benzyl isothiocyanate has been researched along with Glioma in 5 studies
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzyl isothiocyanate (BITC) has been shown to have inhibitory potential for human glioma U87MG cells; however, the effect and mechanism were not fully clear." | 7.81 | The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line. ( Liu, A; Liu, Y; Qi, L; Xue, J; Yang, P; Zhang, L; Zhang, X; Zhu, Y, 2015) |
| "Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment." | 5.40 | Potential mechanisms of benzyl isothiocyanate suppression of invasion and angiogenesis by the U87MG human glioma cell line. ( Jiang, Y; Li, Q; Liu, MY; Qi, LS; Wang, HO; Yang, P; Zhang, GD; Zhang, L; Zhu, Y, 2014) |
| "Malignant glioma, also known as brain cancer, is the most common intracranial tumor, having an extremely high mortality and recurrence rate." | 5.39 | Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells. ( Wang, Q; Yang, P; Zhang, HY; Zhu, Y; Zhuang, JX, 2013) |
| "Benzyl isothiocyanate (BITC) has been shown to have inhibitory potential for human glioma U87MG cells; however, the effect and mechanism were not fully clear." | 3.81 | The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line. ( Liu, A; Liu, Y; Qi, L; Xue, J; Yang, P; Zhang, L; Zhang, X; Zhu, Y, 2015) |
| " Benzyl isothiocyanate (BITC) showed the inhibitory effect of tumor and AGPS activity, therefore, we screened a group of small molecular compound based on BITC by computer-aid design targeting AGPS and the results showed that the derivants could suppress the proliferation, the expression of tumor related genes such as survivin and Bcl-2, and the level of ether lipids such as lysophosphatidic acid ether (LPAe) and platelet activating factor ether (PAFe); however, the activity of caspase-3/8 was improved in glioma U87MG and hepatic carcinoma HepG2 cells in vitro." | 3.81 | Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells. ( Li, WM; Xue, J; Yang, P; Zhang, L; Zhao, M; Zhu, Y, 2015) |
| "Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment." | 1.40 | Potential mechanisms of benzyl isothiocyanate suppression of invasion and angiogenesis by the U87MG human glioma cell line. ( Jiang, Y; Li, Q; Liu, MY; Qi, LS; Wang, HO; Yang, P; Zhang, GD; Zhang, L; Zhu, Y, 2014) |
| "Malignant glioma, also known as brain cancer, is the most common intracranial tumor, having an extremely high mortality and recurrence rate." | 1.39 | Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells. ( Wang, Q; Yang, P; Zhang, HY; Zhu, Y; Zhuang, JX, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Y | 4 |
| Zhuang, JX | 1 |
| Wang, Q | 1 |
| Zhang, HY | 1 |
| Yang, P | 4 |
| Zhang, L | 3 |
| Zhang, GD | 1 |
| Wang, HO | 1 |
| Liu, MY | 1 |
| Jiang, Y | 1 |
| Qi, LS | 1 |
| Li, Q | 1 |
| Liu, A | 1 |
| Zhang, X | 1 |
| Qi, L | 1 |
| Xue, J | 2 |
| Liu, Y | 1 |
| Li, WM | 1 |
| Zhao, M | 1 |
| Lee, CS | 1 |
| Cho, HJ | 1 |
| Jeong, YJ | 1 |
| Shin, JM | 1 |
| Park, KK | 1 |
| Park, YY | 1 |
| Bae, YS | 1 |
| Chung, IK | 1 |
| Kim, M | 1 |
| Kim, CH | 1 |
| Jin, F | 1 |
| Chang, HW | 1 |
| Chang, YC | 1 |
5 other studies available for benzyl isothiocyanate and Glioma
| Article | Year |
|---|---|
Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Flow Cytometry; Gliom | 2013 |
Potential mechanisms of benzyl isothiocyanate suppression of invasion and angiogenesis by the U87MG human glioma cell line.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Cycle; Cell Mo | 2014 |
The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line.
Topics: Alkyl and Aryl Transferases; Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glio | 2015 |
Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Ce | 2015 |
Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.
Topics: Cell Line, Tumor; Cell Movement; Extracellular Matrix; Focal Adhesion Kinase 1; Gene Expression Regu | 2015 |