benzonidazole has been researched along with Disease Models, Animal in 85 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (17.65) | 29.6817 |
| 2010's | 54 (63.53) | 24.3611 |
| 2020's | 16 (18.82) | 2.80 |
| Authors | Studies |
|---|---|
| Batista, R; Chiari, E; de Oliveira, AB; Humberto, JL | 1 |
| Arredondo, C; Basombrío, MA; Boiani, L; Boiani, M; Cerecetto, H; Davies, C; Gerpe, A; González, M; Merlino, A; Pacheco, JP; Porcal, W | 1 |
| Alves Lima, FC; Ferreira da Silva, AB; Gutierrez, FR; Nogueira Silva, JJ; Pavanelli, WR; Santana Silva, J; Wagner Franco, D | 1 |
| Abbott, MJ; Alexander, PW; Armstrong, T; Berven, B; Best, WM; Botero, A; Chaplin, JH; Charman, SA; Chatelain, E; Keenan, M; Kerfoot, M; Khong, A; McManus, JD; Morizzi, J; Nguyen, T; Ryan, E; Scandale, I; Thompson, RA; von Geldern, TW; Wang, SZ; White, KL | 1 |
| de Simone, CA; dos Santos Filho, JM; Ferreira, RS; Guimarães, ET; McKerrow, JH; Meira, CS; Moreira, DR; Soares, MB | 1 |
| Albelda, MT; Arrebola-Vargas, F; Blasco, S; Clares, MP; García-España, E; Gutiérrez-Sánchez, R; Marín, C; Olmo, F; Sánchez-Moreno, M; Soriano, C | 1 |
| Abbott, MJ; Alexander, PW; Best, WM; Botero, A; Campbell, M; Chaplin, JH; Charman, SA; Chatelain, E; Chiu, FC; Cornwall, S; Keenan, M; Khong, A; Koltun, M; Morizzi, J; Perez, C; Ryan, E; Scandale, I; Shackleford, DM; Thompson, RA; von Geldern, TW; White, KL | 1 |
| Alvarez-Manzaneda, EJ; Chahboun, R; Chayboun, I; Guardia, JJ; Marin, C; Messouri, I; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K | 1 |
| Battistuzzi, G; Giannini, G | 1 |
| Battistuzzi, G; Giannini, G; Vignola, D | 1 |
| Aguilar-Suárez, R; Correa-Basurto, J; Galindo-Sevilla, N; Hernández-Luis, F; Márquez-Navarro, A; Mendoza-Martínez, C; Montero-Cortes, MD; Nieto-Meneses, R; Nogueda-Torres, B; Rodriguez-Lezama, A; Rojas-Rojas, Á; Suárez-Contreras, E | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Azqueta, A; Cirauqui, N; Jimenez-Lopez, M; Jiménez-Montes, C; López de Ceráin, A; Marín, C; Martín-Escolano, R; Martin-Montes, A; Moreno-Viguri, E; Pérez-Silanes, S; Sánchez-Moreno, M; Santivañez-Veliz, M; Zamora Ledesma, S | 1 |
| Batista, DDGJ; Caljon, G; da Silva, CF; Hulpia, F; Lin, C; Maes, L; Soeiro, MNC; Van Calenbergh, S; Van Hecke, K | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Ang, CW; Avery, VM; Bernhardt, PV; Blaskovich, MAT; Bolisetti, R; Cooper, MA; Francisco, AF; Franzblau, SG; Hinton, AO; Jackson, CJ; Kelly, JM; Lee, BM; Sykes, ML; Tan, L; Wang, Y; West, NP | 1 |
| Barbosa, C; Carrillo, I; Castillo, C; Díaz-Araya, G; Fuentes-Retamal, S; González-Herrera, F; Guzmán-Rivera, D; Kemmerling, U; Machado, FS; Maya, JD; Quintero, H; Rabelo, RAN; Rates, M | 1 |
| Cevey, ÁC; Goren, NB; Mascolo, PD; Mirkin, GA; Penas, FN; Pieralisi, AV; Sequeyra, AS | 1 |
