benzyloxycarbonylleucyl-leucyl-leucine-aldehyde and Enteritis

benzyloxycarbonylleucyl-leucyl-leucine-aldehyde has been researched along with Enteritis* in 1 studies

Other Studies

1 other study(ies) available for benzyloxycarbonylleucyl-leucyl-leucine-aldehyde and Enteritis

ArticleYear
Regulation of nuclear factor-kappaB in intestinal epithelial cells in a cell model of inflammation.
    Mediators of inflammation, 2003, Volume: 12, Issue:5

    Interleukin-1 (IL-1), an inflammatory cytokine whose levels are elevated in inflamed mucosa, causes part of its effect on intestinal epithelial cells (IEC) through inducing ceramide production.. To study the role of nuclear factor-kappaB (NF-kappaB), a pro-inflammatory and anti-apoptotic factor, in IL-1-treated IEC.. NF-kappaB activity and levels of apoptotic proteins were assessed by electrophoretic mobility shift assay and RNA-protection assay, respectively.. IL-1 and ceramide, which have been shown to partially mediate IL-1 effects on IEC, activated NF-kappaB levels significantly. This activation was due to a decrease in IkappaB-alpha and IkappaB-beta protein levels. Moreover, the ratio of mRNA levels of anti-apoptotic to pro-apoptotic proteins was significantly increased in IL-1-treated IEC.. NF-kappaB may play a key role in the regulation of the expression of pro-inflammatory and/or apoptotic genes in inflammatory bowel disease, making this protein an attractive target for therapeutic intervention.

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Cell Line; Ceramides; Cysteine Proteinase Inhibitors; Enteritis; Epithelial Cells; I-kappa B Proteins; Interleukin-1; Intestinal Mucosa; Leupeptins; NF-kappa B; NF-KappaB Inhibitor alpha; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger

2003
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