berberine has been researched along with Alzheimer Disease in 65 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes." | 9.05 | Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. ( Bell, J; Bligh, A; Katsuno, T; Parkinson, J; Shinjyo, N, 2020) |
| "Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine." | 6.52 | Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015) |
| "Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis." | 5.56 | Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020) |
| "Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)." | 5.46 | Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017) |
| "To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes." | 5.05 | Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. ( Bell, J; Bligh, A; Katsuno, T; Parkinson, J; Shinjyo, N, 2020) |
| "The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia." | 3.83 | Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. ( Abdalla, FH; Adefegha, SA; Baldissarelli, J; da Silva Bernardi, J; de Andrade, CM; de Oliveira, JS; Dornelles, GL; Lenz, LS; Magni, LP; Palma, TV; Pillat, MM; Rubin, MA; Signor, C, 2016) |
| "Our data indicated berberine is a potent suppressor of neuroflammation, presumably through inhibition of NF-κB activation, and suggested berberine has therapeutic potential for the treatment of neuroinflammation that is involved in neurological diseases such as AD." | 3.78 | Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. ( Chen, L; Cui, X; Jia, L; Liu, J; Pan, X; Song, Z; Wang, M, 2012) |
| "Berberine has been investigated by various researchers for its activity against AD." | 2.72 | Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways. ( Akash, MSH; Akbar, M; Rehman, K; Shabbir, A; Shah, MA, 2021) |
| "Berberine is an isoquinoline alkaloid extracted from various Berberis species which is widely used in East Asia for a wide range of symptoms." | 2.61 | Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies. ( Cai, CZ; Li, M; Lu, JH; Su, HX; Wu, MY; Yuan, NN, 2019) |
| "Berberine has been used in traditional Chinese medicine and Ayurvedic medicine." | 2.58 | Berberine Derivatives with Different Pharmacological Activities via Structural Modifications. ( He, F; Liu, Y; Liu, Z; Peng, D; Peng, J; Xiao, D; Xie, X; Zhang, S; Zhou, M; Zou, M, 2018) |
| "Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine." | 2.52 | Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015) |
| "Alzheimer's disease is a chronic neurodegenerative disorder characterized by progressive dementia and deterioration of cognitive function." | 2.50 | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. ( Kim, MH; Kim, SH; Yang, WM, 2014) |
| "Berberine is a natural isoquinoline alkaloid that possesses a wide range of pharmacological effects." | 2.47 | Berberine: a potential multipotent natural product to combat Alzheimer's disease. ( Ji, HF; Shen, L, 2011) |
| "Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome." | 2.47 | Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine. ( Chen, WM; Huang, ZJ; Lan, P; Sun, PH; Zeng, Y, 2011) |
| "Berberine has multiple neuropharmacological properties, such as neuroprection, anti-neuronal apoptosis, improvement of cerebral microcirculation and anti-Alzheimer's disease, and so on." | 2.45 | Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. ( Fu, S; He, F; Pi, R; Ye, M, 2009) |
