bepridil has been researched along with Muscle Contraction in 23 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three kinds of contractions of rat thoracic aortic rings were used to compare suppression by CPU-86017, bepridil (Bep), verapamil (Ver), and nimodipine (Nim) in euthyroid- and Lev-induced hyperthyroidism rats." | 7.70 | p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+. ( Dai, DZ; Jiang, JM, 1998) |
| "Three kinds of contractions of rat thoracic aortic rings were used to compare suppression by CPU-86017, bepridil (Bep), verapamil (Ver), and nimodipine (Nim) in euthyroid- and Lev-induced hyperthyroidism rats." | 3.70 | p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+. ( Dai, DZ; Jiang, JM, 1998) |
| "Heart muscle contraction is regulated via the β-adrenergic response that leads to phosphorylation of Troponin I (TnI) at Ser22/23, which changes the Ca(2+) sensitivity of the cardiac myofilament." | 1.42 | Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate. ( Marston, SB; Messer, AE; Papadaki, M; Vikhorev, PG, 2015) |
| " The influence of bepridil on the dose-response curves of mesenteric arterial strips for CaCl2, norepinephrine and serotonin differed from the influence seen with nifedipine, another Ca++ blocker." | 1.27 | Effects on calmodulin of bepridil, an antianginal agent. ( Hidaka, H; Ishikawa, T; Itoh, H, 1984) |
| "Nitrendipine was far more potent in inhibiting the K-induced contractions than bepridil while the drugs were equipotent in inhibiting NA-induced contractions." | 1.27 | Effects of two new Ca-entry blockers bepridil and nitrendipine on isolated vessels. ( Jespersen, LT; Mikkelsen, E; Pedersen, OL, 1984) |
| "The relaxant effects of five organic calcium antagonists (nicardipine, diltiazem, PY 108068, verapamil and bepridil) on guinea-pig isolated trachea were tested against contractions induced by acetylcholine, histamine, 5-hydroxytryptamine, potassium chloride (KCl) and tetraethylammonium (TEA) in a medium containing the normal amount of calcium and against calcium dose-response curves in a calcium-free, potassium-enriched medium." | 1.27 | Effects of five different organic calcium antagonists on guinea-pig isolated trachea. ( Advenier, C; Cerrina, J; Duroux, P; Floch, A; Renier, A, 1984) |
| "Bepridil was almost as potent as verapamil in this action." | 1.26 | Bepridil (CERM-1978) an verapamil depression of contractions of rabbit aortic rings. ( Mras, S; Sperelakis, N, 1981) |
| "Bepridil was approximately 10 fold less potent than verapamil." | 1.26 | Comparative effects of bepridil and verapamil on isolated coronary and systemic vascular and cardiac muscle. ( Campbell, JK; Marshall, RJ; Winslow, E, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanfilippo, PJ | 1 |
| Urbanski, M | 1 |
| Press, JB | 1 |
| Dubinsky, B | 1 |
| Moore, JB | 1 |
| Papadaki, M | 1 |
| Vikhorev, PG | 1 |
| Marston, SB | 1 |
| Messer, AE | 1 |
| Itoh, H | 2 |
| Ishikawa, T | 1 |
| Hidaka, H | 2 |
| Sperelakis, N | 2 |
| Mras, S | 2 |
| Mikkelsen, E | 1 |
| Jespersen, LT | 1 |
| Pedersen, OL | 1 |
| Advenier, C | 1 |
| Cerrina, J | 1 |
| Duroux, P | 1 |
| Floch, A | 1 |
| Renier, A | 1 |
| Campbell, JK | 2 |
| Marshall, RJ | 3 |
| Winslow, E | 2 |
| Murakami, K | 1 |
| Shindo, K | 1 |
| Ito, KM | 1 |
| Ito, K | 1 |
| Nishimura, M | 1 |
| Matsushita, M | 1 |
| Taquahashi, Y | 1 |
| Shimizu, Y | 1 |
| Satoh, E | 1 |
| Hasegawa, T | 1 |
| Wahr, PA | 1 |
| Metzger, JM | 1 |
| Dai, DZ | 1 |
| Jiang, JM | 1 |
| Chen, JJ | 1 |
| Chang, YL | 1 |
| Teng, CM | 1 |
| Chen, IS | 1 |
| John, GW | 1 |
| Fabrègues, E | 1 |
| Kamal, M | 1 |
| Massingham, R | 1 |
| Fujimoto, S | 1 |
| Aoki, K | 1 |
| Matsuda, T | 1 |
| Adam, LP | 1 |
| Henderson, EG | 1 |
| Maseki, T | 1 |
| Abe, T | 1 |
| Tomita, T | 1 |
| Flaim, SF | 1 |
| Ratz, PH | 1 |
| Swigart, SC | 1 |
| Gleason, MM | 1 |
| Anderson, KA | 1 |
| Tanaka, T | 1 |
| Mitani, Y | 1 |
| Schaeffer, P | 1 |
| Baissat, J | 1 |
| Dureng, G | 1 |
| Lamar, JC | 1 |
| Stoclet, JC | 1 |
| Reiermann, HJ | 1 |
| Rüegg, JC | 1 |
23 other studies available for bepridil and Muscle Contraction
| Article | Year |
|---|---|
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heteroc | 1988 |
Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.
