benzyloxycarbonyl-methionyl-2(s)-cyanopyrrolidine and Body-Weight

The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. The inhibitor (3.0 mg/kg, i.p., 30 min before pre-neurotoxin injection on days 8-14) alleviated depression symptoms and promoted normalization of behavioral activity after drug withdrawal. The obtained data reflected therapeutic antidepressant properties of inhibitor for prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine.

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anxiety; Behavior, Animal; Body Weight; Depressive Disorder; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dopamine; Male; Methionine; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Serine Endopeptidases; Sucrose