bepridil has been researched along with Hypertension in 6 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The short and long term hypotensive effects of oral administration of bepridil were investigated in 26 patients with essential hypertension." | 7.67 | Hypotensive effects of a calcium antagonist, bepridil, in patients with essential hypertension. ( Aoki, K; Sato, K, 1986) |
| "The short and long term hypotensive effects of oral administration of bepridil were investigated in 26 patients with essential hypertension." | 3.67 | Hypotensive effects of a calcium antagonist, bepridil, in patients with essential hypertension. ( Aoki, K; Sato, K, 1986) |
| "Doxazosin is an antihypertensive drug that gives rise to 6- and 7-hydroxydoxazosin during hepatic metabolism." | 1.30 | Doxazosin treatment and peroxidation of low-density lipoprotein among male hypertensive subjects: in vitro and ex vivo studies. ( Arnstad, JE; Brude, IR; Drevon, CA; Nenseter, MS; Valnes, KN; Viken, K, 1999) |
| " It is therefore concluded that continuous control of water intake and analysis of the stability of the drug is essential for the establishment of proper dose-response relationships." | 1.27 | Drinking water and drug dosage in rat studies. ( Jakobsen, P; Jespersen, LT; Mikkelsen, EO; Pedersen, OL, 1983) |
| "Bepridil and diltiazem were studied for their effects on blood pressure (BP) and heart rate (HR) of spontaneously hypertensive rats (SHR) and on vascular tone of femoral and mesenteric arterial strips from SHR." | 1.27 | Comparative effects of bepridil and diltiazem on systemic blood pressure and isolated peripheral arteries in spontaneously hypertensive rats. ( Aoki, K; Fujimoto, S; Matsuda, T, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jespersen, LT | 1 |
| Pedersen, OL | 1 |
| Mikkelsen, EO | 1 |
| Jakobsen, P | 1 |
| Brude, IR | 1 |
| Drevon, CA | 1 |
| Viken, K | 1 |
| Arnstad, JE | 1 |
| Valnes, KN | 1 |
| Nenseter, MS | 1 |
| Fujimoto, S | 2 |
| Aoki, K | 3 |
| Matsuda, T | 2 |
| Sato, K | 1 |
| Montastruc, P | 1 |
| Valet, P | 1 |
| Dang Tran, L | 1 |
| Gaillard, G | 1 |
| Montastruc, JL | 1 |
6 other studies available for bepridil and Hypertension
| Article | Year |
|---|---|
Drinking water and drug dosage in rat studies.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Bepridil; Blood Pressure; Dose-Response Re | 1983 |
Doxazosin treatment and peroxidation of low-density lipoprotein among male hypertensive subjects: in vitro and ex vivo studies.
Topics: Adult; Aged; Amidines; Antihypertensive Agents; Antioxidants; Bepridil; Biphenyl Compounds; Copper; | 1999 |
Effects of bepridil compared to those of its quaternary analogue on femoral arteries from spontaneously hypertensive rats.
Topics: Animals; Bepridil; Caffeine; Calcium Chloride; Femoral Artery; Hypertension; Male; Muscle Contractio | 1990 |
Comparative effects of bepridil and diltiazem on systemic blood pressure and isolated peripheral arteries in spontaneously hypertensive rats.
Topics: Animals; Arteries; Benzazepines; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Hear | 1986 |
Hypotensive effects of a calcium antagonist, bepridil, in patients with essential hypertension.
Topics: Administration, Oral; Bepridil; Blood Pressure; Calcium Channel Blockers; Depression, Chemical; Drug | 1986 |
Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Denervation; Diltiazem; Dogs; Female; H | 1987 |