benzyl isothiocyanate has been researched along with Pancreatic Neoplasms in 13 studies
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two human pancreatic cancer cell lines, PANC-1 and MIAPaCa-2, were treated with BITC and irradiated with X-rays." | 1.37 | Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis. ( Kimura, S; Kubota, N; Ohara, M; Ohnishi, K; Okayasu, R; Tanaka, A, 2011) |
| "Human pancreatic cancer cells (BxPC-3, AsPC-1, Capan-2, MiaPaCa-2, and Panc-1) and immortalized human pancreatic cells (HPDE-6) were treated with vehicle or with BITC at 5-40 microM, cell survival was evaluated by sulforhodamine B assay, and apoptosis by caspase-3 and poly-ADP ribose polymerase cleavage or by a commercial assay for cell death." | 1.35 | The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. ( Sahu, RP; Srivastava, SK, 2009) |
| "Using adenocarcinoma and metastatic pancreatic cancer cells, we investigated whether this dietary isothiocyanate induces apoptosis by converging two major pathways: the death receptor-mediated extrinsic and the mitochondrial intrinsic pathway." | 1.35 | Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation. ( Basu, A; Haldar, S, 2009) |
| "Benzyl isothiocyanate (BITC) has been shown to inhibit chemically induced pancreatic cancer in experimental animals." | 1.33 | Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells. ( Humphreys, I; Loganathan, S; Srivastava, SK; Zhang, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasiappan, R | 1 |
| Jutooru, I | 1 |
| Karki, K | 1 |
| Hedrick, E | 1 |
| Safe, S | 1 |
| Sahu, RP | 5 |
| Srivastava, SK | 8 |
| Epperly, MW | 1 |
| Hanley, AB | 1 |
| Burch, R | 1 |
| Zhang, R | 2 |
| Batra, S | 2 |
| Shi, Y | 1 |
| Basu, A | 1 |
| Haldar, S | 1 |
| Kandala, PK | 1 |
| Boreddy, SR | 2 |
| Pramanik, KC | 1 |
| Ohara, M | 1 |
| Kimura, S | 1 |
| Tanaka, A | 1 |
| Ohnishi, K | 1 |
| Okayasu, R | 1 |
| Kubota, N | 1 |
| Singh, SV | 1 |
| Kuroiwa, Y | 1 |
| Nishikawa, A | 1 |
| Kitamura, Y | 1 |
| Kanki, K | 1 |
| Ishii, Y | 1 |
| Umemura, T | 1 |
| Hirose, M | 1 |
| Loganathan, S | 1 |
| Humphreys, I | 1 |
13 other studies available for benzyl isothiocyanate and Pancreatic Neoplasms
| Article | Year |
|---|---|
Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Gen | 2016 |
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Gen | 2009 |
Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy.
Topics: Apoptosis; Blotting, Western; Carcinoma; Cell Line, Tumor; Cell Proliferation; G2 Phase; Gamma Rays; | 2009 |
Re: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Isothiocyanates; Lepidium sativum; Pancr | 2009 |
Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Enzyme Activation; G2 | 2009 |
Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Prolifer | 2009 |
Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; DNA; Down-Regulation; | 2010 |
Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; C | 2011 |
Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Caspase | 2011 |
Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regul | 2011 |
Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; | 2004 |
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Cell | 2006 |
Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.
Topics: Acetylcysteine; Animals; Apoptosis; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cell Proli | 2006 |