bepridil has been researched along with Myocardial Infarction in 14 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of bepridil on silent myocardial ischemia and on eicosanoid metabolism, 10 patients with chronic stable angina underwent exercise treadmill testing and 48-hour ambulatory electrocardiographic monitoring both before and after 4 weeks of bepridil administration (150 mg/day)." | 9.07 | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. ( Hikita, H; Kanda, Y; Kurita, A; Maruyama, T; Mizuno, K; Nakamura, H; Nishioka, T; Takase, B; Uehata, A, 1994) |
| " This open randomized study was designed to determine the effects of bepridil, a new long-acting calcium antagonist with antiarrhythmic properties, on the course of acute myocardial infarction (AMI)." | 9.06 | Myocardial infarction: is bepridil, a new calcium antagonist, able to improve the course of the acute phase? ( Chassing, A; Cosson, G; Flammang, D; Paillet, R; Pruvot, C; Waynberger, M, 1989) |
| "The effects of the two calcium antagonists bepridil and nifedipine on induced ventricular tachyarrhythmias were studied by programmed electrical stimulation in 15 dogs, 4-8 days after myocardial infarction." | 7.67 | Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs. ( Aidonidis, I; Brachmann, J; Dembowsky, K; Kuebler, W; Seller, H, 1989) |
| "To investigate the effects of bepridil on silent myocardial ischemia and on eicosanoid metabolism, 10 patients with chronic stable angina underwent exercise treadmill testing and 48-hour ambulatory electrocardiographic monitoring both before and after 4 weeks of bepridil administration (150 mg/day)." | 5.07 | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. ( Hikita, H; Kanda, Y; Kurita, A; Maruyama, T; Mizuno, K; Nakamura, H; Nishioka, T; Takase, B; Uehata, A, 1994) |
| " This open randomized study was designed to determine the effects of bepridil, a new long-acting calcium antagonist with antiarrhythmic properties, on the course of acute myocardial infarction (AMI)." | 5.06 | Myocardial infarction: is bepridil, a new calcium antagonist, able to improve the course of the acute phase? ( Chassing, A; Cosson, G; Flammang, D; Paillet, R; Pruvot, C; Waynberger, M, 1989) |
| "Calcium channel blockers were widely prescribed at hospital discharge to elderly patients with myocardial infarction between 1994 and 1995 (n = 51,921), the most commonly prescribed being diltiazem (n = 21,175), nifedipine (n = 12,670), amlodipine (n = 11,683), and verapamil (n = 3639)." | 3.70 | Calcium channel blockers and mortality in elderly patients with myocardial infarction. ( Cascio, WE; Chowdhury, MK; Crouse, JR; Jollis, JG; Massing, MW; Simpson, RJ; Smith, SC, 1999) |
| "The effects of the two calcium antagonists bepridil and nifedipine on induced ventricular tachyarrhythmias were studied by programmed electrical stimulation in 15 dogs, 4-8 days after myocardial infarction." | 3.67 | Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs. ( Aidonidis, I; Brachmann, J; Dembowsky, K; Kuebler, W; Seller, H, 1989) |
| " The effects of the calcium blockers bepridil and verapamil on latency time to ventricular fibrillation (VF) and VF incidence were assessed in 109 anesthetized dogs, submitted to coronary occlusion and reperfusion." | 3.67 | Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction. ( Da-Luz, PL; Da-Silveira, MC; Murad-Neto, A; Pileggi, F, 1988) |
| "The effects of the calcium entry blockers diltiazem, KB-944 [diethyl 4-(benzothiazol-2-yl)benzylphosphonate] and bepridil on the vulnerability of ischemically injured myocardium toward fibrillation were determined in urethane-anesthetized dogs 4 to 7 days after anterior myocardial infarction." | 3.67 | The effects of calcium entry blockade on the vulnerability of infarcted canine myocardium toward ventricular fibrillation. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG, 1986) |
| "The antiarrhythmic and antifibrillatory actions of bepridil, an antianginal agent with cardiac fast and slow channel-blocking activities, were evaluated in conscious dogs 3 to 7 days after anterior myocardial infarction." | 3.67 | Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG; Ventura, A, 1985) |
| "The most important arrhythmia is ventricular tachycardia which degenerates to ventricular fibrillation." | 2.43 | [Strategy for cardiac arrhythmias in acute coronary syndrome]. ( Sugi, K, 2006) |
| "Bepridil was administered either intravenously (5 mg/kg) 15 min before (pretreatment) or 10 min after (post-ligation treatment) coronary-artery ligation, or orally (50 mg/kg per day) for 8 days before coronary ligation." | 1.27 | Reduction of myocardial infarct size in rats under the effect of bepridil. ( de Leiris, J; Richard, V, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugi, K | 1 |
