bepridil has been researched along with Tachycardia in 20 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of intravenous bepridil, a new calcium antagonist with class I and III properties, was tested in 21 patients with sustained ventricular tachyarrhythmias refractory to a mean of five antiarrhythmic agents as assessed by programmed right ventricular stimulation." | 7.68 | Electrophysiologic effects of bepridil in patients with refractory ventricular tachycardia assessed by programmed electrical stimulation. ( Beyer, T; Brachmann, J; Hölzel, C; Kübler, W; Schmitt, C; Schöls, W; Waldecker, B, 1990) |
| "The effects of the two calcium antagonists bepridil and nifedipine on induced ventricular tachyarrhythmias were studied by programmed electrical stimulation in 15 dogs, 4-8 days after myocardial infarction." | 7.67 | Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs. ( Aidonidis, I; Brachmann, J; Dembowsky, K; Kuebler, W; Seller, H, 1989) |
| "Bepridil (2 mg/kg intravenously) was given to 20 patients with atrioventricular (AV) reentrant tachycardia and its effects were compared with those of verapamil (0." | 7.67 | Electrophysiologic and antiarrhythmic actions of bepridil. Comparison with verapamil and ajmaline for atrioventricular reentrant tachycardia. ( Krikler, DM; McKenna, WJ; Rowland, E, 1985) |
| "The antiarrhythmic properties of bepridil on ventricular tachycardia (VT) termination and prevention were studied in 16 patients using programmed electrical stimulation techniques." | 7.67 | [Oral and intravenous bepridil in the treatment of recurrent sustained ventricular tachycardias. Electropharmacological study]. ( Cointe, R; Gérard, R; Labrunie, P; Lévy, S; Metge, M; Valeix, P, 1985) |
| "Bepridil is a molecule which, apart from its anti-anginal properties, also has antiarrhythmic effects due to its calcium antagonist action which depresses antero and retrograde AV conduction in the physiological pathways." | 6.66 | [Treatment of supraventricular and paroxysmal ventricular tachycardia with bepridil]. ( Bonnet, P; Cosnay, P; Fauchier, JP; Néel, C; Quilliet, L; Rouesnel, P, 1985) |
| "Bepridil was found to possess electrophysiologic properties common to class I and IV antiarrhythmic agents." | 5.27 | Bepridil for recurrent sustained ventricular tachycardias: assessment using electrophysiologic testing. ( Cointe, R; Faugere, G; Gerard, R; Levy, S; Metge, M; Valeix, B, 1984) |
| "The effect of intravenous bepridil, a new calcium antagonist with class I and III properties, was tested in 21 patients with sustained ventricular tachyarrhythmias refractory to a mean of five antiarrhythmic agents as assessed by programmed right ventricular stimulation." | 3.68 | Electrophysiologic effects of bepridil in patients with refractory ventricular tachycardia assessed by programmed electrical stimulation. ( Beyer, T; Brachmann, J; Hölzel, C; Kübler, W; Schmitt, C; Schöls, W; Waldecker, B, 1990) |
| "The effects of the two calcium antagonists bepridil and nifedipine on induced ventricular tachyarrhythmias were studied by programmed electrical stimulation in 15 dogs, 4-8 days after myocardial infarction." | 3.67 | Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs. ( Aidonidis, I; Brachmann, J; Dembowsky, K; Kuebler, W; Seller, H, 1989) |
| "Bepridil (2 mg/kg intravenously) was given to 20 patients with atrioventricular (AV) reentrant tachycardia and its effects were compared with those of verapamil (0." | 3.67 | Electrophysiologic and antiarrhythmic actions of bepridil. Comparison with verapamil and ajmaline for atrioventricular reentrant tachycardia. ( Krikler, DM; McKenna, WJ; Rowland, E, 1985) |