| "Berberine is a isoquinoline alkaloid extracted from Chinese herbs such as Coptidis rhizome." | 2.44 | [Advances in the study of berberine and its derivatives]. ( Chen, KX; Li, B; Zhu, WL, 2008) |
| "Berberine (BBR) is an anti-inflammatory and anti-oxidant phytoconstituent." | 1.91 | Investigating Neuroprotective Potential of Berberine, Levetiracetam and their Combination in the Management of Alzheimer's Disease Utilizing Drug Repurposing Strategy. ( Dhaneshwar, S; Mazumder, A; Singh, A, 2023) |
| "Berberine (BBR) is an isoquinoline alkaloid that can target mitochondria and has great prospect in the treatment of AD." | 1.91 | Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy. ( Cai, Z; Pu, Y; Tang, Y; Wang, C; Zou, Q, 2023) |
| "Berberine (BBR) is a natural alkaloid extracted from the herb Coptis chinensis." | 1.91 | Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. ( Chen, J; Chen, M; Feng, W; Li, X; Li, Y; Liu, Q; Liu, X; Tian, J; Wang, C, 2023) |
| "Additionally, the ratio of β-amyloid plaques and the number of activated microglia were evaluated by immunofluorescence staining." | 1.91 | An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer's Disease with Berberine and Palmatine. ( Ge, P; Guo, R; Guo, S; Lei, S; Qi, Y; Wang, N; Wei, X; Wu, W; Xiao, Q; Yang, N; Zhang, Q; Zhao, L; Zhao, X; Zhou, P; Zhu, H, 2023) |
| " Despite having substantial therapeutic potential, it exhibits poor absorption, low oral bioavailability and limited penetration in the brain." | 1.62 | Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance. ( Auti, ST; Kulkarni, YA; Kunde, SS; Raju, M; Wairkar, S, 2021) |
| " However, BBR suffers from poor absorption, bioavailability and brain drug uptake." | 1.62 | Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats. ( Abady, MM; Abdel-Latif, MS; Abdel-Monaem, N; Ghareeb, DA; Nofal, M; Nounou, MI; Saleh, SR; Yassa, NW, 2021) |
| "Berberine has shown an outstanding antioxidant activity, however the low bioavailability limits its applications in pharmaceutical platforms." | 1.62 | Berberine-Albumin Nanoparticles: Preparation, Thermodynamic Study and Evaluation Their Protective Effects Against Oxidative Stress in Primary Neuronal Cells as a Model of Alzheimer's Disease. ( Gao, J; Li, G; Wang, L; Zhang, Y, 2021) |
| "Berberine (BBR) is an alkaloid extracted from Coptidis Rhizoma, also known as Huang-Lian." | 1.62 | Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology. ( Chen, L; Ho, PC; Lian, XL; Lim, MEJ; Shen, W; Tan, EA; Wang, Y; Wong, LR, 2021) |
| "Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis." | 1.56 | Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance. ( Chen, H; Chen, Y; Huang, M; Ji, X; Liang, Y, 2020) |
| "Berberine plays a neuroprotective role in neurodegenerative diseases, including Alzheimer's disease (AD)." | 1.56 | Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells. ( Gao, Y; Shen, K; Sun, X; Yu, S; Zhang, N, 2020) |
| "Berberine (BBR) has neuroprotective effects on many brain diseases, including Alzheimer's disease (AD)." | 1.48 | Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases. ( Cai, Z; Chen, Y; He, W; Wang, C, 2018) |
| "Berberine (BBR) plays an important role in the prevention and treatment of Alzheimer's disease (AD)." | 1.46 | Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation. ( Cai, Z; Chen, Y; He, W; He, Y; Wang, C, 2017) |
