bepridil has been researched along with Disease Models, Animal in 20 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiarrhythmic and antifibrillatory actions of bepridil, an antianginal agent with cardiac fast and slow channel-blocking activities, were evaluated in conscious dogs 3 to 7 days after anterior myocardial infarction." | 3.67 | Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs. ( Lucchesi, BR; Lynch, JJ; Montgomery, DG; Ventura, A, 1985) |
| "In this study, we assessed influence of electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits." | 1.43 | Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. ( Chiba, T; Kondo, N; Takahara, A, 2016) |
| "Bepridil was in vitro effective against promastigotes and intracellular amastigotes of L." | 1.37 | In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR. ( Colombo, FA; Pereira-Chioccola, VL; Reimão, JQ; Tempone, AG, 2011) |
| " In this study, the effect of long-term administration of bepridil on atrial electrical remodeling was evaluated in a comparison of the right and left atrium (RA and LA) in a canine rapid atrial stimulation model." | 1.35 | Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model. ( Fukaya, H; Izumi, T; Kojima, J; Masaki, Y; Moriguchi, M; Niwano, H; Niwano, S; Satoh, D, 2008) |
| "Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system." | 1.32 | Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis. ( Brand-Schieber, E; Werner, P, 2004) |
| "Bepridil is an investigational calcium antagonist that also has fast sodium channel blocking and antidysrhythmic properties." | 1.27 | Cardiac electrophysiologic interactions of bepridil, a new calcium antagonist, with enflurane, halothane, and isoflurane. ( Buben, JA; Hantler, CB; Knight, PR; Landau, SN; Larson, LO; Lucchesi, BR; Lynch, JJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Nunoi, Y | 1 |
| Hagiwara-Nagasawa, M | 1 |
| Kambayashi, R | 1 |
| Goto, A | 1 |
| Chiba, K | 1 |
| Wada, T | 1 |
| Izumi-Nakaseko, H | 1 |
| Matsumoto, A | 1 |
| Watanabe, Y | 1 |
| Sugiyama, A | 1 |
| Shimizu, C | 1 |
| Mitani, Y | 1 |
| Tsuchiya, Y | 1 |
| Nabeshima, T | 1 |
| DeWald, LE | 1 |
| Dyall, J | 1 |
| Sword, JM | 1 |
| Torzewski, L | 1 |
| Zhou, H | 1 |
| Postnikova, E | 1 |
| Kollins, E | 1 |
| Alexander, I | 1 |
| Gross, R | 1 |
| Cong, Y | 1 |
| Gerhardt, DM | 1 |
| Johnson, RF | 1 |
| Olinger, GG | 1 |
| Holbrook, MR | 1 |
| Hensley, LE | 1 |
| Jahrling, PB | 1 |
| Chiba, T | 1 |
| Kondo, N | 1 |
| Takahara, A | 1 |
| Fukaya, H | 2 |
| Niwano, S | 2 |
| Niwano, H | 2 |
| Masaki, Y | 2 |
| Kiryu, M | 1 |
| Hirasawa, S | 1 |
| Sato, D | 1 |
| Moriguchi, M | 2 |
| Izumi, T | 2 |
| Reimão, JQ | 1 |
| Colombo, FA | 1 |
| Pereira-Chioccola, VL | 1 |
| Tempone, AG | 1 |
| Brand-Schieber, E | 1 |
| Werner, P | 1 |
| Shiotani, M | 1 |
| Harada, T | 1 |
| Abe, J | 1 |
| Sawada, Y | 1 |
| Hashimoto, K | 1 |
| Hamada, Y | 1 |
| Horii, I | 1 |
| Larson, LO | 1 |
| Hantler, CB | 1 |
| Lynch, JJ | 2 |
| Landau, SN | 1 |
| Buben, JA | 1 |
| Lucchesi, BR | 2 |
| Knight, PR | 1 |
| Nishida, K | 1 |
| Fujiki, A | 1 |
| Sakamoto, T | 1 |
| Iwamoto, J | 1 |
| Mizumaki, K | 1 |
| Hashimoto, N | 1 |
| Inoue, H | 1 |
| Satoh, D | 1 |
| Kojima, J | 1 |
| Toronyi, E | 1 |
| Hadjipavlou-Litina, D | 1 |
| Jin, ZQ | 1 |
| Chen, X | 1 |
| Calabresi, P | 1 |
| Marfia, GA | 1 |
| Amoroso, S | 1 |
| Pisani, A | 1 |
| Bernardi, G | 1 |
| Chen, XG | 1 |
| Li, Y | 1 |
| Yan, CH | 1 |
| Li, LN | 1 |
| Han, R | 1 |
| Silver, PJ | 1 |
| Monteforte, PB | 1 |
| Montgomery, DG | 1 |
| Ventura, A | 1 |
1 review available for bepridil and Disease Models, Animal
| Article | Year |
|---|---|
[Role of apoptosis in the kidney after reperfusion].
Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Disease Models, Animal; Fendiline; Humans; K | 2008 |
19 other studies available for bepridil and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Characterization of microminipig as a laboratory animal for pharmacological study by analyzing bepridil-induced cardiovascular responses.
Topics: Animals; Animals, Laboratory; Bepridil; Calcium Channel Blockers; Cardiovascular System; Disease Mod | 2020 |
Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.
Topics: Administration, Oral; Alcoholism; Animals; Benzazepines; Bepridil; Calcium, Dietary; Conditioning, P | 2018 |
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.
Topics: Animals; Bepridil; Calcium Channel Blockers; Chlorocebus aethiops; Disease Models, Animal; Female; M | 2018 |
Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits.
Topics: Amiodarone; Animals; Anisoles; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Remodeling; Bepri | 2016 |
Combined effects of up- and downstream therapies on atrial fibrillation in a canine rapid stimulation model.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepri | 2012 |
In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cell Line; Cell Survival; Computer Systems; Cricetinae; | 2011 |
Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.
Topics: Animals; Axons; Bepridil; Calcium Channel Blockers; Calcium Channels, L-Type; Demyelinating Diseases | 2004 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; | 2005 |
Cardiac electrophysiologic interactions of bepridil, a new calcium antagonist, with enflurane, halothane, and isoflurane.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bepridil; Calcium Channel Blockers; Chlo | 1988 |
Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia.
Topics: Animals; Atrial Function; Bepridil; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Mode | 2007 |
Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model.
Topics: Animals; Atrial Fibrillation; Bepridil; Calcium Channel Blockers; Calcium Channels; Cardiac Pacing, | 2008 |
1-[3-(Aryloxy) propyl]-diamines: a new class of non-steroidal basic antiinflammatory agents. Structure-activity studies: Part II.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Bepridil; Biphenyl Compounds; Diamin | 1997 |
A simple reproducible model of free radical-injured isolated heart induced by 1,1-diphenyl-2-picryl-hydrazyl (DPPH).
Topics: Animals; Bepridil; Biphenyl Compounds; Cell Membrane Permeability; Coronary Circulation; Diastole; D | 1998 |
Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons.
Topics: Amiloride; Animals; Bepridil; Calcium Channel Blockers; Corpus Striatum; Disease Models, Animal; Exc | 1999 |
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bep | 2001 |
Differential effects of pharmacological modulators of cardiac myofibrillar ATPase activity in normal and myopathic (BIO 14.6) hamsters.
Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Bepridil; Calcium; Calcium Channel Block | 1988 |
Antiarrhythmic and electrophysiologic effects of bepridil in chronically infarcted conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Blood Pressure; Death, Sudden; Disease Models, Animal; Do | 1985 |