benzonidazole has been researched along with Chagas Disease in 692 studies
*Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (3.90) | 18.7374 |
| 1990's | 39 (5.64) | 18.2507 |
| 2000's | 112 (16.18) | 29.6817 |
| 2010's | 387 (55.92) | 24.3611 |
| 2020's | 127 (18.35) | 2.80 |
| Authors | Studies |
|---|---|
| de Lima, ME; Freire-de-Lima, L; Heise, N; Mendonça-Previato, L; Previato, JO; Ribeiro, TS | 1 |
| Albuquerque, S; Bastos, JK; da Silva Filho, AA; da Silva, R; de Souza, GH; de Souza, VA; Donate, PM; e Silva, ML; Grando, MD; Montanheiro, M; Pereira, AC; Royo, Vde A; Saraiva, J | 1 |
| Brun, R; Buendía, AM; Gilbert, IH; Kaiser, M; Mc Carthy, OK; Pacanowska, DG; Ruiz-Perez, LM; Schipani, A | 1 |
| Boiani, L; Boiani, M; Cerecetto, H; Denicola, A; Gómez-Barrio, A; Gonzalez, M; Nakayama, H; Rojas de Arias, A; Rolan, M; Sanabria, L; Serna, E; Torres de Ortiz, S; Vega, C; Vera de Bilbao, N; Yaluff, G | 1 |
| Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA | 2 |
| Bahia, MT; Carneiro, CM; Lana, M; Macedo, AM; Machado-Coelho, GL; Martins, HR; Martins-Filho, OA; Silva, RM; Toledo, MJ; Valadares, HM; Veloso, VM; Vitelli-Avelar, DM | 1 |
| Aguirre, G; Basombrío, MA; Boiani, L; Boiani, M; Campillo, NE; Castro, A; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Davies, C; González, M; Hernández, P; Krauth-Siegel, RL; Paez, JA; Porcal, W | 1 |
| Alisson-Silva, F; da Silva Ferreira, W; de Lima, ME; Echevarria, A; Freire-de-Lima, L; Mendonça-Previato, L; Previato, JO; Saraiva, VB | 1 |
| Arredondo, C; Basombrío, MA; Boiani, L; Boiani, M; Cerecetto, H; Davies, C; Gerpe, A; González, M; Merlino, A; Pacheco, JP; Porcal, W | 1 |
| Alves Lima, FC; Ferreira da Silva, AB; Gutierrez, FR; Nogueira Silva, JJ; Pavanelli, WR; Santana Silva, J; Wagner Franco, D | 1 |
| Brun, R; Ma, X; Zhou, W | 1 |
| Boiani, L; Boiani, M; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; González, M; Hernández, P; Merlino, A | 1 |
| de Oliveira, BG; dos Santos Filho, JM; Leite, AC; Leite, LF; Lima, MS; Moreira, DR; Soares, MB | 1 |
| Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA | 1 |
| Batista, Dda G; Batista, MM; Boykin, DW; Britto, CC; de Oliveira, GM; do Amaral, PB; Junqueira, A; Lannes-Vieira, J; Lima, MM; Romanha, AJ; Sales Junior, PA; Soeiro, Mde N; Stephens, CE | 1 |
| Basombrío, MA; Chung, MC; Davies, C; Marino Cardozo, R; Mora, MC; Sánchez Negrette, O | 1 |
| Docampo, R; Kaur, G; King-Keller, S; Li, M; Smith, A; Wang, B; Yang, X; Zheng, S | 1 |
| Ayala, E; del Cacho, E; Gállego, M; Gascon, J; López-Chejade, P; Muñoz, J; Pinazo, MJ; Posada, E; Soy, D | 1 |
| Arrebola, F; Campayo, L; Cano, C; Garcia-Aranda, I; Gómez-Contreras, F; Marín, C; Navarro, P; Olmo, F; Ramírez-Macias, I; Rosales, MJ; Sánchez-Moreno, M; Sanz, AM; Yunta, MJ | 1 |
| de Carvalho da Silva, F; de Castro, SL; Ferreira, SB; Ferreira, VF; Kaiser, CR; Pinto, AC; Pinto, AV; Salomão, K | 1 |
| Díaz, JG; Gutiérrez-Sánchez, R; López-Céspedes, A; Marín, C; Olmo, F; Ramírez-Macías, I; Rosales, MJ; Sánchez-Moreno, M; Villegas, N | 1 |
| Bloomer, WD; Brun, R; Kaiser, M; McKenzie, C; Papadopoulou, MV; Prasittichai, C; Torreele, E; Trunz, BB; Wilkinson, SR | 1 |
| Docampo, R; Galizzi, M; Gut, J; Long, TE; Lu, X; Rosenthal, PJ | 1 |
| Brito-Arias, M; Byler, KG; Marquez-Navarro, A; Martínez-Mayorga, K; Nogueda-Torres, B; Torres-Bustillos, LG | 1 |
| Arrebola, F; García-España, E; Gómez-Contreras, F; Huertas, O; Lamarque, L; Marín, C; Miranda, C; Navarro, P; Olmo, F; Pitarch, J; Sánchez-Moreno, M | 1 |
| Abbott, MJ; Alexander, PW; Armstrong, T; Berven, B; Best, WM; Botero, A; Chaplin, JH; Charman, SA; Chatelain, E; Keenan, M; Kerfoot, M; Khong, A; McManus, JD; Morizzi, J; Nguyen, T; Ryan, E; Scandale, I; Thompson, RA; von Geldern, TW; Wang, SZ; White, KL | 1 |
| Campayo, L; Cano, C; Gómez-Contreras, F; Marín, C; Navarro, P; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Sanz, AM; Yunta, MJ | 1 |
| Costa, SP; da Rocha, LF; de Melo, CM; de Oliveira Filho, GB; de Simone, CA; Ferreira, RS; Fradico, JR; Guimarães, ET; Hernandes, MZ; Leite, AC; Meira, CS; Moreira, DR; Pereira, VR; Rabello, MM; Soares, MB; Srivastava, RM | 1 |
| Capaci Rodrigues, G; Capasso, C; Pan, P; Parkkila, S; Scozzafava, A; Supuran, CT; Tolvanen, ME; Vermelho, AB | 1 |
| Biondo, M; Campo, VL; Carneiro, ZA; Carvalho, I; Martins-Teixeira, MB; Sesti-Costa, R; Silva, JS | 1 |
| Alexander, PW; Best, WM; Charman, SA; Chatelain, E; Diao, H; Gregg, AD; Keenan, M; Kerfoot, M; Khong, A; Ryan, E; Scandale, I; Shackleford, DM; Thompson, RC; von Geldern, TW; White, KL | 1 |
| Araya, JE; Fehér, K; González, J; Gutiérrez, B; Illyés, TZ; Kövér, KE; Kumar, AA; Morales, P; Muñoz, C; Osorio, L; Papp, Z; Sagua, H; Szilágyi, L | 1 |
| Arafa, RK; Boykin, DW; Brun, R; Ismail, MA; Jones, SK; Pandharkar, T; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA; Zhu, X | 1 |
| Blau, L; Bosquesi, PL; Chin, CM; Cicarelli, RM; Menegon, RF; Molino, JV; Passerini, GD; Trossini, GH; Vital, DG | 1 |
| Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Kouznetsov, VV; Merchán Arenas, DR; Romero Bohórquez, AR | 1 |
| Lozano, E; Mazzuca, M; Palermo, JA; Sánchez, M; Siless, GE; Sosa, MA | 1 |
| Alba-Soto, CD; Briñón, MC; Gualdesi, MS; Novoa, MM; Raviolo, MA; Solana, ME | 1 |
| Aguiar, AP; Bozza, MT; Capasso, C; Feijó, DF; Pan, P; Parkkila, S; Rodrigues, GC; Supuran, CT; Vermelho, AB; Vullo, D | 1 |
| Abbott, MJ; Alexander, PW; Best, WM; Botero, A; Campbell, M; Chaplin, JH; Charman, SA; Chatelain, E; Chiu, FC; Cornwall, S; Keenan, M; Khong, A; Koltun, M; Morizzi, J; Perez, C; Ryan, E; Scandale, I; Shackleford, DM; Thompson, RA; von Geldern, TW; White, KL | 1 |
| Alves, ÉV; Braga, SF; Coelho, EF; de Oliveira, RB; Duarte, MC; Ferreira, RS; Fradico, JR; Júnior, PA; Lage, PS; Ribeiro, TG; Romanha, AJ; Steindel, M; Tonini, ML | 1 |
| Carreras, L; Chaves-Lemaur, G; Costa, A; Marín, C; Martínez, L; Olmo, F; Ramírez-Macías, I; Rosales, MJ; Rotger, C; Sampedro, A; Sánchez-Moreno, M; Urbanová, K; Vega, M | 1 |
| Arán, VJ; Marín, C; Muro, B; Navarro, P; Ramírez-Macías, I; Reviriego, F; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Brelaz de Castro, MC; da Silva, AC; de Oliveira, AD; de Simone, CA; dos Santos, TA; Ferreira, RS; Leite, AC; Magalhaes Moreira, DR; Pereira, VR; Teixeira de Moraes Gomes, PA; Villela, FS | 1 |
| Bautista, JL; Cabrera-Bravo, M; Guevara-Gómez, Y; Hernández-Luis, F; Martinez, CM; Moreno-Rodríguez, A; Pérez-Campos, E; Pina-Canseco, S; Salazar-Schettino, PM; Torrens, H; Torres, MB | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Calvet, CM; Cameron, MD; Choi, JY; Gut, J; Johnston, JB; Kellar, D; McKerrow, JH; Podust, LM; Roush, WR; Siqueira-Neto, JL; Vieira, DF | 1 |
| Alvarez-Manzaneda, EJ; Chahboun, R; Chayboun, I; Guardia, JJ; Marin, C; Messouri, I; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K | 1 |
| Aguilera-Venegas, B; Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; Lepesheva, GI; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| de Azevedo, RA; Ferreira, AK; Jorge, SD; Palace-Berl, F; Pasqualoto, KF; Silva, MN; Tavares, LC; Teixeira, SF; Zingales, B; Zorzi, RR | 1 |
| Iwasaki, G; Nakajima-Shimada, J; Onizuka, Y; Suto, Y; Yamagiwa, N | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Faral-Tello, P; Mahler, G; Pizzo, C; Robello, C; Saiz, C; Serna, E; Torres, S; Vera, N; Yaluff, G | 1 |
| Andricopulo, AD; Emery, FS; Krogh, R; Magalhaes, LG; Pupo, MT; Santos, GB | 1 |
| Alakurtti, S; Brun, R; Jaffe, CL; Kaiser, M; Kopelyanskiy, D; Moreira, VM; Nasereddin, A; Oksman-Caldentey, KM; Pirttimaa, M; Yli-Kauhaluoma, J | 1 |
| de Moraes, MH; Kamdoum, BC; Kuete, V; Ngadjui, BT; Sandjo, LP; Steindel, M | 1 |
| Arán, VJ; Cumella, J; da Silva, PB; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Ibáñez-Escribano, A; Jagerovic, N; Morales, P; Nogal-Ruiz, JJ; Reviriego, F; Soeiro, Mde N | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 1 |
| Balcazar, DE; Blanco, MM; Carrillo, C; Celentano, AM; Frank, FM; Gaozza, C; Lara, V; López, J; Salerno, A | 1 |
| Azqueta, A; Cirauqui, N; Jimenez-Lopez, M; Jiménez-Montes, C; López de Ceráin, A; Marín, C; Martín-Escolano, R; Martin-Montes, A; Moreno-Viguri, E; Pérez-Silanes, S; Sánchez-Moreno, M; Santivañez-Veliz, M; Zamora Ledesma, S | 1 |
| Balfour, MN; Franco, CH; Freitas-Junior, LH; Moraes, CB; Stefani, HA | 1 |
| Cardoso, MV; da Silva Mendes, CH; da Silva, AC; da Silva, EB; de Castro, MC; de Simone, CA; Dos Santos, TA; Ferreira, RS; Leite, AC; Moreira, DR; Oliveira E Silva, DA; Oliveira, AR; Pereira, VR | 1 |
| Anjos, PSD; Cardoso, MVO; Coelho, PL; de Oliveira Filho, GB; Espíndola, JWP; Ferreira, RS; Leite, ACL; Meira, CS; Moreira, DRM; Oliveira E Silva, DA; Santos, ES; Soares, MBP | 1 |
| Bury, M; da Silva Neto, AL; Franco, CH; Moraes, CB; Murayama, JS; Nunes, SL; Palace-Berl, F; Pasqualoto, KFM; Silva, MN; Tavares, LC; Zingales, B | 1 |
| Alcantara, LM; Cordeiro-da-Silva, A; Costantino, L; Costi, MP; Ellinger, B; Ferrari, S; Franco, CH; Freitas-Junior, LH; Gul, S; Kuzikov, M; Linciano, P; Luciani, R; Macedo, S; Moraes, CB; Pascoalino, B; Quotadamo, A; Santarem, N; Witt, G | 1 |
| Batista, DDGJ; da Silva, CF; da Silva, PB; Ferreira de Almeida Fiuza, L; Krishna Reddy, TR; Nefertiti Silva da Gama, A; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| Batista, MM; Corcoran, O; de Almeida Fiuza, LF; de Nazaré Correia Soeiro, M; Peres, RB; Reddy, TRK; Silva, PB; Ullah, AI | 1 |
| Agusti, R; Ashfaq, M; Chacón-Vargas, KF; Kashif, M; López-Cedillo, JC; Nogueda-Torres, B; Paz-González, AD; Peralta-Cruz, J; Ramírez-Moreno, E; Reyes-Arellano, A; Rivera, G; Uhrig, ML | 1 |
| Brun, R; Calvet, CM; Costi, R; De Leo, A; De Vita, D; Di Santo, R; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Tudino, V | 1 |
| Andrade, CH; Braga, RC; Franco, CH; Freitas-Junior, LH; Melo-Filho, CC; Moraes, CB; Muratov, EN | 1 |
| Clares, MP; Delgado-Pinar, E; García-España, E; Marín, C; Martín-Escolano, J; Martín-Escolano, R; Martin-Montes, Á; Medina-Carmona, E; Molina-Carreño, D; Pitarch-Jarque, J; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Mazzieri, MR; Miana, GE; Quevedo, MA; Ribone, SR; Sánchez-Moreno, M; Vera, DMA | 1 |
| Costa, A; López, C; Marín, C; Martín-Escolano, R; Martin-Montes, Á; Medina-Carmona, E; Rotger, C; Sánchez-Moreno, M; Vega, M | 1 |
