berberine has been researched along with Acute Liver Injury, Drug-Induced in 22 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 5.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 1.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| " Doxorubicin, one of the most potent chemotherapeutic drugs, although highly efficacious, also has adverse side effects, with its targets being liver and cardiac tissue." | 1.56 | Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp. ( Cao, X; Du, X; He, M; Jin, Y; Sun, B; Yang, R; Yang, Y, 2020) |
| "Berberine (BBR) is an isoquinoline alkaloid, reported to have multiple pharmacological functions." | 1.51 | Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways. ( Gu, JG; Han, CY; Liu, CY; Sun, TT; Wang, SS; Xv, GP, 2019) |
| " Based on these reports, a safe oral daily dose limit of not more than 2." | 1.51 | Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes. ( Gao, L; Merz, KH; Schmitz, HJ; Schrenk, D, 2019) |
| "Berberine (BBR) is a natural compound with multiple pharmacological activities such as antioxidant, antiapoptotic and anti-inflammatory effects." | 1.48 | Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. ( Esmaeilizadeh, M; Fatemi, I; Ghaznavi, H; Goudarzi, M; Kalantar, H; Mehrzadi, S, 2018) |
| "When treated with berberine, the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice." | 1.48 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis. ( Fu, G; Huang, W; Qin, C; Wang, H; Yan, H; Zeng, M; Zhang, H; Zhao, L; Zhou, W, 2018) |
| "Berberine (BBR) is a natural alkaloid derived from traditional medicine Rhizoma Coptidis and possesses various pharmacological properties." | 1.48 | Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice. ( Hua, W; Liu, X; Liu, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits." | 1.46 | Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats. ( Hozayen, WG; Mahmoud, AM; Ramadan, SM, 2017) |
| "Doxorubicin, a very potent and often used anti-cancer drug, is largely limited due to the dose-related toxic effects." | 1.38 | Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice. ( Chen, Y; Luo, Y; Tong, N; Zhang, J; Zhao, X, 2012) |
| "Berberine was administered as a single dose at 5 and 10mg/kg intraperitoneally (i." | 1.37 | Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. ( Blagojević, G; Domitrović, R; Jakovac, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, G | 1 |
| Yu, Q | 1 |
| Xu, L | 1 |
| Huang, Z | 1 |
| Mai, L | 1 |
| Jiang, L | 1 |
| Su, Z | 1 |
| Xie, J | 1 |
| Li, Y | 1 |
| Liu, Y | 2 |
| Lin, Z | 1 |
| Chen, J | 1 |
| Phogat, A | 1 |
| Singh, J | 1 |
| Kumar, V | 1 |
| Malik, V | 1 |
| Han, CY | 1 |
| Sun, TT | 1 |
| Xv, GP | 1 |
| Wang, SS | 1 |
| Gu, JG | 1 |
| Liu, CY | 1 |
| Sun, B | 1 |
| Yang, Y | 1 |
| He, M | 1 |
| Jin, Y | 1 |
| Cao, X | 1 |
| Du, X | 1 |
| Yang, R | 1 |
| Wang, K | 1 |
| Rao, J | 1 |
| Zhang, T | 1 |
| Gao, Q | 1 |
| Zhang, J | 2 |
| Guang, C | 1 |
| Ding, L | 1 |
| Qiu, F | 1 |
| Mahmoud, AM | 2 |
| Hozayen, WG | 1 |
| Ramadan, SM | 1 |
| Mehrzadi, S | 1 |
| Fatemi, I | 1 |
| Esmaeilizadeh, M | 1 |
| Ghaznavi, H | 1 |
| Kalantar, H | 1 |
| Goudarzi, M | 1 |
| Su, G | 1 |
| Wang, H | 3 |
| Gao, Y | 1 |
| Chen, G | 1 |
| Pei, Y | 1 |
| Bai, J | 1 |
| Qin, C | 1 |
| Zhang, H | 1 |
| Zhao, L | 1 |
| Zeng, M | 1 |
| Huang, W | 1 |
| Fu, G | 1 |
| Zhou, W | 1 |
| Yan, H | 1 |
| Zhao, Z | 1 |
| Wei, Q | 1 |
| Hua, W | 1 |
| Liu, X | 1 |
| Zhu, Y | 1 |
| Gao, L | 1 |
| Schmitz, HJ | 1 |
| Merz, KH | 1 |
| Schrenk, D | 1 |
| Germoush, MO | 1 |
| Chen, X | 1 |
| Zhang, Y | 2 |
| Zhu, Z | 1 |
| Liu, H | 1 |
| Guo, H | 1 |
| Xiong, C | 1 |
| Xie, K | 1 |
| Zhang, X | 1 |
| Su, S | 1 |
| Vivoli, E | 1 |
| Cappon, A | 1 |
| Milani, S | 1 |
| Piombanti, B | 1 |
| Provenzano, A | 1 |
| Novo, E | 1 |
| Masi, A | 1 |
| Navari, N | 1 |
| Narducci, R | 1 |
| Mannaioni, G | 1 |
| Moneti, G | 1 |
| Oliveira, CP | 1 |
