bepridil has been researched along with Arrhythmias, Cardiac in 28 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was performed to evaluate variability in the pharmacokinetics of bepridil in 38 Japanese patients with arrhythmias, and to investigate the effects of aprindine as well as CYP2D6 and CYP3A5 polymorphisms on the oral clearance of bepridil." | 9.12 | Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias. ( Fujiki, A; Hashimoto, Y; Horiuchi, I; Inoue, H; Iwamoto, J; Oshima, Y; Saigusa, K; Taguchi, M; Tahara, K, 2006) |
| "In 12 patients with recurrent pre-syncope or syncope and suspected sick sinus syndrome, the electrophysiologic properties of bepridil were tested using 1-2 extrastimuli during four basic pacing rates." | 7.67 | [Bepridil--electrophysiologic properties of a new calcium antagonist with an anti-arrhythmia effect]. ( Geibel, A; Henning, B; Hohnloser, S; Just, H; Meinertz, T; Zehender, M, 1988) |
| "Fourteen patients with established atrial fibrillation (longer than three months) that was refractory to treatment were studied to compare the clinical and electrophysiological effects of amiodarone and bepridil." | 7.67 | A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation. ( Krikler, DM; McKenna, WJ; Perelman, MS; Rowland, E, 1987) |
| "The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model." | 7.67 | Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. ( Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B, 1985) |
| " The patients were divided into 3 groups according to the arrhythmias observed and the dosage used." | 6.66 | [Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency]. ( Brechenmacher, C; Deroubaix, G; Dupont, T; Moulinie, E; Pasco, A; Pellet, J; Rio, A; Rossignol, B, 1985) |
| "This study was performed to evaluate variability in the pharmacokinetics of bepridil in 38 Japanese patients with arrhythmias, and to investigate the effects of aprindine as well as CYP2D6 and CYP3A5 polymorphisms on the oral clearance of bepridil." | 5.12 | Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias. ( Fujiki, A; Hashimoto, Y; Horiuchi, I; Inoue, H; Iwamoto, J; Oshima, Y; Saigusa, K; Taguchi, M; Tahara, K, 2006) |
| "In 12 patients with recurrent pre-syncope or syncope and suspected sick sinus syndrome, the electrophysiologic properties of bepridil were tested using 1-2 extrastimuli during four basic pacing rates." | 3.67 | [Bepridil--electrophysiologic properties of a new calcium antagonist with an anti-arrhythmia effect]. ( Geibel, A; Henning, B; Hohnloser, S; Just, H; Meinertz, T; Zehender, M, 1988) |
| "Fourteen patients with established atrial fibrillation (longer than three months) that was refractory to treatment were studied to compare the clinical and electrophysiological effects of amiodarone and bepridil." | 3.67 | A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation. ( Krikler, DM; McKenna, WJ; Perelman, MS; Rowland, E, 1987) |
| "The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model." | 3.67 | Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. ( Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B, 1985) |
| " The patients were divided into 3 groups according to the arrhythmias observed and the dosage used." | 2.66 | [Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency]. ( Brechenmacher, C; Deroubaix, G; Dupont, T; Moulinie, E; Pasco, A; Pellet, J; Rio, A; Rossignol, B, 1985) |
| "Bepridil is a unique calcium antagonist with a broad pharmacologic profile and demonstrated efficacy as an antianginal agent." | 2.38 | Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States. ( Singh, BN, 1992) |
| "Bepridil has been observed to prolong the QT interval in the majority of patients in whom it is used for treatment of angina." | 2.38 | Effects of bepridil on cardiac electrophysiologic properties. ( Prystowsky, EN, 1992) |