| Marshall, RJ | 1 |
| Muir, AW | 1 |
| Takase, B | 1 |
| Kurita, A | 1 |
| Hikita, H | 1 |
| Uehata, A | 1 |
| Nishioka, T | 1 |
| Maruyama, T | 1 |
| Mizuno, K | 1 |
| Nakamura, H | 1 |
| Kanda, Y | 1 |
| Jollis, JG | 1 |
| Simpson, RJ | 1 |
| Chowdhury, MK | 1 |
| Cascio, WE | 1 |
| Crouse, JR | 1 |
| Massing, MW | 1 |
| Smith, SC | 1 |
| Nagashima, S | 1 |
| Uematsu, T | 1 |
| Araki, S | 1 |
| Matsuzaki, T | 1 |
| Fukuchi, M | 1 |
| Hashimoto, H | 2 |
| Nakashima, M | 2 |
| Satoh, N | 1 |
| Flammang, D | 1 |
| Waynberger, M | 1 |
| Paillet, R | 1 |
| Pruvot, C | 1 |
| Cosson, G | 1 |
| Chassing, A | 1 |
| Brachmann, J | 1 |
| Aidonidis, I | 1 |
| Dembowsky, K | 1 |
| Seller, H | 1 |
| Kuebler, W | 1 |
| Da-Luz, PL | 1 |
| Da-Silveira, MC | 1 |
| Murad-Neto, A | 1 |
| Pileggi, F | 1 |
| Lynch, JJ | 2 |
| Montgomery, DG | 2 |
| Lucchesi, BR | 3 |
| Richard, V | 1 |
| de Leiris, J | 1 |
| Ventura, A | 1 |
| Jackson, CV | 1 |
| Mitsos, SE | 1 |
| Simpson, PJ | 1 |
| Driscoll, EM | 1 |
| Dangman, KH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DiME Study: Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Response: A Prospective Randomized and Double-Blinded Non-Inferiority Trial of Safety and Efficacy[NCT01914926] | Phase 4 | 54 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Percent of patient who reached a HR<100bpm within 30 minutes from baseline. (NCT01914926)
Timeframe: 30 minutes
| Intervention | percentage of participants (Number) |
|---|---|
| Metoprolol Study Group | 46.4 |
| Diltiazem Study Group | 95.8 |
1 review available for bepridil and Myocardial Infarction
| Article | Year |
|---|---|
[Strategy for cardiac arrhythmias in acute coronary syndrome].
Topics: Amiodarone; Angina, Unstable; Anti-Asthmatic Agents; Aprindine; Atrial Fibrillation; Bepridil; Elect | 2006 |
2 trials available for bepridil and Myocardial Infarction
| Article | Year |
|---|---|
Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Angina Pectoris; Arachidonic Acids; Bepridil; Chronic Dis | 1994 |
Myocardial infarction: is bepridil, a new calcium antagonist, able to improve the course of the acute phase?
Topics: Acute Disease; Aged; Bepridil; Female; Humans; Male; Myocardial Infarction | 1989 |
11 other studies available for bepridil and Myocardial Infarction
| Article | Year |
|---|---|
The beneficial actions of bepridil in acute myocardial infarction in anaesthetized dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Bepridil; Carbon Dioxide; Coronary Vessels; Dogs; Electro | 1981 |
Calcium channel blockers and mortality in elderly patients with myocardial infarction.
Topics: Aged; Aged, 80 and over; Amlodipine; Bepridil; Calcium Channel Blockers; Diltiazem; Female; Humans; | 1999 |
Antiarrhythmic and electrophysiological effects of SD-3212, a novel Na+ and Ca++ channel blocker, in anaesthetized dogs with myocardial infarction in comparison with its stereoisomer (SD-3211) and bepridil.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Dogs; Electrophysiology; Female | 1992 |
Effects of bepridil and lidocaine on the intraventricular conduction in acutely ischaemic and infarcted canine myocardium.
Topics: Animals; Bepridil; Coronary Disease; Coronary Vessels; Dogs; Electrophysiology; Heart; Heart Conduct | 1990 |
Bepridil versus nifedipine for ventricular tachycardia induced in the late postinfarction phase in conscious dogs.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cardiac Pacing, Artificial; Consciousness; Dogs; Electr | 1989 |
Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dogs; Myocardial Infa | 1988 |
The effects of calcium entry blockade on the vulnerability of infarcted canine myocardium toward ventricular fibrillation.
Topics: Animals; Benzothiazoles; Bepridil; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; E | 1986 |
Reduction of myocardial infarct size in rats under the effect of bepridil.
Topics: Administration, Oral; Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Drug Admini | 1985 |
Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Blood Pressure; Death, Sudden; Disease Models, Animal; Do | 1985 |
Effects of bepridil on regional and global myocardial ischemia/reperfusion-induced injury.
Topics: Adenosine Triphosphate; Animals; Bepridil; Cats; Coronary Circulation; Coronary Disease; Dogs; Femal | 1985 |
Effects of bepridil on transmembrane action potentials recorded from isolated canine cardiac tissues. Studies on normal and infarct-zone Purkinje fibres and ventricular muscle cells.
Topics: Action Potentials; Animals; Bepridil; Dogs; Heart; In Vitro Techniques; Membrane Potentials; Myocard | 1985 |