bepridil has been researched along with Coronary Disease in 26 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of intravenous bepridil (1-[2-(N-benzylanilino)-1-(isobutoxymethyl)ethyl]pyrrolidine ) were studied in 16 patients undergoing cardiac catheterization for evaluation of coronary disease, all with normal base-line hemodynamic and renal functions." | 7.67 | Pharmacokinetics of intravenous bepridil in patients with coronary disease. ( Alpert, JS; Benotti, JR; Brady, PM; Lesko, LJ; McCue, JE; Ockene, IS; Weiner, BH, 1986) |
| "Bepridil (Cordium) is a calcium channel blocker which has been demonstrated to be effective in the preventive treatment of angina." | 6.68 | [Comparison of anti-ischemic effect of bepridil and diltiazem evaluated by exercise test in patients with coronary disease. A multicenter study. Groupe d'Investigateurs]. ( Quilliet, L; Sellier, P, 1997) |
| " The patients were divided into 3 groups according to the arrhythmias observed and the dosage used." | 6.66 | [Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency]. ( Brechenmacher, C; Deroubaix, G; Dupont, T; Moulinie, E; Pasco, A; Pellet, J; Rio, A; Rossignol, B, 1985) |
| "A contrast medium-induced coronary reactive hyperemia (HPR) evidenced an increased hyperemic volume from 9." | 5.27 | Alterations in contrast medium-induced coronary reactive hyperemia after bepridil in patients with coronary artery disease. ( Blanchet, F; Foult, JM; Huyghebaert, MF; Nitenberg, A; Zouiouèche, S, 1985) |
| "The pharmacokinetics of intravenous bepridil (1-[2-(N-benzylanilino)-1-(isobutoxymethyl)ethyl]pyrrolidine ) were studied in 16 patients undergoing cardiac catheterization for evaluation of coronary disease, all with normal base-line hemodynamic and renal functions." | 3.67 | Pharmacokinetics of intravenous bepridil in patients with coronary disease. ( Alpert, JS; Benotti, JR; Brady, PM; Lesko, LJ; McCue, JE; Ockene, IS; Weiner, BH, 1986) |
| "Bepridil (Cordium) is a calcium channel blocker which has been demonstrated to be effective in the preventive treatment of angina." | 2.68 | [Comparison of anti-ischemic effect of bepridil and diltiazem evaluated by exercise test in patients with coronary disease. A multicenter study. Groupe d'Investigateurs]. ( Quilliet, L; Sellier, P, 1997) |
| " The patients were divided into 3 groups according to the arrhythmias observed and the dosage used." | 2.66 | [Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency]. ( Brechenmacher, C; Deroubaix, G; Dupont, T; Moulinie, E; Pasco, A; Pellet, J; Rio, A; Rossignol, B, 1985) |
| "Bepridil is a calcium antagonist with a unique chemical structure and properties that differ from other calcium antagonists (e." | 2.38 | Hemodynamic effects of bepridil in patients with coronary artery disease. ( Narahara, KA, 1992) |
| "Bepridil was more effective than verapamil in protecting against this ischaemic damage." | 1.27 | Protective effects of the calmodulin antagonist bepridil on ischaemia induced in the rat myocardium. ( Hidaka, H; Itoh, H; Kusagawa, M; Shikano, K, 1986) |
| "Treatment with bepridil before and during ischemia did not improve recovery of cardiac function, tissue energy reserves, or mitochondrial function upon reperfusion with control buffer." | 1.27 | Comparison of the effects of bepridil and diltiazem upon globally ischemic rat hearts. ( Harwell, T; Maiorano, P; Watts, J, 1987) |
