Page last updated: 2024-10-23

berberine and Depression

berberine has been researched along with Depression in 14 studies

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"The results of behavioral tests demonstrated that berberine attenuated the depression-like behaviors induced by CORT."8.31Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption. ( Cheng, D; Li, W; Qin, Z; Shi, DD; Tsoi, B; Wang, Z; Zhang, S; Zhang, YD; Zhang, ZJ; Zhao, J, 2023)
"The CUMS model and behavioral evaluation were utilized in this study to evaluate the efficacy of berberine in the treatment of depression."8.31Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. ( Chen, F; Huang, Y; Liu, W; Su, K; Tao, W; Wang, Y; Yang, L; Zhao, M, 2023)
"Proteomic analysis of reserpine-induced depression and the effects of berberine on this were investigated to delineate the possible underlying mechanism."8.12Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine. ( Wang, Y; Yang, N; Zou, L, 2022)
"A high-performance liquid chromatography-tandem mass spectrometry(LC-MS/MS) was developed for simultaneously determining the components(magnoflorine, jatrorrhizine, berberrubine, coptisine, berberine) of Jiaotai Pills and Fluoxetine in plasma of rats with chronic unpredictable mild stress(CUMS)-induced depression to investigate the pharmacokinetic herb-drug interaction of Jiaotai Pills and Fluoxetine in the rats."8.12[Pharmacokinetic interaction of Jiaotai Pills and Fluoxetine in rats with CUMS-induced depression]. ( Cao, Y; Chen, SS; Dai, GL; Ju, WZ; Li, FR; Li, Y; Liu, MC; Wang, YQ; Yang, XY, 2022)
"Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota."5.91Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. ( Ge, PY; Guo, R; Ni, SJ; Qi, YY; Qu, SY; Yang, NY; Yao, ZY; Zhang, QC; Zhao, X; Zhu, HX, 2023)
"Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents."5.46Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017)
"The CUMS model and behavioral evaluation were utilized in this study to evaluate the efficacy of berberine in the treatment of depression."4.31Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. ( Chen, F; Huang, Y; Liu, W; Su, K; Tao, W; Wang, Y; Yang, L; Zhao, M, 2023)
"A high-performance liquid chromatography-tandem mass spectrometry(LC-MS/MS) was developed for simultaneously determining the components(magnoflorine, jatrorrhizine, berberrubine, coptisine, berberine) of Jiaotai Pills and Fluoxetine in plasma of rats with chronic unpredictable mild stress(CUMS)-induced depression to investigate the pharmacokinetic herb-drug interaction of Jiaotai Pills and Fluoxetine in the rats."4.12[Pharmacokinetic interaction of Jiaotai Pills and Fluoxetine in rats with CUMS-induced depression]. ( Cao, Y; Chen, SS; Dai, GL; Ju, WZ; Li, FR; Li, Y; Liu, MC; Wang, YQ; Yang, XY, 2022)
"Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity."3.91Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation. ( Du, LJ; Feng, YL; Gao, HW; Gong, Q; He, LL; Lei, F; Li, J; Luo, YY; Wang, ML; Yan, XJ; Yang, SL, 2019)
"More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression."3.79Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013)
"Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota."1.91Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. ( Ge, PY; Guo, R; Ni, SJ; Qi, YY; Qu, SY; Yang, NY; Yao, ZY; Zhang, QC; Zhao, X; Zhu, HX, 2023)
"BACKGROUND Depression is the 5th most prevalent disorder adversely affecting the health of humans worldwide."1.56Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. ( Chen, H; Liu, L; Wang, N; Wang, X; Yang, T, 2020)
"Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents."1.46Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017)
"Treatment with berberine prevented these changes above."1.43Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice. ( Fang, XY; Hu, CY; Jin, SL; Li, YC; Ma, LG; Pei, YY; Shen, JD, 2016)
"Berberine at lower dose did not affect the locomotor activity and barbiturate-induced sleep time."1.35On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's4 (28.57)24.3611
2020's9 (64.29)2.80