| "Berberine is a primary component of the most functional extracts of Coptidis rhizome used in traditional Chinese medicine for centuries." | 1.40 | Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. ( Abid, MD; Chen, J; Feng, Z; Huang, H; Liu, X; Wan, L; Yan, H; Zhou, J, 2014) |
| "Berberine and palmatine were isolated by flash chromatography and identified by spectrometric methods as main constituents." | 1.39 | Berberis aetnensis and B. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity. ( Bonesi, M; Conforti, F; Loizzo, MR; Menichini, F; Passalacqua, NG; Saab, A; Tundis, R, 2013) |
| "Apoptosis in Alzheimer's disease(AD) was studied by the techniques of immunohistochemistry, neuronal culture and patch clamp." | 1.30 | [Research on the mechanism of neuronal apoptosis in Alzheimer's disease and the effects of tetrohydroberberine on the apoptosis]. ( Xu, CQ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.54) | 18.2507 |
| 2000's | 2 (3.08) | 29.6817 |
| 2010's | 35 (53.85) | 24.3611 |
| 2020's | 27 (41.54) | 2.80 |
| Authors | Studies |
|---|---|
| Shan, WJ | 1 |
| Huang, L | 4 |
| Zhou, Q | 1 |
| Meng, FC | 1 |
| Li, XS | 2 |
| Su, T | 2 |
| Shan, W | 1 |
| Luo, Z | 2 |
| Sun, Y | 2 |
| He, F | 3 |
| Li, X | 7 |
| Hostalkova, A | 2 |
| Marikova, J | 1 |
| Opletal, L | 2 |
| Korabecny, J | 2 |
| Hulcova, D | 1 |
| Kunes, J | 1 |
| Novakova, L | 1 |
| Perez, DI | 2 |
| Jun, D | 2 |
| Kucera, T | 2 |
| Andrisano, V | 1 |
| Siatka, T | 1 |
| Cahlikova, L | 2 |
| Singh, A | 1 |
| Dhaneshwar, S | 1 |
| Mazumder, A | 1 |
| Akbar, M | 1 |
| Shabbir, A | 1 |
| Rehman, K | 1 |
| Akash, MSH | 1 |
| Shah, MA | 1 |
| Raju, M | 1 |
| Kunde, SS | 1 |
| Auti, ST | 1 |
| Kulkarni, YA | 1 |
| Wairkar, S | 1 |
| Guo, Q | 1 |
| Wang, C | 5 |
| Xue, X | 1 |
| Hu, B | 1 |
| Bao, H | 1 |
| Živančević, K | 1 |
| Baralić, K | 1 |
| Bozic, D | 1 |
| Miljaković, EA | 1 |
| Djordjevic, AB | 1 |
| Ćurčić, M | 1 |
| Bulat, Z | 1 |
| Antonijević, B | 1 |
| Bulat, P | 1 |
| Đukić-Ćosić, D | 1 |
| Shayganfard, M | 1 |
| Yang, M | 1 |
| Wang, J | 1 |
| Diddi, S | 1 |
| Lohidasan, S | 1 |
| Arulmozhi, S | 1 |
| Mahadik, KR | 1 |
| Shen, R | 3 |
| Chen, Y | 10 |
| Wang, X | 4 |
| Yang, A | 3 |
| Kou, X | 3 |
| Koly, HK | 1 |
| Sutradhar, K | 1 |
| Rahman, MS | 1 |
| Zou, Q | 1 |
| Pu, Y | 1 |
| Cai, Z | 3 |
| Tang, Y | 1 |
| Xie, M | 1 |
| Gu, S | 1 |
| Hong, Y | 1 |
| Liu, Y | 2 |
| Rong, X | 1 |
| Lu, W | 1 |
| Liu, H | 1 |
| Algradi, AM | 1 |
| Naseem, A | 1 |
| Shu, Z | 1 |
| Wang, Q | 1 |
| Chen, J | 3 |
| Feng, W | 1 |
| Chen, M | 2 |
| Li, Y | 1 |
| Liu, X | 2 |
| Liu, Q | 3 |
| Tian, J | 1 |
| Zhao, X | 1 |
| Ge, P | 1 |
| Lei, S | 1 |
| Guo, S | 1 |
| Zhou, P | 1 |
| Zhao, L | 1 |
| Qi, Y | 1 |
| Wei, X | 1 |
| Wu, W | 1 |
| Wang, N | 1 |
| Guo, R | 1 |
| Yang, N | 1 |
| Xiao, Q | 1 |
| Zhang, Q | 1 |
| Zhu, H | 1 |
| Singh, YP | 1 |
| Kumar, H | 1 |
| Ismail, H | 1 |
| Khalid, D | 1 |
| Waseem, D | 1 |
| Ijaz, MU | 1 |
| Dilshad, E | 1 |
| Haq, IU | 1 |
| Bhatti, MZ | 1 |
| Anwaar, S | 1 |
| Ahmed, M | 1 |
| Saleem, S | 1 |
| Singh, AK | 1 |
| Singh, SK | 1 |
| Nandi, MK | 1 |
| Mishra, G | 1 |
| Maurya, A | 1 |
| Rai, A | 1 |
| Rai, GK | 1 |
| Awasthi, R | 1 |
| Sharma, B | 1 |
| Kulkarni, GT | 1 |
| Liang, Y | 4 |
| Chen, H | 2 |
| Ji, X | 1 |
| Huang, M | 4 |
| Ge, Y | 1 |
| Song, X | 1 |
| Liu, J | 2 |
| Liu, C | 2 |
| Xu, C | 1 |