| Brancaglion, GA; Caldas, IS; Caldas, S; Carvalho, DT; Diniz, LF; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, RRG; Silva, LS; Vilas-Boas, DF | 1 |
| Barbosa, JMC; Cascabulho, CM; Daliry, A; de Melo, TG; de Oliveira, G; Pedra Rezende, Y; Pereira, ENGDS; Salem, KS | 1 |
| Almeida, IC; Begum, K; Cardenas-Ovando, RA; Fernández-Figueroa, EA; Iandra da Silva Ferreira, B; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Roy, S; Silva Grijó Farani, P; Vilar-Pereira, G | 1 |
| Branquinho, RT; de Assis, G; de Lana, M; de Oliveira, MT; Gonçalves, MF; Milagre, MM; Reis, L; Saúde-Guimarães, DA | 1 |
| Aviles, AS; Carneiro, CM; Cunha, LM; da Silva Fonseca, K; de Abreu Vieira, PM; Molina, I; Perin, L | 1 |
| Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU | 1 |
| Cascabulho, CM; Castro, SL; Demarque, KC; Duque, TLA; Guimarães, ACR; Manso, PPA; Menna-Barreto, RF; Meuser-Batista, M; Moura, KCG; Oliveira, GM; Pelajo-Machado, M; Pinto, MDC | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Micheloud, JF; Negrette, OS; Parada, LA; Ragone, PG; Simonazzi, A | 1 |
| Caldas, IS; Diniz, LF; Gonçalves, RV; Gonçalves-Santos, E; González-Lozano, KJ; Mendonça, AAS; Novaes, RD; Souza-Silva, TG | 1 |
| Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D | 1 |
| Búa, J; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Seremeta, KP | 1 |
| Engman, DM; Falk, BA; Li, X; Martinez, SJ; Olson, CL; Romano, PS; Scariot, DB; Scott, EA; Yi, S | 1 |
| Carneiro, CM; Corrêa-Oliveira, R; Fonseca Murta, SM; Molina, I; Sales Junior, PA; Salvador, F; Sánchez-Montalvá, A | 1 |
| Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC | 1 |
| Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML | 1 |
| Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Martinelli, M; Ponce, NE; Sanmarco, LM | 1 |
| Batlle, A; Demaria, A; Frank, FM; Lombardo, ME; Puente, V | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Menezes, APJ; Nascimento, ÁFDSD; Novaes, RD | 1 |
| Chin, CM; da Rosa, JA; de Andrade, CR; Dos Santos, JL; Scarim, CB | 1 |
| Bezerra, FS; Costa, GP; Figueiredo, VP; Horta, AL; Leite, ALJ; Menezes, APJ; Pedrosa, TCF; Ramos, CO; Talvani, A; Vieira, PMA | 1 |
| Bastos, TM; Efstathiou, A; Gaboriaud-Kolar, N; Meira, CS; Rocha, VPC; Skaltsounis, AL; Smirlis, D; Soares, MBP; Vougogiannopoulou, K | 1 |
| Batista, DDGJ; Batista, MM; Britto, C; Da Silva, CF; Guedes-da-Silva, FH; Lepesheva, GI; Moreira, OC; Pavão, BP; Rachakonda, G; Soeiro, MNC; Souza, LRQ; Villalta, F | 1 |
| Gonçalves, RV; Maldonado, IRSC; Mendonça, AAS; Natali, AJ; Novaes, RD; Souza-Silva, TG; Talvani, A | 1 |
| Gonçalves, RV; Maldonado, IRSC; Natali, AJ; Novaes, RD; Santos, EC; Santos, EG; Souza-Silva, TG; Talvani, A | 1 |
| Baez, A; Bazán, PC; Cremonezzi, D; Esteves, B; Fauro, R; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Sanchez Negrete, O; Strauss, M | 1 |
| Alarcon, ML; Bua, J; Fichera, LE; Grosso, NL; Laucella, SA; Riarte, A | 1 |
| Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA | 1 |
| Bahia, MT; Caldas, IS; Daliry, A; de Carvalho, AC; de Figueiredo Diniz, L; Talvani, A; Torres, RM | 1 |
| Branquinho, RT; de Lana, M; de Oliveira-Silva, JC; Mosqueira, VC; Saúde-Guimarães, DA; Simões-Silva, MR | 1 |
| Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL | 1 |
| Araújo, MS; Carneiro, CM; Lana, Md; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Oliveira, MT; Oliveira-Silva, JC; Paiva, NC | 1 |
| Baeza, I; Meza-Toledo, S; Nogueda-Torres, B; Serna, M; Wong, C; Wong-Baeza, C | 1 |
| Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC | 1 |
| Assíria Fontes Martins, T; Bahia, MT; Caldas, IS; Caldas, S; da Silva do Nascimento, ÁF; de Andrade, IM; de Figueiredo Diniz, L; Mazzeti, AL; Ribeiro, I | 1 |
| Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V | 1 |
| Cifuente, D; Lozano, E; Rivarola, HW; Sosa, MA; Spina, R; Strauss, M; Tonn, C | 1 |
| Batista, DG; Britto, C; da Silva, CF; de Araújo, JS; Ferreira, CG; Guedes-da-Silva, FH; Lepesheva, GI; Meuser, MB; Moreira, OC; Simões-Silva, MR; Soeiro, Mde N | 1 |
| Araújo, JS; Bakunov, SA; Bakunova, SM; Batista, DG; Britto, C; Da Silva, CF; Da Silva, PB; Demarque, KC; Fulco, TO; Guedes-da-Silva, FH; Meuser, MB; Moreira, OC; Oliveira, GM; Patrick, DA; Soeiro, MN; Tidwell, RR | 1 |
| Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM | 1 |
| Branquinho, RT; de Mello, CG; Lana, Md; Milagre, MM; Mosqueira, VC; Oliveira, MT; Saúde-Guimarães, DA | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Carnovale, CE; Catania, VA; de Luján Alvarez, M; Francés, DE; Lambertucci, F; Martín-Sanz, P; Motiño, O; Quiroga, AD; Rigalli, JP; Ronco, MT; Villar, S | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Galvão, LMDC; Guedes, PMDM; Lima, WG; Nascimento, ÁFDSD | 1 |
| Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P | 1 |
| Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM | 1 |
| Andrade, SG; Portella, RS | 1 |
| Bendhack, LM; da Silva, GK; da Silva, RS; Do Valle Matta, MA; Franco, DW; Guedes, PM; Gutierrez, FR; Oliveira, FS; Rodrigues, GJ; Silva, JS; Zamboni, DS | 1 |
| Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA | 1 |
| Condon, D; Dhiman, M; Garg, NJ; Guan, Z; Gupta, S; Lui, C; Wen, JJ | 1 |
| Carnovale, C; Francés, D; Manarin, R; Revelli, S; Ronco, MT; Serra, E | 1 |
| Bahia, MT; Cunha-Filho, MS; de Andrade, IM; de Paula, LM; Figueiredo, VP; Maximiano, FP; Sá-Barreto, LC; Talvani, A | 1 |
| Aleixo, DL; de Araújo, SM; de Melo, CS; do Nascimento, A; Ferraz, FN; Gomes, ML; Simoni, GK; Spack, M | 1 |
| Carlier, Y; Cencig, S; Coltel, N; Truyens, C | 1 |
| Ataide Soares, K; Bahia, MT; Carneiro, CM; Chiari, E; Galvão, LM; Guedes, PM; Lana, Md; Tafuri, WL; Veloso, VM | 1 |
| Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA | 1 |
