berberine has been researched along with Carcinoma, Non-Small Cell Lung in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gefitinib-resistant (G-R) nonsmall-cell lung cancer (NSCLC) and rheumatoid arthritis (RA) were studied as conditions representative of malignant and proliferative diseases, respectively." | 3.88 | Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases. ( Fan, XX; Fu, J; He, JX; Huang, J; Jiang, ZB; Kam, RK; Leung, EL; Liu, L; Liu, ZQ; Lu, LL; Luo, LX; Wei, CL; Wu, JL; Xiao, DK; Xie, Y; Yao, XJ; Yuan, ZW; Zheng, YF; Zhou, YL, 2018) |
| "Berberine (BBR) is an active alkaloid extracted from pharmaceutical plants such as Coptis chinensis." | 1.91 | Antitumor effects of erlotinib in combination with berberine in A431 cells. ( Cuan, X; Huang, Y; Luo, R; Sheng, J; Wang, X; Yang, X; Zhao, Y; Zhu, W, 2023) |
| "Berberine is a natural product that has long been used in traditional Chinese medicine due to its antimicrobial, anti-inflammatory and metabolism-regulatory properties." | 1.72 | The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition. ( Chen, H; Chen, Z; Ramalingam, SS; Sun, SY; Vallega, KA; Zhou, J, 2022) |
| "Berberine is an isoquinoline alkaloid which offers a broad range of therapeutical and pharmacological actions against cancer." | 1.72 | Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro. ( Chellappan, DK; Dua, K; Gupta, G; Gupta, PK; Hansbro, PM; Jha, NK; Kumar, P; MacLoughlin, R; Madheswaran, T; Malyla, V; Mehta, M; Oliver, BG; Panneerselvam, J; Patel, VK; Paudel, KR; Singh, SK; Yen, LL; Yin, GHS, 2022) |
| "Berberine has been increasingly popular in colorectal cancer treatment, but little is known about its bioactivity against non-small cell lung cancer (NSCLC)." | 1.72 | Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis. ( Chen, X; Kong, L; Li, J; Li, Z; Ni, L; Ning, B; Ren, H; Xiong, M; Zhang, X, 2022) |
| "Berberine has been found to have potent anticancer activities via distinct molecular mechanism." | 1.62 | Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis. ( Chen, K; Chen, P; Dai, CH; Li, J; Shi, ZH; Su, JY; Wang, Y; Wu, JN, 2021) |
| "Demethyleneberberine (DMB) is a natural active component of medicinal plant Cortex phellodendri chinensis with favorable bioactivity." | 1.62 | Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway. ( Chen, J; Huang, X; Ji, K; Liu, D; Liu, J; Tao, C; Zhang, R, 2021) |
| "Berberine has been illustrated to be a therapeutic agent of NSCLC." | 1.56 | Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells. ( Chang, JM; Chao, WY; Chen, SH; Chung, HC; Kam, KH; Lee, YR; Li, YZ; Wu, JY; Zhao, PW, 2020) |
| "Berberine has been shown to have anti-carcinogenic effects." | 1.35 | p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. ( Akhtar, S; Katiyar, N; Katiyar, SK; Meeran, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 11 (47.83) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, JM | 2 |
| Wu, JY | 2 |
| Chen, SH | 2 |
| Chao, WY | 2 |
| Chuang, HH | 1 |
| Kam, KH | 2 |
| Zhao, PW | 2 |
| Li, YZ | 2 |
| Yen, YP | 1 |
| Lee, YR | 2 |
| Chen, P | 1 |
| Dai, CH | 1 |
| Shi, ZH | 1 |
| Wang, Y | 1 |
| Wu, JN | 1 |
| Chen, K | 1 |
| Su, JY | 1 |
| Li, J | 2 |
| Chen, Z | 2 |
| Vallega, KA | 1 |
| Chen, H | 1 |
| Zhou, J | 1 |
| Ramalingam, SS | 1 |
| Sun, SY | 1 |
| Paudel, KR | 1 |
| Mehta, M | 1 |
| Yin, GHS | 1 |
| Yen, LL | 1 |
| Malyla, V | 1 |
| Patel, VK | 1 |
| Panneerselvam, J | 1 |
| Madheswaran, T | 1 |
| MacLoughlin, R | 1 |
| Jha, NK | 1 |
| Gupta, PK | 1 |
| Singh, SK | 1 |
| Gupta, G | 1 |
| Kumar, P | 1 |
| Oliver, BG | 1 |
| Hansbro, PM | 1 |
| Chellappan, DK | 1 |
| Dua, K | 1 |
| Wang, Q | 1 |
| Wu, H | 1 |
| Wu, Q | 1 |
| Zhong, S | 1 |
| Cuan, X | 1 |
| Yang, X | 1 |
| Zhu, W | 1 |
| Zhao, Y | 2 |
| Luo, R | 1 |
| Huang, Y | 1 |
| Wang, X | 1 |
| Sheng, J | 1 |
| Xu, L | 1 |
| Chung, HC | 1 |
| Chen, J | 2 |
| Huang, X | 2 |
| Tao, C | 2 |
| Wang, L | 1 |
| Li, X | 2 |
| Zeng, Q | 1 |
| Ma, M | 1 |
| Zhang, R | 2 |
| Wu, Z | 1 |
| Liu, J | 1 |
| Liu, D | 1 |
| Ji, K | 1 |
| Ni, L | 1 |
| Li, Z | 2 |
| Ren, H | 1 |
| Kong, L | 1 |
| Chen, X | 1 |
| Xiong, M | 1 |
| Zhang, X | 2 |
| Ning, B | 1 |
| Rao, PC | 1 |
| Begum, S | 1 |
| Sahai, M | 1 |
| Sriram, DS | 1 |
| Dai, B | 1 |
| Ma, Y | 1 |
| Wang, W | 1 |
| Zhan, Y | 1 |
| Zhang, D | 1 |
| Liu, R | 1 |
| Zhang, Y | 1 |
| Fan, XX | 2 |
| Leung, EL | 2 |
| Xie, Y | 2 |
| Liu, ZQ | 1 |
| Zheng, YF | 1 |
| Yao, XJ | 1 |
| Lu, LL | 1 |
| Wu, JL | 1 |
| He, JX | 1 |
| Yuan, ZW | 2 |
| Fu, J | 1 |
| Wei, CL | 1 |
