Page last updated: 2024-10-23

berberine and Cognitive Dysfunction

berberine has been researched along with Cognitive Dysfunction in 18 studies

Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.

Research Excerpts

ExcerptRelevanceReference
"To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes."9.05Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. ( Bell, J; Bligh, A; Katsuno, T; Parkinson, J; Shinjyo, N, 2020)
"The results showed that administration of berberine for 6 months significantly improved cognitive deficits and insulin resistance in naturally aging rats (p<0."7.88Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. ( Chen, L; Guan, F; Guan, Y; Li, J; Lv, X; Teng, F; Xu, J; Yu, Y; Zhang, M; Zhao, Y, 2018)
"Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis."5.56Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020)
"Berberine (BBR) is a herbal alkaloid, which shows many neuroprotective properties in neurodegenerative diseases."5.51Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia. ( Bashiri, H; Ghotbi Ravandi, S; Khodamoradi, M; Nozari, M; Saeedi Goraghani, M; Shabani, M, 2019)
"Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, which exhibits numerous biological effects on gastrointestinal disorders."5.48Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. ( Gong, C; Hua, Y; Kang, Y; Liao, X; Ou, X, 2018)
"Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)."5.46Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017)
"To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes."5.05Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. ( Bell, J; Bligh, A; Katsuno, T; Parkinson, J; Shinjyo, N, 2020)
" Berberine has demonstrated good neuroprotective effects in models of acute cerebral ischemia; however, whether it can alleviate cognitive impairment caused by chronic cerebral hypoperfusion has rarely been investigated."4.12Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats. ( Du, Y; Huang, Y; Li, F; Luo, Y; Tao, Z; Tian, Y; Wang, N; Wang, Q; Wang, Y; Yan, F; Zhao, F; Zheng, Y, 2022)
"The results showed that administration of berberine for 6 months significantly improved cognitive deficits and insulin resistance in naturally aging rats (p<0."3.88Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. ( Chen, L; Guan, F; Guan, Y; Li, J; Lv, X; Teng, F; Xu, J; Yu, Y; Zhang, M; Zhao, Y, 2018)
"Berberine (BBR) is an isoquinoline alkaloid extracted from various berberine species."2.82A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment. ( Devi, B; Sahu, K; Singh, A; Singh, C; Singh, S, 2022)
"Berberine treatment attenuates hippocampal insulin resistance and improves cognitive function."1.91Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. ( Chen, J; Dong, L; Gao, F; Kou, Z; Kuang, F; Li, G; Li, J; Xue, C; Yang, H; Zhang, J; Zhang, S; Zhang, X, 2023)
"Berberine was used to uncover the mechanisms for the treatment of hyperinsulinemia in IR model."1.62Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway. ( Bao, Y; Chen, Q; Han, Y; Liu, C; Liu, W; Liu, X; Wang, J; Wu, N; Ye, Y; Yu, Y, 2021)
"Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis."1.56Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020)
"Berberine (BBR) is a herbal alkaloid, which shows many neuroprotective properties in neurodegenerative diseases."1.51Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia. ( Bashiri, H; Ghotbi Ravandi, S; Khodamoradi, M; Nozari, M; Saeedi Goraghani, M; Shabani, M, 2019)
"Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, which exhibits numerous biological effects on gastrointestinal disorders."1.48Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. ( Gong, C; Hua, Y; Kang, Y; Liao, X; Ou, X, 2018)
"Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)."1.46Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (44.44)24.3611
2020's10 (55.56)2.80

