benztropine and Parkinsonian-Disorders

benztropine has been researched along with Parkinsonian-Disorders* in 7 studies

Trials

1 trial(s) available for benztropine and Parkinsonian-Disorders

Article	Year
Neuroleptic effects on autonomic activity in schizophrenia: between-group and within-subject paradigms and comparisons with controls. Schizophrenia bulletin, 2001, Volume: 27, Issue:3 Effects of fluphenazine on electrodermal activity (EDA) and heart rate (HR) were studied in patients with schizophrenia and normal control subjects during rest periods, presentation of innocuous tones, and a reaction time (RT) task. Two types of analyses were used: (1) between-group analyses-patients taking placebo were compared with patients taking fluphenazine and with control subjects using only data from the first test session; and (2) within-subject analyses-the same patients were tested when taking fluphenazine and when taking placebo. Results showed higher resting EDA and HR and smaller increments to task performance in placebo patients than in control subjects. Fluphenazine attenuated EDA levels but not the tonic response. Fluphenazine attenuated the HR response but did not affect HR level. Placebo patients were electrodermally hyporesponsive to the RT stimuli but not to simple tones. Fluphenazine markedly attenuated responsivity to simple tones but it attenuated responsivity less for RT stimuli. Testing medicated patients may thus produce misleading results with respect to many, but not all, purported autonomic markers of diagnosis in schizophrenia studies. Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Benztropine; Electrocardiography; Female; Fluphenazine; Heart Rate; Humans; Male; Parkinsonian Disorders; Reaction Time; Schizophrenia	2001

Article

Year

Neuroleptic effects on autonomic activity in schizophrenia: between-group and within-subject paradigms and comparisons with controls.

Schizophrenia bulletin, 2001, Volume: 27, Issue:3

Effects of fluphenazine on electrodermal activity (EDA) and heart rate (HR) were studied in patients with schizophrenia and normal control subjects during rest periods, presentation of innocuous tones, and a reaction time (RT) task. Two types of analyses were used: (1) between-group analyses-patients taking placebo were compared with patients taking fluphenazine and with control subjects using only data from the first test session; and (2) within-subject analyses-the same patients were tested when taking fluphenazine and when taking placebo. Results showed higher resting EDA and HR and smaller increments to task performance in placebo patients than in control subjects. Fluphenazine attenuated EDA levels but not the tonic response. Fluphenazine attenuated the HR response but did not affect HR level. Placebo patients were electrodermally hyporesponsive to the RT stimuli but not to simple tones. Fluphenazine markedly attenuated responsivity to simple tones but it attenuated responsivity less for RT stimuli. Testing medicated patients may thus produce misleading results with respect to many, but not all, purported autonomic markers of diagnosis in schizophrenia studies.

Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Benztropine; Electrocardiography; Female; Fluphenazine; Heart Rate; Humans; Male; Parkinsonian Disorders; Reaction Time; Schizophrenia

2001

Other Studies

6 other study(ies) available for benztropine and Parkinsonian-Disorders

Article	Year
[STUDY OF THE ACTION OF BENZTROPINE ON THE EXTRAPYRAMIDAL SYNDROME]. La Presse medicale, 1964, Jan-11, Volume: 72 Topics: Basal Ganglia Diseases; Benztropine; Parasympatholytics; Parkinsonian Disorders; Research	1964
[EXPERIMENTS WITH THE ANTI-PARKINSON AGENT BENZTROPINE RECENTLY INTRODUCED IN FRANCE]. Annales medico-psychologiques, 1963, Volume: 121 Topics: Benztropine; Dementia; France; Geriatrics; Mental Disorders; Parasympatholytics; Parkinsonian Disorders; Psychotic Disorders; Toxicology; Tranquilizing Agents	1963
[BENZTROPINE (COGENTIN) IN DRUG THERAPY OF THE PARKINSON SYNDROME]. Wiener klinische Wochenschrift, 1963, Dec-27, Volume: 75 Topics: Benztropine; Humans; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders	1963
[Cogentin, a medication with prolonged effect in parkinsonism]. Munchener medizinische Wochenschrift (1950), 1960, Apr-01, Volume: 102 Topics: Benztropine; Cardiovascular Agents; Muscle Relaxants, Central; Parkinsonian Disorders	1960
[Cogentin, a new preparation for treatment of parkinsonism; preliminary report]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1958, Apr-01, Volume: 78, Issue:7 Topics: Benztropine; Cardiovascular Agents; Muscle Relaxants, Central; Parkinson Disease; Parkinsonian Disorders	1958
[Benztropine methanesulfonate in the treatment of parkinsonism]. Prensa medica argentina, 1956, Dec-14, Volume: 43, Issue:50 Topics: Benztropine; Cardiovascular Agents; Mesylates; Muscle Relaxants, Central; Parkinson Disease; Parkinsonian Disorders	1956