Page last updated: 2024-10-23

benzyl isothiocyanate and Lung Neoplasms

benzyl isothiocyanate has been researched along with Lung Neoplasms in 23 studies

benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Gefitinib is used to treat patients with lung cancer, but in some patients, the disease becomes gefitinib-resistant."1.48Benzyl Isothiocyanate Induces Apoptotic Cell Death Through Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells ( Chen, HY; Chou, YC; Chung, JG; Hsia, TC; Hsiao, YT; Huang, YP; Jiang, YW; Peng, SF; Yang, JL, 2018)
"This may provide a novel approach for metastasis therapy of lung cancer by dietary isothiocyanates and possibly other types of cancer."1.37Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates. ( Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y, 2011)
"Phenethyl isothiocyanate (PEITC) is a more potent inducer of apoptosis than sulforaphane (SFN) in A549 cells, but SFN induces more ROS generation and oxidative damages than PEITC, suggesting that oxidative stress again is probably not a trigger for apoptosis in these cells."1.35Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells. ( Chung, FL; Mi, L, 2008)
"Phenethyl isothiocyanate (PEITC) is an effective inhibitor of lung tumorigenesis induced in rats and mice by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while benzyl isothiocyanate (BITC) inhibits lung tumorigenesis induced in mice by another tobacco smoke carcinogen, benzo[a]pyrene (BaP)."1.31Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. ( Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M, 2000)
" A dose-response relationship for lung tumor induction by i."1.29Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. ( Hecht, SS; Isaacs, S; Trushin, N, 1994)
" Using an identical dosing regimen, parallel results were observed in the effects of these isothiocyanates on O6-methylguanine formation in the lung, in which PEITC at either dose resulted in considerable inhibition at 2 or 6 h after NNK administration, while BITC or PITC had little effect."1.28Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. ( Amin, SG; Chung, FL; Hecht, SS; Morse, MA, 1989)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's6 (26.09)18.2507
2000's8 (34.78)29.6817
2010's7 (30.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, YP1
Jiang, YW1
Chen, HY1
Hsiao, YT1
Peng, SF1
Chou, YC1
Yang, JL1
Hsia, TC1
Chung, JG1
Kim, M1
Cho, HJ1
Kwon, GT1
Kang, YH1
Kwon, SH1
Her, S1
Park, T1
Kim, Y1
Kee, Y1
Park, JH2
Mi, L2
Chung, FL6
Wu, X2
Zhu, Y2
Yan, H2
Liu, B2
Li, Y2
Zhou, Q2
Xu, K2
Tan, XL1
Shi, M1
Tang, H1
Han, W1
Spivack, SD1
Kim, EJ1
Hong, JE1
Eom, SJ1
Lee, JY1
Wu, H1
Xiao, Z1
Veenstra, TD1
Hecht, SS9
Kenney, PM3
Wang, M3
Upadhyaya, P2
Kuang, YF1
Chen, YH1
von Weymarn, LB1
Chun, JA1
Hollenberg, PF1
Pintão, AM1
Pais, MS1
Coley, H1
Kelland, LR1
Judson, IR1
Isaacs, S1
Trushin, N3
Lin, JM1
Amin, S2
Sticha, KR1
Staretz, ME1
Liang, H1
Witschi, H1
Yang, YM1
Conaway, CC1
Chiao, JW1
Wang, CX1
Whysner, J1
Dai, W1
Reinhardt, J1
Morse, MA3
Reinhardt, JC1
Amin, SG2
Stoner, GD1
Wattenberg, LW1

Reviews

1 review available for benzyl isothiocyanate and Lung Neoplasms

ArticleYear
Chemoprevention of lung cancer by isothiocyanates.
    Advances in experimental medicine and biology, 1996, Volume: 401

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitr

1996

Other Studies

22 other studies available for benzyl isothiocyanate and Lung Neoplasms

ArticleYear
Benzyl Isothiocyanate Induces Apoptotic Cell Death Through Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells
    Anticancer research, 2018, Volume: 38, Issue:9

    Topics: Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm;

2018
Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:1

    Topics: 3T3-L1 Cells; Animals; Cell Cycle; Cell Line; Dietary Fats; Female; Gene Expression Regulation, Neop

2015
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
    Nutrition and cancer, 2008, Volume: 60 Suppl 1

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neopl

2008
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
    BMC cancer, 2010, Jun-09, Volume: 10

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Ca

2010
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
    The Journal of nutrition, 2010, Volume: 140, Issue:8

    Topics: Anticarcinogenic Agents; Brassica; Bronchi; Camellia sinensis; Catechin; Cell Division; Cell Line; C

2010
Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
    Breast cancer research and treatment, 2011, Volume: 130, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor

2011
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
    The British journal of nutrition, 2011, Volume: 106, Issue:12

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cel

2011
Proteomic analysis of covalent modifications of tubulins by isothiocyanates.
    The Journal of nutrition, 2012, Volume: 142, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Prolife

2012
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
    Cancer letters, 2002, Dec-10, Volume: 187, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogens; Chrysenes;

2002
Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:10

    Topics: Annexin A5; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcino

2004
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
    Carcinogenesis, 2006, Volume: 27, Issue:4

    Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Chemoprevention; Cytochrome P-450 CYP2A6; Hu

2006
In vitro and in vivo antitumor activity of benzyl isothiocyanate: a natural product from Tropaeolum majus.
    Planta medica, 1995, Volume: 61, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line; Female; Humans; Isothiocyanates; Leukemia L1210; Lung Neo

1995
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relat

1994
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
    Cancer letters, 1993, Nov-01, Volume: 74, Issue:3

    Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms;

1993
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Cancer letters, 2000, Mar-13, Volume: 150, Issue:1

    Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Di

2000
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
    Carcinogenesis, 2000, Volume: 21, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene

2000
Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors.
    Experimental lung research, 2000, Volume: 26, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Chemoprevention; Cyclohexenes; Dexamethasone; Diet; Disea

2000
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
    Cancer research, 2002, Jan-01, Volume: 62, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyr

2002
Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice.
    Cancer letters, 1990, Volume: 49, Issue:3

    Topics: Animals; Body Weight; Carcinogens; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Thio

1990
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
    Basic life sciences, 1990, Volume: 52

    Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mic

1990
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
    Cancer research, 1989, Jun-01, Volume: 49, Issue:11

    Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Ne

1989
Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice.
    Carcinogenesis, 1987, Volume: 8, Issue:12

    Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Drug Interactions; Isothiocyanates; Lung Neoplasms; Mic

1987