benzothiazide has been researched along with Koch's Disease in 28 studies
benzothiazide: structure
benzthiazide : 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show that treatment of M." | 5.42 | The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. ( Abramovitch, RB; Champion, PA; Colvin, CJ; Johnson, BK; Mba Medie, F; Needle, DB, 2015) |
| "Mycobacterium tuberculosis is one of the worlds' most successful and sophisticated pathogens." | 2.44 | Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection. ( Lin, MY; Ottenhoff, TH, 2008) |
| "We show that treatment of M." | 1.42 | The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. ( Abramovitch, RB; Champion, PA; Colvin, CJ; Johnson, BK; Mba Medie, F; Needle, DB, 2015) |
| "Mycobacterium tuberculosis is the causative agent of tuberculosis, killing millions of people every year." | 1.40 | The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence. ( Butler-Wu, S; Darwin, KH; Festa, RA; Ioerger, TR; Sacchettini, JC; Samanovic, MI; Shi, X, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 16 (57.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Saini, V | 1 |
| Chinta, KC | 1 |
| Reddy, VP | 1 |
| Glasgow, JN | 1 |
| Stein, A | 1 |
| Lamprecht, DA | 1 |
| Rahman, MA | 1 |
| Mackenzie, JS | 1 |
| Truebody, BE | 1 |
| Adamson, JH | 1 |
| Kunota, TTR | 1 |
| Bailey, SM | 1 |
| Moellering, DR | 1 |
| Lancaster, JR | 1 |
| Steyn, AJC | 1 |
| Shanmuga Priya, VG | 1 |
| Bhandare, V | 1 |
| Muddapur, UM | 1 |
| Swaminathan, P | 1 |
| Fandilolu, PM | 1 |
| Sonawane, KD | 1 |
| Pandey, K | 1 |
| Singh, S | 2 |
| Bhatt, P | 1 |
| Sharma, M | 1 |
| Chaudhry, A | 1 |
| Sharma, S | 2 |
| Gaudion, A | 1 |
| Dawson, L | 1 |
| Davis, E | 1 |
| Smollett, K | 1 |
| Saraav, I | 1 |
| Shi, X | 1 |
| Festa, RA | 1 |
| Ioerger, TR | 1 |
| Butler-Wu, S | 1 |
| Sacchettini, JC | 1 |
| Darwin, KH | 1 |
| Samanovic, MI | 1 |
| Rustad, TR | 1 |
| Minch, KJ | 1 |
| Ma, S | 1 |
| Winkler, JK | 1 |
| Hobbs, S | 1 |
| Hickey, M | 1 |
| Brabant, W | 1 |
| Turkarslan, S | 1 |
| Price, ND | 1 |
| Baliga, NS | 1 |
| Sherman, DR | 2 |
| Mehra, S | 3 |
| Foreman, TW | 2 |
| Didier, PJ | 1 |
| Ahsan, MH | 1 |
| Hudock, TA | 2 |
| Kissee, R | 1 |
| Golden, NA | 2 |
| Gautam, US | 3 |
| Johnson, AM | 1 |
| Alvarez, X | 2 |
| Russell-Lodrigue, KE | 1 |
| Doyle, LA | 1 |
| Roy, CJ | 1 |
| Niu, T | 2 |
| Blanchard, JL | 1 |
| Khader, SA | 1 |
| Lackner, AA | 2 |
| Kaushal, D | 3 |
| Voskuil, MI | 3 |
| Schlesinger, LS | 1 |
| Johnson, BK | 1 |
| Colvin, CJ | 1 |
| Needle, DB | 1 |
| Mba Medie, F | 1 |
| Champion, PA | 1 |
| Abramovitch, RB | 1 |
| Veatch, AV | 2 |
| Caskey, J | 1 |
| McGillivray, A | 1 |
| Subramanian, R | 1 |
| Kousoulas, KG | 1 |
| Domenech, P | 1 |
| Zou, J | 1 |
| Averback, A | 1 |
