benzoylecgonine and Cardiomyopathies

benzoylecgonine has been researched along with Cardiomyopathies* in 2 studies

Other Studies

2 other study(ies) available for benzoylecgonine and Cardiomyopathies

Article	Year
Molecular characteristics of cocaine-induced cardiomyopathy in rats. European journal of pharmacology, 1997, Nov-05, Volume: 338, Issue:2 Cocaine abuse induces severe cardiomyopathy. To investigate the molecular effects of acute and prolonged administration of cocaine, mRNAs encoding markers of either mechanical overload, as atrial natriuretic factor (ANF) and alpha- and beta-myosin heavy chains, or fibrosis as type I and III procollagens, were quantitated in the left ventricle of rats 4 h after one injection of cocaine (40 mg/kg, n = 7), or 14 (n = 15) and 28 days (n = 10) after chronic infusion of cocaine (40 mg/kg per day). Plasma cocaine and benzylecgonine concentrations were both significantly augmented during the infusion while plasma levels of triiodothyronine and thyroxine were lowered. Acute injection of cocaine induced ANF gene expression. Cocaine treatment during 28 days resulted in left ventricular hypertrophy (+ 20% after 24 days, P < 0.05) with normal blood pressure, associated with an accumulation of mRNAs encoding ANF and type I and III collagens (+66% and +55%, P < 0.05). Such a chronic treatment also induced a shift from the alpha- to the beta-myosin heavy chain gene expression (-40% and +50%, P < 0.05). In conclusion, cocaine activates markers of both hemodynamic overload and fibrosis. Such an activation may result from direct and/or indirect effects of the drug such as myocardial ischemia, mechanical overload and/or hypothyroidism. Topics: Animals; Atrial Natriuretic Factor; Blotting, Northern; Cardiomyopathies; Cocaine; Collagen; Hemodynamics; Hormones; Male; Myocardium; Myosin Heavy Chains; Narcotics; Rats; Rats, Sprague-Dawley; RNA, Messenger	1997
Sudden death from acute cocaine intoxication in Virginia in 1988. The American journal of psychiatry, 1990, Volume: 147, Issue:12 A review of medical examiners' autopsy records revealed that in 1988, 33 residents of Virginia died of acute cocaine intoxication. The subjects were 19 to 45 years old; most were men, used cocaine intravenously, and used other toxic substances with the lethal dose of cocaine. Topics: Cardiomyopathies; Cocaine; Coronary Disease; Death, Sudden; Ethanol; Female; Heart; Humans; Male; Organ Size; Poisoning; Sex Factors; Substance-Related Disorders; Virginia	1990

Article

Year

Molecular characteristics of cocaine-induced cardiomyopathy in rats.

European journal of pharmacology, 1997, Nov-05, Volume: 338, Issue:2

Cocaine abuse induces severe cardiomyopathy. To investigate the molecular effects of acute and prolonged administration of cocaine, mRNAs encoding markers of either mechanical overload, as atrial natriuretic factor (ANF) and alpha- and beta-myosin heavy chains, or fibrosis as type I and III procollagens, were quantitated in the left ventricle of rats 4 h after one injection of cocaine (40 mg/kg, n = 7), or 14 (n = 15) and 28 days (n = 10) after chronic infusion of cocaine (40 mg/kg per day). Plasma cocaine and benzylecgonine concentrations were both significantly augmented during the infusion while plasma levels of triiodothyronine and thyroxine were lowered. Acute injection of cocaine induced ANF gene expression. Cocaine treatment during 28 days resulted in left ventricular hypertrophy (+ 20% after 24 days, P < 0.05) with normal blood pressure, associated with an accumulation of mRNAs encoding ANF and type I and III collagens (+66% and +55%, P < 0.05). Such a chronic treatment also induced a shift from the alpha- to the beta-myosin heavy chain gene expression (-40% and +50%, P < 0.05). In conclusion, cocaine activates markers of both hemodynamic overload and fibrosis. Such an activation may result from direct and/or indirect effects of the drug such as myocardial ischemia, mechanical overload and/or hypothyroidism.

Topics: Animals; Atrial Natriuretic Factor; Blotting, Northern; Cardiomyopathies; Cocaine; Collagen; Hemodynamics; Hormones; Male; Myocardium; Myosin Heavy Chains; Narcotics; Rats; Rats, Sprague-Dawley; RNA, Messenger

1997

Sudden death from acute cocaine intoxication in Virginia in 1988.

The American journal of psychiatry, 1990, Volume: 147, Issue:12

A review of medical examiners' autopsy records revealed that in 1988, 33 residents of Virginia died of acute cocaine intoxication. The subjects were 19 to 45 years old; most were men, used cocaine intravenously, and used other toxic substances with the lethal dose of cocaine.

Topics: Cardiomyopathies; Cocaine; Coronary Disease; Death, Sudden; Ethanol; Female; Heart; Humans; Male; Organ Size; Poisoning; Sex Factors; Substance-Related Disorders; Virginia

1990