| Ackermann, L; da Silva Júnior, EN; de Castro, SL; Dhawa, U; Jacob, C; Jardim, GAM | 1 |
| Azqueta, A; Cirauqui, N; Marín, C; Martín-Escolano, R; Moreno-Viguri, E; Paucar, R; Pérez-Silanes, S; Sánchez-Moreno, M | 1 |
| Alves, CR; Bourguignon, SC; Calvet, CM; Lara, LS; Lechuga, G; Monteiro, ME; Oliveira, FOR; Pereira, MCS; Santos, MS; Souto, BA; Souza-Silva, F; Viganó, MG | 1 |
| Batista, DDGJ; Caljon, G; da Silva, CF; Hulpia, F; Lin, C; Maes, L; Soeiro, MNC; Van Calenbergh, S; Van Hecke, K | 1 |
| Alba Soto, CD; Areco, Y; Bellera, CL; Buchholz, B; Carrillo, C; Gelpi, RJ; Kelly, J; Miranda, C; Quarroz Braghini, J; Sbaraglini, ML; Talevi, A | 1 |
| Caljon, G; Dessoy, MA; Dias, LC; Koovits, PJ; Kratz, JM; Maes, L; Matheeussen, A; Mowbray, CE | 1 |
| Asís, SE; Buldain, GY; Frank, FM; Muscia, GC; Roldán Pacheco, FJ | 1 |
| Appelqvist, P; Erath, J; Gilbert, IH; Hampton, S; Harrison, JR; Johansson, NG; Kaiser, M; Mathan, V; Pacanowska, DG; Read, KD; Riley, J; Rodriguez, A; Sahlberg, C; Sarkar, S; Stojanovski, L | 1 |
| Avery, VM; Charman, SA; Chatelain, E; Cornwall, S; Denny, WA; Francisco, AF; Keenan, M; Kelly, JM; Marshall, AJ; O'Connor, PD; Perez, CJ; Read, KD; Riley, J; Sykes, ML; Thompson, AM; Thompson, RCA; White, KL; Zulfiqar, B | 1 |
| de Albuquerque, S; Dias, LRS; Lima, CHS; Muri, EMF; Portapilla, GB; Providello, MV; Ribeiro, JLS; Soares, JCAV | 1 |
| Bouton, J; Caljon, G; Cardoso Santos, C; Ferreira de Almeida Fiuza, L; Karalic, I; Maes, L; Mazzarella, MA; Soeiro, MNC; Van Calenbergh, S | 1 |
| Alcolea, V; Atherton, RL; Beltran-Hortelano, I; Kelly, JM; Olmo, F; Pérez-Silanes, S; Rubio-Hernández, M; Sanz-Serrano, J | 1 |
| Bernatchez, JA; Blankenship, LR; Calvet, CM; Chenna, BC; Cole, TR; Cruz-Reyes, J; Drelich, A; Giardini, M; Gomez, J; Goodall, ZT; Hernandez, EA; Laganowsky, A; Li, L; Liu, WR; Meek, TD; Mellott, DM; Moghadamchargari, Z; Rademacher, A; Siqueira-Neto, JL; Thomas, D; Tseng, CK; Wand, AJ; Yang, KS; Zhu, J | 1 |
| Caljon, G; de Oliveira, GM; Donola Girão, R; Hulpia, F; Jaén Batista, DDG; Karalic, I; Lin, C; Maes, L; Mazzeti, AL; Soeiro, MNC; Van Calenbergh, S | 1 |
| Cantizani, J; Cotillo, I; De Rycker, M; Dodd, PG; Ferguson, L; Gilbert, IH; Manzano, P; Marco, M; McGonagle, K; Miles, T; Naylor, C; Osuna-Cabello, M; Paterson, C; Pinto, EG; Read, KD; Riley, J; Scullion, P; Shishikura, Y; Simeons, F; Stojanovski, L; Svensen, N; Tarver, GJ; Thomas, J; Thomas, MG; Wyatt, PG | 1 |
| De Oliveira, CS; Freire, KA; García-Jareño, AB; Lima, DB; Magalhães, EP; Marinho, MM; Martins, AMC; Menezes, RRPPB; Monteiro, ML; Nicolaski Pedron, C; Nunes, JVS; Oliveira Junior, VX; Orzaéz, M; Silva, BP | 1 |
| Ang, CW; Avery, VM; Bernhardt, PV; Blaskovich, MAT; Bolisetti, R; Cooper, MA; Francisco, AF; Franzblau, SG; Hinton, AO; Jackson, CJ; Kelly, JM; Lee, BM; Sykes, ML; Tan, L; Wang, Y; West, NP | 1 |
| Carrilero, B; Gil-Gallardo, L; Iborra, A; Segovia, M; Simón, M | 1 |
| Alvedro, A; Bhattacharyya, T; Cardinal, MV; Enriquez, GF; Freilij, H; Gilleman, Q; Gürtler, RE; Macchiaverna, NP; Martinez de Salazar, P; Mertens, P; Miles, MA; Molina, I; Murphy, N | 1 |
| Arrese-Muñoz, I; Aznar, ML; Bosch-Nicolau, P; Espinosa-Pereiro, J; Franco-Jarava, C; Molina, I; Oliveira-Souto, I; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre-Delcor, N; Sulleiro, E; Treviño, B; Valerio, L | 1 |
| Blondel, A; Coatnoan, N; Cosson, A; Cupif, JF; de Melo, GD; Gouault, N; Minoprio, P; Renault, J; Uriac, P | 1 |
| Brancaglion, GA; Caldas, IS; Caldas, S; Carvalho, DT; Diniz, LF; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, RRG; Silva, LS; Vilas-Boas, DF | 1 |
| Bontempi, I; Cabrera, G; Cacik, P; Marcipar, I; Pacini, MF; Pérez Gianeselli, M; Pérez, AR; Prochetto, E; Rodeles, L; Vicco, M | 1 |
| Bedor, DCG; Frade, VP; Ghilard, FR; Moreira, CHV; Oliveira, CDL; Sabino, EC; Sanches, C | 1 |
| Barbosa, JMC; Cascabulho, CM; Daliry, A; de Melo, TG; de Oliveira, G; Pedra Rezende, Y; Pereira, ENGDS; Salem, KS | 1 |
| Breynaert, A; De Bruyne, T; Hermans, N; Huits, R; Truyens, C; Van Den Broucke, S; Van Esbroeck, M; Van Herreweghe, M | 1 |
| Carneiro, CM; Cunha, ELA; Fonseca, KDS; Lana, M; Pinto, KMC; Sousa, LRD; Torchelsen, FKVDS; Torres, RM; Vieira, PMA | 1 |
| Alvarez-Díaz, N; Arevalo-Rodriguez, I; Comeche, B; Crespillo-Andújar, C; Hamer, DH; Pérez-Molina, JA; Zamora, J | 1 |
| Arrua, EC; Goicoechea, H; Hartwig, O; Lehr, CM; Loretz, B; Murgia, X; Salomon, CJ | 1 |
| Sperandio da Silva, GM | 1 |
| Altcheh, J; Bisio, MMC; García-Bournissen, F; Gulin, JEN; Rocco, D; Solana, ME | 1 |
| Cardoso Santos, E; Dias Novaes, R; Lima, GDA; Oliveira Silva, R; Santana Nogueira, S; Vilela Gonçalves, R | 1 |
| Almeida, MC; Almeida-Silva, J; Andrade, SG; Fernandes, JMP; Menezes, DS; Perez, SAC; Saraiva, RM; Suarez-Fontes, AM; Vannier-Santos, MA; Vasco-Dos-Santos, DR; Viçosa, AL | 1 |
| Barbosa, HS; Barbosa, JMC; Daliry, A; de Castro, SL; de Melo, TG; Lannes-Vieira, J; Pedra-Rezende, Y; Pereira, LD; Salomão, K | 1 |
| Arana-Argaez, VE; Bottazzi, ME; Cruz-Chan, JV; Dumonteil, E; Dzul-Huchim, VM; Gusovsky, F; Hotez, P; Martinez-Vega, PP; Ortega-Lopez, J; Ramirez-Sierra, MJ; Rosado-Vallado, ME; Villanueva-Lizama, LE | 1 |
| Beccacece, A; Carrara, S; Comandini, UV; Corpolongo, A; Del Nonno, F; Giancola, ML; Maffongelli, G; Mariano, A; Montalbano, M; Nicastri, E; Petrone, A | 1 |
| Bartholomeu, DC; Burle-Caldas, GA; Murta, SMF; Reis-Cunha, JL; Resende, DM; Ribeiro, JM; Santi, AMM; Santos, IFM; Silva, PA; Teixeira, SMR | 1 |
| Alcântara, L; Bortoluci, K; Cariste, LM; Castaño Barrios, L; Cunha-Neto, E; Franco, CH; Freitas-Junior, LH; Gibaldi, D; Kalil, J; Lannes-Vieira, J; Moraes, CB; Nascimento, MS; Pandey, RP; Silva, MN; Vasconcelos, JR; Zingales, B | 1 |
| Auckland, LD; Busselman, RE; Bustamante, JM; Collins, S; Hamer, SA; Malcolm, EL; Padilla, AM; Saunders, AB; Tarleton, RL; White, B; Wilson, BF | 1 |
| Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Gibbons, L; Molina, I; Morillo, C; Perelli, L; Prado, N; Reidel, S; Riarte, A; Sosa-Estani, S; Torrico, F; Villar, JC | 1 |
| Altcheh, J; Ballering, G; Bochoeyer, A; Chatelain, E; Falk, N; Freilij, H; Garcia Bournissen, F; Goldsman, A; González, NL; Grippo, M; Jurado, L; Moroni, S; Moscatelli, G | 1 |
| Campos de Oliveira, L; Cerdeira Sabino, E; Cunha-Neto, E; Giordano, RJ; Kuramoto, A; Monteiro, JS; Rodriguez Carnero, LA; Setubal, JC | 1 |
| Baeza, I; Barrera-Aveleida, G; Galarce-Sosa, I; Gómez-Manzo, S; Meza-Toledo, S; Nevárez-Lechuga, I; Nogueda-Torres, B; Reséndiz-Mora, A; Santiago-Hernández, JC; Sotelo-Rodríguez, A; Wong-Baeza, C; Wong-Baeza, I | 1 |
| Alves, LC; da Conceição Alves de Lima, D; da Cruz Filho, IJ; de Lima Aires, A; do Carmo Alves de Lima, M; Dos Santos, FAB; Duarte, DMFA; Marques, DSC; Nogueira, F | 1 |
| Carrilero, B; Franco, F; García-Vázquez, E; Gil-Gallardo, LJ; Iborra, MA; Segovia, M; Simón, M; Vázquez, C | 2 |
| Altcheh, JM; Bournissen, FG; González, N; Moroni, S; Moscatelli, G; Pérez Montilla, CA; Rocco, DM | 1 |
| Lopes, MEASA; Murta, SMF; Ribeiro, JM; Souza-Fagundes, EM; Teixeira-Carvalho, A | 1 |
| Bottazzi, ME; Cruz, JV; Gusovsky, F; Hotez, PJ; Jones, KM; Keegan, B; Kendricks, A; Mangin, EN; Pollet, J; Reynolds, CL; Versteeg, L; Villanueva, LE | 1 |
| Almeida, IC; Begum, K; Cardenas-Ovando, RA; Fernández-Figueroa, EA; Iandra da Silva Ferreira, B; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Roy, S; Silva Grijó Farani, P; Vilar-Pereira, G | 1 |
| Assmann, CE; Bottari, NB; Castro, MFV; Chitolina Schetinger, MR; da Rocha, MIUM; da Silva, AS; da Veiga, ML; de Souza, LAF; Dutra da Silva, A; Ferreira, DASP; Fracasso, M; Gundel, S; Monteiro, SG; Morsch, VM; Ourique, AF; Reichert, KP | 1 |
| Alonso-Padilla, J; Barrera, P; Bastida, J; Feresin, GE; Martinez-Peinado, N; Ortiz, JE; Piñeiro, M; Sosa, M | 1 |
| Auckland, LD; Bustamante, JM; Hamer, SA; Hodo, CL; McCain, S; Saunders, AB; Tarleton, RL; Wang, W; White, BE; Wilkerson, GK | 1 |
| da Silva Barros, M; de Arruda, TR; de Lorena, VMB; de Morais, CNL; Diniz, GTN; Dos Santos Oliveira, KK; Higino, TMM; Nascimento, AV; Rafael Moreira, L; Soares, AKA; Souza, VMO; Torres, DJL | 1 |
| Gonçalves, LO; Guimarães, PAS; Liarte, DB; Lima, DA; Murta, SMF; Reis-Cunha, JL; Ruiz, JC | 1 |
| Altcheh, J; Alves, F; Bisio, M; Caruso, M; Fernandes, J; Garcia-Bournissen, F; Gonzalez, N; Miranda, MR; Monla, C; Moran, L; Moroni, S; Moscatelli, G; Patiño, OL; Ramirez, T; Riarte, A; Ribeiro, I; Vaina, M; Valdez, M | 1 |
| Becker, I; Cabrera, N; De la Mora-De la Mora, I; Enríquez-Flores, S; Flores-López, LA; García-Torres, I; Hernández, R; Herrera-López, J; López-Velázquez, G; Pérez-Montfort, R | 1 |
| Auckland, LD; Hamer, S; McCain, S; Rivas, AE; Sim, RR; Tarleton, RL; Weidner, B; White, B | 1 |
| Arsuaga, M; Chamorro, S; Crespillo-Andújar, C; Lanza, VF; Martín, O; Monge-Maillo, B; Navia, B; Norman, FF; Olavarrieta, L; Pérez-Molina, JA; Serrano-Villar, S; Trigo, E | 1 |
| Arruda, CCP; Baroni, ACM; Cardoso, IA; Carvalho, DB; Costa, PAN; das Neves, AR; de Albuquerque, S; Gaspari, PDM; Lopes, NP; Luccas, PH; Nonato, MC; Pelizaro, BI; Piranda, EM; Portapilla, GB; Shiguemoto, CYK; Silva, F | 1 |
| Costa Oliveira, CND; Lorena, VMB; Moreira, LR; Nascimento, AV; Oliveira, KKDS; Paiva Cavalcanti, M; Saraiva, KLA; Silva Júnior, CDD; Silva, AC; Soares, AKA | 1 |
| Bottazzi, ME; Dean, DA; Hossain, E; Hotez, PJ; Jones, KM; Kane, SS; Kendricks, AL; Leão, AC; Liu, Z; McCall, LI; Pollet, J; Sankaranarayanan, K; Ulrich vonBargen, R; Wheeler, K | 1 |
| Barron, S; Dean, DA; Harris, M; Hossain, E; Jimenez Sandoval, M; Kane, SS; Katemauswa, M; Klechka, L; Lesani, M; Liu, Z; McCall, LI; Pan, C; Roach, J; Schaefer, M; Ulrich vonBargen, R; Wheeler, K; Xiong, Y | 1 |
| Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Olmo, F; Taylor, MC; Ward, AI | 1 |
| Branquinho, RT; de Assis, G; de Lana, M; de Oliveira, MT; Gonçalves, MF; Milagre, MM; Reis, L; Saúde-Guimarães, DA | 1 |
| Caldas, IS; Novaes, RD; Santos, EG | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Corral, R; Freilij, H; García Bournissen, F; González, N; Moroni, S; Moscatelli, G; Schijman, A | 1 |
| Bartholomeu, DC; Costa-Martins, AG; Petravicius, PO; Reis-Cunha, JL; Silva, MN; Teixeira, MMG; Zingales, B | 1 |
