bepridil has been researched along with Colorectal Neoplasms in 2 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To achieve an adequate plasma concentration of bepridil, a calcium channel blocker, which reverts multidrug resistance (MDR) in vitro, when administered in combination with vinblastine in patients with advanced colorectal cancer, a tumor characterized by high MDR1 gene expression." | 5.07 | Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil. ( Giaccone, G; Kuiper, CM; Linn, SC; Pinedo, HM; van der Valk, P; van Groeningen, CJ; van Kalken, CK; van Tellingen, O, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Linn, SC | 2 |
| van Kalken, CK | 1 |
| van Tellingen, O | 1 |
| van der Valk, P | 1 |
| van Groeningen, CJ | 1 |
| Kuiper, CM | 1 |
| Pinedo, HM | 2 |
| Giaccone, G | 2 |
1 trial available for bepridil and Colorectal Neoplasms
| Article | Year |
|---|---|
Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1994 |
1 other study available for bepridil and Colorectal Neoplasms
| Article | Year |
|---|---|
Complete remission of metastatic colorectal cancer: a pitfall in a multidrug resistance reversal trial.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Bepridil; Clinical Trials as Topic; Colorectal Neoplas | 1994 |