benzyl isothiocyanate has been researched along with Lung Neoplasms in 23 studies
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gefitinib is used to treat patients with lung cancer, but in some patients, the disease becomes gefitinib-resistant." | 1.48 | Benzyl Isothiocyanate Induces Apoptotic Cell Death Through Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells ( Chen, HY; Chou, YC; Chung, JG; Hsia, TC; Hsiao, YT; Huang, YP; Jiang, YW; Peng, SF; Yang, JL, 2018) |
| "This may provide a novel approach for metastasis therapy of lung cancer by dietary isothiocyanates and possibly other types of cancer." | 1.37 | Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates. ( Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y, 2011) |
| "Phenethyl isothiocyanate (PEITC) is a more potent inducer of apoptosis than sulforaphane (SFN) in A549 cells, but SFN induces more ROS generation and oxidative damages than PEITC, suggesting that oxidative stress again is probably not a trigger for apoptosis in these cells." | 1.35 | Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells. ( Chung, FL; Mi, L, 2008) |
| "Phenethyl isothiocyanate (PEITC) is an effective inhibitor of lung tumorigenesis induced in rats and mice by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while benzyl isothiocyanate (BITC) inhibits lung tumorigenesis induced in mice by another tobacco smoke carcinogen, benzo[a]pyrene (BaP)." | 1.31 | Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. ( Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M, 2000) |
| " A dose-response relationship for lung tumor induction by i." | 1.29 | Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. ( Hecht, SS; Isaacs, S; Trushin, N, 1994) |
| " Using an identical dosing regimen, parallel results were observed in the effects of these isothiocyanates on O6-methylguanine formation in the lung, in which PEITC at either dose resulted in considerable inhibition at 2 or 6 h after NNK administration, while BITC or PITC had little effect." | 1.28 | Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. ( Amin, SG; Chung, FL; Hecht, SS; Morse, MA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, YP | 1 |
| Jiang, YW | 1 |
| Chen, HY | 1 |
| Hsiao, YT | 1 |
| Peng, SF | 1 |
| Chou, YC | 1 |
| Yang, JL | 1 |
| Hsia, TC | 1 |
| Chung, JG | 1 |
| Kim, M | 1 |
| Cho, HJ | 1 |
| Kwon, GT | 1 |
| Kang, YH | 1 |
| Kwon, SH | 1 |
| Her, S | 1 |
| Park, T | 1 |
| Kim, Y | 1 |
| Kee, Y | 1 |
| Park, JH | 2 |
| Mi, L | 2 |
| Chung, FL | 6 |
| Wu, X | 2 |
| Zhu, Y | 2 |
| Yan, H | 2 |
| Liu, B | 2 |
| Li, Y | 2 |
| Zhou, Q | 2 |
| Xu, K | 2 |
| Tan, XL | 1 |
| Shi, M | 1 |
| Tang, H | 1 |
| Han, W | 1 |
| Spivack, SD | 1 |
| Kim, EJ | 1 |
| Hong, JE | 1 |
| Eom, SJ | 1 |
| Lee, JY | 1 |
| Wu, H | 1 |
| Xiao, Z | 1 |
| Veenstra, TD | 1 |
| Hecht, SS | 9 |
| Kenney, PM | 3 |
| Wang, M | 3 |
| Upadhyaya, P | 2 |
| Kuang, YF | 1 |
| Chen, YH | 1 |
| von Weymarn, LB | 1 |
| Chun, JA | 1 |
| Hollenberg, PF | 1 |
| Pintão, AM | 1 |
| Pais, MS | 1 |
| Coley, H | 1 |
| Kelland, LR | 1 |
| Judson, IR | 1 |
| Isaacs, S | 1 |
| Trushin, N | 3 |
| Lin, JM | 1 |
| Amin, S | 2 |
| Sticha, KR | 1 |
| Staretz, ME | 1 |
| Liang, H | 1 |
| Witschi, H | 1 |
| Yang, YM | 1 |
| Conaway, CC | 1 |
| Chiao, JW | 1 |
| Wang, CX | 1 |
| Whysner, J | 1 |
| Dai, W | 1 |
| Reinhardt, J | 1 |
| Morse, MA | 3 |
| Reinhardt, JC | 1 |
| Amin, SG | 2 |
| Stoner, GD | 1 |
| Wattenberg, LW | 1 |
1 review available for benzyl isothiocyanate and Lung Neoplasms
| Article | Year |
|---|---|
Chemoprevention of lung cancer by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitr | 1996 |
22 other studies available for benzyl isothiocyanate and Lung Neoplasms
| Article | Year |
|---|---|
Benzyl Isothiocyanate Induces Apoptotic Cell Death Through Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells
Topics: Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; | 2018 |
Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice.
Topics: 3T3-L1 Cells; Animals; Cell Cycle; Cell Line; Dietary Fats; Female; Gene Expression Regulation, Neop | 2015 |
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neopl | 2008 |
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Ca | 2010 |
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
Topics: Anticarcinogenic Agents; Brassica; Bronchi; Camellia sinensis; Catechin; Cell Division; Cell Line; C | 2010 |
Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor | 2011 |
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cel | 2011 |
Proteomic analysis of covalent modifications of tubulins by isothiocyanates.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Prolife | 2012 |
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogens; Chrysenes; | 2002 |
Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcino | 2004 |
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Chemoprevention; Cytochrome P-450 CYP2A6; Hu | 2006 |
In vitro and in vivo antitumor activity of benzyl isothiocyanate: a natural product from Tropaeolum majus.
Topics: Animals; Antineoplastic Agents; Cell Line; Female; Humans; Isothiocyanates; Leukemia L1210; Lung Neo | 1995 |
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relat | 1994 |
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; | 1993 |
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Di | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene | 2000 |
Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Chemoprevention; Cyclohexenes; Dexamethasone; Diet; Disea | 2000 |
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyr | 2002 |
Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Thio | 1990 |
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mic | 1990 |
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Ne | 1989 |
Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Drug Interactions; Isothiocyanates; Lung Neoplasms; Mic | 1987 |