berberine has been researched along with Brain Ischemia in 20 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS)." | 9.22 | [Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke]. ( Chai, MJ; Li, HS; Li, Y; Lu, DD; Wang, H; Wang, P; Yang, F; Zhao, J, 2016) |
| "Existing research indicates that anti-inflammatory and antioxidant properties of berberine play major roles in coping with oxidative stress in neurodegenerative diseases, but it is not known if this isoquinoline alkaloid affects inflammatory cytokines such as interleukin 10 in focal cerebral ischemia." | 7.88 | Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines. ( Aboutaleb, N; Maleki, SN; Souri, F, 2018) |
| "To investigate the effect of berberine on angiogenesis and signal transduction pathway of hypoxia-inducible growth factor-1α (HIF-1α) / vascular endothelial growth factor (VEGF) in rats with cerebral ischemia-reperfusion injury." | 7.88 | Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury. ( Liu, H; Ma, C; Ren, X, 2018) |
| "Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke." | 7.85 | Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. ( Fu, X; Kong, L; Wang, J; Yang, M; Zhang, Q, 2017) |
| "Berberine (BBR) is an anti-inflammatory alkaloid compound extracted from herbs." | 5.62 | Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis. ( Li, Z; Lu, E; Sheng, Q; Zhao, Y, 2021) |
| "Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability." | 5.62 | Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model. ( Azadi, R; Jaafari, MR; Kazemi, NM; Mousavi, SE; Rezayat, SM; Yousefi-Manesh, H, 2021) |
| "Berberine is an alkaloid derived from herb the Berberis sp." | 5.40 | Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014) |
| "Berberine is a candidate clinical neuroprotective agent against ischemic stroke." | 5.38 | PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. ( Chai, Y; Du, L; Hu, J; Kheir, MM; Lei, F; Li, H; Wan, H; Wang, Y; Xing, D; Yuan, Z, 2012) |
| "This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS)." | 5.22 | [Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke]. ( Chai, MJ; Li, HS; Li, Y; Lu, DD; Wang, H; Wang, P; Yang, F; Zhao, J, 2016) |
| " Berberine has demonstrated good neuroprotective effects in models of acute cerebral ischemia; however, whether it can alleviate cognitive impairment caused by chronic cerebral hypoperfusion has rarely been investigated." | 4.12 | Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats. ( Du, Y; Huang, Y; Li, F; Luo, Y; Tao, Z; Tian, Y; Wang, N; Wang, Q; Wang, Y; Yan, F; Zhao, F; Zheng, Y, 2022) |
| "Existing research indicates that anti-inflammatory and antioxidant properties of berberine play major roles in coping with oxidative stress in neurodegenerative diseases, but it is not known if this isoquinoline alkaloid affects inflammatory cytokines such as interleukin 10 in focal cerebral ischemia." | 3.88 | Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines. ( Aboutaleb, N; Maleki, SN; Souri, F, 2018) |
| "To investigate the effect of berberine on angiogenesis and signal transduction pathway of hypoxia-inducible growth factor-1α (HIF-1α) / vascular endothelial growth factor (VEGF) in rats with cerebral ischemia-reperfusion injury." | 3.88 | Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury. ( Liu, H; Ma, C; Ren, X, 2018) |
