bepridil has been researched along with Ventricular Fibrillation in 15 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated." | 9.14 | Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation. ( Hata, Y; Ito, H; Kohno, K; Kusano, KF; Miura, D; Morita, H; Murakami, M; Nagase, S; Nakagawa, K; Nakamura, K; Nishii, N; Ohe, T; Tada, T; Tanaka, M; Toh, N, 2010) |
| "The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model." | 7.67 | Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. ( Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B, 1985) |
| "Cilostazol was discontinued 2 days before replacement because of its antiplatelet effects." | 5.40 | Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes. ( Ayabe, R; Ebata, Y; Fukui, A; Nakagawa, M; Okada, N; Shinohara, T; Takahashi, N; Yufu, K, 2014) |
| "It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated." | 5.14 | Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation. ( Hata, Y; Ito, H; Kohno, K; Kusano, KF; Miura, D; Morita, H; Murakami, M; Nagase, S; Nakagawa, K; Nakamura, K; Nishii, N; Ohe, T; Tada, T; Tanaka, M; Toh, N, 2010) |
| " The effects of the calcium blockers bepridil and verapamil on latency time to ventricular fibrillation (VF) and VF incidence were assessed in 109 anesthetized dogs, submitted to coronary occlusion and reperfusion." | 3.67 | Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction. ( Da-Luz, PL; Da-Silveira, MC; Murad-Neto, A; Pileggi, F, 1988) |
| "The effects of the calcium entry blockers diltiazem, KB-944 [diethyl 4-(benzothiazol-2-yl)benzylphosphonate] and bepridil on the vulnerability of ischemically injured myocardium toward fibrillation were determined in urethane-anesthetized dogs 4 to 7 days after anterior myocardial infarction." | 3.67 | The effects of calcium entry blockade on the vulnerability of infarcted canine myocardium toward ventricular fibrillation. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG, 1986) |
| "The antiarrhythmic and antifibrillatory actions of bepridil, an antianginal agent with cardiac fast and slow channel-blocking activities, were evaluated in conscious dogs 3 to 7 days after anterior myocardial infarction." | 3.67 | Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG; Ventura, A, 1985) |
| "The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model." | 3.67 | Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. ( Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B, 1985) |
| "The most important arrhythmia is ventricular tachycardia which degenerates to ventricular fibrillation." | 2.43 | [Strategy for cardiac arrhythmias in acute coronary syndrome]. ( Sugi, K, 2006) |
| "Cilostazol was discontinued 2 days before replacement because of its antiplatelet effects." | 1.40 | Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes. ( Ayabe, R; Ebata, Y; Fukui, A; Nakagawa, M; Okada, N; Shinohara, T; Takahashi, N; Yufu, K, 2014) |
| "However, ventricular tachycardia (VT)/ventricular fibrillation (VF) occurred spontaneously and converted to sinus rhythm with direct current shock (300 J)." | 1.31 | [Successful hybrid therapy combined with oral bepridil and ICD in a patient with amiodarone refractory life-threatening ventricular tachyarrhythmia associated with ischemic cardiomyopathy]. ( Abe, H; Nakashima, Y; Oginosawa, Y; Okazaki, M; Suzuki, Y, 2002) |
| "Amiodarone was without effect." | 1.26 | Comparative antidysrhythmic profiles of bepridil, amiodarone and disopyramide in the guinea-pig and dog. ( Basiez, M; Beaughard, M; Duchene-Marullaz, P; Labrid, C; Leinot, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aizawa, Y | 2 |
| Yamakawa, H | 1 |
| Takatsuki, S | 1 |
| Katsumata, Y | 1 |
| Nishiyama, T | 1 |
| Kimura, T | 1 |
| Nishiyama, N | 1 |
| Fukumoto, K | 1 |
| Tanimoto, Y | 1 |
| Tanimoto, K | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 1 |
| Fukuda, K | 1 |
| Katsuumi, G | 1 |
| Shimizu, W | 1 |
| Watanabe, H | 1 |
| Noda, T | 1 |
| Nogami, A | 1 |
| Ohkubo, K | 1 |
| Makiyama, T | 1 |
| Takehara, N | 1 |
| Kawamura, Y | 1 |
| Hosaka, Y | 1 |
| Sato, M | 1 |
| Fukae, S | 1 |
| Chinushi, M | 2 |
| Oda, H | 1 |
| Okabe, M | 1 |
| Kimura, A | 1 |
| Maemura, K | 1 |
| Watanabe, I | 1 |
| Kamakura, S | 2 |
| Horie, M | 1 |
