berberine has been researched along with Cancer of Pancreas in 20 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate apoptotic effects of berberine, a significant alkaloids component existing in Rhizoma coptidis, and its possible acting mechanism in insulinoma cells." | 7.91 | Berberine Induces Cell Apoptosis through Cytochrome C/Apoptotic Protease-Activating Factor 1/Caspase-3 and Apoptosis Inducing Factor Pathway in Mouse Insulinoma Cells. ( Fang, X; Gao, SH; Liu, JL; Miao, XL; Mo, FF; Mu, QQ; Wang, M; Yin, HP; Yu, N; Zhang, DW; Zhao, DD, 2019) |
| "Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation." | 6.82 | Effects of Berberine against Pancreatitis and Pancreatic Cancer. ( Gagacev, F; O'Neill, EJ; Tsiani, E; Vlavcheski, F, 2022) |
| "Co-treatment with berberine inhibited such effects." | 5.40 | Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets. ( Gao, Y; Huang, Y; Liu, J; Liu, L; Xu, G; Yu, X, 2014) |
| "To investigate apoptotic effects of berberine, a significant alkaloids component existing in Rhizoma coptidis, and its possible acting mechanism in insulinoma cells." | 3.91 | Berberine Induces Cell Apoptosis through Cytochrome C/Apoptotic Protease-Activating Factor 1/Caspase-3 and Apoptosis Inducing Factor Pathway in Mouse Insulinoma Cells. ( Fang, X; Gao, SH; Liu, JL; Miao, XL; Mo, FF; Mu, QQ; Wang, M; Yin, HP; Yu, N; Zhang, DW; Zhao, DD, 2019) |
| " Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with the isoquinoline alkaloid berberine (0." | 3.80 | Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. ( Eibl, G; Ming, M; Rozengurt, E; Sinnett-Smith, J; Soares, HP; Wang, J; Young, SH, 2014) |
| "Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation." | 2.82 | Effects of Berberine against Pancreatitis and Pancreatic Cancer. ( Gagacev, F; O'Neill, EJ; Tsiani, E; Vlavcheski, F, 2022) |
| "Metformin and BBR both activate AMP-activated protein kinase (AMPK) which is a key mediator of glucose metabolism." | 2.61 | Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells. ( Abrams, SL; Akula, SM; Bueno-Silva, B; Candido, S; Cervello, M; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lin, HL; Lombardi, P; Mao, W; Martelli, AM; Matias de Alencar, S; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ramazzotti, G; Ratti, S; Rosalen, PL; Steelman, LS, 2019) |
| "Berberine (BBR) is a natural product found in many fruits and berries and used in traditional medicine for centuries." | 1.72 | Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53. ( Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Falzone, L; Follo, ML; Libra, M; Lombardi, P; Martelli, AM; McCubrey, JA; Montalto, G; Ratti, S; Steelman, LS, 2022) |
| "KRas is frequently mutated in pancreatic cancers." | 1.62 | GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. ( Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS, 2021) |
| "Berberine (BBR) is a common nutraceutical consumed by millions worldwide." | 1.51 | Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. ( Abrams, SL; Candido, S; Cervello, M; Cocco, L; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lombardi, P; Mao, W; Martelli, AM; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ratti, S; Rosalen, PL; Steelman, LS, 2019) |
| "Using multiple human pancreatic cancer cells we found that combination treatment with Nx and GEM resulted in significant alterations of proteins in the STAT3/NF-κB signaling axis culminating in growth inhibition in a synergistic manner." | 1.46 | Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells. ( Chan, DE; Freeman, JW; Ghosh, R; Gong, J; Kumar, AP; Muñoz, AR; Payton-Stewart, F; Pingali, S, 2017) |
| "Pancreatic cancer is the fourth leading cause of cancer death." | 1.42 | Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines. ( Chung, N; Kim, EJ; Park, SH; Sung, JH, 2015) |
| "Co-treatment with berberine inhibited such effects." | 1.40 | Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets. ( Gao, Y; Huang, Y; Liu, J; Liu, L; Xu, G; Yu, X, 2014) |
| "Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide." | 1.36 | Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells. ( Efferth, T; Hoheisel, JD; Pinto-Garcia, L; Torres, A; Youns, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 8 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, SL | 5 |
| Akula, SM | 4 |
| Steelman, LS | 5 |
| Follo, ML | 1 |
| Cocco, L | 4 |
| Ratti, S | 5 |
| Martelli, AM | 5 |
| Libra, M | 4 |
| Falzone, L | 2 |
| Candido, S | 4 |
| Montalto, G | 4 |
| Cervello, M | 4 |
| Lombardi, P | 4 |
| McCubrey, JA | 6 |
| Gizak, A | 4 |
| Duda, P | 2 |
| Vlavcheski, F | 2 |
| O'Neill, EJ | 2 |
| Gagacev, F | 2 |
| Tsiani, E | 2 |
| Ruvolo, PP | 1 |
| Liu, J | 2 |
| Luo, X | 1 |
| Guo, R | 1 |
| Jing, W | 1 |
| Lu, H | 1 |
| Wang, X | 1 |
| Liu, Y | 1 |
| Xu, W | 1 |
| Jia, L | 1 |
| Chi, D | 1 |
| Yu, J | 1 |
| Wang, J | 2 |
| He, Z | 1 |
| Liu, X | 1 |
| Wang, Y | 1 |