| Espínola, EE; Espinoza, E; Guzman, A; Hirayama, K; Kamel, MG; Kikuchi, M; Mizukami, S; Mochizuki, K; Na-Bangchang, K; Nishizawa, JE; Quiroga, B; Revollo, J; Rios Morgan, S; Roca, Y; Russomando, G; Sanchez, Z; Tien Huy, N; Vargas Ortiz, R; Vásquez Velásquez, C; Zambrana Ortega, A | 1 |
| Aviles, AS; Carneiro, CM; Cunha, LM; da Silva Fonseca, K; de Abreu Vieira, PM; Molina, I; Perin, L | 1 |
| Egui, A; López, MC; Pérez-Antón, E; Segovia, M; Simón, M; Thomas, MC | 1 |
| Caldas, IS; Chagas-Paula, DA; Diniz, LF; Fernandes, VHC; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, CM; Rodrigues, MR; Veloso, MP; Vilas-Boas, DF | 1 |
| Arsuaga, M; Crespillo-Andújar, C; Díaz-Menéndez, M; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Trigo, E | 1 |
| Chappuis, F; Jackson, Y; Wyssa, B | 1 |
| Egui, A; Gómez, I; López, MC; Segovia, M; Simón, M; Thomas, MC | 1 |
| Campos-Estrada, C; Carillo, I; Castillo, C; González-Herrera, F; Greif, G; Guzmán-Rivera, D; Kemmerling, U; Liempi, A; Maya, JD; Robello, C | 1 |
| Carneiro, CM; Carvalho, LM; Correa-Oliveira, R; de Carvalho, TV; Fonseca, KDS; Madeira, JV; Medeiros, LDF; Molina, I; Perin, L; Vieira, PMA | 1 |
| Bahia, MT; Gonçalves, KR; Mazzeti, AL; Mosqueira, VCF; Oliveira, LT; Schaun, GC | 1 |
| Arruda, HMBDS; Gontijo, MKCL; Noronha, EF; Toledo, MI | 1 |
| Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU | 1 |
| Goterris, L; Molina, I; Moure, Z; Oliveira, I; Pou, D; Pumarola, T; Salvador, F; Sánchez-Montalvá, A; Sao-Aviles, A; Serre-Delcor, N; Silgado, A; Sulleiro, E; Tavares de Oliveira, M; Treviño, B | 1 |
| Cascabulho, CM; Castro, SL; Demarque, KC; Duque, TLA; Guimarães, ACR; Manso, PPA; Menna-Barreto, RF; Meuser-Batista, M; Moura, KCG; Oliveira, GM; Pelajo-Machado, M; Pinto, MDC | 1 |
| Carrilero, B; Gil-Gallardo, LJ; Iborra, MA; Romay-Barja, M; Segovia, M; Simón, M; Vázquez, C | 1 |
| Bialek, SR; Montgomery, SP; Perez-Zetune, V; Stillwaggon, E | 1 |
| Alonso-Padilla, J; Cortes-Serra, N; Fernandez-Becerra, C; Gascon, J; Losada-Galvan, I; Pinazo, MJ | 1 |
| Arrúa, EC; Bua, J; Esteva, MI; Fichera, LE; Laucella, SA; Natale, MA; Prado, NG; Rial, MS; Salomon, CJ | 1 |
| Bangher, M; Bosch-Nicolau, P; Correa-Oliveira, R; de Paula, AMB; Eloi, S; Fernández, ML; Molina, I; Molina-Morant, D; Ribeiro, ALP; Salvador, F; Sanchez-Montalva, A; Sosa-Estani, S; Sulleiro, E; Villar, JC | 1 |
| Balthazar Nardotto, GH; Correa-Oliveira, R; da Silva Fonseca, K; Fernanda Rodrigues Bastos Mendes, T; Martins Carneiro, C; Melo de Abreu Vieira, P; Molina, I; Oliveira Paiva, B; Perin, L; Pinto, L | 1 |
| de Almeida Araújo, EJ; Lovo-Martins, MI; Lucchetti, BFC; Malvezi, AD; Martins-Pinge, MC; Pereira, RS; Pinge-Filho, P; Santos, JP; Tavares, ER; Verri, WA; Yamada-Ogatta, SF; Yamauchi, LM | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Micheloud, JF; Negrette, OS; Parada, LA; Ragone, PG; Simonazzi, A | 1 |
| Caldas, IS; Diniz, LF; Gonçalves, RV; Gonçalves-Santos, E; González-Lozano, KJ; Mendonça, AAS; Novaes, RD; Souza-Silva, TG | 2 |
| Alcântara, L; Antonini, L; Botelho Pereira Soares, M; Haddad Franco, C; Holanda Freitas-Junior, L; Mai, A; Matutino Bastos, T; Mautone, N; Moraes, CB; Ragno, R; Rotili, D; Sabatino, M; Schenkman, S; Silvio Moretti, N | 1 |
| Arán, VJ; Batista, DDGJ; Batista, MM; Cumella, J; da Silva, CF; de Oliveira, GM; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Peres, RB; Silva da Gama Nefertiti, A; Soeiro, MNC | 1 |
| Maguire, JH; Manne-Goehler, J; Reich, MR; Yoshioka, K | 1 |
| Abril, M; Álvarez, MG; Bertocchi, G; Castro Eiro, M; Cura, C; Fernández, M; Hernández, Y; Laucella, S; Lococo, B; Lopez-Albizu, C; Natale, MA; Ramírez, JC; Schijman, A; Sosa-Estani, S; Tarleton, RL; Viotti, R | 1 |
| Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC | 1 |
| Braissant, O; Fesser, AF; Kaiser, M; Kelly, JM; Mäser, P; Olmo, F | 1 |
| Couto, NRB; Frade, VP; Oliveira, CDL; Sanches, C; Simões, NS | 1 |
| Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC | 1 |
| Althabe, F; Belizán, JM; Bergel, E; Berrueta, M; Buekens, P; Cafferata, ML; Capparelli, EV; Ciganda, Á; Danesi, E; Dumonteil, E; Gibbons, L; Gulayin, PE; Herrera, C; Klein, K; Momper, JD; Rossi, S; Schijman, AG; Shaffer, JG; Sosa-Estani, S; Stella, CB; Toscani, MA | 1 |
| Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D | 1 |
| Alonso-Padilla, J; Alonso-Vega, C; Cortés-Serra, N; Gascón, J; Losada Galván, I; Pinazo, MJ | 1 |
| Apodaca Michel, B; Baptista Mora, A; Calizaya Tapia, NA; Du Plessis, JD; Lucuy Espinoza, M; Navarro, M; Oltmanns, K; Parisi, S; Pritsch, M; Rivera Rojas, AA; Rubilar, G; Saveedra Irala, C; Shock, JP; Terán, C; Zoller, T | 1 |
| Acharyya, N; Acosta, D; de Araujo, FF; Debrabant, A; Elói-Santos, SM; Martins-Filho, OA; Nagarkatti, R; Teixeira-Carvalho, A | 1 |
| Digirolamo, FA; Galceran, F; Miranda, MR; Pereira, CA; Reigada, C; Sayé, M; Valera-Vera, EA | 1 |
| Branquinho, RT; de Lana, M; Milagre, MM; Reis, LES; Silva, GN; Silva, RR; Silva, TM; Torchelsen, FKVDS | 1 |
| Cunha-Neto, E; Kalil, J; Moore, CE; Nascimento, MS; Pandey, RP; Raj, VS | 1 |
| Búa, J; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Seremeta, KP | 1 |
| Gonzalez Garay, AG; Martinez Garcia, M; Reyes, PP; Vallejo, M | 1 |
| C B Q Figueiredo, R; Carrazone, C; Esmeraldo, AAM; G A M Cavalcanti, M; Gomes, YM; Higino, TMM; Júnior, WO; Lorena, VMB; Martins, SM; Moreira, LR; Nascimento, AV; Neves, PAF; Soares, AKA | 1 |
| Cotta-de-Almeida, V; de Araújo-Jorge, TC; de Meis, J; Ferreira-Reis, R; Lannes-Vieira, J; Marins-Dos-Santos, A; Olivieri, BP; Silva, AA | 1 |
| Alves da Silva, D; Chaves, LL; de Lima, LRM; de Paula, RCM; García-Villén, F; Hallwass, F; Oliveira, ACJ; Oliveira, TC; Ribeiro, FOS; Rolim-Neto, PJ; Silva-Filho, EC; Soares, MFR; Soares-Sobrinho, JL; Viseras, C | 1 |
| Britto, C; Castaño Barrios, L; Cruz Moreira, O; Lannes-Vieira, J; Martins Batista, A; Mata Dos Santos, HA; Resende Pereira, I; Silva, AAD; Vilar-Pereira, G | 1 |
| Fukami, T; Honma, T; Inaoka, DK; Kita, K; Koyama, H; Matsuo, Y; Nakagawa, Y; Nara, T; Ogawa, N; Sekimata, K; Shirouzu, M; Tanaka, A; Tsuganezawa, K; Yuki, H | 1 |
| Carrilero, B; Egui, A; López, MC; López-Ruz, MÁ; Pérez-Antón, E; Segovia, M; Simón, M; Thomas, MC | 1 |
| Bottazzi, ME; Cruz-Chan, JV; Damania, A; González-López, C; Gusovsky, F; Hotez, PJ; Jones, KM; Keegan, B; Pollet, J; Versteeg, L; Villanueva-Lizama, LE; Villar, MJ | 1 |
| de Abreu, AP; de Ornelas Toledo, MJ; de Souza Fernandes, N; Lucas da Silva, HF; Sarto, MPM; Zanusso Junior, G | 1 |
| Busch, MP; Buss, LF; Franco, LAM; Lindoso, JAL; Manuli, ER; Martins, RCR; Moreira, CHV; Oliveira, LC; Pereira, AC; Sabino, EC | 1 |
| Albareda, MC; Alvarez, MG; Bertocchi, GL; Bua, J; Castro Eiro, MD; Cesar, G; Laucella, SA; Lococo, B; Natale, MA; Nuñez, M; Shen, H; Tarleton, RL; Viotti, R | 1 |
| Barnabé, C; Brenière, SF; Coral-Almeida, M; Costales, JA; Sereno, D; Vela, A | 1 |
| Arias, E; Bizai, ML; Bottasso, O; Fabbro, D; Marcipar, I; Olivera, V; Suasnabar, S | 1 |
| Almeida, IC; Alonso-Vega, C; Barboza, T; Barreira, F; Bilbe, G; Blum, B; Correia, E; Garcia, W; Gascón, J; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F; Vaillant, M | 1 |
| Engman, DM; Falk, BA; Li, X; Martinez, SJ; Olson, CL; Romano, PS; Scariot, DB; Scott, EA; Yi, S | 1 |
| da Silva Nascimento, DDS; de Moura Ferraz, LR; Ferreira, AS; Junior, SA; Rolim, LA; Rolim-Neto, PJ; Silva, JYR; Tabosa, AÉGA | 1 |
| Batista, LR; Correia, D; da Silva, DAA; da Silva, MV; de Resende, LAPR; de Sousa, RC; Helmo, FR; Lages-Silva, E; Llaguno, M; Machado, JR; Oliveira, CJF; Rodrigues, DBR; Rodrigues, V | 1 |
| Aoki, MP; Eberhardt, N; García, MC; Jimenez-Kairuz, AF; Ponce, NE; Sanmarco, LM | 1 |
| da Costa, KM; Freire-de-Lima, L; Mendonça-Previato, L; Previato, JO; Salustiano, EJ; Valente, RDC | 1 |
| Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE | 1 |
| Abegg, CP; de Abreu, AP; Fernandes, NS; Gomes, ML; Sarto, MPM; Teston, APM; Toledo, MJO | 1 |
| Bottari, NB; da Silva, AD; da Silva, AS; Fracasso, M; Monteiro, SG; Reichert, K; Schetinger, MRC | 1 |
| Alteri, E | 1 |
| Barreira, F; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F | 1 |
| Fortaleza, CMCB; Nunes da Costa, EAP; Victória, C | 1 |
| Cardona-Castro, N; García-Huertas, P | 1 |
| Bern, C; Cabeza, J; Castro, R; Clark, T; Gilman, RH; Lora, MH; Lozano, D; Mejia, C; Pajuelo, MJ; Reimer-McAtee, MJ; Terle, J; Torrico, F; Valencia, E | 1 |
| Almeida, SR; Atala, MM; Busser, FD; Carneiro, N; Carvalho, NB; de Freitas, VLT; de Oliveira, CMR; Ferrufino, RQ; Furucho, CR; Hage, M; Leite, RM; Luna, E; Martinelli, L; Sátolo, CG; Shikanai Yasuda, MA; Silva, RA; Viñas, PA; Wanderley, DM | 1 |
| Muñoz Casas Del Valle, P | 1 |
| Abi-Saab Arrieche, M; Aguilar, NG; Alves, RV; Chaves, GC; Mechali, D; Reis, PO; Ribeiro, I; Rode, J; Stobbaerts, E | 1 |
| Lazarin-Bidóia, D; Nakamura, CV; Peron, F; Rodrigues-Filho, E; Silva, SO; Ud Din, Z; Ueda-Nakamura, T | 1 |
| Brasil, PEAAD; Brum-Soares, LM; Cubides, JC; Fux, CP; Hasslocher-Moreno, AM; Holanda, MT; Mediano, MFF; Mejía, RA; Sangenis, LHC; Saraiva, RM; Silvestre de Sousa, A; Sperandio da Silva, GM | 1 |
| Urbina, JA | 3 |
| Leite, ALJ; Lopes, LR; Paula Costa, G; Reis Mota, LWD; Talvani, A; Vieira, PMA | 1 |
| Álvarez, MG; Bertocchi, G; Lococo, B; Vigliano, C; Viotti, R | 1 |
| Bahia, MT; Batista, DGJ; Batista, MM; Cardoso-Santos, C; D'Almeida-Melo, I; Da Silva, CF; Da Silva, PB; De Araújo, JS; Demarque, KC; Oliveira, GM; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| García, GA; García-Huertas, P; González, L; Mejía-Jaramillo, AM; Murta, SMF; Triana-Chávez, O | 1 |
| Alpern, JD; Lopez-Velez, R; Stauffer, WM | 1 |
| Agüero, F; Alvarez, VE; Cazzulo, JJ; Karpiak, J; Landaburu, LU; Madauss, KP; Salas-Sarduy, E | 1 |
| Zingales, B | 1 |
| Alonso, V; Leonardi, D; Real, D; Rocha, SC; Salomon, CJ; Santos Souza, HF; Serra, E; Silber, AM | 1 |
| Agreda-Rudenko, D; Cucunubá, ZM; Duque, S; Flórez, C; Herazo, R; Nicholls, RS; Olivera, MJ; Valencia-Hernández, CA | 1 |
| Acarregui, A; Elizondo, E; Esquisabel, A; Herráez, R; Oliver, L; Pedraz, JL; Veciana, J; Ventosa, N; Viñas, M; Vinuesa, T | 1 |
| Carneiro, CM; Corrêa-Oliveira, R; Fonseca Murta, SM; Molina, I; Sales Junior, PA; Salvador, F; Sánchez-Montalvá, A | 1 |
| Cevey, ÁC; Donato, M; Gelpi, RJ; Goren, NB; Mirkin, GA; Penas, FN; Rada, MJ | 1 |