| Shinjyo, N | 1 |
| Parkinson, J | 1 |
| Bell, J | 1 |
| Katsuno, T | 1 |
| Bligh, A | 1 |
| Lin, L | 1 |
| Li, C | 1 |
| Zhang, D | 1 |
| Yuan, M | 1 |
| Chen, CH | 1 |
| Li, M | 4 |
| Zhang, N | 2 |
| Gao, Y | 1 |
| Yu, S | 1 |
| Sun, X | 1 |
| Shen, K | 1 |
| Saleh, SR | 1 |
| Abady, MM | 1 |
| Nofal, M | 1 |
| Yassa, NW | 1 |
| Abdel-Latif, MS | 1 |
| Nounou, MI | 1 |
| Ghareeb, DA | 2 |
| Abdel-Monaem, N | 1 |
| Li, L | 1 |
| Song, L | 1 |
| Ye, C | 2 |
| Diao, S | 1 |
| Xiong, Y | 1 |
| She, Y | 1 |
| Zhong, X | 1 |
| Zhang, Y | 1 |
| Wang, L | 1 |
| Li, G | 1 |
| Gao, J | 1 |
| Wong, LR | 1 |
| Tan, EA | 1 |
| Lim, MEJ | 1 |
| Shen, W | 1 |
| Lian, XL | 1 |
| Wang, Y | 1 |
| Chen, L | 2 |
| Ho, PC | 1 |
| Xiao, D | 1 |
| Liu, Z | 1 |
| Zhang, S | 1 |
| Zhou, M | 1 |
| Zou, M | 1 |
| Peng, J | 1 |
| Xie, X | 1 |
| Peng, D | 1 |
| Lohan, S | 1 |
| Raza, K | 1 |
| Mehta, SK | 1 |
| Bhatti, GK | 1 |
| Saini, S | 1 |
| Singh, B | 1 |
| Jiang, Y | 1 |
| Gao, H | 1 |
| Turdu, G | 1 |
| He, W | 2 |
| He, Y | 1 |
| Hussien, HM | 1 |
| Abd-Elmegied, A | 1 |
| Hafez, HS | 1 |
| Ahmed, HEA | 1 |
| El-Moneam, NA | 1 |
| Lin, X | 1 |
| de Oliveira, JS | 2 |
| Abdalla, FH | 2 |
| Dornelles, GL | 2 |
| Palma, TV | 2 |
| Signor, C | 2 |
| da Silva Bernardi, J | 2 |
| Baldissarelli, J | 2 |
| Lenz, LS | 2 |
| de Oliveira, VA | 1 |
| Chitolina Schetinger, MR | 1 |
| Melchiors Morsch, VM | 1 |
| Rubin, MA | 2 |
| de Andrade, CM | 2 |
| Cai, ZY | 1 |
| Wang, CL | 1 |
| Lu, TT | 1 |
| Yang, WM | 2 |
| Chlebek, J | 1 |
| Doležal, R | 1 |
| Štěpánková, Š | 1 |
| Macáková, K | 1 |
| Hrabinová, M | 1 |
| Yuan, NN | 1 |
| Cai, CZ | 1 |
| Wu, MY | 1 |
| Su, HX | 1 |
| Lu, JH | 2 |
| Kapoor, S | 1 |
| Bonesi, M | 1 |
| Loizzo, MR | 1 |
| Conforti, F | 1 |
| Passalacqua, NG | 1 |
| Saab, A | 1 |
| Menichini, F | 1 |
| Tundis, R | 1 |
| Durairajan, SS | 2 |
| Huang, YY | 1 |
| Yuen, PY | 1 |
| Chen, LL | 2 |
| Kwok, KY | 1 |
| Liu, LF | 2 |
| Song, JX | 1 |
| Han, QB | 1 |
| Xue, L | 1 |
| Chung, SK | 2 |
| Huang, JD | 2 |
| Baum, L | 1 |
| Senapati, S | 1 |
| Zhou, J | 1 |
| Abid, MD | 1 |
| Yan, H | 1 |
| Huang, H | 1 |
| Wan, L | 1 |
| Feng, Z | 1 |
| Yu, D | 1 |
| Tao, BB | 1 |
| Yang, YY | 1 |
| Du, LS | 1 |
| Yang, SS | 1 |
| He, XJ | 1 |
| Zhu, YW | 1 |
| Yan, JK | 1 |
| Yang, Q | 1 |
| Kim, MH | 1 |
| Kim, SH | 1 |
| Jiang, W | 1 |
| Li, S | 1 |
| Yang, X | 1 |
| Chang, RC | 1 |
| Hao, JR | 1 |
| Sun, N | 1 |
| Lei, L | 1 |
| Li, XY | 1 |
| Yao, B | 1 |
| Sun, K | 1 |
| Hu, R | 1 |
| Zhang, X | 1 |
| Shi, XD | 1 |
| Gao, C | 1 |
| Adefegha, SA | 1 |
| Magni, LP | 1 |
| Pillat, MM | 1 |
| Jiang, X | 1 |
| Chen, S | 1 |
| Guo, Y | 1 |
| Li, B | 1 |
| Zhu, WL | 1 |
| Chen, KX | 1 |
| Ye, M | 1 |
| Fu, S | 1 |
| Pi, R | 1 |
| Kulkarni, SK | 1 |
| Dhir, A | 1 |
| Ji, HF | 2 |
| Shen, L | 2 |
| Habtemariam, S | 1 |
| Jiang, H | 1 |
| Ding, K | 1 |
| Zhu, F | 1 |
| Wu, F | 1 |
| Ma, Y | 1 |
| Liu, G | 1 |
| Li, Z | 1 |
| Pei, Z | 1 |
| Huang, ZJ | 1 |
| Zeng, Y | 1 |
| Lan, P | 1 |
| Sun, PH | 1 |
| Chen, WM | 1 |
| Yuan, Q | 1 |
| Jia, L | 1 |
| Song, Z | 1 |
| Pan, X | 1 |
| Cui, X | 1 |
| Wang, M | 1 |
| Xu, CQ | 1 |
16 reviews available for berberine and Alzheimer Disease
| Article | Year |
|---|---|
Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Oxidative Stress | 2021 |
Berberine: Is it a Promising Agent for Mental Disorders Treatment?
