bepridil has been researched along with HbS Disease in 5 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bepridil did not inhibit intracellular hemoglobin S polymerization even at 200 microM, as shown by oxygen scan ektacytometry." | 1.29 | Bepridil as an antisickling agent: membrane internalization and cell rigidity. ( Acquaye, C; Féo, C; Johnson, RM; Sarnaik, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, RM | 1 |
| Acquaye, C | 1 |
| Féo, C | 1 |
| Sarnaik, S | 1 |
| Reilly, MP | 2 |
| Horiuchi, K | 1 |
| Asakura, T | 2 |
| Ellory, JC | 2 |
| Nash, GB | 1 |
| Stone, PC | 1 |
| Culliford, SJ | 1 |
| Horwitz, E | 1 |
| Stuart, J | 2 |
| Johnston, MN | 1 |
5 other studies available for bepridil and HbS Disease
| Article | Year |
|---|---|
Bepridil as an antisickling agent: membrane internalization and cell rigidity.
Topics: Anemia, Sickle Cell; Antisickling Agents; Bepridil; Chlorpromazine; Endocytosis; Erythrocyte Count; | 1994 |
Dose-dependent red blood cell volume increase induced by bepridil.
Topics: Anemia, Sickle Cell; Bepridil; Dialysis; Dose-Response Relationship, Drug; Erythrocyte Membrane; Ery | 1993 |
Mode of action and comparative efficacy of pharmacological agents that inhibit calcium-dependent dehydration of sickle cells.
Topics: Anemia, Sickle Cell; Azepines; Bepridil; Calcium; Calcium Channel Blockers; Erythrocytes, Abnormal; | 1992 |
Bepridil protects sickle cells against the adverse rheological effects of cyclical deoxygenation.
Topics: Anemia, Sickle Cell; Bepridil; Erythrocyte Deformability; Erythrocytes, Abnormal; Humans; Oxygen | 1989 |
Antisickling effect of bepridil.
Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Bepridil; Erythrocytes; Humans; In Vitro Techniq | 1986 |