berberine has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we studied the molecular mechanism of berberine in cell culture model with TDP-43 proteinopathies, and found that berberine is able to reverse the processing of insoluble TDP-43 aggregates formation through deregulation of mTOR/p70S6K signal and activation of autophagic degradation pathway." | 3.83 | Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. ( Chang, CF; Chen, CL; Huang, CC; Lee, KH; Lee, YC; Lin, HC; Shen, CJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rusmini, P | 1 |
| Cristofani, R | 1 |
| Tedesco, B | 1 |
| Ferrari, V | 1 |
| Messi, E | 1 |
| Piccolella, M | 1 |
| Casarotto, E | 1 |
| Chierichetti, M | 1 |
| Cicardi, ME | 1 |
| Galbiati, M | 1 |
| Geroni, C | 1 |
| Lombardi, P | 1 |
| Crippa, V | 1 |
| Poletti, A | 1 |
| Chang, CF | 1 |
| Lee, YC | 1 |
| Lee, KH | 1 |
| Lin, HC | 1 |
| Chen, CL | 1 |
| Shen, CJ | 1 |
| Huang, CC | 1 |
2 other studies available for berberine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives.
Topics: Amyotrophic Lateral Sclerosis; Autophagy; Berberine; Biological Products; Cell Line; Frontotemporal | 2020 |
Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Berberine; Cell Line, Tumor; Frontotemporal Lobar Degenerati | 2016 |