bepridil has been researched along with Granulocytic Leukemia, Chronic in 2 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bepridil was identified predominantly in the octanol phase in the octanol/water partitioning studies." | 1.28 | Response of human chronic myeloid leukemia cells to mitoxantrone cytotoxicity: potentiation by bepridil, a calcium channel antagonist. ( Advani, SH; Chitnis, MP; Parekh, HK; Shallom, JM, 1991) |
| "Bepridil was found to be highly lipid soluble at physiological pH, and this property could be responsible for the modulation of the ADR activity observed in this study." | 1.28 | Bepridil enhances adriamycin-induced DNA biosynthesis inhibition in human myeloid leukemia cells. ( Advani, S; Chitnis, M; Parekh, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parekh, HK | 1 |
| Shallom, JM | 1 |
| Advani, SH | 1 |
| Chitnis, MP | 1 |
| Parekh, H | 1 |
| Advani, S | 1 |
| Chitnis, M | 1 |
2 other studies available for bepridil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Response of human chronic myeloid leukemia cells to mitoxantrone cytotoxicity: potentiation by bepridil, a calcium channel antagonist.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bepridil; DNA, Neoplasm; Drug Synergism; Humans; Leu | 1991 |
Bepridil enhances adriamycin-induced DNA biosynthesis inhibition in human myeloid leukemia cells.
Topics: Bepridil; DNA, Neoplasm; Doxorubicin; Drug Synergism; Humans; Leukemia, Myelogenous, Chronic, BCR-AB | 1990 |