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benzyl isothiocyanate and Adenocarcinoma

benzyl isothiocyanate has been researched along with Adenocarcinoma in 10 studies

benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood."7.76p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010)
"We have shown previously that cruciferous vegetable constituent benzyl isothiocyanate (BITC) suppresses viability of cultured MCF-7 and MDA-MB-231 human breast cancer cells and retards mammary cancer development in MMTV-neu mice by causing apoptosis, but the mechanism of cell death is not fully understood."3.76p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. ( Kim, SH; Singh, SV, 2010)
"It has previously been observed that allyl isothiocyanate, a compound naturally present in the diet, is more cytotoxic toward the human colorectal adenocarcinoma cell line HT29 in its control transformed state than after exposure to sodium butyrate or to dimethylformamide, which slow growth and induce differentiation (detransformation)."3.69Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29. ( Fyfe, D; Johnson, IT; Musk, SR; Smith, TK; Stening, P; Stephenson, P, 1995)
"Exposure of prostate cancer cells (LNCaP, 22Rv1, C4-2, and PC-3) to pharmacologically applicable concentrations of PEITC, benzyl isothiocyanate (BITC), and SFN (2."1.42CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. ( Amjad, AI; Chinni, SR; Parikh, R; Sakao, K; Singh, SV; Vyas, AR, 2015)
"Benzyl isothiocyanate (BITC) is an important compound found in plant food and has been shown to have anti-cancer effects on human cancer cells, but its effect on prostate cancer cells in vitro remains unknown."1.37The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway. ( Chiu, TH; Chueh, FS; Chung, JG; Huang, YT; Ji, BC; Liu, KC; Wu, PP; Yang, JL; Yang, JS, 2011)
"Using adenocarcinoma and metastatic pancreatic cancer cells, we investigated whether this dietary isothiocyanate induces apoptosis by converging two major pathways: the death receptor-mediated extrinsic and the mitochondrial intrinsic pathway."1.35Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation. ( Basu, A; Haldar, S, 2009)
" However, whereas it increased the number of aberrations four-fold, it was not able to raise SCE levels by more than 50% and there was a levelling-off in the dose-response curve."1.29Cytotoxic and clastogenic effects of benzyl isothiocyanate towards cultured mammalian cells. ( Astley, SB; Edwards, SM; Hubert, RB; Johnson, IT; Musk, SR; Stephenson, P, 1995)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Han, KWW1
Po, WW1
Sohn, UD1
Kim, HJ1
Sakao, K1
Vyas, AR1
Chinni, SR1
Amjad, AI1
Parikh, R1
Singh, SV2
Basu, A1
Haldar, S1
Kim, SH1
Liu, KC1
Huang, YT1
Wu, PP1
Ji, BC1
Yang, JS1
Yang, JL1
Chiu, TH1
Chueh, FS1
Chung, JG1
Kuroiwa, Y1
Nishikawa, A1
Kitamura, Y1
Kanki, K1
Ishii, Y1
Umemura, T1
Hirose, M1
Wattenberg, LW1
Musk, SR2
Astley, SB1
Edwards, SM1
Stephenson, P2
Hubert, RB1
Johnson, IT2
Smith, TK1
Stening, P1
Fyfe, D1
Kirlin, WG1
Cai, J1
Thompson, SA1
Diaz, D1
Kavanagh, TJ1
Jones, DP1

Other Studies

10 other studies available for benzyl isothiocyanate and Adenocarcinoma

ArticleYear
Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells.
    Biomolecules, 2019, 12-06, Volume: 9, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Biological Products; C

2019
CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:5

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Chemoprevention; Humans; Isothio

2015
Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.
    International journal of oncology, 2009, Volume: 35, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Prolifer

2009
p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:6

    Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tum

2010
The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway.
    International journal of oncology, 2011, Volume: 38, Issue:3

    Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Caspase

2011
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
    Cancer letters, 2006, Sep-28, Volume: 241, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Cell

2006
Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure.
    Cancer research, 1981, Volume: 41, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Benz(a)Anthracenes; Cyanates; Di

1981
Cytotoxic and clastogenic effects of benzyl isothiocyanate towards cultured mammalian cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Adenocarcinoma; Animals; Cell Survival; CHO Cells; Chromosome Aberrations; Colorectal Neoplasms; Cri

1995
Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29.
    Nutrition and cancer, 1995, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Allyl Compounds; Anticarcinogenic Agents; Butyrates; Butyric Acid; Cell Differentiat

1995
Glutathione redox potential in response to differentiation and enzyme inducers.
    Free radical biology & medicine, 1999, Volume: 27, Issue:11-12

    Topics: Adenocarcinoma; Butyrates; Cell Differentiation; Cell Size; Colonic Neoplasms; Enzyme Induction; Gen

1999