| Leone, JL | 1 |
| Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC | 1 |
| Melton, L | 1 |
| Alonso-Vega, C; Alves, F; Curto, MA; de la Barra, A; Flevaud, L; García, L; Gascón, J; Irazu, L; Molina, I; Ortiz, L; Parrado, R; Ramírez, JC; Ribeiro, I; Rodríguez, M; Schijman, AG; Sulleiro, E; Torrico, F; Villarroel, S | 1 |
| Morrow, T | 1 |
| Chakradhar, S | 1 |
| Gonçalves, RV; Novaes, RD | 2 |
| Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML | 2 |
| Kian, D; Massago, M; Toledo, MJO; Zanusso Junior, G | 1 |
| Cubides, JC; Hasslocher-Moreno, AM; Holanda, MT; Mediano, MFF; Sangenis, LHC; Saraiva, RM; Sousa, AS; Sperandio da Silva, GM | 1 |
| Aldasoro, E; Calvo-Cano, A; Casellas, A; Gascon, J; Pinazo, MJ; Posada, E; Requena-Méndez, A; Sanz, S; Serret, N; Soy, D | 1 |
| Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F | 1 |
| Aguilera, E; Alvarez, G; Bilbao, NV; Cerecetto, H; González, M; Serna, E; Torres, S; Varela, J; Yaluff, G | 1 |
| Busch, MP; Caillaudeau, J; Cardoso, CS; de Oliveira, LC; Ferreira, AM; Granjon, E; Gueyffier, L; Lee, TH; Liehl, P; Oliveira, CDL; Pottel, H; Ribeiro, ALP; Sabino, EC; Zrein, M | 1 |
| Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME | 1 |
| Alves, AÉG; Amariz, IAE; Costa, SPM; Ferraz, LRM; Ferreira, AS; Lima, ÁAN; Nascimento, DDSDS; Rolim Neto, PJ; Rolim, LA | 1 |
| Antinori, S; Bestetti, G; Bianco, R; Cogliati, C; Corbellino, M; De Maio, G; Egidi, AM; Galimberti, L; Galli, M; Garelli, S; Gismondo, MR; Grande, R; Lai, A; Mileto, D; Oreni, L; Petullà, M; Repetto, EC; Ricaboni, D; Ridolfo, AL; Torzillo, D; Traversi, L; Villa, AM | 1 |
| Chopra, S; Dasgupta, A; Thakare, R | 1 |
| Andrade-Lima, L; Borsoi, J; da Silva Lara, L; Henriques-Pons, A; Lopes Alberto Duque, T; Magalhães Calvet, C; Souza Pereira, MC; Veiga Pereira, L | 1 |
| Calbacho Robles, M; Crespillo-Andújar, C; Norman, FF; Pérez-Molina, JA | 1 |
| Albuquerque, EL; Barroso Neto, IL; Bezerra, EM; de Menezes, RRPPB; Dos Santos, RP; Freire, VN; Lima, DB; Magalhães, EP; Martins, AM; Mello, CP; Oliveira, MF; Sales, FAM; Tessarolo, LD | 1 |
| Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Schver, GCRM; Soares Sobrinho, JL; Soares, MFR; Vieira, ACQM | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Martinelli, M; Ponce, NE; Sanmarco, LM | 1 |
| Báez, AL; Bazán, PC; Bustamante, JM; Lo Presti, MS; Nakamura, CV; Paglini-Oliva, P; Rivarola, HW; Rodrigues, JHS; Strauss, M | 1 |
| Bastos, MM; Batista, DDGJ; Bianco, MDCAD; Boechat, N; da Gama, ANS; da Silva, CF; da Silva, PB; de Oliveira, AP; Fontes, FV; Hoelz, LVB; Leite, DI; Peres, RB; Soeiro, MNC; Villar, JDF | 1 |
| García, MC; Jimenez-Kairuz, A; Manzo, RH | 1 |
| Cuéllar, A; Egui, A; González, JM; López, MC; Pérez-Antón, E; Puerta, CJ; Segovia, M; Thomas, MC | 1 |
| Chamorro-Tojeiro, S; Crespillo-Andújar, C; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA | 1 |
| Aiub, CAF; Araujo-Lima, CF; Batista, MM; Felzenszwalb, I; Peres, RB; Silva, PB; Soeiro, MNC | 1 |
| Camargo, RS; Carneiro, ZA; de Albuquerque, S; do Vale, GT; Portapilla, GB; Providello, MV; Tirapelli, CR | 1 |
| Brancaglion, GA; Caldas, IS; Cardoso Machado, JV; Carvalho, DT; Dos Santos, EG; Fernandes Júnior, AÁ; Silveira, AT; Toyota, AE; Vilas Boas, DF | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Gonzo, E; Parada, L; Simonazzi, A | 1 |
| Crespillo-Andújar, C; López-Polín, A; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Venanzi-Rullo, E | 1 |
| Allen, CK; Brown, MN; Dougherty, CP; Herwaldt, BL; Jolly, JP; Yu, P; Yu, Y | 1 |
| Forsyth, CJ; Garcia Bournissen, F; Kratz, JM; Sosa-Estani, S | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A | 1 |
| Batlle, A; Demaria, A; Frank, FM; Lombardo, ME; Puente, V | 1 |
| Albareda, MC; Alvarez, MG; Bua, J; Castro Eiro, MD; Cooley, G; De Rissio, AM; Fernandez, M; Fichera, LE; Laucella, SA; Lococo, B; Natale, MA; Nuñez, M; Scollo, K; Serjan, A; Shen, H; Tarleton, RL; Viotti, R | 1 |
| Altcheh, J; Alves, F; Blum, B; Damasceno Sousa, G; Galindo Bedor, DC; Garcia-Bournissen, F; Pereira de Santana, D; Ribeiro, I; Tavares Cavalcanti Bedor, NC; Viturino da Silva, JW | 1 |
| Benatar, AF; Búa, J; Esteva, MI; Fichera, LE; López Alarcón, M; Prado, NG; Rial, MS; Riarte, AR; Scalise, ML | 1 |
| Chin, CM; da Rosa, JA; de Andrade, CR; Dos Santos, JL; Scarim, CB | 1 |
| Bezerra, FS; Costa, GP; Figueiredo, VP; Horta, AL; Leite, ALJ; Menezes, APJ; Pedrosa, TCF; Ramos, CO; Talvani, A; Vieira, PMA | 1 |
| Egui, A; Lasso, P; López, MC; Pérez-Antón, E; Thomas, MC | 1 |
| Bierrenbach, AL; Busch, MP; Cardoso, CS; Colosimo, EA; Ferreira, AM; Ferreira, JE; Lee, TH; Oliveira, CDL; Oliveira, LC; Reingold, AL; Ribeiro, ALP; Sabino, EC; Silva, JLP | 1 |
| Bastos, TM; Efstathiou, A; Gaboriaud-Kolar, N; Meira, CS; Rocha, VPC; Skaltsounis, AL; Smirlis, D; Soares, MBP; Vougogiannopoulou, K | 1 |
| Avalos Esquivel, JL; Crespo, M; García López, E; Grau, S; Horcajada, JP; López Montesinos, I; Mir, M; Molina-Morant, D; Monge, I; Montero, M; Mounteis Oliva, E; Pascual, J; Sorlí, L; Sulleiro, E; Veliz Espinosa, G | 1 |
| Carneiro, ZA; Chaves, JDS; de Albuquerque, S; de Almeida, MV; de Oliveira, LP; de Oliveira, RJ; Ellena, J; Guerra, W; Guilardi, S; Lopes, CD; Lopes, NP; Moreira, MB; Netto, AVG; Paixão, DA; Pivatto, M; Sousa, LM | 1 |
| da Silva-Júnior, AA; de Menezes, RPRPB; Fernandes-Pedrosa, MF; Martins, AMC; Sarmento, VHV; Streck, L | 1 |
| Borchardt, RA; Tzizik, DM | 1 |
| Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F | 1 |
| Alves-Silva, LS; Amarante, E; Barral-Netto, M; Barreto, LO; Camara, EJN; Carvalho, JS; Chiacchio, G; Cunha, M; Gatto, R; Guimarães, BAC; Lessa, RA; Mendonca, VRR; Souza, LCL | 1 |
| Batista, DDGJ; Batista, MM; Britto, C; Da Silva, CF; Guedes-da-Silva, FH; Lepesheva, GI; Moreira, OC; Pavão, BP; Rachakonda, G; Soeiro, MNC; Souza, LRQ; Villalta, F | 1 |
| Buekens, P; Dumonteil, E; Herrera, C | 1 |
| Abril, M; Alonso-Padilla, J; Barreira, F; Bottazzi, ME; Cortés-Serra, N; Gascón, J; Hotez, PJ; Pinazo, MJ; Sosa-Estani, S | 1 |
| Echeverria, LE; Morillo, CA | 1 |
| Dolgalev, I; Dominguez-Bello, MG; Frattaroli, P; Heguy, A; Hevia, A; Hoashi, M; Iraola, G; Maldonado, DP; Mojica, M; Montacutti, V; Robello, C | 1 |
| Bahia, MT; Bastos, MM; Batista, MM; Boechat, N; Da Silva, PB; De Araújo, JS; De Azevedo, LD; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| Alonso-Padilla, J; Cortes-Serra, N; Gascon, J; Pinazo, MJ; Reverter, JC; Tassies, D | 1 |
| Albareda, MC; Alvarez, MG; Castro Eiro, MD; Cesar, GL; Laucella, SA; Natale, MA | 1 |
| Couceiro, KDN; Doria, SS; Ferreira, JMBB; Guerra, JAO; Guerra, MDGVB; Lira, EDF; Ortiz, JV; Pereira, BVM; Silva, MRHDSE; Silva, PRLD | 1 |
| Herrero-Martínez, JM; Lizasoain Hernández, M; Losada Galván, I; Madrid Pascual, O; Pérez-Ayala, A | 1 |
| Cebrián, R; Maqueda, M; Marín, C; Martín-Escolano, J; Martín-Escolano, R; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Assíria, T; Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Ribeiro, I; WonDollinger, RS | 1 |
| Custodio Leite, TO | 1 |
| Brandão Peres, R; Britto, C; Cristina Demarque, K; da Cruz Moreira, O; de Melo Oliveira, G; de Nazaré Correia Soeiro, M; Diego de Souza Campos, J; Finamore Araújo, P; França da Silva, C; Lima da Costa, K; Machado Cascabulho, C; Meuser Batista, M; Nefertiti da Gama, A; Rocha Simões-Silva, M | 1 |
| Assy, JGPL; Berreta, OCP; Esper, HR; França, FOS; Freitas, VLT; Lopes, MH; Shimoda, EY | 1 |
| Asti, L; Bartsch, SM; Bottazzi, ME; Falcón-Lezama, JA; Hotez, PJ; Lee, BY; Meymandi, S; Randall, S; Strych, U | 1 |
| Gonçalves, RV; Maldonado, IRSC; Mendonça, AAS; Natali, AJ; Novaes, RD; Souza-Silva, TG; Talvani, A | 1 |
| Burki, T | 1 |
| Carneiro, CM; Cunha, ELA; Cunha, LM; de Lana, M; de Oliveira, MT; Fonseca, KDS; Torchelsen, FKVDS; Vieira, PMA | 1 |
| Arrúa, EC; Bedogni, GR; Okulik, NB; Salomon, CJ; Seremeta, KP | 1 |
| Castellanos Domínguez, YZ; Cucunubá, ZM; Hernández, Y; Herrera, VM; Pérez Carreño, JG; Prado, NG; Váquiro Herrera, E; Vásquez, SM; Villar, JC | 1 |
| Kratz, JM | 1 |
| Carneiro, ACA; Carvalho, ACC; Costa, GP; Ferreira, CS; Gonçalves, RV; Leite, ALJ; Menezes, APJ; Nogueira, KOPC; Ramos, IPR; Sarandy, MM; Silva, BM; Talvani, A | 1 |
| Bronzon da Costa, CM; Bulhões Portapilla, G; de Albuquerque, S; Ferreira Anchieta, N; Goulart, A; Leite Braga, GÚ; Pereira, LM; Sampaio Oliveira, PA; Voltarelli Providello, M; Wainwright, M | 1 |
| Gonçalves, RV; Maldonado, IRSC; Natali, AJ; Novaes, RD; Santos, EC; Santos, EG; Souza-Silva, TG; Talvani, A | 1 |
| Muñoz-Calderon, A; Schijman, AG; Sulleiro, E | 1 |
| Espinoza, B; Martínez, I; Martínez-Hernández, F; Nogueda, B | 1 |
| Baez, A; Bazán, PC; Cremonezzi, D; Esteves, B; Fauro, R; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Sanchez Negrete, O; Strauss, M | 1 |
| Alarcon, ML; Bua, J; Fichera, LE; Grosso, NL; Laucella, SA; Riarte, A | 1 |
| Campos-Estrada, C; Duaso, J; Ferreira, J; Galanti, N; Kemmerling, U; Lapier, M; Leiva, M; López-Muñoz, R; Maya, JD; Molina-Berríos, A | 1 |
| Bruballa, AC; De Rissio, AM; Garavaglia, PA; García, GA; Irazu, LE; Riarte, A; Rodríguez, MA; Ruiz, AM; Santamaría, AL | 1 |
| Albajar-Viñas, P; Díaz-Menéndez, M; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Sojo-Dorado, J | 1 |
| Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP | 1 |
| Cabello, A; Fernández-Roblas, R; Górgolas, M; Peremarch, CP; Pérez-Tanoira, R; Rincón, JM; Robles, I; Williams, F | 1 |
| Coura, JR; de Macedo, RC; Ferreira, AG; Junqueira, AC; Pinto, AY; Santos, LC; Valente, SA; Valente, Vda C | 1 |
| Arias, E; Bizai, ML; Denner, S; Fabbro, D; Olivera, V; Pravia, C; Ruiz, AM; Velazquez, E | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Anyanwu, A; Bosserman, E; Herwaldt, B; Huprikar, S; Ketterer, D; Montgomery, S; Moore, A; Neofytos, D; Patel, G; Pinney, S; Qvarnstrom, Y; Silveira, F; Steurer, F; Striker, R | 1 |
| Alonso-Vega, C; Billot, C; Torrico, F | 1 |
| Basombrío, MA; Cimino, RO; D'Amato, AM; Diosque, P; Gil, JF; Lacunza, CD; Lauthier, JJ; Nasser, JR; Orellana, V; Pérez Brandán, C; Ragone, PG; Rumi, MM; Tomasini, N | 1 |
| Adams, M; Batista, Dda G; Batista, MM; Brun, R; da Silva, CF; da Silva, PB; De Araújo, JS; De Mieri, M; de Souza, EM; Hamburger, M; Hammer, ER; Lionel, J; Schühly, W; Soeiro, Mde N; Zimmermann, S | 1 |