| Meher, AK | 1 |
| Rakus, D | 3 |
| Ruvolo, P | 1 |
| Follo, MY | 2 |
| Lertpiriyapong, K | 2 |
| Murata, RM | 2 |
| Rosalen, PL | 2 |
| Mao, W | 2 |
| Ramazzotti, G | 1 |
| Bueno-Silva, B | 1 |
| Matias de Alencar, S | 1 |
| Lin, HL | 1 |
| Zhang, YL | 1 |
| Zhang, X | 1 |
| Miao, XZ | 1 |
| Yuan, YY | 1 |
| Gao, J | 1 |
| Li, X | 1 |
| Liu, YG | 1 |
| Tan, P | 1 |
| Liu, L | 1 |
| Gao, Y | 1 |
| Yu, X | 1 |
| Xu, G | 1 |
| Huang, Y | 1 |
| Park, SH | 2 |
| Sung, JH | 2 |
| Chung, N | 2 |
| Jin, X | 1 |
| Yan, TH | 1 |
| Yan, L | 1 |
| Li, Q | 1 |
| Wang, RL | 1 |
| Hu, ZL | 1 |
| Jiang, YY | 1 |
| Sun, QY | 1 |
| Cao, YB | 1 |
| Ming, M | 1 |
| Sinnett-Smith, J | 1 |
| Soares, HP | 1 |
| Young, SH | 1 |
| Eibl, G | 1 |
| Rozengurt, E | 1 |
| Kim, EJ | 1 |
| Fang, X | 1 |
| Miao, XL | 1 |
| Liu, JL | 1 |
| Zhang, DW | 1 |
| Wang, M | 1 |
| Zhao, DD | 1 |
| Mu, QQ | 1 |
| Yu, N | 1 |
| Mo, FF | 1 |
| Yin, HP | 1 |
| Gao, SH | 1 |
| Gong, J | 1 |
| Muñoz, AR | 1 |
| Pingali, S | 1 |
| Payton-Stewart, F | 1 |
| Chan, DE | 1 |
| Freeman, JW | 1 |
| Ghosh, R | 1 |
| Kumar, AP | 1 |
| Pinto-Garcia, L | 1 |
| Efferth, T | 1 |
| Torres, A | 1 |
| Hoheisel, JD | 1 |
| Youns, M | 1 |
| Iizuka, N | 1 |
| Oka, M | 1 |
| Yamamoto, K | 1 |
| Tangoku, A | 1 |
| Miyamoto, K | 1 |
| Miyamoto, T | 1 |
| Uchimura, S | 1 |
| Hamamoto, Y | 1 |
| Okita, K | 1 |
| Leng, SH | 1 |
| Lu, FE | 1 |
| Xu, LJ | 1 |
2 reviews available for berberine and Cancer of Pancreas
| Article | Year |
|---|---|
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Effects of Berberine against Pancreatitis and Pancreatic Cancer.
Topics: Berberine; Humans; Inflammation; Pancreas; Pancreatic Neoplasms; Pancreatitis | 2022 |
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells.
Topics: AMP-Activated Protein Kinases; Berberine; Cell Proliferation; Humans; Metformin; Neoplasm Proteins; | 2019 |
18 other studies available for berberine and Cancer of Pancreas
| Article | Year |
|---|---|
Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53.
Topics: Apoptosis; Berberine; Cell Line, Tumor; Humans; Imidazoles; Pancreatic Neoplasms; Piperazines; Proto | 2022 |
APR-246-The Mutant TP53 Reactivator-Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells.
Topics: Berberine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Humans; Pancreatic Ne | 2022 |
TP53/miR-34a-associated signaling targets
Topics: Antineoplastic Agents; Apoptosis; Berberine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ce | 2020 |
Cell Metabolomics Reveals Berberine-Inhibited Pancreatic Cancer Cell Viability and Metastasis by Regulating Citrate Metabolism.
Topics: Berberine; Cell Survival; Citrates; Humans; Metabolome; Metabolomics; Neoplasm Metastasis; Pancreati | 2020 |
Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer.
Topics: Animals; Berberine; Humans; Irinotecan; Liposomes; Mice; Pancreatic Neoplasms; Tissue Distribution | 2021 |
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compound | 2021 |
Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells.
Topics: Aged; Apoptosis; Berberine; Cell Cycle; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Gene Expression | 2019 |
Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells.
Topics: Apoptosis; Berberine; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pancreatic | 2020 |
Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; Glucose; Insulin | 2014 |
Berberine diminishes side population and down-regulates stem cell-associated genes in the pancreatic cancer cell lines PANC-1 and MIA PaCa-2.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Berberine; Biomarkers, Tumor; Ce | 2014 |
Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC "click" chemistry as potential anticancer agents.
Topics: Antineoplastic Agents; Berberine; Breast Neoplasms; Cell Line, Tumor; Click Chemistry; Drug Design; | 2014 |
Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.
Topics: Acetyl-CoA Carboxylase; Adenocarcinoma; AMP-Activated Protein Kinases; Animals; Berberine; Carcinoma | 2014 |
Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Caspase 3; | 2015 |
Berberine Induces Cell Apoptosis through Cytochrome C/Apoptotic Protease-Activating Factor 1/Caspase-3 and Apoptosis Inducing Factor Pathway in Mouse Insulinoma Cells.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; Berberine; Ca | 2019 |
Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Berberine; Cell Line, Tumor; Deoxycytidin | 2017 |
Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Caspase Inhibitors; Caspases; Cell Line, Tu | 2010 |
Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray.
Topics: Antineoplastic Agents; Berberine; Biomarkers, Tumor; Cell Division; Coptis chinensis; DNA Primers; D | 2003 |
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion.
Topics: Animals; Berberine; Blood Glucose; Cells, Cultured; Cholesterol; Cholesterol, HDL; Cricetinae; Diabe | 2004 |