| Syed, N | 1 |
| Curtis, D | 1 |
| Donato, S | 1 |
| Reed, MB | 2 |
| Bandyopadhyay, N | 1 |
| LoBato, DN | 1 |
| Gentry, KM | 1 |
| Cavigli, A | 1 |
| Mueller, M | 1 |
| Hwang, SA | 1 |
| Hunter, RL | 1 |
| Bader, JS | 1 |
| Lin, MY | 3 |
| Ottenhoff, TH | 4 |
| Black, GF | 1 |
| Thiel, BA | 1 |
| Ota, MO | 1 |
| Parida, SK | 1 |
| Adegbola, R | 1 |
| Boom, WH | 1 |
| Dockrell, HM | 2 |
| Franken, KL | 3 |
| Friggen, AH | 2 |
| Hill, PC | 1 |
| Klein, MR | 4 |
| Lalor, MK | 1 |
| Mayanja, H | 1 |
| Schoolnik, G | 1 |
| Stanley, K | 1 |
| Weldingh, K | 1 |
| Kaufmann, SH | 1 |
| Walzl, G | 1 |
| Bartek, IL | 1 |
| Rutherford, R | 1 |
| Gruppo, V | 1 |
| Morton, RA | 1 |
| Morris, RP | 1 |
| Visconti, KC | 1 |
| Ryan, GJ | 1 |
| Schoolnik, GK | 2 |
| Lenaerts, A | 1 |
| Majumdar, SD | 1 |
| Sharma, D | 1 |
| Vashist, A | 1 |
| Kaur, K | 1 |
| Taneja, NK | 1 |
| Chauhan, S | 1 |
| Challu, VK | 1 |
| Ramanathan, VD | 1 |
| Balasangameshwara, V | 1 |
| Kumar, P | 1 |
| Tyagi, JS | 1 |
| Flores Valdez, MA | 1 |
| Isaza, JP | 1 |
| Duque, C | 1 |
| Gomez, V | 1 |
| Robledo, J | 1 |
| Barrera, LF | 1 |
| Alzate, JF | 1 |
| Lee, JH | 1 |
| Ammerman, NC | 1 |
| Nolan, S | 1 |
| Geiman, DE | 1 |
| Lun, S | 1 |
| Guo, H | 1 |
| Bishai, WR | 2 |
| Hegde, SR | 1 |
| Rajasingh, H | 1 |
| Das, C | 1 |
| Mande, SS | 1 |
| Mande, SC | 1 |
| Parish, T | 1 |
| Smith, DA | 1 |
| Roberts, G | 1 |
| Betts, J | 1 |
| Stoker, NG | 1 |
| Ohno, H | 1 |
| Zhu, G | 1 |
| Mohan, VP | 1 |
| Chu, D | 1 |
| Kohno, S | 1 |
| Jacobs, WR | 1 |
| Chan, J | 1 |
| Sun, R | 1 |
| Converse, PJ | 1 |
| Ko, C | 1 |
| Tyagi, S | 1 |
| Morrison, NE | 1 |
| Roupie, V | 1 |
| Romano, M | 1 |
| Zhang, L | 1 |
| Korf, H | 1 |
| Huygen, K | 2 |
| Gagneux, S | 1 |
| Deriemer, K | 1 |
| Small, PM | 1 |
| Barry, CE | 1 |
| Geluk, A | 1 |
| Smith, SG | 1 |
| Stewart, AL | 1 |
| Verduyn, MJ | 1 |
| van Meijgaarden, KE | 1 |
| Shiloh, MU | 1 |
| Manzanillo, P | 1 |
| Cox, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of Immune Responses in Treatment-induced Latency in Pulmonary Tuberculosis[NCT01154959] | Phase 3 | 120 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for benzothiazide and Koch's Disease
| Article | Year |
|---|---|
Immunogenic potential of latency associated antigens against Mycobacterium tuberculosis.
Topics: Animals; Antigens, Bacterial; Bacterial Proteins; DNA-Binding Proteins; Humans; Latent Tuberculosis; | 2014 |
Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection.
Topics: Animals; Antitubercular Agents; Genome; Host-Pathogen Interactions; Humans; Immunity, Cellular; Myco | 2008 |
26 other studies available for benzothiazide and Koch's Disease
| Article | Year |
|---|---|
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis.