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Antioxidants; Berberine; Humans; Mental Disorders | 2023 |
Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Berberine; Cholinesterase Inhibitors | 2023 |
Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Berberine; Humans; Neuro | 2019 |
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Berberine; Brain; Cholinergic Agonists; Cognitive Dysfunct | 2020 |
Berberine Derivatives with Different Pharmacological Activities via Structural Modifications.
Topics: Alzheimer Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; An | 2018 |
Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review.
Topics: Acetylcholinesterase; Alzheimer Disease; Berberine; Cholinesterase Inhibitors; Curcumin; Drugs, Chin | 2017 |
Berberine: Pathways to protect neurons.
Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Berberine; Brain Ischemia; Encephalomyelitis, A | 2018 |
Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies.
Topics: Alzheimer Disease; Animals; Berberine; Disease Models, Animal; Mice; Neuroprotective Agents; Rats | 2019 |
Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Berberine; Coptis; Curcuma; Curcumin; Ginsenosides; Humans; Isoflavones; | 2014 |
Therapeutic potential of berberine against neurodegenerative diseases.
Topics: Alzheimer Disease; Animals; Berberine; Blood-Brain Barrier; Disease Models, Animal; Humans; Medicine | 2015 |
[Advances in the study of berberine and its derivatives].
Topics: Alzheimer Disease; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Be | 2008 |
Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research.
Topics: Alzheimer Disease; Animals; Berberine; Brain Ischemia; Humans; Neuroprotective Agents | 2009 |
Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders.
Topics: Alzheimer Disease; Animals; Berberine; Central Nervous System Diseases; Humans; Molecular Structure | 2010 |
Berberine: a potential multipotent natural product to combat Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Anticholes | 2011 |
Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine.
Topics: Alzheimer Disease; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antimalarials; Antineop | 2011 |
49 other studies available for berberine and Alzheimer Disease
| Article | Year |
|---|---|
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Berberine; Bu | 2011 |
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Berberine; Binding Sites; Butyrylcho | 2012 |
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Berberis; Blood-Brain Barrier; Butyrylcholineste | 2019 |
Investigating Neuroprotective Potential of Berberine, Levetiracetam and their Combination in the Management of Alzheimer's Disease Utilizing Drug Repurposing Strategy.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Anticonvulsants; Antioxidants; Berberine; Drug Rep | 2023 |
Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Berberine; Biological Availability; Disease Models, | 2021 |
SOCS1 Mediates Berberine-Induced Amelioration of Microglial Activated States in N9 Microglia Exposed to
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginase; Berberine; Cell Line; China; Cytokines; Humans; | 2021 |
Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening.
Topics: Alzheimer Disease; Berberine; Biomarkers; Cheminformatics; Computational Chemistry; Databases, Factu | 2022 |
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice.
Topics: Alzheimer Disease; Animals; Berberine; Cognition; Cognitive Dysfunction; Cytokines; Disease Models, | 2022 |
Standardization and Ameliorative effect of Kalyanaka ghrita in β-amyloid induced memory impairment in wistar rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Berberine; Br | 2023 |
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod | 2023 |
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod | 2023 |
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod | 2023 |
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod | 2023 |
Acetylcholinesterase inhibition of Alzheimer's disease: identification of potential phytochemicals and designing more effective derivatives to manage disease condition.
Topics: Acetylcholinesterase; Alzheimer Disease; Anthocyanins; Berberine; Cholinesterase Inhibitors; Diterpe | 2023 |
Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy.
