benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone and Bacteremia

benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone has been researched along with Bacteremia* in 1 studies

Other Studies

1 other study(ies) available for benzyloxycarbonylvalyl-alanyl-aspartyl-fluoromethyl-ketone and Bacteremia

ArticleYear
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Nov-15, Volume: 171, Issue:10

    The role of alveolar macrophages (AM) in host defense against pulmonary infection has been difficult to establish using in vivo models. This may reflect a reliance on models of fulminant infection. To establish a unique model of resolving infection, with which to address the function of AM, C57BL/6 mice received low-dose intratracheal administration of pneumococci. Administration of low doses of pneumococci produced a resolving model of pulmonary infection characterized by clearance of bacteria without features of pneumonia. AM depletion in this model significantly increased bacterial outgrowth in the lung. Interestingly, a significant increase in the number of apoptotic AM was noted with the low-dose infection as compared with mock infection. Caspase inhibition in this model decreased AM apoptosis and increased the number of bacteremic mice, indicating a novel role for caspase activation in pulmonary innate defense against pneumococci. These results suggest that AM play a key role in clearance of bacteria from the lung during subclinical infection and that induction of AM apoptosis contributes to the microbiologic host defense against pneumococci.

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Bacteremia; Caspase Inhibitors; Cell Count; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Immunologic; Female; Immunity, Innate; Injections, Intraperitoneal; Intubation, Intratracheal; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Up-Regulation

2003