Page last updated: 2024-10-23

benzyl isothiocyanate and Liver Neoplasms

benzyl isothiocyanate has been researched along with Liver Neoplasms in 7 studies

benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables."5.43Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells. ( Chen, Y; Dong, X; Guo, J; Li, M; Li, W; Lin, B; Lu, Y; Zhang, X; Zhu, M, 2016)
" Benzyl isothiocyanate (BITC) showed the inhibitory effect of tumor and AGPS activity, therefore, we screened a group of small molecular compound based on BITC by computer-aid design targeting AGPS and the results showed that the derivants could suppress the proliferation, the expression of tumor related genes such as survivin and Bcl-2, and the level of ether lipids such as lysophosphatidic acid ether (LPAe) and platelet activating factor ether (PAFe); however, the activity of caspase-3/8 was improved in glioma U87MG and hepatic carcinoma HepG2 cells in vitro."3.81Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells. ( Li, WM; Xue, J; Yang, P; Zhang, L; Zhao, M; Zhu, Y, 2015)
"Benzyl isothiocyanate (BITC) is a member of the isothiocyanate compounds that found in cruciferous vegetables."1.48Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF. ( Helmy, MW; Omran, G; Salahuddin, A; Zakaria, S, 2018)
"Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables."1.43Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells. ( Chen, Y; Dong, X; Guo, J; Li, M; Li, W; Lin, B; Lu, Y; Zhang, X; Zhu, M, 2016)
"Benzyl isothiocyanate (BITC) is a hydrolysis compound of glucotropaeolin in cruciferous vegetables."1.35Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells. ( Hwang, ES; Lee, HJ, 2008)
"Liver neoplasms were seen in Groups 1, 2 and 3."1.29Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Mori, H; Okumura, A; Sugie, S; Tanaka, T, 1993)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zakaria, S1
Helmy, MW1
Salahuddin, A1
Omran, G1
Kim, M1
Cho, HJ1
Kwon, GT1
Kang, YH1
Kwon, SH1
Her, S1
Park, T1
Kim, Y1
Kee, Y1
Park, JH1
Zhu, Y1
Li, WM1
Zhang, L1
Xue, J1
Zhao, M1
Yang, P1
Zhu, M1
Li, W1
Guo, J1
Lu, Y1
Dong, X1
Lin, B1
Chen, Y1
Zhang, X1
Li, M1
Scharf, G1
Prustomersky, S1
Knasmuller, S1
Schulte-Hermann, R1
Huber, WW1
Hwang, ES1
Lee, HJ1
Sugie, S1
Okumura, A1
Tanaka, T1
Mori, H1

Other Studies

7 other studies available for benzyl isothiocyanate and Liver Neoplasms

ArticleYear
Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Caspase 3;

2018
Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:1

    Topics: 3T3-L1 Cells; Animals; Cell Cycle; Cell Line; Dietary Fats; Female; Gene Expression Regulation, Neop

2015
Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:1

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Ce

2015
Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells.
    Oncotarget, 2016, 11-15, Volume: 7, Issue:46

    Topics: alpha-Fetoproteins; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Movement

2016
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
    Nutrition and cancer, 2003, Volume: 45, Issue:1

    Topics: 4-Butyrolactone; Allyl Compounds; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Diterpenes; Do

2003
Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:7

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Down-Regulation;

2008
Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transfe

1993