| "The antiarrhythmic and antifibrillatory actions of bepridil, an antianginal agent with cardiac fast and slow channel-blocking activities, were evaluated in conscious dogs 3 to 7 days after anterior myocardial infarction." | 3.67 | Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG; Ventura, A, 1985) |
| "The antiarrhythmic properties of bepridil on ventricular tachycardia (VT) termination and prevention were studied in 16 patients using programmed electrical stimulation techniques." | 3.67 | [Oral and intravenous bepridil in the treatment of recurrent sustained ventricular tachycardias. Electropharmacological study]. ( Cointe, R; Gérard, R; Labrunie, P; Lévy, S; Metge, M; Valeix, P, 1985) |
| "Bepridil is a molecule which, apart from its anti-anginal properties, also has antiarrhythmic effects due to its calcium antagonist action which depresses antero and retrograde AV conduction in the physiological pathways." | 2.66 | [Treatment of supraventricular and paroxysmal ventricular tachycardia with bepridil]. ( Bonnet, P; Cosnay, P; Fauchier, JP; Néel, C; Quilliet, L; Rouesnel, P, 1985) |
| " If side effects intervene that may cause continued therapy to be intolerable, changing the antiarrhythmic agent, as opposed to decreasing the dosage to an ineffective range, may be appropriate." | 1.27 | New directions in antiarrhythmic drug therapy. ( Somberg, JC, 1984) |
| "Bepridil was found to possess electrophysiologic properties common to class I and IV antiarrhythmic agents." | 1.27 | Bepridil for recurrent sustained ventricular tachycardias: assessment using electrophysiologic testing. ( Cointe, R; Faugere, G; Gerard, R; Levy, S; Metge, M; Valeix, B, 1984) |
| "Bepridil has been shown to block both slow- and fast-channel activity in the heart." | 1.27 | Electrophysiologic and antiarrhythmic properties of bepridil. ( Prystowsky, EN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (85.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zelesko, MJ | 1 |
| McComsey, DF | 1 |
| Hageman, WE | 1 |
| Nortey, SO | 1 |
| Baker, CA | 1 |
| Maryanoff, BE | 1 |
| Doki, K | 1 |
| Sekiguchi, Y | 1 |
| Kuga, K | 1 |
| Aonuma, K | 1 |
| Homma, M | 1 |
| Somberg, JC | 2 |
| Levy, S | 2 |
| Cointe, R | 2 |
| Metge, M | 2 |
| Faugere, G | 1 |
| Valeix, B | 1 |
| Gerard, R | 2 |
| Keren, G | 1 |
| Tepper, D | 1 |
| Butler, B | 2 |
| Torres, V | 2 |
| Leclercq, JF | 1 |
| Kural, S | 1 |
| Valère, PE | 1 |
| Bellorini, M | 1 |
| Gillot, JP | 1 |
| Angelard, T | 1 |
| Touboul, JL | 1 |
| Dewilde, J | 1 |
| Gamerman, J | 1 |
| Boucher, M | 1 |
| Dubray, C | 1 |
| Duchêne-Marullaz, P | 1 |
| Schmitt, C | 1 |
| Brachmann, J | 2 |
| Hölzel, C | 1 |
| Waldecker, B | 1 |
| Schöls, W | 1 |
| Beyer, T | 1 |
| Kübler, W | 1 |
| Nestico, PF | 1 |
| Morganroth, J | 1 |
| Horowitz, LN | 1 |
| Mulhern, C | 1 |
| Aidonidis, I | 1 |
| Dembowsky, K | 1 |
| Seller, H | 1 |
| Kuebler, W | 1 |
| Manouvrier, J | 1 |
| Sagot, M | 1 |
| Caron, C | 1 |
| Vaskmann, G | 1 |
| Leroy, R | 1 |
| Reade, R | 1 |
| Ducloux, G | 1 |
| Roy, D | 1 |
| Montigny, M | 1 |
| Klein, GJ | 1 |
| Sharma, AD | 1 |
| Cassidy, D | 1 |
| Pinaud, D | 1 |
| Chabanier, A | 1 |
| Vergnoux, H | 1 |
| Bontemps, T | 1 |
| Virot, P | 1 |
| Blanc, P | 1 |
| Doumeix, JJ | 1 |
| Leymarie, JL | 1 |
| Gueret, P | 1 |
| Bensaid, J | 1 |
| Somberg, J | 1 |
| Flowers, D | 1 |
| Miura, D | 1 |
| Gottlieb, S | 1 |
| Prystowsky, EN | 1 |
| Rowland, E | 1 |
| McKenna, WJ | 1 |
| Krikler, DM | 1 |
| Lynch, JJ | 1 |
| Montgomery, DG | 1 |
| Ventura, A | 1 |
| Lucchesi, BR | 1 |
| Fauchier, JP | 1 |
| Cosnay, P | 1 |
| Néel, C | 1 |
| Rouesnel, P | 1 |
| Bonnet, P | 1 |
| Quilliet, L | 1 |
| Labrunie, P | 1 |
| Valeix, P | 1 |
2 trials available for bepridil and Tachycardia
| Article | Year |
|---|---|
Bepridil hydrochloride for treatment of benign or potentially lethal ventricular arrhythmias.