| Huang, J | 1 |
| Xiao, DK | 1 |
| Luo, LX | 1 |
| Jiang, ZB | 1 |
| Zhou, YL | 1 |
| Kam, RK | 1 |
| Liu, L | 2 |
| Xiao, Y | 1 |
| Tian, C | 1 |
| Huang, T | 2 |
| Han, B | 1 |
| Wang, M | 1 |
| Ma, H | 1 |
| Ye, X | 1 |
| Fu, L | 1 |
| Chen, W | 1 |
| Guo, W | 1 |
| Wang, J | 1 |
| Tian, Y | 1 |
| Shi, D | 1 |
| Qiu, H | 1 |
| Xiao, X | 1 |
| Kang, T | 1 |
| Huang, W | 1 |
| Wang, S | 1 |
| Deng, W | 1 |
| Chen, L | 1 |
| Yang, J | 1 |
| Zheng, M | 1 |
| Kong, X | 1 |
| Cai, YD | 1 |
| Jiang, G | 1 |
| Li, L | 1 |
| Wu, X | 1 |
| Dong, S | 1 |
| Tong, X | 1 |
| Zhou, H | 1 |
| Ma, WZ | 1 |
| Liu, Y | 1 |
| Yu, H | 1 |
| Zhang, C | 1 |
| Cheng, Y | 1 |
| Hu, L | 1 |
| Meng, X | 1 |
| Peng, PL | 2 |
| Hsieh, YS | 1 |
| Wang, CJ | 1 |
| Hsu, JL | 1 |
| Chou, FP | 2 |
| Kuo, WH | 1 |
| Tseng, HC | 1 |
| Katiyar, SK | 1 |
| Meeran, SM | 1 |
| Katiyar, N | 1 |
| Akhtar, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Phase II Trial of Gefitinib and Berberine in Patients With Advanced Non-small Cell Lung Cancer and Activating EGFR Mutations[NCT03486496] | Phase 2 | 50 participants (Anticipated) | Interventional | 2018-06-05 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for berberine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer.
Topics: Aged; Berberine; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Double-Blind Method; Fem | 2008 |
22 other studies available for berberine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
9-O-Terpenyl-Substituted Berberrubine Derivatives Suppress Tumor Migration and Increase Anti-Human Non-Small-Cell Lung Cancer Activity.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Berberine; Bromides; Carcinogenesis; Carcinoma, Non-Sm | 2021 |
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis.
Topics: Animals; Apoptosis; Autophagic Cell Death; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2021 |
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition.
Topics: Acrylamides; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Berberine; Biological Pro | 2022 |
Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro.
Topics: Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla | 2022 |
Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway.
Topics: Animals; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell | 2023 |
Antitumor effects of erlotinib in combination with berberine in A431 cells.
Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Erb | 2023 |
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification.
Topics: Autophagy; Berberine; Carcinoma, Non-Small-Cell Lung; Humans; I-kappa B Kinase; Lung Neoplasms; Mole | 2023 |
Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells.
Topics: A549 Cells; Antineoplastic Agents; Berberine; Bromides; Carcinoma, Non-Small-Cell Lung; Cell Cycle; | 2020 |
Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Carcinoma, Non-Small-C | 2020 |
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellul | 2021 |
Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2022 |
Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells.
Topics: A549 Cells; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Proli | 2017 |
Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators.
Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Berberin | 2017 |
Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases.
Topics: AMP-Activated Protein Kinases; Arthritis, Rheumatoid; Berberine; Carcinoma, Non-Small-Cell Lung; Cel | 2018 |
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Biomarkers, Tumor; Bod | 2018 |
Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.
Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tu | 2013 |
The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
Topics: Animals; Antineoplastic Agents; Arsenicals; Berberine; Carcinogenesis; Carcinoma, Non-Small-Cell Lun | 2015 |
[Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells].
Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2015 |
Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS.
Topics: Antineoplastic Agents; Berberine; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Line, T | 2015 |
Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2006 |
Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.
Topics: Acridine Orange; Animals; Autophagy; Berberine; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lun | 2008 |
p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.
Topics: Animals; Apoptosis; Berberine; Blotting, Western; Bronchi; Carcinoma, Non-Small-Cell Lung; Caspase 3 | 2009 |