Authors

AuthorsStudies
Tian, Y2
Zheng, Y2
Wang, Q1
Yan, F2
Tao, Z1
Zhao, F2
Wang, Y2
Huang, Y1
Li, F2
Du, Y1
Wang, N2
Luo, Y2
Sahu, K1
Singh, S1
Devi, B1
Singh, C1
Singh, A1
Wang, R1
Yang, M1
Wang, J2
Li, J3
Xue, C1
Yang, H1
Zhang, J1
Li, G1
Kuang, F1
Chen, J1
Zhang, S1
Gao, F1
Kou, Z1
Zhang, X1
Dong, L1
Wang, RH1
Zhou, R1
Ding, Y1
Zhou, ZX1
Chen, Y4
Liang, Y3
Chen, H2
Ji, X2
Huang, M3
Shinjyo, N1
Parkinson, J1
Bell, J1
Katsuno, T1
Bligh, A1
Wu, N1
Liu, W1
Han, Y1
Ye, Y1
Liu, X1
Yu, Y2
Chen, Q1
Bao, Y1
Liu, C1
Ye, C1
Xiong, Y1
She, Y1
Zhong, X1
Zhang, JH1
Zhang, JF1
Song, J1
Bai, Y1
Deng, L1
Feng, CP1
Xu, XY1
Guo, HX1
Gao, X1
Gu, Y1
Jin, C1
Zheng, JF1
Zhen, Z1
Su, H1
He, W1
Wang, C1
He, Y1
Cai, Z1
Zhao, Y1
Teng, F1
Guan, Y1
Xu, J2
Lv, X1
Guan, F1
Zhang, M1
Chen, L1
Ou, X1
Hua, Y1
Liao, X1
Gong, C1
Kang, Y1
Ghotbi Ravandi, S1
Shabani, M1
Bashiri, H1
Saeedi Goraghani, M1
Khodamoradi, M1
Nozari, M1
Liu, P1
Li, Y1
Qi, X1
Liu, D1
Chi, T1
Liu, H1
Zou, L1
Zhang, Z1
Li, X1
An, L1
Jiang, X1
Liu, Q1
Chen, S1
Guo, Y1

Reviews

2 reviews available for berberine and Cognitive Dysfunction

ArticleYear
A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment.
    Current drug targets, 2022, Volume: 23, Issue:9

    Topics: Berberine; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction; Humans; Neuroprotective

2022
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
    Journal of integrative medicine, 2020, Volume: 18, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Berberine; Brain; Cholinergic Agonists; Cognitive Dysfunct

2020

Other Studies

16 other studies available for berberine and Cognitive Dysfunction

ArticleYear
Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Berberine; Brain Ischemia; Carotid Artery, Common; Cognitive Dysf

2022
Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage via regulation of the ERK/Nrf2 pathway.
    Journal of chemical neuroanatomy, 2022, Volume: 123

    Topics: Animals; Berberine; Brain Ischemia; Cognitive Dysfunction; Hippocampus; MAP Kinase Signaling System;

2022
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice.
    Journal of nutritional science and vitaminology, 2022, Volume: 68, Issue:3

    Topics: Alzheimer Disease; Animals; Berberine; Cognition; Cognitive Dysfunction; Cytokines; Disease Models,

2022
Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment.
    Life sciences, 2023, Nov-15, Volume: 333

    Topics: Animals; Berberine; Cognitive Dysfunction; Hippocampus; Insulin; Insulin Resistance; Memory Disorder

2023
[Effects of berberine on learning and memory ability in vascular cognitive impairment rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2019, Jul-28, Volume: 35, Issue:4

    Topics: Animals; Berberine; Cognitive Dysfunction; Hippocampus; Inflammation; Maze Learning; Memory; Oxidati

2019
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 121

    Topics: Alzheimer Disease; Animals; Autophagy; Beclin-1; Berberine; Cathepsin D; Cells, Cultured; Cognitive

2020
Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway.
    BioFactors (Oxford, England), 2021, Volume: 47, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Berberine; Cell Line, Tumor; Cognitive Dysfunction; Diabetes Mellitu

2021
Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease.
    Cells, 2021, 05-11, Volume: 10, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Berberine; Brain; Cerebrovascular Circ

2021
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.
    The American journal of Chinese medicine, 2021, Volume: 49, Issue:6

    Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fa

2021
Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:6

    Topics: Alzheimer Disease; Animals; Berberine; Biomarkers; Blotting, Western; Cognitive Dysfunction; Glutath

2017
Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats.
    The journal of nutrition, health & aging, 2018, Volume: 22, Issue:6

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Berberine; Cognition; Cognitive Dysfunction; Diet, Hi

2018
Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats.
    Molecular medicine reports, 2018, Volume: 18, Issue:3

    Topics: Acute Disease; Animals; Apoptosis; Berberine; Blood-Brain Barrier; Cognition; Cognitive Dysfunction;

2018
Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.
    Neuroscience letters, 2019, 07-27, Volume: 706

    Topics: Animals; Animals, Newborn; Berberine; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Mal

2019
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:9

    Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase

2019
Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.
    International immunopharmacology, 2016, Volume: 38

    Topics: Aged; Aging; Animals; Anti-Inflammatory Agents; Berberine; Calcium-Binding Proteins; Cell Line; Cogn

2016
Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease.
    Experimental gerontology, 2017, Volume: 91

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac

2017