| Bustamante, JM; Craft, JM; Crowe, BD; Ketchie, SA; Tarleton, RL | 1 |
| Altcheh, J; Bisio, M; Bournissen, FG; Burgos, JM; Fink, V; Freilij, H; Lattner, J; Moscatelli, G; Schijman, AG | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA | 1 |
| Albajar-Viñas, P; Coura, JR; Dias, JC; Diniz, GA; Lana, Md; Machado-Coelho, GL; Machado-de-Assis, GF; Montoya, RA; Torres, RM | 1 |
| Altcheh, J; Dana, DD; García-Bournissen, F; Marsón, ME; Mastrantonio, G | 1 |
| Bern, C; Castellon, M; Gilman, RH; Lozano Beltran, DF; Solano Mercado, MA; Sullca, W; Tornheim, JA; Torrico, F | 1 |
| Ayala, AP; Boechat, N; Ellena, J; Honorato, SB; Mendes Filho, J; Mendonça, JS; Oliveira, AC | 1 |
| Ferraz, LR; Figueirêdo, CB; Lima Leite, AC; Lyra, MA; Neves de Lima, ÁA; Peixoto, MS; Rolim Neto, PJ; Rolim, LA; Santos, FL; Soares-Sobrinho, JL | 1 |
| Aguilera-Venegas, B; Arán, VJ; Olea-Azar, C; Speisky, H | 1 |
| Beaulieu, C; Black, WC; Isabel, E; Massé, F; Mellon, C; Methot, N; Nath-Chowdhury, M; Ndao, M; Nicoll-Griffith, DA; Vasquez-Camargo, F | 1 |
| Alves, CL; Cruz, AK; de Medeiros, MH; de Moura, MB; de Souza-Pinto, NC; Franco, GR; Furtado, C; Garcia, JB; Kunrath-Lima, M; Macedo, AM; Machado, CR; Mendes, IC; Motta, MC; Passos-Silva, DG; Pena, SD; Rajão, MA; Schamber-Reis, BL; Teixeira, SM; Vieira-da-Rocha, JP; Zuma, AA | 1 |
| Fujikura, Y; Imai, K; Iwata, O; Kawana, A; Kurane, I; Maeda, T; Mikita, K; Misawa, K; Miura, S; Miyahira, Y; Nagumo, M; Ono, T; Sayama, Y | 1 |
| Branquinho, RT; de Lana, M; de Oliveira-Silva, JC; Mosqueira, VC; Saúde-Guimarães, DA; Simões-Silva, MR | 1 |
| Fisa, R; Fumadó, V; Gállego, M; Gascón, J; Juncosa, T; Posada, E | 1 |
| Bustamante, JM; Tarleton, RL | 1 |
| Batista, MM; Boykin, DW; Da Silva, PB; Farahat, AA; Kumar, A; Soeiro, MN; Timm, BL | 1 |
| Bakunov, SA; Bakunova, SM; Batista, MM; da Silva, CF; da Silva, FH; da Silva, PB; Jones, SK; Patrick, DA; Soeiro, Mde N; Tidwell, RR; Timm, BL | 1 |
| Blanco-Grau, A; Cabezos, J; Gómez i Prat, J; Molina, I; Pahissa, A; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L; Vidal, X | 1 |
| Albajar-Viñas, P; Dias, JC | 1 |
| Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL | 1 |
| Altcheh, J; Ballering, G; Bisio, M; García-Bournissen, F; Giglio, N; Koren, G; Marson, ME; Mastrantonio, G; Moroni, S; Moscatelli, G | 1 |
| Moraes, CM; Pasqualotto, AC; Poloni, JA; Rotta, LN; Seelig, DC | 1 |
| Flash, CA; Goodman, JC; Patel, SM; Stager, CE; Woc-Colburn, L; Yasukawa, K | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Palmeiro-Roldán, R; Torrado-Durán, S; Torrado-Santiago, S | 1 |
| Bibolini, J; Cicora, F; Escurra, V; González, I; Petroni, J; Roberti, J | 1 |
| Alvarenga Americano do Brasil, PE; da Costa Chambela, M; da Silva, JA; de Sousa, AS; Hasslocher-Moreno, AM; Magalhães Saraiva, R; Mediano, MF; Rodrigues da Costa, A; Sperandio da Silva, GM; Xavier, SS | 1 |
| Alonso, C; Carrilero, B; Fernández-Villegas, A; López, MC; Marañón, C; Moralo, S; Murcia, L; Segovia, M; Téllez, C; Thomas, MC | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Cornou, L; García-Bournissen, F; Marson, ME; Mastrantonio, G; Moroni, S; Moscatelli, G | 1 |
| Manne-Goehler, J; Ramsey, JM; Reich, MR; Salgado, MO; Wirtz, VJ | 1 |
| Carneiro, ZA; da Silva, RS; Milanezi, C; Santos, M; Sesti-Costa, R; Silva, GK; Silva, JS; Silva, MC | 1 |
| Cerutti, S; Marson, ME; Martínez, N; Mastrantonio, GE; Raba, J | 1 |
| Basombrio, MA; Davies, C; Dey, N; Garg, NJ; Negrette, OS; Parada, LA | 1 |
| Aldasoro, E; Gascon, J; Munoz, J; Oliveira, I; Pinazo, MJ; Posada, E; Requena-Méndez, A; Serret, N | 1 |
| Aznar, C; Bisio, M; Blanchet, D; Brenière, SF; Demar-Pierre, M; Djossou, F; Mayence, C; Schijman, AG; Simon, S; Véron, V | 1 |
| Angheben, A; Anselmi, M; Bisoffi, Z; Buonfrate, D; Chiampan, A; Gobbi, F; Mainardi, P; Marocco, S; Postiglione, C; Repetto, E; Tais, S | 1 |
| de Araujo, FF; Debrabant, A; Gupta, C; Marino, AP; Nagarkatti, R | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Palmeiro-Roldán, R; Torrado, S; Torrado-Santiago, S | 1 |
| Eells, SJ; Hernandez, S; Meymandi, SK; Miller, DA; Miller, LG; Rodriguez De Armas, L; Traina, MM | 1 |
| Batista, MA; Béla, SR; Campi-Azevedo, AC; Correa-Oliveira, R; Eloi-Santos, SM; Gomes, JA; Martins-Filho, OA; Peruhype-Magalhães, V; Sathler-Avelar, R; Schachnik, NC; Silveira-Lemos, D; Silvestre, KF; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Morilla, MJ; Romero, EL | 1 |
| Califano, AN; Echevarria, RN; Padró, JM; Pellegrino Vidal, RB; Reta, MR | 1 |
| Chaplin, JH; Keenan, M | 1 |
| Araújo, MS; Carneiro, CM; Lana, Md; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Oliveira, MT; Oliveira-Silva, JC; Paiva, NC | 1 |
| Imai, K; Kawana, A; Kurane, I; Maeda, T; Mikita, K; Miura, S; Miyahira, Y; Osa, M; Sayama, Y | 1 |
| García, MC; Jimenez-Kairuz, AF; Manzo, RH | 1 |
| Aldasoro, E; Gascón, J; Guerrero, L; Mejía, T; Posada, E; Serret, N; Soy, D; Urbina, JA | 1 |
| Baeza, I; Meza-Toledo, S; Nogueda-Torres, B; Serna, M; Wong, C; Wong-Baeza, C | 1 |
| Bastos, DS; Carvalho, TV; Cupertino, MC; Neves, MM; Novaes, RD; Oliveira, JM; Oliveira, LL; Santos, EC; Talvani, A | 1 |
| Araújo, SM; Barbosa, Md; Gomes, ML; Gruendling, AP; Kaneshima, EN; Massago, M; Monteiro, WM; Teston, AP; Toledo, MJ | 1 |
| Almeida, IC; Bustamante, J; Gascon, J; Lopez, MC; Pinazo, MJ; Thomas, MC | 1 |
| Campos-Estrada, C; Ferreira, J; González-Herrera, F; Kemmerling, U; Lapier, M; Liempi, A; López-Muñoz, R; Maya, JD; Pesce, B | 1 |
| Manne-Goehler, J; Reich, MR; Wirtz, VJ | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Freilij, H; García-Bournissen, F; Moroni, S; Moscatelli, G | 1 |
| Albareda, MC; Laucella, SA | 1 |
| Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC | 1 |
| Bocanegra, C; Molina, I; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L | 1 |
| Assíria Fontes Martins, T; Bahia, MT; Caldas, IS; Caldas, S; da Silva do Nascimento, ÁF; de Andrade, IM; de Figueiredo Diniz, L; Mazzeti, AL; Ribeiro, I | 1 |
| Bahia, MT; Bastos, DS; Cupertino, MC; Fietto, JL; Klein, RC; Novaes, RD; Oliveira, LL; Santos, EC; Silva, EA; Talvani, A | 1 |
| Anibal, Fde F; Costa, FC; da Silva, MT; de Lima, GM; Portapilla, GB; Silva-Jardim, I; Thiemann, OH | 1 |
| Almirante, B; Molina, I; Salvador, F; Sánchez-Montalvá, A; Sao Avilés, A; Serre, N; Treviño, B | 1 |
| Morel, CM; Thota, S | 1 |
| Marín, C; Martín-Escolano, R; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K | 1 |
| Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V | 1 |
| Aparicio, G; Artaza, MÁ; Ferrer, B; García-Prat, M; Martínez-Gallo, M; Molina, I; Sala-Cunill, A; Salvador, F; Sánchez-Montalvá, A; Sao Avilés, A; Viñas, L | 1 |
| Alba Soto, CD; Curto, MLA; Lammel, EM; Miranda, CG; Schijman, AG; Solana, ME | 1 |
| Cifuente, D; Lozano, E; Rivarola, HW; Sosa, MA; Spina, R; Strauss, M; Tonn, C | 1 |
| Avezum, Á; Cordeiro Mattos, AJ; Oliveira, GB | 1 |
| Batista, DG; Britto, C; da Silva, CF; de Araújo, JS; Ferreira, CG; Guedes-da-Silva, FH; Lepesheva, GI; Meuser, MB; Moreira, OC; Simões-Silva, MR; Soeiro, Mde N | 1 |
| Ciapponi, A; Comandé, D; Cuesta, CB; Hicks, E; Roberts, KN; Sguassero, Y; Sosa-Estani, S | 1 |
| Friedman, JM; Garg, NJ; Lora, JN; Machado, FS; Moraes, DN; Nagajyothi, J; Nunes, MC; Ribeiro, AL; Spray, DC; Tanowitz, HB; Weiss, OS | 1 |
| Angheben, A; Aprili, G; Bisoffi, Z; Boix, L; Buonfrate, D; Gandini, G; Gobbi, F; Pupella, S | 1 |
| Ramos, C; Vela-Bahena, LE; Vergara, R; Vite, L | 1 |
| Abril, M; Albizu, CL; Álvarez, MG; Bertocchi, G; Cura, C; Fernández, M; Hernández, Y; Lococo, B; Ramírez, JC; Schijman, A; Sosa-Estani, S; Viotti, R | 1 |
| Díaz, ML; Escobar, P; González Rugeles, CI; Leal, S; López-Muñoz, R; Mantilla, JC; Molina-Berríos, A; Solari, A | 1 |
| Abras, A; Aldasoro, E; de Almeida, IC; de Lazzari, E; Gallego, M; Gascon, J; Izquierdo, L; Marques, AF; Muñoz, J; Pinazo, MJ; Posada, Ede J; Reverter, JC; Tassies, D; Tebar, S | 1 |
| Bermudez, J; Davies, C; Palma, S; Real, JP; Simonazzi, A | 1 |
| Cunha-Filho, MS; Infante, CM; Pinho, LA; Sá-Barreto, LC | 1 |
| Bellón, T; Cabañas, R; Cachafeiro, L; González-Ramos, J; Herranz-Pinto, P; Noguera-Morel, L; Ramírez, E; Ruiz-Bravo, E; Tong, HY | 1 |
| Araújo, JS; Bakunov, SA; Bakunova, SM; Batista, DG; Britto, C; Da Silva, CF; Da Silva, PB; Demarque, KC; Fulco, TO; Guedes-da-Silva, FH; Meuser, MB; Moreira, OC; Oliveira, GM; Patrick, DA; Soeiro, MN; Tidwell, RR | 1 |
| Cannata, JJ; Garavaglia, PA; García, GA; Laverrière, M | 1 |
| Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN | 1 |
| Alzate, AH; Campos, ML; Davanço, MG; Padilha, EC; Peccinini, RG; Rolim, LA; Rolim-Neto, PJ; Rosa, TA | 1 |
| Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A | 1 |
| Batista, C; Bottazzi, ME; Gascon, J; Gold, S; Hotez, PJ; Moriana, S; Navarro, M; Pecoul, B; Pereiro, A; Pinazo, MJ; Ribeiro, I; Stobbaerts, E; Torrico, F; Vilasanjuan, R | 1 |
| Costa, CA; Faccini, CC; Fragata, Cda S; Fragata-Filho, AA; França, FF; Lourenço, AM | 1 |
| Altcheh, J; Bournissen, FG; Fernández, ML; Marson, ME; Mastrantonio, G; Ramirez, JC; Riarte, AR; Schijman, AG | 1 |
| Caldas, IS; Gonçalves, RV; Novaes, RD; Rodrigues, JP; Santos, EC; Sartini, MV; Souza, RL | 1 |
| Bezerra, RC; Buccheri, R; Freitas, VL; Kassab, MJ; Khoury, Z; Shikanai-Yasuda, MA; Silva, SC; Vidal, JE | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM | 1 |
| Albareda, MC; Alvarez, MG; Bertocchi, GL; Castro Eiro, M; Cooley, G; Laucella, SA; Lococo, B; Perez-Mazliah, DE; Tarleton, RL; Viotti, R | 1 |
| Britto, C; Cruz Moreira, O; da Silva, AA; de Souza Ruivo, LA; Lannes-Vieira, J; Resende Pereira, I; Vilar-Pereira, G | 1 |
| Ayala, V; Bisio, M; Burgos, JM; Contreras, A; Coppede, M; Elean, JC; García-Bournissen, F; Gómez, KA; Grippo, V; Herrera, V; Juiz, NA; Lafón, SO; Levin, MJ; Levitus, G; Longhi, SA; López, C; Mujica, HD; Niborski, LL; Ramirez, JC; Schijman, AG | 1 |
| Briceno, L; Mosca, W | 1 |
| Arán, VJ; Batista, MM; DA Silva, CF; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Menna-Barreto, RF; Soeiro, Mde N | 1 |
| Branquinho, RT; de Mello, CG; Lana, Md; Milagre, MM; Mosqueira, VC; Oliveira, MT; Saúde-Guimarães, DA | 1 |
| Moreno-Viguri, E; Paucar, R; Pérez-Silanes, S | 1 |