| "A contrast medium-induced coronary reactive hyperemia (HPR) evidenced an increased hyperemic volume from 9." | 1.27 | Alterations in contrast medium-induced coronary reactive hyperemia after bepridil in patients with coronary artery disease. ( Blanchet, F; Foult, JM; Huyghebaert, MF; Nitenberg, A; Zouiouèche, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (73.08) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasanuki, H | 1 |
| Hill, JA | 2 |
| O'Brien, JT | 1 |
| Scott, E | 1 |
| Conti, CR | 1 |
| Pepine, CJ | 2 |
| Sellier, P | 1 |
| Quilliet, L | 1 |
| Narahara, KA | 1 |
| van Amsterdam, FT | 2 |
| Punt, NC | 2 |
| Haas, M | 2 |
| Zaagsma, J | 2 |
| Hashimoto, H | 1 |
| Satoh, N | 1 |
| Nakashima, M | 1 |
| Puech, P | 1 |
| Coumel, P | 1 |
| Maison Blanche, P | 1 |
| Coudray, P | 1 |
| Massingham, R | 1 |
| Van Zwieten, PA | 2 |
| Remme, WJ | 2 |
| Kruyssen, DA | 1 |
| Van Hoogenhuyze, DC | 2 |
| Hofman, B | 1 |
| Krauss, XH | 2 |
| Storm, CJ | 2 |
| Shikano, K | 1 |
| Kusagawa, M | 1 |
| Itoh, H | 1 |
| Hidaka, H | 1 |
| Reifart, N | 1 |
| Marston, W | 1 |
| Zierler, MK | 1 |
| Taylor, AD | 1 |
| Kaltenbach, M | 1 |
| Khuri, SF | 1 |
| Boddeke, EW | 1 |
| Wilffert, B | 1 |
| Heynis, JB | 1 |
| Hugtenburg, JG | 1 |
| Jap, WT | 1 |
| Veldsema-Currie, RD | 1 |
| Beaughard, M | 1 |
| Lamar, JC | 1 |
| Piris, P | 1 |
| Tisne-Versailles, J | 1 |
| Watts, JA | 1 |
| Lesko, LJ | 1 |
| Benotti, JR | 1 |
| Alpert, JS | 1 |
| Brady, PM | 1 |
| McCue, JE | 1 |
| Weiner, BH | 1 |
| Ockene, IS | 1 |
| Watts, J | 1 |
| Maiorano, P | 1 |
| Harwell, T | 1 |
| Hofman, A | 1 |
| Kruyssen, HA | 1 |
| Josephson, MA | 1 |
| Mody, T | 1 |
| Coyle, K | 1 |
| Singh, BN | 1 |
| Haerer, VW | 1 |
| Stauch, M | 1 |
| Foult, JM | 1 |
| Nitenberg, A | 1 |
| Blanchet, F | 1 |
| Zouiouèche, S | 1 |
| Huyghebaert, MF | 1 |
| Tamari, I | 1 |
| Borer, JS | 1 |
| Moses, JW | 1 |
| Goldberg, HL | 1 |
| Fisher, J | 1 |
| Wallis, JB | 1 |
| Halle, A | 1 |
| Jackson, CV | 1 |
| Mitsos, SE | 1 |
| Simpson, PJ | 1 |
| Driscoll, EM | 1 |
| Lucchesi, BR | 2 |
| Lynch, JJ | 1 |
| Rahwan, RG | 1 |
| Rio, A | 1 |
| Pasco, A | 1 |
| Dupont, T | 1 |
| Deroubaix, G | 1 |
| Moulinie, E | 1 |
| Rossignol, B | 1 |
| Pellet, J | 1 |
| Brechenmacher, C | 1 |
3 reviews available for bepridil and Coronary Disease
| Article | Year |
|---|---|
[New generation of antiarrhythmic drug].
Topics: Amiodarone; Anti-Arrhythmia Agents; Bepridil; Coronary Disease; Humans; Randomized Controlled Trials | 1994 |
Hemodynamic effects of bepridil in patients with coronary artery disease.
Topics: Bepridil; Coronary Disease; Hemodynamics; Humans; Oxygen Consumption | 1992 |
Bepridil: a pharmacological reappraisal of its potential beneficial effects in angina and tissue protection following ischemia.
Topics: Angina Pectoris; Animals; Bepridil; Coronary Disease; Humans | 1989 |
5 trials available for bepridil and Coronary Disease
| Article | Year |
|---|---|
Effects of bepridil on exercise tolerance in chronic stable angina: a double-blind, randomized, placebo-controlled, crossover trial.
Topics: Aged; Angina Pectoris; Bepridil; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Clinical | 1984 |
Effects of bepridil on the resting electrocardiogram.
Topics: Aged; Angina Pectoris; Anti-Arrhythmia Agents; Bepridil; Clinical Trials as Topic; Coronary Disease; | 1984 |
[Comparison of anti-ischemic effect of bepridil and diltiazem evaluated by exercise test in patients with coronary disease. A multicenter study. Groupe d'Investigateurs].
