benztropine and Diabetes-Mellitus--Type-2

The neutral amino acid transporter B. A CHO-based cell line was generated, stably expressing collectrin and B. We characterized a series of novel inhibitors of the B. The tools established in this study can be widely used to identify new transport inhibitors. Using these tools, we were able to identify compounds that can be used to study epithelial transport, to induce protein restriction, or be developed further through medicinal chemistry.

Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Benztropine; CHO Cells; Cricetulus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drosophila; Female; High-Throughput Screening Assays; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Structure-Activity Relationship