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| Alarcón, A; Hahn, A; Jantausch, B; Montgomery, SP; Morgan, M; Scavo, L; Wong, EC | 1 |
| Carrilero, B; Ferrer, F; Franco, F; Murcia, L; Roig, M; Segovia, M | 1 |
| Brunoro, GV; Caminha, MA; de Moura, KC; Faça, VM; Ferreira, AT; Menna-Barreto, RF; Perales, J; Trugilho, M; Valente, RH | 1 |
| Gutiérrez, C; López-Vélez, R; Monge-Maillo, B; Norman, FF; Pérez-Molina, JA; Vallejo, A | 1 |
| Antunes, AF; Barbosa, Md; Ferreira, JM; Guerra, JA; Maduro, SG; Pereira, BV | 1 |
| Campos-Estrada, C; Castro, L; Cortes, L; Díaz, MV; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Miranda, MR; Morello, A; Pereira, CA; Reigada, C; Seguel, V | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Catania, VA; Luquita, MG; Pellegrino, JM; Perdomo, VG; Rigalli, JP; Ruiz, ML | 1 |
| Alvarellos, E; Alvarellos, T; Caeiro, JP; Cordeiro, E; Kohout, I; Rodriguez Schulz, DG; Sánchez, AG | 1 |
| Carnovale, CE; Catania, VA; de Luján Alvarez, M; Francés, DE; Lambertucci, F; Martín-Sanz, P; Motiño, O; Quiroga, AD; Rigalli, JP; Ronco, MT; Villar, S | 1 |
| Andrades, ED; Andrades-Grassi, FA; Andrades-Grassi, JE; Cabrera, H; García, LC; Grassi, HC; Lobo-Sulbarán, ML; Velásquez, A | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Galvão, LMDC; Guedes, PMDM; Lima, WG; Nascimento, ÁFDSD | 1 |
| Adeyemi, OS; Eseola, AO; Fonseca-Berzal, C; Gómez-Barrio, A; Molina, MT | 1 |
| Alarcón de Noya, B; Castro, J; Colmenares, C; Díaz-Bello, Z; Gutiérrez, H; Naranjo, L; Noya, O; Noya-Alarcón, O; Ossenkopp, J; Quinci, G; Ruiz-Guevara, R; Suárez, JA; Torres, J | 1 |
| Alonso-Pacheco, ML; González-Ramos, J; Herranz-Pinto, P; Mora-Rillo, M | 1 |
| Cardoso, JM; Carneiro, CM; Correa-Oliveira, R; Fonseca, KD; Mathias, FA; Molina, I; Moreira da Silva, R; Perin, L; Reis, LE; Vieira, PM | 1 |
| Carrilero, B; Murcia, L; Roig, M; Segovia, M; Simón, M | 1 |
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| Apt, W; Beloscar, J; Bonilla, LR; Colombo, H; Cuneo, C; Del Carmen Bangher, M; Echeverria, LE; Gao, P; Gascon, J; Mallagray, M; McCarthy, M; Meeks, B; Milesi, R; Molina, I; Morillo, CA; Perez-Molina, JA; Sosa-Estani, S; Waskin, H; Wei, B; Wyss, F; Yusuf, S | 1 |
| Bahia, MT; Bloomer, WD; Gonçalves, KR; Mazzeti, AL; Mendes, PF; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Bahia, MT; de Araújo, SM; de Lana, M; de Ornelas Toledo, MJ; Gomes, ML; Marangon, AV; Martins-Filho, OA; Miyamoto, CT | 1 |
| Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM | 1 |
| Elói-Santos, SM; Faria, AM; Gontijo, ED; Martins-Filho, OA; Pinto Dias, JC; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| de Souza, JL; Ianni, BM; Mady, C | 1 |
| Bahia, MT; Caldas, S; Crepalde, GP; de Assis Cáu, SB; de Lana, M; Dos Santos, FM; Machado-Coelho, GL; Veloso, VM | 1 |
| Bahia, MT; de Lana, M; dos Santos, DM; Guedes, PM; Machado-Coelho, GL; Talvani, A | 1 |
| Lamas, MC; Leonardi, D; Olivieri, AC; Salomón, CJ | 1 |
| A, IZ; B, WA; G, IH; H, IN; H, MT; L, MI; M, LJ; P, JS; V, AM; V, PM | 1 |
| Mejía-Jaramillo, AM; Peña, VH; Triana-Chávez, O | 1 |
| Bottasso, E; Bottasso, O; Manarin, R; Revelli, S; Serra, E | 1 |
| Gargiullo, G; Papayanis, C; Sica, RE | 1 |
| Altcheh, J; Della Védova, CO; Garcia-Bournissen, F; Giglio, N; Koren, G; Mastrantonio, G | 1 |
| Develoux, M; Le Loup, G; Lescure, FX; Pialoux, G | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Lococo, B; Petti, M; Vigliano, C; Viotti, R | 1 |
| Balbinot, MM; Fernandes, CD; Liarte, DB; Romanha, A; Scholl, D; Steindel, M; Tiecher, FM | 1 |
| Bestetti, RB; Theodoropoulos, TA | 1 |
| Ferreira, AG; Harada, GS; Pinto, AY; Valente, SA; Valente, Vda C | 1 |
| Alba Soto, CD; Fernández, MC; González Cappa, SM; Poncini, CV; Postan, M; Solana, ME | 1 |
| Alquichire, C; Diazgranados, CA; Franco-Paredes, C; Mantilla, M; Saavedra-Trujillo, CH; Valderrama, SL | 1 |
| Albajar Viñas, P; Castillo, S; Chambi, W; Ellman, T; Flevaud, L; Lima, MA; Palma, PP; Parreño, F; Roddy, P; Yun, O | 1 |
| Budni, P; Colepicolo, P; Dalmarco, EM; Farias, MS; Filho, DW; Fröde, TS; Oliveira-Silva, D; Parisotto, EB; Pedrosa, RC; Ribeiro, CM | 1 |
| Altcheh, J; Bisio, M; Burgos, JM; Freilij, H; Levin, MJ; Petrucelli, N; Schijman, AG | 1 |
| Fernández, MC; González Cappa, SM; Solana, ME | 1 |
| Fernández-González, MC; López-Velez, R; Moreno, S; Pérez-Ayala, A; Pérez-Molina, JA; Zamora, J | 1 |
| Bahia, MT; Caldas, IS; Carneiro, CM; Diniz, LF; Lana, M; Machado-Coelho, GL; Martins, TA; Oliveira, Rde P; Santos, DM; Talvani, A | 1 |
| Albareda, MC; Alvarez, MG; Armenti, A; Bertocchi, G; Cooley, G; Laucella, SA; Lococo, B; Mazliah, DP; Postan, M; Tarleton, RL; Viotti, R | 1 |
| Arán, VJ; Boiani, L; Carrasco-Pozo, C; Cerecetto, H; Cosoy, HS; González, M; Lavaggi, ML; Maya, JD; Olea-Azar, C; Rodríguez, J | 1 |
| Bowling, J; Walter, EA | 1 |
| Brutus, L; Chippaux, JP; Clavijo, AN; Postigo, JR; Santalla, JA; Schneider, D | 1 |
| Bassets, G; Escribà, JM; Lima, MA; Marchiol, A; Palma, PP; Ponce, C; Ponce, E; Romero, Ade D; Viñas, PA; Zúniga, C | 1 |
| Bendhack, LM; da Silva, GK; da Silva, RS; Do Valle Matta, MA; Franco, DW; Guedes, PM; Gutierrez, FR; Oliveira, FS; Rodrigues, GJ; Silva, JS; Zamboni, DS | 1 |
| Ibrahim, K; Le Loup, G; Malvy, D | 1 |
| Albajar-Viñas, P; Bahia, MT; Coura, JR; Dias, JC; Lana, Md; Lopes, LA; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Montoya, RA; Wendling, AP | 1 |
| Albuquerque, S; do Prado, JC; Kuehn, CC; Loria, RM; Oliveira, LG; Santos, CD; Toldo, MP | 1 |
| Holen, Ø | 1 |
| Machado, FS; Tanowitz, HB; Teixeira, MM | 1 |
| Bersani-Amado, CA; Cuman, RK; Gomes, ML; Marques-Araujo, S; Pupulin, AR; Takejima, E; Toledo, MJ | 1 |
| Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA | 1 |
| Corrêa, RR; Correia, D; dos Reis, MA; Faleiros, AC; Guimarães, CS; Oliveira, FA; Ramirez, LE; Silva, AC; Silva, AE; Teixeira, AC; Teixeira, Vde P | 1 |
| Caires, AC; Matsuo, AL; Pascoalino, BS; Ramos, TC; Rodrigues, EG; Schenkman, S; Silva, LS; Torrecilhas, AC; Travassos, LR | 1 |
| Bua, J; Bustos, PL; Fichera, LE; Gonzalez, MN; Grosso, NL; Perrone, AE; Postan, M | 1 |
| Condon, D; Dhiman, M; Garg, NJ; Guan, Z; Gupta, S; Lui, C; Wen, JJ | 1 |
| Carrilero, B; Iborra, MA; Muñoz, MJ; Murcia, L; Segovia, M | 1 |
| Correia, D; Fuzissaki, J; Lages-Silva, E; Molina, RJ; Niederhaur, S; Oliveira, LF; Prata, A; Silva, VJ | 1 |
| Aras, R; Bastos, CJ; de Araújo, EG; de Jesus, RS; Dias, JP; Freire, MS; Grassi, MF; Mota, G; Prazeres, J; Reis, F | 1 |
| Clayton, J | 2 |
| Gascon, J; Muñoz, J; Oliveira, I; Torrico, F | 1 |
| Bocchi, EA; Issa, VS | 1 |
| Correia, LP; de La Roca Soares, MF; de Souza, FS; Lopes, PQ; Macêdo, RO; Rolim-Neto, PJ; Soares-Sobrinho, JL | 1 |
| Altcheh, J; Biancardi, M; Freilij, H; Liesenfeld, O; Mayer, JP; Weinke, T | 1 |
| Apt, W | 2 |
| Asensi, V; Miró, JM; Rodríguez-Guardado, A; Tuset, M | 1 |
| Cañavate, C; Díaz-Menéndez, M; Flores, M; López-Vélez, R; Monge-Maillo, B; Navarro, M; Norman, F; Pérez-Ayala, A; Pérez-Molina, JA; Peris-García, J | 1 |
| Gascón, J; Guerrero, L; Pinazo, MJ; Posada, E; Ribas, J; Soy, D | 1 |
| Chiari, E; D'ávila, DA; Galvão, LM; Gontijo, ED; Macedo, AM; Moreno, M; Silva, MN; Zingales, B | 1 |
| Altcheh, J; Freilij, H; Garcia-Bournissen, F; Moroni, S; Moscatelli, G | 1 |
| Ferreira, J; Kemmerling, U; López-Muñoz, R; Maya, JD; Morello, A; Orellana, M | 1 |
| Bahia, MT; Cunha-Filho, MS; de Andrade, IM; de Paula, LM; Figueiredo, VP; Maximiano, FP; Sá-Barreto, LC; Talvani, A | 1 |
| Arias, E; Bizai, ML; Bottasso, O; del Barco, M; Denner, S; Diez, C; Fabbro, DL; Mancipar, I; Marcipar, I; Mendicino, D; Olivera, V; Streiger, M | 1 |
| Barea, E; Caballero, AB; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M | 1 |
| Beranger, C; Boulliat, C; Coilliot, C; Gaillard, K; Oliver, M; Rouault, M; Wolf, A | 1 |
| Bahia, MT; Costa, GH; Cunha-Filho, MS; de Sá Barreto, LC; Maximiano, FP | 1 |
| Guedes, PM; Gutierrez, FR; Silva, GK; Silva, JS | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Carrilero, B; Fernández-Villegas, A; Gascon, J; López, MC; Marañón, C; Pinazo, MJ; Posada, E; Segovia, M; Thomas, MC | 1 |
| Batista, Dda G; Batista, MM; Boykin, DW; Britto, CC; de Oliveira, GM; Rodrigues, AC; Soeiro, Mde N; Stephens, CE | 1 |
| Ayala, E; Fisa, R; Gállego, M; Gascon, J; Monteagudo, J; Muñoz, J; Pinazo, MJ; Posada, Ede J; Reverter, JC; Tàssies, D | 1 |
| Fernández, GJ; Mejía-Jaramillo, AM; Palacio, L; Triana-Chávez, O | 1 |
| Akay, S; Banerjee, M; Boykin, DW; Correia Soeiro, MD; DA Silva, CF; DA Silva, PB; Daliry, A; Farahat, AA; Fisher, MK; Hu, L; Kumar, A; Liu, Z; Stephens, CE | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Cooley, G; De Rissio, AM; Laucella, S; Lococo, B; Petti, M; Tarleton, R; Vigliano, C; Viotti, R | 1 |
| Carrilero, B; Martínez-Lage, L; Murcia, L; Segovia, M | 1 |
| Aleixo, DL; de Araújo, SM; de Melo, CS; do Nascimento, A; Ferraz, FN; Gomes, ML; Simoni, GK; Spack, M | 1 |
| Dias Filho, BP; Kaneshima, EN; Nakamura, CV; Sarragiotto, MH; Silva, SO; Tonin, LT; Ueda-Nakamura, T; Valdez, RH; Yamada-Ogatta, SF; Yamauchi, LM | 1 |
| Hall, BS; Wilkinson, SR | 1 |
| Altcheh, JM; Cardoni, RL; Corral, RS; Cutrullis, RA; Freilij, HL; Moroni, S; Moscatelli, GF; Petray, PB; Volta, BJ | 1 |
| Salomon, CJ | 1 |
| Garg, NJ; Wen, JJ | 1 |
| Aguiar, C; Almeida, EA; Batista, AM; Costa, SC; Guariento, ME; Pavan, TB; Wanderley, JS | 1 |
| Chambela, MC; de Sousa, AS; do Brasil, PE; Hasslocher-Moreno, AM; Sperandio da Silva, GM; Xavier, SS | 1 |
| Levy, MZ; Manne, J; Reich, MR; Snively, CS | 1 |
| Agil, A; Alvarez-Manzaneda, E; Chahboun, R; Es-Samti, H; Fernández, A; Guardia, JJ; Marín, C; Ramírez-Macías, I; Sánchez-Moreno, M; Zentar, H | 1 |
| Albesa, I; Becerra, MC; Gea, S; Guiñazú, N; Hergert, LY; Mazzieri, MR; Pellegrini, A | 1 |
| de Lana, M; de Souza, J; Moreira da Silva, R; Oliveira, LT; Silva Barcellos, NM | 1 |
| Albajar Viñas, P; Carrilero, B; Murcia, L; Segovia, M | 1 |
| Albareda, MC; Alvarez, MG; Argüello, RJ; Armenti, AH; Bertocchi, G; Laucella, SA; Meckert, PC; Tarleton, RL; Vigliano, C | 1 |
| Ballesteros, LA; Basile, L; Rodrigo, C; Roure, S; Sabrià, M; Valerio-Sallent, L | 1 |
| Elói-Santos, SM; Gontijo, ED; Martins-Filho, OA; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Marcondes de Rezende, J; Rassi, A | 1 |
| Galimberti, RL; Maqueda, MG; Piñero, MC; Riganti, J; Volonteri, VI | 1 |
