bepridil has been researched along with Alzheimer Disease in 2 studies
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition to Alzheimer's disease, compounds with dual properties may also be useful for drug development targeting other membrane proteins." | 1.36 | Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. ( Ha, HR; Haass, C; Hamid, R; Herms, J; Hopson, J; Kamp, F; Lichtenthaler, SF; Mayer, TU; Mitterreiter, S; Nelson, DJ; Page, RM; Rossner, S; Stahl, T; Steiner, H; Winkler, E; Zeitschel, U, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mitterreiter, S | 1 |
| Page, RM | 1 |
| Kamp, F | 1 |
| Hopson, J | 1 |
| Winkler, E | 1 |
| Ha, HR | 1 |
| Hamid, R | 1 |
| Herms, J | 1 |
| Mayer, TU | 1 |
| Nelson, DJ | 1 |
| Steiner, H | 1 |
| Stahl, T | 1 |
| Zeitschel, U | 1 |
| Rossner, S | 1 |
| Haass, C | 1 |
| Lichtenthaler, SF | 1 |
| Arai, H | 1 |
| Kashiwagi, S | 1 |
| Nagasaka, Y | 1 |
| Uchida, K | 1 |
| Hoshii, Y | 1 |
| Nakamura, K | 1 |
2 other studies available for bepridil and Alzheimer Disease
| Article | Year |
|---|---|
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
Topics: Alzheimer Disease; Amiodarone; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precur | 2010 |
Oxidative modification of apolipoprotein E in human very-low-density lipoprotein and its inhibition by glycosaminoglycans.
Topics: Adult; Aldehydes; Alzheimer Disease; Amidines; Apolipoproteins E; Bepridil; Biphenyl Compounds; Chel | 1999 |