benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone and Malaria

benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone has been researched along with Malaria* in 1 studies

Other Studies

1 other study(ies) available for benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone and Malaria

ArticleYear
Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes.
    Apoptosis : an international journal on programmed cell death, 2002, Volume: 7, Issue:2

    Infection of mice with Plasmodium Berghei Anka (PbA) leads to a thrombocytopenia, due to a reduced platelet life span, eventually associated with a syndrome of severe or cerebral malaria (CM). Thrombocytopenia was associated with an increase in the number of microparticles (mcp) in plasma. More than >60% of these mcp were of platelet origin, as seen by staining with an anti-platelet antibody. The thrombocytopenia and the amount of mcp were decreased in mice treated with anti CD40L mAb, suggesting that CD40L is the main effector of the thrombocytopenia. Caspase-1, -3, -6, -8, -9 were activated in platelets from infected mice, as seen by the binding of labeled probes or the amount of pro-caspase-3. Treatment of infected mice with the caspases inhibitor ZVAD-fmk decreased the number of mcp and the thrombocytopenia, showing that platelet caspases are responsible for platelet fragmentation. In addition, the caspase inhibitor also caused a decrease in the mortality associated with CM, indicating a critical role of caspases in the expression of CM.

    Topics: Amino Acid Chloromethyl Ketones; Animals; Blood Platelets; Blotting, Western; Caspase 1; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; CD40 Ligand; Cricetinae; Cysteine Proteinase Inhibitors; Disease Models, Animal; Enzyme Activation; Flow Cytometry; Malaria; Megakaryocytes; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Peptides; Plasmodium berghei; Protein Binding; Thrombocytopenia; Time Factors; Tumor Necrosis Factor-alpha

2002
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