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benzyl isothiocyanate and Breast Cancer

benzyl isothiocyanate has been researched along with Breast Cancer in 22 studies

benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma

Research Excerpts

ExcerptRelevanceReference
"Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models."7.83Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. ( Baty, CJ; Croix, CS; Sehrawat, A; Singh, RP; Singh, SV; Tailor, D; Watkins, S, 2016)
"We showed previously that garden cress constituent benzyl isothiocyanate (BITC) inhibits self-renewal of breast cancer stem cells (bCSC) in vitro and in vivo."7.81The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. ( Kim, SH; Singh, SV, 2015)
"We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo."7.79Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. ( Kim, SH; Sehrawat, A; Singh, SV; Vogt, A, 2013)
"Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood."7.78Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. ( Bommareddy, A; Hahm, ER; Kim, SH; Sehrawat, A; Singh, SV; Xiao, D, 2012)
"Benzyl isothiocyanate (BITC) is a promising anticancer constituent of edible cruciferous vegetables with in vivo efficacy against chemically induced as well as oncogene-driven breast cancer in experimental rodents."7.78Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration. ( Kim, SH; Sehrawat, A; Singh, SV, 2012)
"Molecular effects of obesity, a well-established risk factor for breast cancer progression, are mediated by adipocytokine leptin."7.77Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. ( Kim, SH; Nagalingam, A; Saxena, NK; Sharma, D; Singh, SV, 2011)
"We showed previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) inhibits growth of cultured and xenografted human breast cancer cells and suppresses mammary cancer development in a transgenic mouse model."7.77Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. ( Sehrawat, A; Singh, SV, 2011)
"Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables such as garden cress, inhibits growth of human breast cancer cell lines in culture."7.76Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. ( Arlotti, JA; Bommareddy, A; Singh, SV; Warin, R; Xiao, D, 2010)
"We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood."7.76p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010)
"Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood."7.74Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. ( Powolny, AA; Singh, SV; Xiao, D, 2008)
"Chemoprevention of breast cancer is feasible with the use of non-toxic phytochemicals from edible and medicinal plants."5.43Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. ( Sehrawat, A; Singh, SV, 2016)
"The inhibition of breast cancer stem cells is observed at pharmacologic concentrations of BITC."5.39Benzyl isothiocyanate: double trouble for breast cancer cells. ( Rao, CV, 2013)
"Cancer chemoprevention by benzyl isothiocyanate (BITC), which is derived from cruciferous vegetables like garden cress, in a transgenic mouse model of breast cancer is associated with inhibition of breast cancer stem-like cells (bCSC), but the molecular regulators of this effect remain elusive."3.91Role of Krüppel-like Factor 4-p21 ( Kim, SH; Singh, SV, 2019)
"Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models."3.83Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. ( Baty, CJ; Croix, CS; Sehrawat, A; Singh, RP; Singh, SV; Tailor, D; Watkins, S, 2016)
"We showed previously that garden cress constituent benzyl isothiocyanate (BITC) inhibits self-renewal of breast cancer stem cells (bCSC) in vitro and in vivo."3.81The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. ( Kim, SH; Singh, SV, 2015)
"We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo."3.79Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. ( Kim, SH; Sehrawat, A; Singh, SV; Vogt, A, 2013)
"Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood."3.78Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. ( Bommareddy, A; Hahm, ER; Kim, SH; Sehrawat, A; Singh, SV; Xiao, D, 2012)
"Benzyl isothiocyanate (BITC) is a promising anticancer constituent of edible cruciferous vegetables with in vivo efficacy against chemically induced as well as oncogene-driven breast cancer in experimental rodents."3.78Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration. ( Kim, SH; Sehrawat, A; Singh, SV, 2012)
"Molecular effects of obesity, a well-established risk factor for breast cancer progression, are mediated by adipocytokine leptin."3.77Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. ( Kim, SH; Nagalingam, A; Saxena, NK; Sharma, D; Singh, SV, 2011)
"We showed previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) inhibits growth of cultured and xenografted human breast cancer cells and suppresses mammary cancer development in a transgenic mouse model."3.77Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. ( Sehrawat, A; Singh, SV, 2011)
"Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables such as garden cress, inhibits growth of human breast cancer cell lines in culture."3.76Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. ( Arlotti, JA; Bommareddy, A; Singh, SV; Warin, R; Xiao, D, 2010)
"We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood."3.76p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010)
"Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood."3.74Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. ( Powolny, AA; Singh, SV; Xiao, D, 2008)
"Benzyl isothiocyanate (BITC) has been reported to exhibit antitumor properties in various cancer types; however, the underlying mechanisms of its action remain unclear."1.51Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway. ( Chen, J; Fan, L; Fan, W; Fu, S; Guo, L; Lin, L; Liu, H; Wang, B; Wei, H; Xie, B; Zhao, L, 2019)
"Chemoprevention of breast cancer is feasible with the use of non-toxic phytochemicals from edible and medicinal plants."1.43Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. ( Sehrawat, A; Singh, SV, 2016)
"The inhibition of breast cancer stem cells is observed at pharmacologic concentrations of BITC."1.39Benzyl isothiocyanate: double trouble for breast cancer cells. ( Rao, CV, 2013)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (13.64)29.6817
2010's19 (86.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pore, SK1
Hahm, ER3
Latoche, JD1
Anderson, CJ2
Shuai, Y1
Singh, SV16
Roy, R1
White, AG1
Kim, SH8
Xie, B2
Zhao, L1
Guo, L1
Liu, H1
Fu, S1
Fan, W1
Lin, L1
Chen, J1
Wang, B1
Fan, L1
Wei, H1
Sehrawat, A7
Rao, CV1
Duval, R1
Xu, X1
Bui, LC1
Mathieu, C1
Petit, E1
Cariou, K1
Dodd, RH1
Dupret, JM1
Rodrigues-Lima, F1
Croix, CS1
Baty, CJ1
Watkins, S1
Tailor, D1
Singh, RP1
Nagalingam, A2
Kuppusamy, P1
Muniraj, N1
Langford, P1
Győrffy, B1
Saxena, NK2
Sharma, D2
Xiao, D4
Powolny, AA1
Kang, L1
Ding, L1
Wang, ZY1
Warin, R1
Arlotti, JA1
Bommareddy, A2
Kim, EJ1
Eom, SJ1
Hong, JE1
Lee, JY1
Choi, MS1
Park, JH1
Vogt, A1
Vogel, V1