Topics: Bepridil; Calcium Channel Blockers; Cardiac Complexes, Premature; Clinical Trials as Topic; Electroc | 1986 |
[Treatment of supraventricular and paroxysmal ventricular tachycardia with bepridil].
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Bepridil; Clinical Trials as Topic; Femal | 1985 |
18 other studies available for bepridil and Tachycardia
| Article | Year |
|---|---|
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
Topics: Amidines; Aminophylline; Angina Pectoris; Animals; Benzilates; Biological Assay; Dogs; Glucagon; Hea | 1983 |
Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
Topics: Anti-Arrhythmia Agents; Bepridil; Bignoniaceae; Cytochrome P-450 CYP2D6; DNA, Complementary; Female; | 2015 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benz | 1984 |
Bepridil for recurrent sustained ventricular tachycardias: assessment using electrophysiologic testing.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Bepridil; Cardiac Pacing, Artificial; Ele | 1984 |
The effect of bepridil, verapamil, and quinidine in the prevention of ventricular tachycardia induced by programmed electrical stimulation in the digitalized dog.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Dogs; Electric Stimulation; Electrocardiography; Electrop | 1984 |
[Bepridil and torsades de pointes].
Topics: Aged; Bepridil; Calcium; Electrocardiography; Female; Half-Life; Heart Rate; Humans; Hypokalemia; Ma | 1983 |
[A case of torsade de point under bepridil treatment].
Topics: Aged; Bepridil; Female; Humans; Pyrrolidines; Tachycardia | 1982 |
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Fe | 1991 |
Electrophysiologic effects of bepridil in patients with refractory ventricular tachycardia assessed by programmed electrical stimulation.
Topics: Aged; Bepridil; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart; Humans; | 1990 |
Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cardiac Pacing, Artificial; Consciousness; Dogs; Electr | 1989 |
Nine cases of torsade de pointes with bepridil administration.
Topics: Aged; Angina Pectoris; Bepridil; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Ele | 1986 |
Electrophysiologic effects and long-term efficacy of bepridil for recurrent supraventricular tachycardias.
Topics: Administration, Oral; Adult; Bepridil; Electrophysiology; Female; Follow-Up Studies; Humans; Injecti | 1987 |
[Bepridil and torsades de pointes. Apropos of 11 cases].
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bepridil; Electrocardiography; Female; Humans; Male | 1987 |
Prolongation of QT interval and antiarrhythmic action of bepridil.
Topics: Aged; Anti-Arrhythmia Agents; Bepridil; Cardiac Pacing, Artificial; Electrocardiography; Female; Hem | 1985 |
Electrophysiologic and antiarrhythmic properties of bepridil.
Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Electroc | 1985 |
Electrophysiologic and antiarrhythmic actions of bepridil. Comparison with verapamil and ajmaline for atrioventricular reentrant tachycardia.
Topics: Ajmaline; Anti-Arrhythmia Agents; Atrioventricular Node; Bepridil; Electrophysiology; Humans; Pyrrol | 1985 |
Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Blood Pressure; Death, Sudden; Disease Models, Animal; Do | 1985 |
[Oral and intravenous bepridil in the treatment of recurrent sustained ventricular tachycardias. Electropharmacological study].
Topics: Administration, Oral; Anti-Arrhythmia Agents; Bepridil; Dose-Response Relationship, Drug; Drug Evalu | 1985 |