Topics: Animals; Copper; Cystathionine beta-Synthase; Cytokines; Disease Models, Animal; Electron Transport | 2020 |
Molecular modeling approach to identify inhibitors of Rv2004c (rough morphology and virulent strain gene), a DosR (dormancy survival regulator) regulon protein from
Topics: Bacterial Proteins; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacteri | 2022 |
DosR proteins of Mycobacterium tuberculosis upregulate effector T cells and down regulate T regulatory cells in TB patients and their healthy contacts.
Topics: Antigens, Bacterial; Bacterial Proteins; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyt | 2019 |
Characterisation of the Mycobacterium tuberculosis alternative sigma factor SigG: its operon and regulon.
Topics: Animals; Base Sequence; Cells, Cultured; DNA Damage; Female; Gene Expression Profiling; Gene Express | 2013 |
The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.
Topics: Animals; Copper; Disease Models, Animal; Female; Gene Expression Regulation, Bacterial; Gene Knockou | 2014 |
Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network.
Topics: Cloning, Molecular; Gene Expression Regulation, Bacterial; Gene Regulatory Networks; Humans; Isoniaz | 2014 |
The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.
Topics: Animals; Bacterial Proteins; Disease Models, Animal; DNA-Binding Proteins; Hypoxia; Macaca mulatta; | 2015 |
Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease.
Topics: Animals; Bacterial Proteins; Hypoxia; Mycobacterium tuberculosis; Protein Kinases; Regulon; Tubercul | 2015 |
The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.
Topics: Animals; Antigens, Bacterial; Bacterial Proteins; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases | 2015 |
Sequencing-relative to hybridization-based transcriptomics approaches better define Mycobacterium tuberculosis stress-response regulons.
Topics: Bacterial Proteins; Diamide; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regula | 2016 |
Unique Regulation of the DosR Regulon in the Beijing Lineage of Mycobacterium tuberculosis.
Topics: Animals; Bacterial Proteins; Beijing; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; L | 2017 |
Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis.
Topics: Anaerobiosis; Animals; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bact | 2017 |
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
Topics: Adolescent; Adult; Aged; Antigens, Bacterial; Bacterial Proteins; Cells, Cultured; Child; DNA-Bindin | 2009 |
The DosR regulon of M. tuberculosis and antibacterial tolerance.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Disease Models, Animal; DNA-Binding Proteins; Dr | 2009 |
Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis.
Topics: Adaptation, Physiological; Anaerobiosis; Animals; Bacterial Proteins; Cell Line; Gene Expression Reg | 2010 |
DosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions.
Topics: BCG Vaccine; Gene Expression Regulation, Bacterial; Humans; Lymphocyte Activation; Mycobacterium tub | 2010 |
Whole genome shotgun sequencing of one Colombian clinical isolate of Mycobacterium tuberculosis reveals DosR regulon gene deletions.
Topics: Adult; Bacterial Proteins; Colombia; DNA-Binding Proteins; Gene Deletion; Genes, Bacterial; Genome, | 2012 |
Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Catalase; Drug Resistance, Multiple, Bacterial; | 2012 |
Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling.
Topics: Cell Communication; Computational Biology; Gene Regulatory Networks; Genome, Bacterial; Latent Tuber | 2012 |
The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence.
Topics: Animals; Bacterial Proteins; Cell Line; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, | 2003 |
The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis.
Topics: Animals; Female; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Hypoxia; | 2003 |
Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set.
Topics: Animals; Bacterial Proteins; Cell Line; Colony Count, Microbial; Consensus Sequence; Disease Models, | 2004 |
Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice.
Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Epitope Mapping; Epitopes, B-Lymphocyte; Epitop | 2007 |
The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated.
Topics: Animals; China; DNA Primers; Gene Expression Regulation, Bacterial; Glycolipids; Humans; Mice; Mycob | 2007 |
Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.
Topics: Adolescent; Adult; Animals; Antigens, Bacterial; Bacterial Proteins; BCG Vaccine; Cattle; Female; Hu | 2007 |
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
Topics: Animals; Carbon Monoxide; Cells, Cultured; Gene Expression Regulation, Bacterial; Heme Oxygenase-1; | 2008 |