benzyl isothiocyanate has been researched along with Breast Cancer in 22 studies
benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models." | 7.83 | Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. ( Baty, CJ; Croix, CS; Sehrawat, A; Singh, RP; Singh, SV; Tailor, D; Watkins, S, 2016) |
| "We showed previously that garden cress constituent benzyl isothiocyanate (BITC) inhibits self-renewal of breast cancer stem cells (bCSC) in vitro and in vivo." | 7.81 | The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. ( Kim, SH; Singh, SV, 2015) |
| "We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo." | 7.79 | Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. ( Kim, SH; Sehrawat, A; Singh, SV; Vogt, A, 2013) |
| "Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood." | 7.78 | Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. ( Bommareddy, A; Hahm, ER; Kim, SH; Sehrawat, A; Singh, SV; Xiao, D, 2012) |
| "Benzyl isothiocyanate (BITC) is a promising anticancer constituent of edible cruciferous vegetables with in vivo efficacy against chemically induced as well as oncogene-driven breast cancer in experimental rodents." | 7.78 | Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration. ( Kim, SH; Sehrawat, A; Singh, SV, 2012) |
| "Molecular effects of obesity, a well-established risk factor for breast cancer progression, are mediated by adipocytokine leptin." | 7.77 | Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. ( Kim, SH; Nagalingam, A; Saxena, NK; Sharma, D; Singh, SV, 2011) |
| "We showed previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) inhibits growth of cultured and xenografted human breast cancer cells and suppresses mammary cancer development in a transgenic mouse model." | 7.77 | Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. ( Sehrawat, A; Singh, SV, 2011) |
| "Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables such as garden cress, inhibits growth of human breast cancer cell lines in culture." | 7.76 | Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. ( Arlotti, JA; Bommareddy, A; Singh, SV; Warin, R; Xiao, D, 2010) |
| "We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood." | 7.76 | p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010) |
| "Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood." | 7.74 | Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. ( Powolny, AA; Singh, SV; Xiao, D, 2008) |
| "Chemoprevention of breast cancer is feasible with the use of non-toxic phytochemicals from edible and medicinal plants." | 5.43 | Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. ( Sehrawat, A; Singh, SV, 2016) |
| "The inhibition of breast cancer stem cells is observed at pharmacologic concentrations of BITC." | 5.39 | Benzyl isothiocyanate: double trouble for breast cancer cells. ( Rao, CV, 2013) |
| "Cancer chemoprevention by benzyl isothiocyanate (BITC), which is derived from cruciferous vegetables like garden cress, in a transgenic mouse model of breast cancer is associated with inhibition of breast cancer stem-like cells (bCSC), but the molecular regulators of this effect remain elusive." | 3.91 | Role of Krüppel-like Factor 4-p21 ( Kim, SH; Singh, SV, 2019) |
| "Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models." | 3.83 | Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. ( Baty, CJ; Croix, CS; Sehrawat, A; Singh, RP; Singh, SV; Tailor, D; Watkins, S, 2016) |
| "We showed previously that garden cress constituent benzyl isothiocyanate (BITC) inhibits self-renewal of breast cancer stem cells (bCSC) in vitro and in vivo." | 3.81 | The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. ( Kim, SH; Singh, SV, 2015) |
| "We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo." | 3.79 | Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. ( Kim, SH; Sehrawat, A; Singh, SV; Vogt, A, 2013) |
| "Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood." | 3.78 | Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. ( Bommareddy, A; Hahm, ER; Kim, SH; Sehrawat, A; Singh, SV; Xiao, D, 2012) |
| "Benzyl isothiocyanate (BITC) is a promising anticancer constituent of edible cruciferous vegetables with in vivo efficacy against chemically induced as well as oncogene-driven breast cancer in experimental rodents." | 3.78 | Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration. ( Kim, SH; Sehrawat, A; Singh, SV, 2012) |
| "Molecular effects of obesity, a well-established risk factor for breast cancer progression, are mediated by adipocytokine leptin." | 3.77 | Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. ( Kim, SH; Nagalingam, A; Saxena, NK; Sharma, D; Singh, SV, 2011) |
| "We showed previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) inhibits growth of cultured and xenografted human breast cancer cells and suppresses mammary cancer development in a transgenic mouse model." | 3.77 | Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. ( Sehrawat, A; Singh, SV, 2011) |