| Albajar-Viñas, P; Bahia, MT; Dias, JC; Do Bem, VA; Lana, M; Machado-de-Assis, GF; Martins-Filho, OA; Silva, AR; Torres, RM | 1 |
| Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL | 1 |
| Alvarez-Manzaneda, E; Chahboun, R; Gutierrez-Sánchez, R; Marín, C; Messouri, I; Olmo, F; Ramírez-Macías, I; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Burgos, LG; Canese, A; Melo, M; Ojeda, A; Ortiz, BD | 1 |
| López-Vélez, R; Navarro, M; Norman, FF; Pérez-Molina, JA | 1 |
| de Almeida, LR; de Souza, AS; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Rocha, MS; Silva, AA; Silva, RR; Vilar-Pereira, G | 1 |
| Voelker, R | 1 |
| Batlle, A; Ciccarelli, AB; Frank, FM; Lombardo, ME; Malchiodi, EL; Puente, V | 1 |
| Cruz-Zetina, G; del Rio-Rodriguez, R; López, R; Monteon, V; Ramos-Ligonio, A | 1 |
| Alvarez, MG; Bertocchi, G; Lococo, B; Petti, M; Vigliano, C; Viotti, R | 1 |
| Bottasso, E; Lamas, MC; Manarin, R; Revelli, S; Salomón, CJ; Serra, E | 1 |
| Carlier, Y; Cencig, S; Coltel, N; Truyens, C | 1 |
| Albareda, MC; Alvarez, MG; Armenti, AH; Bertocchi, G; Cooley, G; Laucella, SA; Lococo, BE; Perez-Mazliah, DE; Petti, M; Tarleton, RL; Viotti, R | 1 |
| Azevedo, MA; Bahia, MT; Caldas, IS; da Matta Guedes, PM; da Silva do Nascimento, AF; de Figueiredo Diniz, L; de Lima, WG; dos Santos, FM; Martins, TA; Neto, RM; Talvani, A; Torres, RM | 1 |
| Gascon, J; Guerrero, L; Pinazo, MJ; Posada, E; Rodríguez, E; Soy, D | 1 |
| Bahia, MT; Barbosa, MG; Bossolani, GD; de Araújo, SM; Gomes, ML; Monteiro, WM; Reis, D; Teston, AP; Toledo, MJ | 1 |
| Barrett, MP; Croft, SL | 1 |
| Amador, C; Arjona, FJ; Caro, E; Cuadrado, JM; Gallegos, I; Gutiérrez, F; Jover, F; Martínez-Peinado, C; Pérez-Chacón, F; Ponce, Y; Ramos, JM; Tello, A; Torrús, D | 1 |
| Fernández, GJ; Mejía-Jaramillo, AM; Montilla, M; Nicholls, RS; Triana-Chávez, O | 1 |
| Bastos, JK; Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; e Silva, ML; Esperandim, VR; Rezende, KC; Saraiva, J | 1 |
| Brutus, L; Chippaux, JP; Postigo, JR; Salas-Clavijo, AN; Santalla, JA; Schneider, D | 1 |
| Bandyopadhyay, D; Banik, BK; Nogueda-Torres, B; Rivera, G; Samano, S; Sanchez-Torres, LE; Villalobos-Rocha, JC | 1 |
| Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J | 1 |
| Cerecetto, H; González, M | 1 |
| Alves, RO; Gazzinelli, RT; Murta, SM; Romanha, AJ; Ropert, C; Silva, JS | 1 |
| Bozza, MT; Freire-De-Lima, CG; Gibaldi, D; Heise, N; Mendonça-Previato, L; Previato, JO; Saraiva, VB | 1 |
| Ataide Soares, K; Bahia, MT; Carneiro, CM; Chiari, E; Galvão, LM; Guedes, PM; Lana, Md; Tafuri, WL; Veloso, VM | 1 |
| Araújo-Jorge, T; Cotta-De-Almeida, V; Olivieri, BP | 1 |
| Bahia, MT; Barnabé, C; Carneiro, CM; de Lana, M; Martins-Filho, OA; Tafuri, WL; Tibayrenc, M; Toledo, MJ | 1 |
| Basombrío, MA; Nasser, JR; Segura, MA | 1 |
| Gallerano, RR; Sosa, RR | 1 |
| Fragata-Filho, AA; Levy, AM; Pereira-Chioccola, VL; Rodrigues, MM; Schenkman, S | 1 |
| Araujo, G; Armenti, A; de Rissio, AM; Lococo, B; Ruiz Vera, B; Segura, EL; Sosa-Estani, S; Vigliano, C; Viotti, R | 1 |
| Alves, CF; Bahia, MT; Carneiro, CM; Cruz, RE; Lana, M; Machado-Coelho, GL; Martins, HR; Tafuri, WL; Toledo, MJ; Veloso, VM | 1 |
| Barbosa, RA; Bello, V; Lobo, MC; Sousa, AA | 1 |
| Lopez, MO; Montanari, JA; Morilla, MJ; Petray, PB; Prieto, MJ; Romero, EL | 1 |
| Afonso, LC; Bahia, MT; Chiari, E; de Lana, M; Guedes, PM; Machado-Coelho, GL; Tafuri, WL; Urbina, JA; Veloso, VM | 1 |
| Amigorena, S; Bottasso, O; Guermonprez, P; Nocito, AL; Pascutti, MF; Pitashny, M; Revelli, S; Serra, E; Wietzerbin, J | 1 |
| Aires, AI; Almeida, IC; Andrade, AL; Andrade, JG; Covas, DT; Martelli, CM; Oliveira, RM; Silva, LS; Silva, SA; Soussumi, LM; Travassos, LR | 1 |
| Campos-de-Carvalho, AC; Garcia, S; Ramos, CO; Ribeiro-Dos-Santos, R; Rodrigues, MM; Senra, JF; Soares, MB; Vilas-Boas, F | 1 |
| Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA | 1 |
| Roldán, EJ | 1 |
| Araujo-Jorge, TC; Cotta-de-Almeida, V; Farias-De-Oliveira, DA; Olivieri, BP | 1 |
| Altclas, J; De Rissio, AM; Dictar, M; García, MM; Luna, C; Riarte, A; Salgueira, C; Sinagra, A; Verón, MT | 1 |
| Reyes, PA; Vallejo, M | 1 |
| Althabe, F; Belizan, JM; Rubinstein, A; Sosa-Estani, S | 1 |
| González, P; González-Coloma, A; Illana, A; Longoni, SS; Marín, C; Mateo, H; Reina, M; Rodríguez-González, I; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Alonso-Vega, C; Córdova, M; Suárez, E; Torrico, F | 1 |
| Weir, E | 1 |
| Araújo-Jorge, T; Cotta-de-Almeida, V; de Castro, SL; de Souza, AP; Olivieri, BP | 1 |
| Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A | 1 |
| Cassels, BK; Faúndez, M; Ferreira, A; Ferreira, J; Galanti, N; Iturriaga-Vásquez, P; Maya, JD; Morello, A | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Lococo, B; Petti, M; Postan, M; Vigliano, C; Viotti, R | 1 |
| Pinto Dias, JC | 1 |
| Bartel, LC; Castro, JA; de Mecca, MM | 1 |
| de Arias, AR; de Bilbao, NV; Ferreira, ME; Fournet, A; Hocquemiller, R; Lagoutte, D; Nakayama, H; Poupon, E; Schinini, A; Serna, E; Soriano-Agatón, F | 1 |
| Borges, JD; Dias, JC; Elói-Santos, SM; Lana, M; Martins-Filho, OA; Massara, RL; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Copstein, JL; D'Albuquerque, LA; Filho, HL; Gonzalez, AM; Larrea, FI; Mansero, JM; Oliveira e Silva, A; Perón, G; Ribeiro, MA | 1 |
| Braz, LM; Gakiya, E; Ibrahim, KY; Lopes, MH; Nunes Westphalen, EV; Oliveira, OC; Sartori, AM; Shikanai-Yasuda, MA | 1 |
| Caetano, PK; Calvi, SA; de Carvalho, TB; Lima, CR; Machado, JM; Nagoshi, LR; Persi, E; Picka, MM; Ribeiro, DA; Salvadori, DM | 1 |
| Bustamante, JM; Enders, JE; Fernández, AR; Fretes, RE; Paglini-Oliva, P; Presti, MS; Rivarola, HW | 1 |
| Barbosa, LR; Caetano, W; Hsu, HW; Itri, R; Pessoa, A; Rangel-Yagui, CO; Tavares, LC | 1 |
| Aguirre-Alvarado, C; Baeza, I; Nogueda, B; Rodríguez-Páez, L; Wong, C; Zaragoza-Martínez, F | 1 |
| Corachan, M; Fumadó, V; Gascon, J; Muñoz, J; Portús, M | 1 |
| Doyle, PS; Engel, JC; McKerrow, JH; Zhou, YM | 1 |
| Guañabens, N; Moll, C; Moreno, A; Muñoz, J; Peris, P | 1 |
| Jannin, J; Villa, L | 1 |
| El Masri, M; Karcz, DA; Lennox, HA; Tales, H | 1 |
| Bahia, MT; Caldas, S; de Lana, M; Diniz, LF; Machado-Coelho, GL; Santos, FM; Veloso, VM | 1 |
| de Lana, M; Elói-Santos, SM; Martins-Filho, OA; Massara, RL; Pinto Dias, JC; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Bahia, MT; Carneiro, CM; Figueiredo, LM; Lana, M; Macedo, AM; Machado-Coelho, GL; Martins, HR; Martins-Filho, OA; Valamiel-Silva, JC; Vitelli-Avelar, DM | 1 |
| Ajana, F; Bonnard, P; Canestri, A; Carlier, Y; Danis, M; Develoux, M; Dorent, R; Elghouzzi, MH; Gay, F; Guiard-Schmid, JB; Jauréguiberry, S; Lescure, FX; Melliez, H; Pialoux, G; Rolla, V | 1 |
| Bixby, LM; Bustamante, JM; Tarleton, RL | 1 |
| Aleixo, DL; Araújo, SM; Bersani-Amado, CA; de Melo, CS; Ferraz, FN; Gomes, ML; Kaneshima, EN; Toledo, MJ | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Carneiro, CM; da Matta Guedes, PM; de Lana, M; Talvani, A | 1 |
| Raaflaub, J; Richle, RW | 1 |
| Raether, W; Seidenath, H | 1 |
| Cabeza Meckert, P; Chambó, JG; Gelpi, R; Laguens, RP | 1 |
| Carpintero, DJ | 1 |
| Castro, JA; de Toranzo, EG; Masana, M | 1 |
| Manigot, DA | 1 |
| Pérez Lloret, A; Roldán, EJ | 1 |
| Raaflaub, J | 1 |
| Barrett, PA; Beveridge, E; Bull, D; Caldwell, IC; Islip, PJ; Neal, RA; Woods, NC | 1 |
| Abitbol, H | 1 |
| Brener, Z; Cançado, JR; Krettli, AU | 1 |
| Brener, Z; Filardi, LS | 2 |
| Rassi, A | 1 |
| Almuna, R; Capetillo, M; Gottlieb, B; Reyes, H; Salgado, E | 1 |
| Calixto, MA; Teixeira, AR; Teixeira, ML | 1 |
| Britto, C; Cardoso, MA; Hasslocher-Moreno, A; Morel, CM; Oelemann, W; Pirmez, C; Santoro, A; Vanni, CM; Wincker, P; Xavier, SS | 1 |
| Jardim, E; Takayanagui, OM | 1 |
| Almiron, M; Campetella, O; Frasch, AC; Ganzález Cappa, SM; Guillen, I; Leguizamón, MS; Russomando, G | 1 |
| Amato Neto, V; Gama-Rodrigues, J; Iriya, K; Mester, M; Okumura, M | 1 |
| de Castro, SL | 1 |
| Cancado, JR; Galvao, LM; Gazzinelli, RT; Krautz, G; Krettli, AU; Lima, PC; Scharfstein, J | 1 |
| Kirchhoff, LV | 1 |
| Armenti, H; Segura, E; Vigliano, C; Viotti, R | 1 |
| Acuña, G; Brengues, C; Cuny, G; Labarca, J; Muñoz, S; Oddó, D; Saavedra, H; Sepúlveda, C; Solari, A; Veas, F | 1 |
| Bellotti, G; Bocchi, EA; de Lourdes Higuchi, M; Fiorelli, A; Jatene, A; Kalil, J; Pilleggi, F; Stolf, N; Uip, D | 1 |
| Bogitsh, BJ; Carter, CE; Jones, MM; Lane, JE; Molenda, JJ; Rodrigues, RR; Singh, PK; Zimmerman, LJ | 1 |
| Almeida Silva, S; Almeida, IC; de Andrade, AL; de Andrade, JG; de Andrade, SS; de Oliveira, RM; Luquetti, A; Martelli, CM; Travassos, LR; Zicker, F | 1 |
| Bestetti, RB | 1 |
| Almirón, M; Campetella, O; Frasch, AC; González-Cappa, SM; Leguizamón, MS; Luquetti, A; Rassi, A; Russomando, G | 1 |
| Borges, AS; Ferreira, MS; Nishioka, Sde A; Nunes-Araújo, FR; Rocha, A; Silvestre, MT | 1 |
| Murta, SM; Romanha, AJ | 1 |
| Bayo, R; Ceraso, D; De Rissio, A; Dengra, C; Dictar, M; Koziner, B; Luna, C; Riarte, A; Segura, E; Sinagra, A; Verón, MT | 1 |
| Barnabé, C; Carrière, V; Laurent, JP; Noël, S; Oury, B; Quesney, V; Revollo, S; Tibayrenc, M | 1 |
| Brener, Z; Gazzinelli, RT; Murta, SM; Romanha, AJ | 1 |
| Acosta, N; Almiron, M; Calcena, MF; Candia, N; de Guillen, I; de Tomassone, MM; Figueredo, A; Russomando, G; Vera, N | 1 |
| Brener, Z; Carvalho-Oliveira, L; Ferreira, LR; Gazzinelli, RT; Michailowsky, V; Murta, SM; Pereira, ME; Romanha, AJ | 1 |
| Porcel, BM; Ruiz, AM; Segura, EL; Sosa Estani, S; Velazquez, E; Yampotis, C | 1 |
| Rassi Júnior, A; Rassi, A | 1 |
| Bottasso, O; Le Page, C; Piaggio, E; Revelli, S; Wietzerbin, J | 1 |
| Laucella, SA; Riarte, A; Segura, EL; Sosa, ES | 1 |
| Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA | 1 |
| Alves, RO; Gazzinelli, RT; Murta, SM; Romanha, AJ; Ropert, C | 1 |
| Segura, EL; Sosa Estani, S | 1 |
| Cançado, JR | 1 |
| Amato Neto, V | 1 |
| Bonté, F; Ferreira, ME; Fournet, A; Lavault, M; Nakayama, H; Rojas de Arias, A; Samudio, M; Schinini, A; Torres de Ortiz, S; Vera de Bilbao, N | 1 |
| Blanco, SB; Chuit, R; Cura, EN; Flores, I; Garbarino, G; Gürtler, RE; Segura, EL; Tulián, L; Villalonga, JF | 1 |
| Araújo, MS; Brener, Z; Martins-Filho, OA; Pereira, ME | 1 |
| Araújo-Jorge, TC; de Castro, SL; de Souza, AP; Olivieri, BP | 1 |