Authors

AuthorsStudies
Yang, N1
Zou, L1
Wang, Y3
Ge, PY1
Qu, SY1
Ni, SJ1
Yao, ZY1
Qi, YY1
Zhao, X1
Guo, R1
Yang, NY1
Zhang, QC1
Zhu, HX1
Yang, XY1
Dai, GL1
Chen, SS1
Li, Y1
Liu, MC1
Li, FR1
Cao, Y1
Wang, YQ1
Ju, WZ1
Huang, M1
He, Y1
Tian, L1
Yu, L1
Cheng, Q1
Li, Z1
Gao, L1
Gao, S1
Yu, C1
Qin, Z1
Shi, DD1
Li, W1
Cheng, D1
Zhang, YD1
Zhang, S1
Tsoi, B1
Zhao, J1
Wang, Z1
Zhang, ZJ1
Yang, L1
Huang, Y1
Chen, F1
Su, K1
Zhao, M1
Tao, W1
Liu, W1
Gong, Q1
Yan, XJ1
Lei, F1
Wang, ML1
He, LL1
Luo, YY1
Gao, HW1
Feng, YL1
Yang, SL1
Li, J1
Du, LJ1
Wang, QS1
Li, K1
Gao, LN1
Zhang, Y1
Lin, KM1
Cui, YL1
Yang, T1
Wang, X1
Liu, L1
Chen, H1
Wang, N1
Zhang, JH1
Yang, HZ1
Su, H1
Song, J1
Bai, Y1
Deng, L1
Feng, CP1
Guo, HX1
Gao, X1
Gu, Y1
Zhen, Z1
Lu, Y1
Zhu, X1
Sun, Y1
Zhang, C1
Liu, H1
Arora, V1
Chopra, K1
Shen, JD1
Ma, LG1
Hu, CY1
Pei, YY1
Jin, SL1
Fang, XY1
Li, YC1
Kulkarni, SK1
Dhir, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188]Phase 2/Phase 3113 participants (Actual)Interventional2018-04-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for berberine and Depression

ArticleYear
Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:1

    Topics: Animals; Antipsychotic Agents; Berberine; Depression; Male; Mice; Mice, Inbred ICR; Proteomics; Rese

2022
Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.
    Phytotherapy research : PTR, 2023, Volume: 37, Issue:1

    Topics: Animals; Berberine; Chromatography, Liquid; Depression; Disease Models, Animal; Indoleamine-Pyrrole

2023
[Pharmacokinetic interaction of Jiaotai Pills and Fluoxetine in rats with CUMS-induced depression].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:18

    Topics: Animals; Berberine; Chromatography, Liquid; Depression; Drugs, Chinese Herbal; Fluoxetine; Rats; Tan

2022
Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats.
    Journal of affective disorders, 2023, 03-15, Volume: 325

    Topics: Animals; Antidepressive Agents; Berberine; Brain-Derived Neurotrophic Factor; Depression; Disease Mo

2023
Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption.
    Journal of neuroinflammation, 2023, Mar-01, Volume: 20, Issue:1

    Topics: Animals; Berberine; Depression; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Dis

2023
Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65.
    International immunopharmacology, 2023, Volume: 123

    Topics: Animals; Berberine; Depression; Hippocampus; Inflammasomes; Inflammation; Interleukin-18; Mice; NLR

2023
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
    Molecular brain, 2019, 12-30, Volume: 12, Issue:1

    Topics: Animals; Behavior, Animal; Berberine; Cell Survival; Corticosterone; Depression; Disease Models, Ani

2019
Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects.
    Biomaterials science, 2020, May-21, Volume: 8, Issue:10

    Topics: Administration, Intranasal; Animals; Antidepressive Agents; Berberine; Blood-Brain Barrier; Depressi

2020
Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Jun-02, Volume: 26

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Berberine; Depression; Disease Models, Animal; Dop

2020
Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats.
    The American journal of Chinese medicine, 2021, Volume: 49, Issue:5

    Topics: Animals; Berberine; Blood Glucose; Depression; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug

2021
Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays.
    Molecular medicine reports, 2017, Volume: 15, Issue:5

    Topics: Animals; Behavior, Animal; Berberine; Bifidobacterium; Body Weight; Depression; Disease Models, Anim

2017
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
    Journal of affective disorders, 2013, Volume: 151, Issue:3

    Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc

2013
Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice.
    Neuroscience letters, 2016, Feb-12, Volume: 614

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Berberine; Brain-Derived Neurotrophic Factor; Cort

2016
On the mechanism of antidepressant-like action of berberine chloride.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De

2008