benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinal has been researched along with Hypertension* in 1 studies
1 other study(ies) available for benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinal and Hypertension
| Article | Year |
|---|---|
A proteasome inhibitor lessens the increased aortic endothelin-1 content in deoxycorticosterone acetate-salt hypertensive rats.
Deoxycorticosterone acetate (DOCA)-salt-treated rats developed marked hypertension after 4 weeks with an increase in aortic endothelin-1. Treatment of DOCA-salt hypertensive rats with a proteasome inhibitor, N-benzyloxycarbonyl-Ile-Glu(O-t-Bu)-Ala-leucinal, significantly reduced the elevation in systolic blood pressure and the effect was accompanied by a decrease in aortic endothelin- content. Thus, a proteasome-dependent proteolytic pathway appears to play an important role in the enhanced production of endothelin-1 in blood vessels and the consequent increase in blood pressure in this model of hypertension. Topics: Animals; Aorta; Blood Pressure; Cysteine Endopeptidases; Desoxycorticosterone; Endothelin-1; Enzyme Inhibitors; Hypertension; Male; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1998 |