Topics: Alzheimer Disease; Animals; Berberine; Mice; Mitophagy; Protein Kinases; Ribose; Ubiquitin-Protein L | 2023 |
Study on the mechanism of Coptis chinensis Franch. And its main active components in treating Alzheimer's disease based on SCFAs using Orbitrap Fusion Lumos Tribrid MS.
Topics: Alzheimer Disease; Animals; Berberine; Coptis; Coptis chinensis; Drugs, Chinese Herbal; Medicine, Ch | 2023 |
Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice.
Topics: Alzheimer Disease; Animals; Berberine; Brain; Ferroptosis; Iron; Kelch-Like ECH-Associated Protein 1 | 2023 |
An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer's Disease with Berberine and Palmatine.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Cytokines; Exosomes; Mice; Neuroinflam | 2023 |
Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking.
Topics: Acetylcholinesterase; Aluminum Chloride; Alzheimer Disease; Amyloid Precursor Protein Secretases; An | 2023 |
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance.
Topics: Alzheimer Disease; Animals; Autophagy; Beclin-1; Berberine; Cathepsin D; Cells, Cultured; Cognitive | 2020 |
The Combined Therapy of Berberine Treatment with lncRNA BACE1-AS Depletion Attenuates Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Berberine; Cell Line, Tumor; Gene Knockdown Tec | 2020 |
Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer's Disease Mouse Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflam | 2020 |
Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Berberine; Cell Survival; Cells, Cultured; Down | 2020 |
Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Male; Neuroprotective Agents; Rats; Ra | 2021 |
Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Cells, Cultured; Gene Expression Regul | 2020 |
Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac | 2021 |
Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Berberine; Brain; Cerebrovascular Circ | 2021 |
Berberine-Albumin Nanoparticles: Preparation, Thermodynamic Study and Evaluation Their Protective Effects Against Oxidative Stress in Primary Neuronal Cells as a Model of Alzheimer's Disease.
Topics: Albumins; Alzheimer Disease; Berberine; Cells, Cultured; Humans; Hydrogen Peroxide; Molecular Dockin | 2021 |
Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; CHO Cells; Cricetulus; Inflammation; M | 2021 |
Anti-Alzheimer's potential of berberine using surface decorated multi-walled carbon nanotubes: A preclinical evidence.
Topics: Adsorption; Alzheimer Disease; Animals; Berberine; Cell Line; Fullerenes; Humans; Male; Nanotubes, C | 2017 |
Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation.
Topics: Alzheimer Disease; Animals; Berberine; Biomarkers; Blotting, Western; Cognitive Dysfunction; Glutath | 2017 |
Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats.
Topics: Alzheimer Disease; Animals; Berberine; Biomarkers; Environmental Pollutants; Female; Hippocampus; In | 2018 |
Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2018 |
Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Antio | 2019 |
Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice.
Topics: Alzheimer Disease; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Amyloid beta | 2019 |
In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Berberine; Biological Transport; Blood-Brain Bar | 2019 |
Comment on "Berberine and its emerging benefits in psychiatric conditions especially Alzheimer's disease".
Topics: Alzheimer Disease; Berberine | 2013 |
Berberis aetnensis and B. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity.
Topics: Alkaloids; Alzheimer Disease; Antioxidants; Berberine; Berberis; Cholinesterase Inhibitors; Humans; | 2013 |
Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Cell Survival; Disease Models | 2014 |
Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Berberine; Cell Line, Tumor; Cell Shape; Malond | 2014 |
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Brain; Cell Survival; Cogniti | 2015 |
Editorial: Bioactive Small Molecules in Regulating Inflammation and Metabolic Disorder.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Humans; Inflammation; Metabol | 2016 |
L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Berberine; Cyclic AMP-Dependent Protein Kinases; D | 2015 |
Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Anxiety; Berberine; B | 2016 |
Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac | 2017 |
The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy.
Topics: Alzheimer Disease; Berberine; Berberis; Cholinesterase Inhibitors; Plant Bark; Plant Stems | 2011 |
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Cholinesterase I | 2011 |
Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2011 |
Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Berberine; Butyrylcholinesterase; Drug Design; Hydrophobic | 2012 |
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precur | 2012 |
Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Berberine; Blotting, Western; Cells, Cultured; En | 2012 |
[Research on the mechanism of neuronal apoptosis in Alzheimer's disease and the effects of tetrohydroberberine on the apoptosis].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Berberine; Cells, Cultured; Hippocampus; Humans | 1999 |