| "Bepridil is a calcium antagonist with a unique electrophysiologic profile, a long elimination half-life, and demonstrated efficacy as an antianginal agent in the setting of chronic stable angina." | 2.38 | Bepridil therapy: guidelines for patient selection and monitoring of therapy. ( Singh, BN, 1992) |
| "Bepridil is an anti-anginal agent with a novel chemical structure." | 2.37 | Bepridil: a review of its pharmacology and clinical efficacy as an anti-anginal agent with anti-arrhythmic properties. ( Alpert, JS; Coumel, P; Greeff, K; Krikler, DM; Remme, WJ; Schönbaum, E; Verduyn, CW, 1985) |
| " Serious adverse reactions necessitate a change in antiarrhythmic therapy, as opposed to lowering drug dosage to an ineffective level." | 2.37 | Antiarrhythmic drug therapy. Recent advances and current status. ( Somberg, J, 1985) |
| "The effects of bepridil (Bep) in combination with anisodamine (Ani) on myocardial ischemia and reperfusion injury induced by ligating the left coronary artery were studied in rats." | 1.29 | [Protective effects of bepridil in combination with anisodamine on myocardial ischemia and reperfusion injury in rats]. ( Chen, JM; Cui, JY; Dong, HY; Gu, SL; Peng, ZY; Zhou, J, 1995) |
| "The presence of a left bundle branch block (LBBB) may hamper the electrocardiographic diagnosis of diseases that involve the QRS complexes." | 1.28 | [Drug-induced major anomalies of ventricular repolarization masked by a left branch block]. ( Dujardin, JJ; Haiat, R; Joly, P; Kacet, S; Nicolai, P, 1989) |
| "Bepridil has both slow channel blocking properties and fast channel blocking effects and thus possesses an antiarrhythmic effect beyond the prolongation of repolarization." | 1.27 | Calcium channel blockers that prolong the QT interval. ( Somberg, JC, 1985) |
| "Bepridil has been shown to block both slow- and fast-channel activity in the heart." | 1.27 | Electrophysiologic and antiarrhythmic properties of bepridil. ( Prystowsky, EN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (67.86) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Kimura, A | 1 |
| Murakami, S | 1 |
| Taguchi, M | 1 |
| Fujiki, A | 2 |
| Iwamoto, J | 1 |
| Inoue, H | 1 |
| Tahara, K | 1 |
| Saigusa, K | 1 |
| Horiuchi, I | 1 |
| Oshima, Y | 1 |
| Hashimoto, Y | 1 |
| Kane, KA | 1 |
| Winslow, E | 1 |
| Flammang, D | 1 |
| Waynberger, M | 1 |
| Jansen, FH | 1 |
| Paillet, R | 1 |
| Coumel, P | 2 |
| Marshall, RJ | 1 |
| Muir, AW | 1 |
| Ponsonnaille, J | 1 |
| Citron, B | 1 |
| Threil, F | 1 |
| Heiligenstein, D | 1 |
| Gras, H | 1 |
| Gu, SL | 1 |
| Chen, JM | 1 |
| Cui, JY | 1 |
| Peng, ZY | 1 |
| Dong, HY | 1 |
| Zhou, J | 1 |
| Singh, BN | 3 |
| Prystowsky, EN | 2 |
| Boucher, M | 1 |
| Dubray, C | 1 |
| Duchêne-Marullaz, P | 2 |
| Alpert, JS | 1 |
| Greeff, K | 1 |
| Krikler, DM | 2 |
| Remme, WJ | 1 |
| Schönbaum, E | 1 |
| Verduyn, CW | 1 |
| Kojima, M | 1 |
| Sperelakis, N | 1 |
| Haiat, R | 1 |
| Nicolai, P | 1 |
| Dujardin, JJ | 1 |
| Joly, P | 1 |
| Kacet, S | 1 |
| Somberg, J | 1 |
| Zehender, M | 1 |
| Geibel, A | 1 |
| Henning, B | 1 |
| Hohnloser, S | 1 |
| Meinertz, T | 1 |
| Just, H | 1 |
| Osaka, T | 1 |
| Kodama, I | 1 |
| Toyama, J | 1 |
| Yamada, K | 1 |
| Chollet-Debord, F | 1 |
| Moins, N | 1 |
| Gachon, P | 1 |
| Perelman, MS | 1 |
| McKenna, WJ | 1 |
| Rowland, E | 1 |
| Somberg, JC | 1 |
| Nademanee, K | 1 |
| Feld, G | 1 |
| Piontek, M | 1 |
| Schwab, M | 1 |
| Upward, JW | 1 |
| Daly, K | 1 |
| Campbell, S | 1 |
| Bergman, G | 1 |
| Jewitt, DE | 1 |
| Pelleg, A | 1 |
| Pardo, Y | 1 |
| Belhassen, B | 1 |
| Shargordsky, B | 1 |
| Chagnac, A | 1 |
| Laniado, S | 1 |
| Rio, A | 1 |
| Pasco, A | 1 |
| Dupont, T | 1 |
| Deroubaix, G | 1 |
| Moulinie, E | 1 |
| Rossignol, B | 1 |
| Pellet, J | 1 |
| Brechenmacher, C | 1 |
6 reviews available for bepridil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
[Present status in and prospects for anti-arrhythmic drug therapy: How to use type III anti-arrhythmic agents].
