Page last updated: 2024-08-21

benzoxazoles and Muscular Dystrophy, Duchenne

benzoxazoles has been researched along with Muscular Dystrophy, Duchenne in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Chatzopoulou, M; Claridge, TDW; Davies, KE; Davies, SG; Elsey, DJ; Emer, E; Fletcher, AM; Harriman, S; Robinson, N; Rowley, JA; Russell, AJ; Tinsley, JM; Weaver, R; Wilkinson, IVL; Willis, NJ; Wilson, FX; Wynne, GM1
Burch, P; Charles, PD; Chatzopoulou, M; Davies, KE; Davies, SG; Dugdale, H; Geese, M; Lomow, A; Mohammed, S; Moir, L; Monecke, S; Perkins, KJ; Rastinejad, F; Russell, AJ; Squire, SE; Tinsley, JM; Vuorinen, A; Wilkinson, IVL; Wilson, FX; Wynne, GM1
Babbs, A; Berg, A; Chatzopoulou, M; Davies, KE; Davies, SG; Edwards, B; Elsey, DJ; Emer, E; Guiraud, S; Harriman, S; Lecci, C; Moir, L; Peters, D; Robinson, N; Rowley, JA; Russell, AJ; Squire, SE; Tinsley, JM; Wilson, FX; Wynne, GM1
Davies, KE; Harriman, S; Hughes, I; Layton, G; Muntoni, F; Roper, H; Spinty, S; Tejura, B; Tinsley, J1
Davies, KE; Robinson, N; Tinsley, J1
Blat, S; Blat, Y1
Davies, K; Hughes, I; Layton, G; Muntoni, F; Ricotti, V; Robinson, N; Roper, H; Spinty, S; Tejura, B; Tinsley, J1
Chancellor, DR; Davies, KE; De Moor, O; Dorgan, CR; Johnson, PD; Lambert, AG; Lawrence, D; Lecci, C; Maillol, C; Middleton, PJ; Nugent, G; Poignant, SD; Potter, AC; Price, PD; Pye, RJ; Storer, R; Tinsley, JM; van Well, R; Vickers, R; Vile, J; Wilkes, FJ; Wilson, FX; Wren, SP; Wynne, GM1

Reviews

1 review(s) available for benzoxazoles and Muscular Dystrophy, Duchenne

ArticleYear
Drug Discovery of Therapies for Duchenne Muscular Dystrophy.
    Journal of biomolecular screening, 2015, Volume: 20, Issue:10

    Topics: Animals; Antioxidants; Benzoxazoles; Calcium; Disease Models, Animal; Drug Discovery; Dystrophin; Gene Expression; Humans; Muscular Dystrophy, Duchenne; Oxadiazoles

2015

Trials

3 trial(s) available for benzoxazoles and Muscular Dystrophy, Duchenne

ArticleYear
A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet.
    Clinical pharmacology in drug development, 2019, Volume: 8, Issue:7

    Topics: Administration, Oral; Adolescent; Benzoxazoles; Child; Diet; Double-Blind Method; Drug Administration Schedule; Humans; Male; Muscular Dystrophy, Duchenne; Suspensions; Utrophin

2019
Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers.
    Journal of clinical pharmacology, 2015, Volume: 55, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Arginine; Benzothiazoles; Benzoxazoles; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Half-Life; Healthy Volunteers; Humans; Male; Middle Aged; Muscular Dystrophy, Duchenne; No-Observed-Adverse-Effect Level; Utrophin; Young Adult

2015
Safety, Tolerability, and Pharmacokinetics of SMT C1100, a 2-Arylbenzoxazole Utrophin Modulator, following Single- and Multiple-Dose Administration to Pediatric Patients with Duchenne Muscular Dystrophy.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Benzoxazoles; Child; Child, Preschool; Humans; Male; Muscular Dystrophy, Duchenne; Utrophin

2016

Other Studies

4 other study(ies) available for benzoxazoles and Muscular Dystrophy, Duchenne

ArticleYear
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-
    Journal of medicinal chemistry, 2020, 03-12, Volume: 63, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoxazoles; Humans; Liver; Metabolic Networks and Pathways; Metabolome; Mice; Muscular Dystrophy, Duchenne; Naphthalenes; Naphthols; Rats; Stereoisomerism; Utrophin

2020
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
    Angewandte Chemie (International ed. in English), 2020, 02-03, Volume: 59, Issue:6

    Topics: Animals; Benzoxazoles; Cycloaddition Reaction; Drug Design; Humans; Kinetics; Mice; Molecular Probes; Muscular Dystrophy, Duchenne; Myoblasts; Naphthalenes; Protein Binding; Proteomics; Receptors, Aryl Hydrocarbon; Up-Regulation; Utrophin

2020
2-Arylbenzo[
    Journal of medicinal chemistry, 2020, 07-23, Volume: 63, Issue:14

    Topics: Animals; Benzoxazoles; Escherichia coli; Mice, Inbred mdx; Molecular Structure; Muscular Dystrophy, Duchenne; Mutagenicity Tests; Rats; Salmonella typhimurium; Stereoisomerism; Structure-Activity Relationship; Up-Regulation; Utrophin

2020
Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Animals; Benzoxazoles; Cell Line; Mice; Muscular Dystrophy, Duchenne; Naphthalenes; Structure-Activity Relationship; Up-Regulation; Utrophin

2011
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