| Baeza, I; Chena, MA; Elizondo, S; Nogueda, B; Rodríguez-Páez, L; Wong, C | 1 |
| Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A | 1 |
| de Arias, AR; de Bilbao, NV; Ferreira, ME; Fournet, A; Hocquemiller, R; Lagoutte, D; Nakayama, H; Poupon, E; Schinini, A; Serna, E; Soriano-Agatón, F | 1 |
| Bustamante, JM; Enders, JE; Fernández, AR; Fretes, RE; Paglini-Oliva, P; Presti, MS; Rivarola, HW | 1 |
| Doyle, PS; Engel, JC; McKerrow, JH; Zhou, YM | 1 |
| Bonté, F; Ferreira, ME; Fournet, A; Lavault, M; Nakayama, H; Rojas de Arias, A; Samudio, M; Schinini, A; Torres de Ortiz, S; Vera de Bilbao, N | 1 |
| Bottasso, OA; Piaggio, E; Pitashny, M; Revelli, SS; Roggero, E; Wietzerbin, J | 1 |
| Ferreira, ME; Fournet, A; Nakayama, H; Rojas de Arias, A; Schinini, A; Torres, S; Vera de Bilbao, N | 1 |
2 review(s) available for benzonidazole and Disease Models, Animal
| Article | Year |
|---|---|
The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Experimental and Clinical Treatment of Chagas Disease: A Review.
Topics: Animals; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Drug Compounding; Humans; Incidence; Latin America; Nanoparticles; Nifurtimox; Nitroimidazoles; Observational Studies as Topic; Randomized Controlled Trials as Topic; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
83 other study(ies) available for benzonidazole and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and trypanocidal activity of ent-kaurane glycosides.
Topics: Animals; Disease Models, Animal; Diterpenes, Kaurane; Glycosides; Male; Mice; Molecular Conformation; Parasitic Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Benzoxazoles; Chagas Disease; Disease Models, Animal; Female; Mice; Parasitemia; Treatment Outcome; Trypanosoma cruzi | 2008 |
Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.
Topics: Animals; Chagas Disease; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Nitroimidazoles; Spectrophotometry, Ultraviolet; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.
Topics: Animals; Cell Line; Chagas Disease; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Inhibitory Concentration 50; Male; Mice; Nuclear Magnetic Resonance, Biomolecular; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.
Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Oxadiazoles; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi; Trypanosomiasis | 2012 |
Scorpiand-like azamacrocycles prevent the chronic establishment of Trypanosoma cruzi in a murine model.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cells, Cultured; Chlorocebus aethiops; Chronic Disease; Disease Models, Animal; Escherichia coli; Female; Humans; Ligands; Macrocyclic Compounds; Mice; Mice, Inbred BALB C; Molecular Structure; Superoxide Dismutase; Trypanosoma cruzi; Vero Cells | 2013 |
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.