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Drug Therapy, Combination; Human | 2006 |
Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Arrhythmias, Cardiac; Bepridil; Chronic Disease; El | 1992 |
Effects of bepridil on cardiac electrophysiologic properties.
Topics: Arrhythmias, Cardiac; Atrioventricular Node; Bepridil; Electrocardiography; Humans | 1992 |
Bepridil therapy: guidelines for patient selection and monitoring of therapy.
Topics: Arrhythmias, Cardiac; Bepridil; Drug Synergism; Humans; Torsades de Pointes | 1992 |
Bepridil: a review of its pharmacology and clinical efficacy as an anti-anginal agent with anti-arrhythmic properties.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Bepridil; Calcium; Electrocardiography; Hemodynamics | 1985 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrh | 1985 |
2 trials available for bepridil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.
Topics: Adult; Aged; Algorithms; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bepridil; Cytochro | 2006 |
[Efficacy of oral bepridil in ventricular arrhythmias in stable coronary insufficiency].
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Clinical Trials | 1985 |
20 other studies available for bepridil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Different voltage dependence of I
Topics: Action Potentials; Amiodarone; Arrhythmias, Cardiac; Bepridil; Calcium Channels, L-Type; Computer Si | 2021 |
Antidysrhythmic and electrophysiological effects of a new antianginal agent, bepridil.
Topics: Aconitine; Action Potentials; Anesthesia; Angina Pectoris; Animals; Anti-Arrhythmia Agents; Arrhythm | 1980 |
Electrophysiological profile of bepridil, a new anti-anginal drug with calcium blocking properties.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Electrocardi | 1983 |
The beneficial actions of bepridil in acute myocardial infarction in anaesthetized dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Bepridil; Carbon Dioxide; Coronary Vessels; Dogs; Electro | 1981 |
[The electrophysiologic effects of intravenously administered bepridil].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Bepridil; Bundle o | 1982 |
[Protective effects of bepridil in combination with anisodamine on myocardial ischemia and reperfusion injury in rats].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Drug Therapy, Combination; Male; My | 1995 |
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Fe | 1991 |
Effects of calcium channel blockers on ouabain-induced oscillatory afterpotentials in organ-cultured young embryonic chick hearts.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Chick Embryo; | 1986 |
[Drug-induced major anomalies of ventricular repolarization masked by a left branch block].
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Beprid | 1989 |
Bepridil.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Bepridil; Humans; Middle Aged; Pyrrolidines | 1988 |
[Bepridil--electrophysiologic properties of a new calcium antagonist with an anti-arrhythmia effect].
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blo | 1988 |
Effects of bepridil on ventricular depolarization and repolarization of rabbit isolated hearts with particular reference to its possible proarrhythmic properties.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Electroencephalography; Guinea Pigs; Heart Ventricles; In V | 1988 |
Comparison of verapamil and bepridil, two slow channel inhibitors, in protection against calcium-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Blood Pressure; Calcium; Electrocardiography; Heart Rate; M | 1986 |
A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bepridil; Chron | 1987 |
Calcium channel blockers that prolong the QT interval.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Dogs; Electrocardiography; Heart | 1985 |
Comparative electrophysiologic profiles of calcium antagonists with particular reference to bepridil.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Cardia | 1985 |
Electrophysiologic and antiarrhythmic properties of bepridil.
Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Electroc | 1985 |
Electrophysiologic, hemodynamic and metabolic effects of intravenous bepridil hydrochloride.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Bepridil; Blood Pressure; Child; Electrocardiography; Elect | 1985 |
Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Constriction; Coronary Vessels; Dogs; Female; Heart Rate; M | 1985 |