| Makita, N | 1 |
| Minamino, T | 1 |
| Shinohara, T | 1 |
| Ebata, Y | 1 |
| Ayabe, R | 1 |
| Fukui, A | 1 |
| Okada, N | 1 |
| Yufu, K | 1 |
| Nakagawa, M | 1 |
| Takahashi, N | 1 |
| Murakami, M | 1 |
| Nakamura, K | 1 |
| Kusano, KF | 1 |
| Morita, H | 1 |
| Nakagawa, K | 1 |
| Tanaka, M | 1 |
| Tada, T | 1 |
| Toh, N | 1 |
| Nishii, N | 1 |
| Nagase, S | 1 |
| Hata, Y | 1 |
| Kohno, K | 1 |
| Miura, D | 1 |
| Ohe, T | 1 |
| Ito, H | 1 |
| Iijima, K | 1 |
| Sato, A | 1 |
| Furushima, H | 1 |
| Oginosawa, Y | 1 |
| Abe, H | 1 |
| Suzuki, Y | 1 |
| Okazaki, M | 1 |
| Nakashima, Y | 1 |
| Sugao, M | 1 |
| Fujiki, A | 1 |
| Nishida, K | 1 |
| Sakabe, M | 1 |
| Tsuneda, T | 1 |
| Iwamoto, J | 1 |
| Mizumaki, K | 1 |
| Inoue, H | 1 |
| Sugi, K | 1 |
| Labrid, C | 1 |
| Leinot, M | 1 |
| Beaughard, M | 1 |
| Basiez, M | 1 |
| Duchene-Marullaz, P | 1 |
| Da-Luz, PL | 1 |
| Da-Silveira, MC | 1 |
| Murad-Neto, A | 1 |
| Pileggi, F | 1 |
| Lynch, JJ | 2 |
| Montgomery, DG | 2 |
| Lucchesi, BR | 2 |
| Schwartz, A | 1 |
| Matlib, MA | 1 |
| Balwierczak, J | 1 |
| Lathrop, DA | 1 |
| Ventura, A | 1 |
| Pelleg, A | 1 |
| Pardo, Y | 1 |
| Belhassen, B | 1 |
| Shargordsky, B | 1 |
| Chagnac, A | 1 |
| Laniado, S | 1 |
2 reviews available for bepridil and Ventricular Fibrillation
| Article | Year |
|---|---|
[Clinical care for patients with possible Brugada syndrome].
Topics: Anti-Arrhythmia Agents; Bepridil; Bundle-Branch Block; Calcium Channel Blockers; Death, Sudden, Card | 2006 |
[Strategy for cardiac arrhythmias in acute coronary syndrome].
Topics: Amiodarone; Angina, Unstable; Anti-Asthmatic Agents; Aprindine; Atrial Fibrillation; Bepridil; Elect | 2006 |
1 trial available for bepridil and Ventricular Fibrillation
| Article | Year |
|---|---|
Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.
Topics: Adult; Aged; Aged, 80 and over; Bepridil; Brugada Syndrome; Calcium Channel Blockers; Electrocardiog | 2010 |
12 other studies available for bepridil and Ventricular Fibrillation
| Article | Year |
|---|---|
Efficacy and safety of bepridil for prevention of ICD shocks in patients with Brugada syndrome and idiopathic ventricular fibrillation.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Bepridil; Brugada Syndrome; Cohort Studies; Defibrillators, Imp | 2013 |
Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Bepridil; Follow-Up Studies; Heart Conduction System; Humans; Male; M | 2014 |
Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes.
Topics: Adult; Anti-Arrhythmia Agents; Bepridil; Cilostazol; Death, Sudden, Cardiac; Dose-Response Relations | 2014 |
Short-coupling premature ventricular complexes from the left ventricle triggered isoproterenol-resistant electrical storm in a patient with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Bepridil; Brugada Syndrome; Cardiotonic Agents; Electrocardiography; | 2013 |
[Successful hybrid therapy combined with oral bepridil and ICD in a patient with amiodarone refractory life-threatening ventricular tachyarrhythmia associated with ischemic cardiomyopathy].
Topics: Administration, Oral; Aged; Bepridil; Defibrillators, Implantable; Humans; Male; Myocardial Ischemia | 2002 |
Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide.
Topics: Adult; Bepridil; Disopyramide; Drug Therapy, Combination; Heart Rate; Humans; Male; Middle Aged; Ven | 2005 |
Comparative antidysrhythmic profiles of bepridil, amiodarone and disopyramide in the guinea-pig and dog.
Topics: Aconitine; Amiodarone; Animals; Anti-Arrhythmia Agents; Benzofurans; Bepridil; Disopyramide; Dogs; F | 1981 |
Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dogs; Myocardial Infa | 1988 |
The effects of calcium entry blockade on the vulnerability of infarcted canine myocardium toward ventricular fibrillation.
Topics: Animals; Benzothiazoles; Bepridil; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; E | 1986 |
Pharmacology of calcium antagonists.
Topics: Action Potentials; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Coronary Vess | 1985 |
Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Blood Pressure; Death, Sudden; Disease Models, Animal; Do | 1985 |
Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Constriction; Coronary Vessels; Dogs; Female; Heart Rate; M | 1985 |