| "Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke." | 3.85 | Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. ( Fu, X; Kong, L; Wang, J; Yang, M; Zhang, Q, 2017) |
| "Berberine has multiple neuropharmacological properties, such as neuroprection, anti-neuronal apoptosis, improvement of cerebral microcirculation and anti-Alzheimer's disease, and so on." | 2.45 | Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. ( Fu, S; He, F; Pi, R; Ye, M, 2009) |
| "Berberine (BBR) is an anti-inflammatory alkaloid compound extracted from herbs." | 1.62 | Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis. ( Li, Z; Lu, E; Sheng, Q; Zhao, Y, 2021) |
| "Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability." | 1.62 | Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model. ( Azadi, R; Jaafari, MR; Kazemi, NM; Mousavi, SE; Rezayat, SM; Yousefi-Manesh, H, 2021) |
| "Berberine is an alkaloid derived from herb the Berberis sp." | 1.40 | Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. ( Frozza, RL; Hoppe, JB; Menezes, Bde M; Salbego, CG; Simões Pires, EN, 2014) |
| "Berberine is a candidate clinical neuroprotective agent against ischemic stroke." | 1.38 | PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. ( Chai, Y; Du, L; Hu, J; Kheir, MM; Lei, F; Li, H; Wan, H; Wang, Y; Xing, D; Yuan, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Y | 3 |
| Li, Z | 1 |
| Lu, E | 1 |
| Sheng, Q | 1 |
| Azadi, R | 1 |
| Mousavi, SE | 1 |
| Kazemi, NM | 1 |
| Yousefi-Manesh, H | 1 |
| Rezayat, SM | 1 |
| Jaafari, MR | 1 |
| Tian, Y | 2 |
| Zheng, Y | 2 |
| Wang, Q | 1 |
| Yan, F | 2 |
| Tao, Z | 1 |
| Zhao, F | 2 |
| Wang, Y | 2 |
| Huang, Y | 1 |
| Li, F | 1 |
| Du, Y | 1 |
| Wang, N | 2 |
| Luo, Y | 2 |
| Ni, SJ | 1 |
| Yao, ZY | 1 |
| Wei, X | 1 |
| Heng, X | 1 |
| Qu, SY | 1 |
| Zhao, X | 1 |
| Qi, YY | 1 |
| Ge, PY | 1 |
| Xu, CP | 1 |
| Yang, NY | 1 |
| Cao, Y | 1 |
| Zhu, HX | 1 |
| Guo, R | 1 |
| Zhang, QC | 1 |
| Wang, R | 1 |
| Maleki, SN | 1 |
| Aboutaleb, N | 1 |
| Souri, F | 1 |
| Zhang, Q | 1 |
| Fu, X | 1 |
| Wang, J | 1 |
| Yang, M | 1 |
| Kong, L | 1 |
| Li, Y | 2 |
| Wang, P | 1 |
| Chai, MJ | 1 |
| Yang, F | 1 |
| Li, HS | 1 |
| Zhao, J | 1 |
| Wang, H | 1 |
| Lu, DD | 1 |
| Yang, J | 1 |
| Yan, H | 1 |
| Li, S | 2 |
| Zhang, M | 1 |
| Lin, X | 1 |
| Zhang, N | 1 |
| Liu, H | 1 |
| Ren, X | 1 |
| Ma, C | 1 |
| Zhu, J | 1 |
| Cao, D | 1 |
| Guo, C | 1 |
| Liu, M | 1 |
| Tao, Y | 1 |
| Zhou, J | 1 |
| Wang, F | 2 |
| Wei, J | 1 |
| Zhang, Y | 1 |
| Fang, W | 1 |
| Chai, YS | 2 |
| Hu, J | 3 |
| Lei, F | 3 |
| Wang, YG | 2 |
| Yuan, ZY | 2 |
| Lu, X | 2 |
| Wang, XP | 1 |
| Du, F | 2 |
| Zhang, D | 1 |
| Xing, DM | 2 |
| Du, LJ | 2 |
| Wu, C | 1 |
| Chen, J | 1 |
| Lu, P | 1 |
| Chen, C | 1 |
| Fu, M | 1 |
| Fang, J | 1 |
| Gao, J | 1 |
| Zhu, L | 1 |
| Liang, R | 1 |
| Shen, X | 1 |
| Yang, H | 1 |
| Simões Pires, EN | 1 |
| Frozza, RL | 1 |
| Hoppe, JB | 1 |
| Menezes, Bde M | 1 |
| Salbego, CG | 1 |
| Jiang, JF | 1 |
| Ye, M | 1 |
| Fu, S | 1 |
| Pi, R | 1 |
| He, F | 1 |
| Chai, Y | 1 |
| Kheir, MM | 1 |
| Li, H | 1 |
| Yuan, Z | 1 |
| Wan, H | 1 |
| Xing, D | 1 |
| Du, L | 1 |
| Zhao, G | 1 |
| Cheng, L | 1 |
| Zhou, HY | 1 |
| Fu, LY | 1 |
| Yao, WX | 1 |
| Wu, JF | 1 |
| Liu, TP | 1 |
2 reviews available for berberine and Brain Ischemia
| Article | Year |
|---|---|
Berberine: Pathways to protect neurons.
Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Berberine; Brain Ischemia; Encephalomyelitis, A | 2018 |
Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research.
Topics: Alzheimer Disease; Animals; Berberine; Brain Ischemia; Humans; Neuroprotective Agents | 2009 |
1 trial available for berberine and Brain Ischemia
| Article | Year |
|---|---|
[Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke].
Topics: Anti-Inflammatory Agents; Berberine; Brain Ischemia; Carotid Intima-Media Thickness; Humans; Interle | 2016 |
17 other studies available for berberine and Brain Ischemia
| Article | Year |
|---|---|
Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis.
Topics: Animals; Berberine; Brain Ischemia; DNA-Binding Proteins; NF-kappa B; PPAR gamma; Pyroptosis; Rats; | 2021 |
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Brain; Brain Ischemia; Carotid Artery Diseases; Diseas | 2021 |
Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Brain Ischemia; Carotid Artery, Common; Cognitive Dysf | 2022 |
Vagus nerve stimulated by microbiota-derived hydrogen sulfide mediates the regulation of berberine on microglia in transient middle cerebral artery occlusion rats.
Topics: Animals; Berberine; Brain Ischemia; Hydrogen Sulfide; Infarction, Middle Cerebral Artery; Microbiota | 2022 |
Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage via regulation of the ERK/Nrf2 pathway.
Topics: Animals; Berberine; Brain Ischemia; Cognitive Dysfunction; Hippocampus; MAP Kinase Signaling System; | 2022 |
Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Brain; Brain Ischemia; Male; Neuroprotec | 2018 |
Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach.
Topics: Berberine; Brain Ischemia; Drugs, Chinese Herbal; Flavonoids; Humans; Iridoids; Medicine, Chinese Tr | 2017 |
Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF-TrkB-PI3K/Akt Signaling Pathway.
Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Brain-Derived Neurotrophic Factor; Infarction, Middle | 2018 |
Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury.
Topics: Animals; Berberine; Brain Ischemia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Random Allocati | 2018 |
Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Brain; Brain Ischemia; Cell Line; Cell Movement; | 2019 |
Effect of berberine on cell cycle arrest and cell survival during cerebral ischemia and reperfusion and correlations with p53/cyclin D1 and PI3K/Akt.
Topics: Animals; Berberine; Brain Ischemia; Cell Cycle Checkpoints; Cell Survival; Cells, Cultured; Cyclin D | 2013 |
An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.
Topics: Algorithms; Animals; Berberine; Brain Ischemia; Cerebrum; Drug Combinations; Drug Compounding; Drug | 2013 |
Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved.
Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Caspase 3; Cell Survival; Disease Models, Animal; Dos | 2014 |
Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Cell Cycle Checkpoints; Cell Survival; Hippocampus; M | 2014 |
PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.
Topics: Animals; Apoptosis; Berberine; Brain Ischemia; Caspase 3; Enzyme Activation; Gene Expression Regulat | 2012 |
Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus.
Topics: Animals; Anti-Arrhythmia Agents; Berberine; Brain Infarction; Brain Ischemia; Cell Membrane; Dose-Re | 2004 |
[Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion].
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Berberine; Brain Ischemia; Male; Plate | 1995 |