1 |
| Huang, Y | 1 |
| Guo, Y | 1 |
| Li, P | 1 |
| Chen, X | 1 |
| Wen, Y | 1 |
| Han, Q | 1 |
| Liu, F | 1 |
| Bandyopadhyay, S | 2 |
| Patra, PH | 1 |
| Mahanti, A | 1 |
| Mondal, DK | 1 |
| Dandapat, P | 1 |
| Samanta, I | 1 |
| Lodh, C | 1 |
| Bera, AK | 1 |
| Bhattacharyya, D | 1 |
| Sarkar, M | 1 |
| Baruah, KK | 1 |
| Xia, X | 1 |
| Wang, H | 3 |
| Niu, X | 1 |
| Liu, Z | 3 |
| Qi, Z | 1 |
| Wang, S | 1 |
| Liu, S | 2 |
| Chen, C | 3 |
| Yu, Z | 2 |
| Li, Y | 2 |
| Fichna, J | 3 |
| Storr, M | 1 |
| Tao, C | 1 |
| Pan, Q | 2 |
| Zheng, L | 2 |
| Li, Q | 1 |
| Song, Z | 2 |
| Wang, K | 1 |
| Li, K | 1 |
| Song, A | 1 |
| Kreis, M | 1 |
| Cheng, ZF | 1 |
| Zhang, YQ | 1 |
| Liu, FC | 1 |
| Wan, R | 1 |
| Xu, XF | 1 |
| Wang, XP | 1 |
| Yang, WJ | 1 |
| Xia, YJ | 1 |
| Liu, H | 1 |
| Yan, QL | 1 |
| Yan, DX | 1 |
| Guo, CY | 1 |
| Tong, HH | 1 |
| Chow, AS | 1 |
| Chan, HM | 1 |
| Chow, AH | 1 |
| Wan, YK | 1 |
| Williams, ID | 1 |
| Shek, FL | 1 |
| Chan, CK | 1 |
| Joshi, PV | 1 |
| Shirkhedkar, AA | 1 |
| Prakash, K | 1 |
| Maheshwari, VL | 1 |
| Zhang, Y | 1 |
| Wang, X | 1 |
| Sha, S | 1 |
| Liang, S | 1 |
| Zhao, L | 1 |
| Liu, L | 1 |
| Chai, N | 1 |
| Wu, K | 1 |
| Donowitz, M | 1 |
| Wicks, J | 1 |
| Cusolito, S | 1 |
| Sharp, GW | 1 |
| Zhu, B | 1 |
| Ahrens, FA | 1 |
| Schiller, LR | 1 |
| Yeşilada, E | 1 |
| Küpeli, E | 1 |
| Akhter, MH | 2 |
| Sabir, M | 2 |
| Bhide, NK | 2 |
| Zhang, MF | 1 |
| Shen, YQ | 1 |
| Rabbani, GH | 1 |
| Butler, T | 1 |
| Knight, J | 1 |
| Sanyal, SC | 1 |
| Alam, K | 1 |
2 reviews available for berberine and Diarrhea
| Article | Year |
|---|---|
Pharmacotherapy of diarrheal diseases: an approach based on physiologic principles.
Topics: Administration, Oral; Anti-Inflammatory Agents; Berberine; Calcium Channel Blockers; Calmodulin; Chl | 1984 |
Review article: anti-diarrhoeal pharmacology and therapeutics.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Animals; Antidiarrheals; Berberine; Biological T | 1995 |
3 trials available for berberine and Diarrhea
| Article | Year |
|---|---|
A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Berberine; Diarrhea; Double-Blind Method; Female; Humans; Irritable Bowel Syn | 2015 |
Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae.
Topics: Adult; Bacterial Toxins; Berberine; Berberine Alkaloids; Cholera; Clinical Trials as Topic; Diarrhea | 1987 |
Clinical trial of berberine in acute watery diarrhoea.
Topics: Acute Disease; Adult; Berberine; Berberine Alkaloids; Cholera; Clinical Trials as Topic; Diarrhea; D | 1985 |
20 other studies available for berberine and Diarrhea
| Article | Year |
|---|---|
Cannabidiol-Decorated Berberine-Loaded Microemulsions Improve IBS-D Therapy Through Ketogenic Diet-Induced Cannabidiol Receptors Overexpression.
Topics: Animals; Berberine; Brain-Derived Neurotrophic Factor; Cannabidiol; Diarrhea; Diet, Ketogenic; Irrit | 2023 |
Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.
Topics: Adult; Berberine; Diarrhea; Dietary Supplements; Female; Gastrointestinal Diseases; Humans; Male; Mi | 2020 |
Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets.
Topics: Animals; Bacteria; Berberine; Diarrhea; Drugs, Chinese Herbal; Flavonoids; Gastrointestinal Microbio | 2019 |
Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.
Topics: Animals; Berberine; Bifidobacterium; Diarrhea; Disease Models, Animal; Faecalibacterium; Fecal Micro | 2019 |
Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis.
Topics: Animals; Berberine; Biodiversity; Cecum; Colon; Diarrhea; Dysbiosis; Fatty Acids; Feces; Gastrointes | 2019 |
Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice.
Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Irri | 2019 |
Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks (Poephagus grunniens) with haemorrhagic diarrhoea.
Topics: Animals; Anti-Bacterial Agents; Berberine; Cattle; Cattle Diseases; Diarrhea; DNA, Bacterial; Drug R | 2013 |
Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid.
Topics: Animals; Antidiarrheals; Berberine; Biphenyl Compounds; Coptis; Diarrhea; Dose-Response Relationship | 2014 |
Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications.
Topics: Animals; Anti-Inflammatory Agents; Antidiarrheals; Antineoplastic Agents; Berberine; Berberis; Cardi | 2014 |
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
Topics: Animals; Berberine; Diarrhea; Disease Models, Animal; Female; Gastrointestinal Motility; Irritable B | 2015 |
Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats.
Topics: Animals; Antidiarrheals; Berberine; Colon; Diarrhea; Duodenum; Gastrins; Gastrointestinal Hormones; | 2009 |
Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Berberine; Cholinesterase Inhibitors; Diarrhea; Drugs, C | 2009 |
Process-induced phase transformation of berberine chloride hydrates.
Topics: Antidiarrheals; Berberine; Crystallography, X-Ray; Diarrhea; Drug Compounding; Drugs, Chinese Herbal | 2010 |
Antidiarrheal activity, chemical and toxicity profile of Berberis aristata.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antidiarrheals; Berberine; Berberis; Ciproflox | 2011 |
Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model.
Topics: Animals; Antidiarrheals; Aquaporin 4; Berberine; Cell Line; Coptis; Diarrhea; Drugs, Chinese Herbal; | 2012 |
Effect of berberine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in jejunum of pigs.
Topics: Animals; Animals, Suckling; Antidiarrheals; Berberine; Berberine Alkaloids; Body Water; Diarrhea; Do | 1982 |
Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 2002 |
Possible mechanism of antidiarrhoeal effect of berberine.
Topics: Administration, Oral; Animals; Antidiarrheals; Berberine; Berberine Alkaloids; Diarrhea; Dogs; Femal | 1979 |
Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats.
Topics: Animals; Berberine; Berberine Alkaloids; Cholera Toxin; Diarrhea; Digestive System; Female; Male; Ra | 1977 |
[Antidiarrheal and anti-inflammatory effects of berberine].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Berberine Alkaloids; Capillary Permeabi | 1989 |