Topics: Abietanes; Animals; Antiprotozoal Agents; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells | 2015 |
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Mice; Parasitemia; Plasmodium falciparum; Protein Binding; Rats; Triazoles; Trypanosoma brucei rhodesiense | 2015 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Malaria; Mice; Parasites; Plasmodium falciparum; Protein Isoforms | 2015 |
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Leishmania major; Malaria; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium vivax; Quinazolines; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Topics: Animals; Cells, Cultured; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Mannich Bases; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Discovery of Pyrrolo[2,3-
Topics: Administration, Oral; Animals; Chagas Disease; Crystallography, X-Ray; Disease Models, Animal; Male; Mice; Molecular Conformation; Nucleosides; Pyridines; Pyrroles; Structure-Activity Relationship; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Nitroreductases; Trypanosoma cruzi; Tuberculosis | 2022 |
Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Docosahexaenoic Acids; Female; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nitroimidazoles; Parasite Load; Receptors, Formyl Peptide; Trypanosoma cruzi | 2021 |
Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Chagas Cardiomyopathy; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Morpholines; Myocytes, Cardiac; Nitroimidazoles; Primary Cell Culture; RAW 264.7 Cells | 2021 |
4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Chagas Disease; Disease Models, Animal; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart Diseases; Heart Function Tests; Humans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanosoma cruzi | 2022 |
Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Mice; MicroRNAs; Nitroimidazoles; Pentoxifylline; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Activity of the sesquiterpene lactone goyazensolide against
Topics: Animals; Bridged-Ring Compounds; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Furans; Mice; Nitroimidazoles; Sesquiterpenes; Sesterterpenes; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocardiography; Male; Mice; Naphthoquinones; Nitroimidazoles; Parasitemia; Time Factors; Trypanocidal Agents | 2020 |
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Chagas Disease; Chronic Disease; Disease Models, Animal; Excipients; Female; Heart; Mice; Myocardium; Nitroimidazoles; Parasitemia; Poloxamer; Quadriceps Muscle; Random Allocation; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations; Female; Glycogen; Hepatitis; Mice; Muscle, Skeletal; Myositis; NADH, NADPH Oxidoreductases; Nitroimidazoles; Parasite Load; Parasitemia; Peroxidase; Thioridazine; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Female; Mice; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Mice; Nanoparticle Drug Delivery System; Nitroimidazoles; Phagocytes; Polyethylene Glycols; Sulfides; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease.
Topics: Animals; Antibodies, Protozoan; Cell Line; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Drug Carriers; Female; Heart; Inflammation; Mice; Mice, Inbred C3H; Nanoparticles; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes.
Topics: Adhesiveness; Administration, Oral; Animals; Capsules; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Gelatin; Hydrophobic and Hydrophilic Interactions; Kinetics; Male; Mice, Inbred BALB C; Nitroimidazoles; Particle Size; Polyelectrolytes; Polymethacrylic Acids; Rheology; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
Topics: Animals; Ascorbic Acid; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Mice, Inbred C3H; Nitroimidazoles; Parasite Load; Parasitemia; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chronic Disease; Collagen Type III; Disease Models, Animal; Disease Progression; DNA, Protozoan; Dogs; Drug Resistance; Fibrosis; Heart; Myocardium; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.
Topics: Animals; Chagas Disease; Disease Models, Animal; Inflammation; Kidney; Liver; Male; Mice; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 2018 |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Carvedilol; Catalase; Chagas Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mice, Inbred C57BL; Myocardium; Nitroimidazoles; Oxidative Stress; Parasitemia; Protein Carbonylation; Reference Values; Reproducibility of Results; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Flow Cytometry; Indoles; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Protozoan Proteins; Sterol 14-Demethylase; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis.
Topics: Animals; Antioxidants; Cardiotonic Agents; Catalase; Chagas Cardiomyopathy; Chagas Disease; Cytokines; Disease Models, Animal; Heart; Inflammation; Interleukin-10; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Chagas Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Heart; Male; Myocarditis; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Running; Trypanosoma cruzi | 2019 |
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Female; Intestines; Kidney; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua.
Topics: Allopurinol; Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Mice; Nicaragua; Nitroimidazoles; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2013 |
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
Anti-adrenergic and muscarinic receptor autoantibodies in a canine model of Chagas disease and their modulation by benznidazole.
Topics: Animals; Autoantibodies; Chagas Cardiomyopathy; Disease Models, Animal; Dogs; Humans; Immunosuppressive Agents; Nitroimidazoles; Receptor, Muscarinic M2; Receptors, Adrenergic, beta | 2014 |
Sesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Lactones; Mice; Nanocapsules; Nitroimidazoles; Sesquiterpenes; Trypanosoma cruzi | 2014 |
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
Topics: Animals; Antibodies, Protozoan; Area Under Curve; Brazil; Chagas Disease; Child; Disease Models, Animal; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Flow Cytometry; Humans; Inflammation; Mice; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Primary Cell Culture; Remission Induction; Statistics, Nonparametric; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Esters; Isoenzymes; Male; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Female; Immunoglobulin G; Itraconazole; Mice; Myocardium; Nitroimidazoles; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
Topics: Administration, Oral; Animals; Chagas Disease; Dimethyl Sulfoxide; Disease Models, Animal; Diterpenes; Heart; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Salvia; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Gene Expression; Imidazoles; Immunosuppressive Agents; Male; Mice; Nitroimidazoles; Oxadiazoles; Parasitemia; Sex Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.
