benztropine and Intellectual-Disability

benztropine has been researched along with Intellectual-Disability* in 5 studies

Trials

2 trial(s) available for benztropine and Intellectual-Disability

Article	Year
Efficacy of benztropine therapy for drooling. Developmental medicine and child neurology, 1989, Volume: 31, Issue:3 This study assessed the efficacy of synthetic anticholinergic benztropine and incidence of side-effects in 20 developmentally-disabled patients with severe drooling. The double-blind, placebo-controlled, crossover protocol included one-week baseline, two-week placebo and two-week benztropine conditions (mean dose 3.8 mg). A significant decrease in drooling during the benztropine condition relative to placebo was demonstrated and conservative response rates (calculated by deleting placebo responders), ranged up to 65 to 70 per cent. For patients completing the protocol the incidence of side-effects did not differ across conditions and minor problems such as a dry mouth were eliminated by small dose adjustments. More serious cholinergic side-effects, which resolved within 24 to 48 hours, necessitated discontinuation of the drug in three patients. This study demonstrates that synthetic anticholinergics can provide an important therapeutic alternative to surgical and behavioral therapies for drooling. Topics: Adolescent; Adult; Benztropine; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intellectual Disability; Male; Sialorrhea; Tropanes	1989
Safety and effectiveness of haloperidol for mentally retarded behaviorally disordered and hyperkinetic patients. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:11 Topics: Adolescent; Adult; Affective Symptoms; Aged; Benztropine; Child; Clinical Trials as Topic; Female; Haloperidol; Humans; Hyperkinesis; Intellectual Disability; Male; Middle Aged	1973

Article

Year

Efficacy of benztropine therapy for drooling.

Developmental medicine and child neurology, 1989, Volume: 31, Issue:3

This study assessed the efficacy of synthetic anticholinergic benztropine and incidence of side-effects in 20 developmentally-disabled patients with severe drooling. The double-blind, placebo-controlled, crossover protocol included one-week baseline, two-week placebo and two-week benztropine conditions (mean dose 3.8 mg). A significant decrease in drooling during the benztropine condition relative to placebo was demonstrated and conservative response rates (calculated by deleting placebo responders), ranged up to 65 to 70 per cent. For patients completing the protocol the incidence of side-effects did not differ across conditions and minor problems such as a dry mouth were eliminated by small dose adjustments. More serious cholinergic side-effects, which resolved within 24 to 48 hours, necessitated discontinuation of the drug in three patients. This study demonstrates that synthetic anticholinergics can provide an important therapeutic alternative to surgical and behavioral therapies for drooling.

Topics: Adolescent; Adult; Benztropine; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intellectual Disability; Male; Sialorrhea; Tropanes

1989

Safety and effectiveness of haloperidol for mentally retarded behaviorally disordered and hyperkinetic patients.

Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:11

Topics: Adolescent; Adult; Affective Symptoms; Aged; Benztropine; Child; Clinical Trials as Topic; Female; Haloperidol; Humans; Hyperkinesis; Intellectual Disability; Male; Middle Aged

1973

Other Studies

3 other study(ies) available for benztropine and Intellectual-Disability

Article	Year
Neuroleptic malignant syndrome with the addition of aripiprazole to olanzapine. The American journal of psychiatry, 2008, Volume: 165, Issue:11 Topics: Adult; Aggression; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Benztropine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Intellectual Disability; Male; Neuroleptic Malignant Syndrome; Neurologic Examination; Olanzapine; Piperazines; Quinolones; Risk Factors	2008
Management of akathisia in a severely retarded adolescent male with help of an anticholinergic drug assay. Lancet (London, England), 1981, Aug-22, Volume: 2, Issue:8243 Topics: Adolescent; Akathisia, Drug-Induced; Benztropine; Diagnosis, Differential; Dyskinesia, Drug-Induced; Humans; Intellectual Disability; Male; Psychomotor Agitation; Tropanes	1981
An unusual case of akathisia. The American journal of psychiatry, 1979, Volume: 136, Issue:8 Topics: Adult; Aggression; Akathisia, Drug-Induced; Benztropine; Humans; Intellectual Disability; Male; Psychomotor Agitation; Thioridazine	1979