beraprost and Carcinoma--Lewis-Lung

beraprost has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for beraprost and Carcinoma--Lewis-Lung

Article	Year
Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. International journal of oncology, 2015, Volume: 46, Issue:2 Prostaglandin I2 (PGI2) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI2 affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was to clarify the effects of PGI2 on tumor metastasis in a mouse lung metastasis model using Lewis lung carcinoma (LLC) cells. The mice were treated continuously with beraprost sodium (BPS), a PGI2 analog, for 3 weeks and then examined for lung metastases. The number and size of lung metastases were decreased significantly by BPS treatment. In addition, scanning electron microscopy and immunohistochemistry revealed that BPS increased the number of tumor‑associated pericytes and improved intratumor hypoxia. Collectively, this study suggests that BPS attenuated vascular functional maturation in metastatic tumors. Topics: Animals; Blood Vessels; Carcinoma, Lewis Lung; Epoprostenol; Humans; Lung Neoplasms; Mice; Neovascularization, Pathologic; Pericytes	2015

Article

Year

Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis.

International journal of oncology, 2015, Volume: 46, Issue:2

Prostaglandin I2 (PGI2) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI2 affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was to clarify the effects of PGI2 on tumor metastasis in a mouse lung metastasis model using Lewis lung carcinoma (LLC) cells. The mice were treated continuously with beraprost sodium (BPS), a PGI2 analog, for 3 weeks and then examined for lung metastases. The number and size of lung metastases were decreased significantly by BPS treatment. In addition, scanning electron microscopy and immunohistochemistry revealed that BPS increased the number of tumor‑associated pericytes and improved intratumor hypoxia. Collectively, this study suggests that BPS attenuated vascular functional maturation in metastatic tumors.

Topics: Animals; Blood Vessels; Carcinoma, Lewis Lung; Epoprostenol; Humans; Lung Neoplasms; Mice; Neovascularization, Pathologic; Pericytes

2015