| "Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables such as garden cress, inhibits growth of human breast cancer cell lines in culture." | 3.76 | Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. ( Arlotti, JA; Bommareddy, A; Singh, SV; Warin, R; Xiao, D, 2010) |
| "We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood." | 3.76 | p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010) |
| "Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood." | 3.74 | Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. ( Powolny, AA; Singh, SV; Xiao, D, 2008) |
| "Benzyl isothiocyanate (BITC) has been reported to exhibit antitumor properties in various cancer types; however, the underlying mechanisms of its action remain unclear." | 1.51 | Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway. ( Chen, J; Fan, L; Fan, W; Fu, S; Guo, L; Lin, L; Liu, H; Wang, B; Wei, H; Xie, B; Zhao, L, 2019) |
| "Chemoprevention of breast cancer is feasible with the use of non-toxic phytochemicals from edible and medicinal plants." | 1.43 | Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. ( Sehrawat, A; Singh, SV, 2016) |
| "The inhibition of breast cancer stem cells is observed at pharmacologic concentrations of BITC." | 1.39 | Benzyl isothiocyanate: double trouble for breast cancer cells. ( Rao, CV, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 19 (86.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pore, SK | 1 |
| Hahm, ER | 3 |
| Latoche, JD | 1 |
| Anderson, CJ | 2 |
| Shuai, Y | 1 |
| Singh, SV | 16 |
| Roy, R | 1 |
| White, AG | 1 |
| Kim, SH | 8 |
| Xie, B | 2 |
| Zhao, L | 1 |
| Guo, L | 1 |
| Liu, H | 1 |
| Fu, S | 1 |
| Fan, W | 1 |
| Lin, L | 1 |
| Chen, J | 1 |
| Wang, B | 1 |
| Fan, L | 1 |
| Wei, H | 1 |
| Sehrawat, A | 7 |
| Rao, CV | 1 |
| Duval, R | 1 |
| Xu, X | 1 |
| Bui, LC | 1 |
| Mathieu, C | 1 |
| Petit, E | 1 |
| Cariou, K | 1 |
| Dodd, RH | 1 |
| Dupret, JM | 1 |
| Rodrigues-Lima, F | 1 |
| Croix, CS | 1 |
| Baty, CJ | 1 |
| Watkins, S | 1 |
| Tailor, D | 1 |
| Singh, RP | 1 |
| Nagalingam, A | 2 |
| Kuppusamy, P | 1 |
| Muniraj, N | 1 |
| Langford, P | 1 |
| Győrffy, B | 1 |
| Saxena, NK | 2 |
| Sharma, D | 2 |
| Xiao, D | 4 |
| Powolny, AA | 1 |
| Kang, L | 1 |
| Ding, L | 1 |
| Wang, ZY | 1 |
| Warin, R | 1 |
| Arlotti, JA | 1 |
| Bommareddy, A | 2 |
| Kim, EJ | 1 |
| Eom, SJ | 1 |
| Hong, JE | 1 |
| Lee, JY | 1 |
| Choi, MS | 1 |
| Park, JH | 1 |
| Vogt, A | 1 |
| Vogel, V | 1 |
22 other studies available for benzyl isothiocyanate and Breast Cancer
| Article | Year |
|---|---|
Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate.
Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Coculture Techniques; Female; Human | 2018 |
AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Synergism; Female; F | 2019 |
Role of Krüppel-like Factor 4-p21
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Movement; Cyclin-Dependent Kinase Inhibitor p21; Female; | 2019 |
Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.
Topics: Animals; Apoptosis; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Cell Proliferation; Fe | 2019 |
Dietary chemopreventative benzyl isothiocyanate inhibits breast cancer stem cells in vitro and in vivo.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; Diet; Epithelial-Mesenc | 2013 |
Benzyl isothiocyanate: double trouble for breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Diet; Epithelial-Mesenchymal Transition; Female; Humans; Isoth | 2013 |
The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Gen | 2015 |
Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Breast Neoplasms; | 2016 |
Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens.
Topics: Acetylation; Amines; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; DNA Adducts; Enzy | 2016 |
Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Disease Models, Anima | 2016 |
Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes.
Topics: AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Hum | 2017 |
Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Catalase; Cell Line, Tumor; Cell | 2008 |
Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Es | 2009 |
Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Immunohistochemistry; In Situ Nick-End | 2010 |
p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tum | 2010 |
Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell | 2011 |
Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cadherins; Cell Differentiation; Cell Movem | 2011 |
Benzyl isothiocyanate inhibits basal and hepatocyte growth factor-stimulated migration of breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Hepatocyte Growth Factor; Humans | 2012 |
Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells.
Topics: Acetylation; Animals; Autophagy; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Forkhead Box | 2012 |
Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Cell Move | 2012 |
Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Disease Progression; Epitheli | 2013 |
Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Assoc | 2006 |