Other Studies

22 other studies available for benzyl isothiocyanate and Breast Cancer

ArticleYear
Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate.
    Carcinogenesis, 2018, 02-09, Volume: 39, Issue:2

    Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Coculture Techniques; Female; Human

2018
AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:6

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Synergism; Female; F

2019
Role of Krüppel-like Factor 4-p21
    Cancer prevention research (Philadelphia, Pa.), 2019, Volume: 12, Issue:3

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Movement; Cyclin-Dependent Kinase Inhibitor p21; Female;

2019
Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.
    Molecular medicine reports, 2019, Volume: 20, Issue:2

    Topics: Animals; Apoptosis; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Cell Proliferation; Fe

2019
Dietary chemopreventative benzyl isothiocyanate inhibits breast cancer stem cells in vitro and in vivo.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; Diet; Epithelial-Mesenc

2013
Benzyl isothiocyanate: double trouble for breast cancer cells.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:8

    Topics: Animals; Apoptosis; Breast Neoplasms; Diet; Epithelial-Mesenchymal Transition; Female; Humans; Isoth

2013
The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate.
    Breast cancer research and treatment, 2015, Volume: 149, Issue:3

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Gen

2015
Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:5

    Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Breast Neoplasms;

2016
Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens.
    Oncotarget, 2016, Feb-23, Volume: 7, Issue:8

    Topics: Acetylation; Amines; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; DNA Adducts; Enzy

2016
Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate.
    Mitochondrion, 2016, Volume: 30

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Disease Models, Anima

2016
Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes.
    Scientific reports, 2017, 01-10, Volume: 7

    Topics: AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Hum

2017
Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.
    The Journal of biological chemistry, 2008, Oct-31, Volume: 283, Issue:44

    Topics: Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Catalase; Cell Line, Tumor; Cell

2008
Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.
    Oncology reports, 2009, Volume: 21, Issue:1

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Es

2009
Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate.
    Molecular carcinogenesis, 2010, Volume: 49, Issue:5

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Immunohistochemistry; In Situ Nick-End

2010
p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:6

    Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tum

2010
Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.
    Carcinogenesis, 2011, Volume: 32, Issue:3

    Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell

2011
Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:7

    Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cadherins; Cell Differentiation; Cell Movem

2011
Benzyl isothiocyanate inhibits basal and hepatocyte growth factor-stimulated migration of breast cancer cells.
    Molecular and cellular biochemistry, 2012, Volume: 359, Issue:1-2

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Hepatocyte Growth Factor; Humans

2012
Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Acetylation; Animals; Autophagy; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Forkhead Box

2012
Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration.
    Breast cancer research and treatment, 2012, Volume: 134, Issue:3

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Cell Move

2012
Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.
    Carcinogenesis, 2013, Volume: 34, Issue:4

    Topics: Animals; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Disease Progression; Epitheli

2013
Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:11

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Assoc

2006