Topics: Bepridil; Calcium Channel Blockers; Coronary Disease; Diltiazem; Double-Blind Method; Exercise Test; | 1997 |
[Comparative study of the mid-term electrocardiographic and clinical tolerability of bepridil versus diltiazem in patients with coronary disease].
Topics: Aged; Bepridil; Coronary Disease; Diltiazem; Double-Blind Method; Electrocardiography; Electrocardio | 1990 |
[Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency].
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Clinical Trials | 1985 |
18 other studies available for bepridil and Coronary Disease
| Article | Year |
|---|---|
Stereoisomers of calcium antagonists distinguish a myocardial and vascular mode of protection against cardiac ischemic injury.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cardiomyopathies; Coronary Circulation; Coronary Diseas | 1990 |
Effects of bepridil and lidocaine on the intraventricular conduction in acutely ischaemic and infarcted canine myocardium.
Topics: Animals; Bepridil; Coronary Disease; Coronary Vessels; Dogs; Electrophysiology; Heart; Heart Conduct | 1990 |
Calcium antagonists show two modes of protection in ischemic heart failure.
Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diastole; Dose- | 1990 |
Acute hemodynamic and antiischemic properties of intravenous bepridil in coronary artery disease.
Topics: Adult; Aged; Bepridil; Calcium Channel Blockers; Cardiac Catheterization; Cardiac Pacing, Artificial | 1989 |
Protective effects of the calmodulin antagonist bepridil on ischaemia induced in the rat myocardium.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Bepridil; Calmodulin; Coronary Disease; Drug In | 1986 |
Effects of bepridil on regional myocardial ischemia and comparison with verapamil.
Topics: Animals; Bepridil; Calcium Channel Blockers; Carbon Dioxide; Coronary Circulation; Coronary Disease; | 1986 |
The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts.
Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Coronary | 1988 |
Effects of bepridil and nifedipine on regional myocardial contractility during ischaemia in anaesthetized dogs.
Topics: Anesthesia; Animals; Bepridil; Coronary Circulation; Coronary Disease; Dogs; Myocardial Contraction; | 1986 |
Protection of ischemic hearts by Ca2+ antagonists.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Energy Metabolism | 1986 |
Pharmacokinetics of intravenous bepridil in patients with coronary disease.
Topics: Aged; Bepridil; Calcium Channel Blockers; Coronary Disease; Female; Humans; Injections, Intravenous; | 1986 |
Comparison of the effects of bepridil and diltiazem upon globally ischemic rat hearts.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bepridil; Calcium; Coronary Disease; Diltiaz | 1987 |
Dose related coronary and systemic haemodynamic effects of intravenous bepridil in patients with coronary artery disease.
Topics: Adult; Angina Pectoris; Anti-Arrhythmia Agents; Bepridil; Coronary Circulation; Coronary Disease; Do | 1987 |
Effects on hemodynamics and left ventricular ejection fraction of intravenous bepridil for impaired left ventricular function secondary to coronary artery disease.
Topics: Adult; Aged; Bepridil; Calcium Channel Blockers; Coronary Disease; Depression, Chemical; Dose-Respon | 1987 |
[Hemodynamic effects of a new calcium antagonist, bepridil, in patients with coronary artery disease].
Topics: Bepridil; Calcium Channel Blockers; Coronary Disease; Hemodynamics; Humans; Middle Aged; Pulmonary W | 1987 |
Alterations in contrast medium-induced coronary reactive hyperemia after bepridil in patients with coronary artery disease.
Topics: Adult; Bepridil; Coronary Circulation; Coronary Disease; Female; Humans; Hyperemia; Ioxaglic Acid; M | 1985 |
Hemodynamic assessment of intravenous bepridil administration in ischemic heart disease.
Topics: Adult; Aged; Bepridil; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Female; Hemodynam | 1985 |
Effects of bepridil on regional and global myocardial ischemia/reperfusion-induced injury.
Topics: Adenosine Triphosphate; Animals; Bepridil; Cats; Coronary Circulation; Coronary Disease; Dogs; Femal | 1985 |
Antifibrillatory actions of bepridil and butyl-MDI, two intracellular calcium antagonists.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium; Calcium Channel Blockers; Coronary Circulation; | 1985 |