| Parola, M | 1 |
| Marra, F | 1 |
| Zhou, JY | 1 |
| Zhou, SW | 1 |
| Zhang, KB | 1 |
| Tang, JL | 1 |
| Guang, LX | 1 |
| Ying, Y | 1 |
| Xu, Y | 1 |
| Zhang, L | 1 |
| Li, DD | 1 |
| Ye, X | 1 |
| Feng, Y | 1 |
| Tong, Y | 1 |
| Ng, KM | 1 |
| Tsao, S | 1 |
| Lau, GK | 1 |
| Sze, C | 1 |
| Tang, J | 1 |
| Shen, J | 1 |
| Kobayashi, S | 1 |
| Ranawat, L | 1 |
| Bhatt, J | 1 |
| Patel, J | 1 |
| Domitrović, R | 1 |
| Jakovac, H | 1 |
| Blagojević, G | 1 |
| Zhao, X | 1 |
| Tong, N | 1 |
| Chen, Y | 1 |
| Luo, Y | 1 |
| Zhang, BJ | 1 |
| Xu, D | 1 |
| Guo, Y | 1 |
| Ping, J | 1 |
| Chen, LB | 1 |
| Janbaz, KH | 1 |
| Gilani, AH | 1 |
| Virtanen, P | 1 |
| Lassila, V | 1 |
| Njimi, T | 1 |
| Mengata, DE | 1 |
22 other studies available for berberine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Ch | 2021 |
Berberine mitigates acetamiprid-induced hepatotoxicity and inflammation via regulating endogenous antioxidants and NF-κB/TNF-α signaling in rats.
Topics: Animals; Antioxidants; Berberine; Chemical and Drug Induced Liver Injury; Inflammation; Mammals; Neo | 2023 |
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Berberine; Carbon Tetrachloride; Chemical and Dru | 2019 |
Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Berberine; Chemical and Drug Induced Liver Injur | 2020 |
Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity.
Topics: Activation, Metabolic; Animals; Berberine; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 2020 |
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats.
Topics: Animals; Apoptosis; Berberine; Chemical and Drug Induced Liver Injury; Heme Oxygenase (Decyclizing); | 2017 |
Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats.
Topics: Alanine Transaminase; Animals; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Berberi | 2018 |
¹H-NMR-Based Metabonomics of the Protective Effect of Coptis chinensis and Berberine on Cinnabar-Induced Hepatotoxicity and Nephrotoxicity in Rats.
Topics: Animals; Berberine; Blood; Chemical and Drug Induced Liver Injury; Coptis; Kidney Diseases; Magnetic | 2017 |
Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis.
Topics: Animals; Berberine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dysbiosis; Fecal | 2018 |
Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Inflam | 2018 |
Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Berberine; Cells, Cultured; Chelidonium; Chemical and Drug | 2019 |
Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines.
Topics: Animals; Berberine; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytokines; Cytoprotect | 2014 |
Protective effect of berberine on doxorubicin‑induced acute hepatorenal toxicity in rats.
Topics: Animals; Berberine; Chemical and Drug Induced Liver Injury; Doxorubicin; Kidney Diseases; Male; Rats | 2016 |
NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; Humans; Inflammasomes; In | 2016 |
Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats.
Topics: Animals; Berberine; Blood Glucose; Body Weight; Chemical and Drug Induced Liver Injury; Diabetes Mel | 2008 |
Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; Chemica | 2009 |
Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats.
Topics: Animals; Antioxidants; Berberine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzy | 2010 |
Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Berberine; Carbon Tetrachloride; Chemical and D | 2011 |
Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Body Weight; Chemical and Dru | 2012 |
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; | 2008 |
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ber | 2000 |
Natural protoberberine alkaloids from Enantia chlorantha, palmatine, columbamine and jatrorrhizine for thioacetamide-traumatized rat liver.
Topics: Acetamides; Animals; Berberine; Berberine Alkaloids; Chemical and Drug Induced Liver Injury; Drug Co | 1988 |