Topics: Amides; Amidines; Animals; Chagas Disease; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Parasitic Sensitivity Tests; Structure-Activity Relationship; Survival Analysis; Terphenyl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
Topics: Animals; Cells, Cultured; Chagas Cardiomyopathy; Chagas Disease; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Humans; Immunologic Factors; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2016 |
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Synergism; Heart; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Animals; Chagas Disease; Chronic Disease; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Humans; Lactones; Mice; Nanocapsules; Nitroimidazoles; Polyethylene Glycols; Sesquiterpenes; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis.
Topics: Animals; Antioxidants; Chagas Disease; Disease Models, Animal; Down-Regulation; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitroimidazoles; Oxidative Stress; Sepsis; Toll-Like Receptor 4; Trypanocidal Agents | 2017 |
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dogs; Immunoglobulin G; Male; Mice; Myocarditis; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Hemoglobins; Iron; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Siderophores; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting myocarditis in benznidazole-treated mice.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Chagas Cardiomyopathy; Dendritic Cells; Disease Models, Animal; Drug Resistance; Mice; Myocarditis; Myocardium; Nitroimidazoles; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Drug Resistance; Drug Synergism; Female; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroimidazoles; Organometallic Compounds; Parasitemia; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.
Topics: Analysis of Variance; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Heart Function Tests; Hemodynamics; Lipid Peroxidation; Mitochondria, Heart; Nitroimidazoles; Oxidative Stress; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trypanosoma cruzi | 2010 |
Benznidazole treatment attenuates liver NF-κB activity and MAPK in a cecal ligation and puncture model of sepsis.
Topics: Animals; Cecum; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Exudates and Transudates; Gene Expression Regulation; Leukocyte Count; Ligation; Liver; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Punctures; RNA, Messenger; Sepsis; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.
Topics: Animals; Chagas Disease; Chemical Precipitation; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Excipients; Female; Hardness Tests; Hypromellose Derivatives; Methylcellulose; Mice; Nitroimidazoles; Polymers; Solubility; Solvents; Tablets; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Different forms of administration of biotherapy 7dH in mice experimentally infected by Trypanosoma cruzi produce different effects.
Topics: Animals; Chagas Disease; Disease Models, Animal; Homeopathy; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
The dog as model for chemotherapy of the Chagas' disease.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Dogs; Drug Resistance; Female; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Mice; Models, Chemical; NAD; Nifurtimox; Nitroimidazoles; Oxamic Acid; Species Specificity; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2005 |
Treatment of experimental chronic chagas disease with trifluralin.
Topics: Animals; Chagas Disease; Disease Models, Animal; Electrocardiography; Heart; Herbicides; Male; Mice; Mice, Inbred Strains; Myocarditis; Nitroimidazoles; Trifluralin; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.
Topics: Alkaloids; Animals; Carbolines; Chagas Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi; Zanthoxylum | 2007 |
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Mice; Nitroimidazoles; Thioridazine; Trypanocidal Agents | 2007 |
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Homeodomain Proteins; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Topics: Acute Disease; Administration, Oral; Alkaloids; Animals; Benzylisoquinolines; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents | 2000 |
Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cells, Cultured; Chagas Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Heart; Interferon-gamma; Macrophages, Peritoneal; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Rats; Rats, Inbred Strains; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
Topics: Animals; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Phytotherapy; Plant Extracts; Quinolines; Rutaceae; Trypanocidal Agents; Trypanosoma cruzi | 2001 |