benzyl isothiocyanate has been researched along with Carcinoma, Hepatocellular in 5 studies
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables." | 5.43 | Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells. ( Chen, Y; Dong, X; Guo, J; Li, M; Li, W; Lin, B; Lu, Y; Zhang, X; Zhu, M, 2016) |
| " Benzyl isothiocyanate (BITC) showed the inhibitory effect of tumor and AGPS activity, therefore, we screened a group of small molecular compound based on BITC by computer-aid design targeting AGPS and the results showed that the derivants could suppress the proliferation, the expression of tumor related genes such as survivin and Bcl-2, and the level of ether lipids such as lysophosphatidic acid ether (LPAe) and platelet activating factor ether (PAFe); however, the activity of caspase-3/8 was improved in glioma U87MG and hepatic carcinoma HepG2 cells in vitro." | 3.81 | Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells. ( Li, WM; Xue, J; Yang, P; Zhang, L; Zhao, M; Zhu, Y, 2015) |
| "Benzyl isothiocyanate (BITC) is a member of the isothiocyanate compounds that found in cruciferous vegetables." | 1.48 | Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF. ( Helmy, MW; Omran, G; Salahuddin, A; Zakaria, S, 2018) |
| "Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables." | 1.43 | Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells. ( Chen, Y; Dong, X; Guo, J; Li, M; Li, W; Lin, B; Lu, Y; Zhang, X; Zhu, M, 2016) |
| "Benzyl isothiocyanate (BITC) is a hydrolysis compound of glucotropaeolin in cruciferous vegetables." | 1.35 | Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells. ( Hwang, ES; Lee, HJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 1 |
| Yamanaka, M | 1 |
| Abe-Kanoh, N | 1 |
| Liu, X | 1 |
| Zhu, B | 1 |
| Munemasa, S | 1 |
| Nakamura, T | 1 |
| Murata, Y | 1 |
| Nakamura, Y | 1 |
| Zakaria, S | 1 |
| Helmy, MW | 1 |
| Salahuddin, A | 1 |
| Omran, G | 1 |
| Zhu, Y | 1 |
| Li, WM | 1 |
| Zhang, L | 1 |
| Xue, J | 1 |
| Zhao, M | 1 |
| Yang, P | 1 |
| Zhu, M | 1 |
| Li, W | 1 |
| Guo, J | 1 |
| Lu, Y | 1 |
| Dong, X | 1 |
| Lin, B | 1 |
| Chen, Y | 1 |
| Zhang, X | 1 |
| Li, M | 1 |
| Hwang, ES | 1 |
| Lee, HJ | 1 |
5 other studies available for benzyl isothiocyanate and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Sur | 2017 |
Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Caspase 3; | 2018 |
Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Ce | 2015 |
Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells.
Topics: alpha-Fetoproteins; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Movement | 2016 |
Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Down-Regulation; | 2008 |