benzoylecgonine has been researched along with Carcinoma--Hepatocellular* in 1 studies
1 other study(ies) available for benzoylecgonine and Carcinoma--Hepatocellular
| Article | Year |
|---|---|
Response of the human hepatic tissue cultures Hep-G2 and WRL-68 to cocaine.
The hydrolytic metabolism of cocaine into benzoylecgonine, ecgonine methyl ester, and ecgonine was studied in the human hepatoma cell line Hep-G2 and in the nontumorigenic fetal hepatic cell line WRL-68. Also, the toxicological response of these cells to cocaine was compared to previously published results obtained with perfused liver cells and in vivo systems. Our experiments indicated that Hep-G2 appear to have similar metabolic and toxicological patterns to in vivo and perfused cell systems. The WRL-68 tissue culture system was found to be less similar. These results suggest Hep-G2 cells can be utilized to study cocaine metabolism and toxicology, and possibly in studies involving other xenobiotic compounds. Topics: Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line; Chromatography, Gas; Cocaine; Humans; Liver; Mass Spectrometry; Tumor Cells, Cultured | 1995 |