Topics: Animals; Bepridil; Calcium; Catechin; Humans; Mice; Muscle Contraction; Mutation; Myofibrils; Phosph | 2015 |
Effects on calmodulin of bepridil, an antianginal agent.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Arrhythmia Agents; Bepridil; Calmodulin; Cattle; | 1984 |
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, | 1983 |
Effects of two new Ca-entry blockers bepridil and nitrendipine on isolated vessels.
Topics: Adult; Aged; Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Female; Femoral Vein; Hum | 1984 |
Effects of five different organic calcium antagonists on guinea-pig isolated trachea.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relati | 1984 |
Bepridil (CERM-1978) an verapamil depression of contractions of rabbit aortic rings.
Topics: Animals; Aorta; Bepridil; Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Epinephri | 1981 |
Comparative effects of bepridil and verapamil on isolated coronary and systemic vascular and cardiac muscle.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Chloride; Coronary Vessels; Female; Guinea Pigs; In Vitr | 1982 |
Effects of semotiadil fumarate (SD-3211) and its enantiomer, SD-3212, on the changes in cytosolic Ca2+ and tension caused by KCl and norepinephrine in isolated rat aortas.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Bepridil; Calcium; Calcium Channel Blockers; Cytos | 1995 |
Twitch potentiation induced by caffeine in the mouse diaphragm depends on external calcium ions in the absence of potassium ions.
Topics: Animals; Bepridil; Caffeine; Calcium; Calcium Channel Blockers; Diaphragm; In Vitro Techniques; Male | 1997 |
Role of Ca2+ and cross-bridges in skeletal muscle thin filament activation probed with Ca2+ sensitizers.
Topics: Adenosine Triphosphate; Animals; Bepridil; Biophysical Phenomena; Biophysics; Caffeine; Calcium; Fem | 1999 |
p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+.
Topics: Animals; Aorta, Thoracic; Bepridil; Berberine; Biological Transport, Active; Calcium; Calcium Channe | 1998 |
Vasorelaxing and antioxidant constituents from Hernandia nymphaeifolia.
Topics: Alkaloids; Animals; Antioxidants; Bepridil; Biphenyl Compounds; China; Dioxoles; Drugs, Chinese Herb | 2001 |
Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.
Topics: Animals; Bepridil; Caffeine; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; | 1991 |
Effects of bepridil compared to those of its quaternary analogue on femoral arteries from spontaneously hypertensive rats.
Topics: Animals; Bepridil; Caffeine; Calcium Chloride; Femoral Artery; Hypertension; Male; Muscle Contractio | 1990 |
Calcium channel effectors are potent non-competitive blockers of acetylcholine receptors.
Topics: Animals; Bepridil; Calcium Channel Agonists; Calcium Channels; Cell Membrane; Electric Conductivity; | 1990 |
Pharmacological properties of contraction caused by sodium removal in muscle strips isolated from canine coronary artery.
Topics: Amiloride; Animals; Arteries; Bepridil; Coronary Vessels; Dogs; Female; Male; Muscle Contraction; Mu | 1990 |
Bepridil hydrochloride alters potential-dependent and receptor-operated calcium channels in vascular smooth muscle of rabbit aorta.
Topics: Action Potentials; Animals; Aorta; Bepridil; Calcium; Calcium Channel Blockers; Coronary Circulation | 1985 |
Interactions between calcium entry blockers and vecuronium bromide in anaesthetized cats.
Topics: Acetylcholine; Animals; Bepridil; Calcium Channel Blockers; Cats; Dose-Response Relationship, Drug; | 1985 |
The binding of the calcium channel blocker, bepridil, to calmodulin.
Topics: Animals; Bepridil; Binding, Competitive; Calcium Channel Blockers; Calmodulin; Cattle; Chickens; Enz | 1986 |
Effects of bepridil and of its quaternary derivative on rat tail artery.
Topics: Animals; Arteries; Bepridil; Calcium Channel Blockers; Cecum; Guinea Pigs; In Vitro Techniques; Male | 1986 |
Investigations on calmodulin antagonistic effects of bepridil in intact and skinned fibres of smooth muscle.
Topics: Animals; Bepridil; Calcium; Calmodulin; Colon; In Vitro Techniques; Male; Muscle Contraction; Muscle | 1986 |
The effects of bepridil, compared with calcium-channel inhibitors and calmodulin antagonists on both spontaneous activity and contractions induced by potassium or phenylephrine in rat portal vein.
Topics: Animals; Bepridil; Calcium Channel Blockers; Calmodulin; In Vitro Techniques; Male; Muscle Contracti | 1986 |