berberine has been researched along with Astrocytoma, Grade IV in 11 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway." | 7.88 | Berberine inhibits angiogenesis in glioblastoma xenografts by targeting the VEGFR2/ERK pathway. ( Huang, X; Jin, F; Xie, T; Zhao, X, 2018) |
| " However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer." | 5.51 | Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. ( Dunbar, GL; Maiti, P; Plemmons, A, 2019) |
| "Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251, and U118 glioblastoma cells." | 5.42 | Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway. ( Gong, Y; Li, X; Liu, Q; Liu, Z; Shao, C; Wei, Z; Xu, X; Zhang, X; Zhao, M, 2015) |
| "Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear." | 5.36 | Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. ( Eom, KS; Kim, HJ; Kim, TY; Park, R; So, HS, 2010) |
| "Berberine treatment of T98G cell lines inhibited cell proliferation and induced cell death in a dose (50-200 microg/ml) dependent manner with an IC50 value of 134 microg/ml, which was associated with an increase in G1 arrest." | 5.35 | Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. ( Eom, KS; Hong, JM; Kim, JM; Kim, TY; Park, R; So, HS; Youn, MJ, 2008) |
| "Protoberberines are a new class of organic cations that are dual poisons of topoisomerases I and II." | 5.30 | Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. ( Desai, SD; LaVoie, EJ; Li, TK; Liu, AA; Liu, LF; Makhey, D; Mao, Y; Rubin, EH; Sanders, MM; Wu, HY, 1998) |
| "To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway." | 3.88 | Berberine inhibits angiogenesis in glioblastoma xenografts by targeting the VEGFR2/ERK pathway. ( Huang, X; Jin, F; Xie, T; Zhao, X, 2018) |
| " However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer." | 1.51 | Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. ( Dunbar, GL; Maiti, P; Plemmons, A, 2019) |
| "Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251, and U118 glioblastoma cells." | 1.42 | Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway. ( Gong, Y; Li, X; Liu, Q; Liu, Z; Shao, C; Wei, Z; Xu, X; Zhang, X; Zhao, M, 2015) |
| "Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear." | 1.36 | Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. ( Eom, KS; Kim, HJ; Kim, TY; Park, R; So, HS, 2010) |
| "Berberine treatment of T98G cell lines inhibited cell proliferation and induced cell death in a dose (50-200 microg/ml) dependent manner with an IC50 value of 134 microg/ml, which was associated with an increase in G1 arrest." | 1.35 | Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. ( Eom, KS; Hong, JM; Kim, JM; Kim, TY; Park, R; So, HS; Youn, MJ, 2008) |
| "Protoberberines are a new class of organic cations that are dual poisons of topoisomerases I and II." | 1.30 | Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. ( Desai, SD; LaVoie, EJ; Li, TK; Liu, AA; Liu, LF; Makhey, D; Mao, Y; Rubin, EH; Sanders, MM; Wu, HY, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Bibak, B | 1 |
| Shakeri, F | 1 |
| Keshavarzi, Z | 1 |
| Mollazadeh, H | 1 |
| Javid, H | 1 |
| Jalili-Nik, M | 1 |
| Sathyapalan, T | 1 |
| Afshari, AR | 1 |
| Sahebkar, A | 1 |
| Maiti, P | 1 |
| Plemmons, A | 1 |
| Dunbar, GL | 1 |
| Palma, TV | 1 |
| Lenz, LS | 1 |
| Bottari, NB | 1 |
| Pereira, A | 1 |
| Schetinger, MRC | 1 |
| Morsch, VM | 1 |
| Ulrich, H | 1 |
| Pillat, MM | 1 |
| de Andrade, CM | 1 |
| Jin, F | 1 |
| Xie, T | 1 |
| Huang, X | 1 |
| Zhao, X | 1 |
| Liu, Q | 1 |
| Xu, X | 1 |
| Zhao, M | 1 |
| Wei, Z | 1 |
| Li, X | 2 |
| Zhang, X | 2 |
| Liu, Z | 1 |
| Gong, Y | 1 |
| Shao, C | 1 |
| Wang, J | 2 |
| Qi, Q | 1 |
| Feng, Z | 1 |
| Huang, B | 1 |
| Chen, A | 1 |
| Prestegarden, L | 1 |
| Eom, KS | 2 |
| Kim, HJ | 1 |
| So, HS | 2 |
| Park, R | 2 |
| Kim, TY | 2 |
| Wang, DY | 1 |
| Yeh, CC | 1 |
| Lee, JH | 1 |
| Hung, CF | 1 |
| Chung, JG | 1 |
| Yount, G | 1 |
| Qian, Y | 1 |
| Moore, D | 1 |
| Basila, D | 1 |
| West, J | 1 |
| Aldape, K | 1 |
| Arvold, N | 1 |
| Shalev, N | 1 |
| Haas-Kogan, D | 1 |
| Hong, JM | 1 |
| Youn, MJ | 1 |
| Kim, JM | 1 |
| Sanders, MM | 1 |
| Liu, AA | 1 |
| Li, TK | 1 |
| Wu, HY | 1 |
| Desai, SD | 1 |
| Mao, Y | 1 |
| Rubin, EH | 1 |
| LaVoie, EJ | 1 |
| Makhey, D | 1 |
| Liu, LF | 1 |
1 review available for berberine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma Multiforme Therapy.
Topics: Apoptosis; Berberine; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans | 2022 |
10 other studies available for berberine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Berberine; Biological Availability; Brain | 2019 |
Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity.
Topics: AMP-Activated Protein Kinases; Apoptosis; Berberine; Caspase 3; Cell Line, Tumor; Cell Proliferation | 2020 |
Berberine inhibits angiogenesis in glioblastoma xenografts by targeting the VEGFR2/ERK pathway.
Topics: Angiogenesis Inhibitors; Animals; Berberine; Cell Line, Tumor; Cell Survival; Dose-Response Relation | 2018 |
Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway.
Topics: Animals; Apoptosis; Berberine; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellula | 2015 |
Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Autophagy; Autophagy-Rela | 2016 |
Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Berberine; C | 2010 |
Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells.
Topics: Arylamine N-Acetyltransferase; Astrocytoma; Base Sequence; Berberine; Brain Neoplasms; DNA Adducts; | 2002 |
Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro.
Topics: Berberine; Cell Line, Tumor; Combined Modality Therapy; Glioblastoma; Humans; Neuroglia; Radiation-S | 2004 |
Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway.
Topics: Apoptosis; Berberine; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Cycle Proteins; | 2008 |
Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells.
Topics: Antineoplastic Agents; Berberine; Berberine Alkaloids; Biogenic Amines; Enzyme Inhibitors; Glioblast | 1998 |