| Castro, JA | 1 |
| Altclas, J; De Rissio, A; Feldman, L; Jaimovich, G; Luna, C; Milovic, V; Requejo, A; Riarte, A; Salgueira, C; Sinagra, A | 1 |
| Giovannoni, AG; Montero, A | 1 |
| Bottasso, OA; Piaggio, E; Pitashny, M; Revelli, SS; Roggero, E; Wietzerbin, J | 1 |
| Anacleto, C; dos Santos, WG; Moreira, ES; Murta, SM; Nirdé, P; Romanha, AJ | 1 |
| Bahia, MT; Carneiro, CM; Chiari, E; Lana, M; Tafuri, WL; Toledo, MJ; Veloso, VM | 1 |
| Ferreira, ME; Fournet, A; Nakayama, H; Rojas de Arias, A; Schinini, A; Torres, S; Vera de Bilbao, N | 1 |
| Andrade, SG; Andrade, ZA; Lima, ES | 1 |
| Prata, A | 1 |
| de Castro, SL; Rodriques Coura, J | 1 |
| Buschiazzo, H; de Alaniz, MJ; Marra, CA; Zaidenberg, A | 1 |
| da Silva, JS; Souza, SC; Takahashi, CS | 1 |
| Frasch, AC; Jazín, EE; Luquetti, AO; Rassi, A | 1 |
| Andrade, SG; Freitas, LA; Peyrol, S; Pimentel, AR; Sadigursky, M | 1 |
| Barbieri, GP; Gorla, NB; Larripa, IB; Ledesma, OS | 2 |
| Córdoba, JC; Solórzano, E; Souto Maior, I; Teixeira, AR | 1 |
| Gallerano, RH; Marr, JJ; Sosa, RR | 1 |
| Cunha Neto, E; Rizzo, LV; Silva, R; Teixeira, AR | 1 |
| Alves, MJ; Augusto, O; Brener, Z; Colli, W; Tsuhako, MH | 1 |
| Lazcano, F; Passalacqua, W; Thambo, S; Van Cauwelaert, R | 1 |
| de Rezende, JM; de Souza, AA; Luquetti, AO; Miles, MA; Póvoa, MM; Rassi, A; Rodrigues, I | 1 |
| De Melo-Souza, SE; Defaria, CR; Rassi, A | 1 |
| de Arruda Júnior, ER | 1 |
| Moya, PR; Trombotto, GT | 1 |
| Castro, JA; Diaz de Toranzo, EG | 1 |
| Gutteridge, WE | 1 |
| Andrade, SG; Magalhães, JB; Pontes, AL | 1 |
| Gallerano, RH; Meirovich, CI; Montrull, HL; Sosa, RR | 1 |
71 review(s) available for benzonidazole and Chagas Disease
| Article | Year |
|---|---|
Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Cell Line, Tumor; Cell Proliferation; Chagas Disease; Humans; Leishmania; Neglected Diseases; Neoplasms; Quinones; Trypanosoma cruzi | 2019 |
Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis.
Topics: Adult; Chagas Disease; Child; Humans; Nitroimidazoles; Observational Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials.
Topics: Allopurinol; Chagas Disease; Drug Therapy, Combination; Humans; Nitroimidazoles; Randomized Controlled Trials as Topic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Direct evidence gap on fixed versus adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: Systematic review and individual patient data meta-analysis.
Topics: Adult; Cardiomyopathies; Chagas Disease; Evidence Gaps; Humans; Trypanosoma cruzi | 2023 |
The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review.
Topics: Adult; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis.
Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2020 |
New Approaches for the Treatment of Chagas Disease.
Topics: Animals; Chagas Disease; Drug Repositioning; Humans; Neglected Diseases; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Placebos; Randomized Controlled Trials as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis.
Topics: Chagas Disease; Drug Resistance; Genetic Variation; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Topics: Animals; Chagas Disease; Drug Development; Drug Resistance; Humans; Medicine, Traditional; Molecular Targeted Therapy; Nifurtimox; Nitroimidazoles; Plant Preparations; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Topics: Animals; Argentina; Biological Evolution; Chagas Disease; Drug Resistance; Genetic Variation; Genotype; Humans; Nifurtimox; Nitroimidazoles; Serologic Tests; Trypanosoma cruzi | 2018 |
Experimental and Clinical Treatment of Chagas Disease: A Review.
Topics: Animals; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Drug Compounding; Humans; Incidence; Latin America; Nanoparticles; Nifurtimox; Nitroimidazoles; Observational Studies as Topic; Randomized Controlled Trials as Topic; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole.
Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Nitroimidazoles; Solubility; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
An update on benznidazole for the treatment of patients with Chagas disease.
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis.
Topics: Age Factors; Chagas Disease; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Nitroimidazoles; Prospective Studies; Sex Factors; Trypanocidal Agents | 2018 |
Clinical and pharmacological profile of benznidazole for treatment of Chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Humans; Neglected Diseases; Nitroimidazoles; Public Health; Trypanocidal Agents | 2018 |
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Mice; Models, Theoretical; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Dynamics of T Cells Repertoire During Trypanosoma cruzi Infection and its Post-Treatment Modulation.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; Disease Progression; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Risk Factors; Trypanosoma cruzi | 2019 |
Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America.
Topics: Chagas Disease; Health Services Accessibility; Humans; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
American Trypanosomiasis (Chagas Disease).
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Clinical Trials as Topic; Disease Progression; Disease Vectors; Humans; Nitroimidazoles; Triatominae; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review.
Topics: Chagas Disease; Dosage Forms; Humans; Nanostructures; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2019 |
Drug discovery for chagas disease: A viewpoint.
Topics: Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Role of nucleic acid amplification assays in monitoring treatment response in chagas disease: Usefulness in clinical trials.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Drug Resistance; Humans; Nifurtimox; Nitroimidazoles; Nucleic Acids; Parasite Load; Real-Time Polymerase Chain Reaction; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.
Topics: Chagas Disease; Drug Design; Humans; Indazoles; NADH, NADPH Oxidoreductases; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Potential new clinical therapies for Chagas disease.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Drug Therapy, Combination; Humans; Nifurtimox; Nitroimidazoles; Sterols; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis.
Topics: Animals; Chagas Disease; Humans; Lactones; Nanocapsules; Nanomedicine; Nitroimidazoles; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
A new era for chagas disease drug discovery?
Topics: 14-alpha Demethylase Inhibitors; Chagas Disease; Clinical Trials as Topic; Drug Discovery; Humans; Nitroimidazoles | 2015 |
Chronic Chagas disease with advanced cardiac complications in Japan: Case report and literature review.
Topics: Animals; Chagas Disease; Chronic Disease; Female; Heart Failure; Humans; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2015 |
Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease.
Topics: Antigens, Protozoan; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Drug Discovery for Paediatric Chagas Disease.
Topics: Antiparasitic Agents; Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2018 |
Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Child; Chronic Disease; Cohort Studies; Disease Progression; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Hemagglutination Tests; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Randomized Controlled Trials as Topic; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Xenodiagnosis | 2015 |
Developments in the management of Chagas cardiomyopathy.
Topics: Animals; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Disease Management; Electrocardiography; Heart Failure; Humans; Nanotechnology; Nitroimidazoles; Stem Cell Transplantation; Trypanocidal Agents; Vaccines | 2015 |
Chagas disease and transfusion medicine: a perspective from non-endemic countries.
Topics: Adult; Blood Donors; Blood Safety; Chagas Disease; Donor Selection; Emigration and Immigration; Enzyme-Linked Immunosorbent Assay; Europe; Female; Global Health; Health Services Needs and Demand; Humans; Infant, Newborn; Latin America; Male; Mass Screening; Nifurtimox; Nitroimidazoles; North America; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Transfusion Reaction; Travel; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Current drug therapy and pharmaceutical challenges for Chagas disease.
Topics: Americas; Chagas Disease; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
[What is not searched, it is difficult to find: Chagas' disease].
Topics: Chagas Cardiomyopathy; Chagas Disease; Emigrants and Immigrants; Humans; Italy; Neglected Diseases; Nifurtimox; Nitroimidazoles; Prevalence; South America; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Challenges in Chagas Disease Drug Discovery: A Review.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; RNA, Protozoan; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Benznidazole and Chagas disease: can an old drug be the answer to an old problem?
Topics: Adolescent; Adult; Chagas Disease; Child; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2008 |
Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.
Topics: Argentina; Chagas Cardiomyopathy; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities.
Topics: Age Factors; Animals; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease.
Topics: Allopurinol; Chagas Disease; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Neoplasms; Nitroimidazoles; Perioperative Care; Postoperative Complications; Recurrence; Trypanocidal Agents | 2009 |
Chagasic encephalitis in HIV patients: common presentation of an evolving epidemiological and clinical association.
Topics: Adult; Anticonvulsants; Antiretroviral Therapy, Highly Active; Chagas Disease; Female; HIV Infections; Humans; Immunocompromised Host; Meningoencephalitis; Nitroimidazoles; Seizures; Trypanocidal Agents | 2009 |
Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Nitroimidazoles; Treatment Outcome; Young Adult | 2009 |
Recognizing and meeting the challenge of Chagas disease in the USA.
Topics: Chagas Disease; Guidelines as Topic; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2009 |
Congenital transmission of Chagas disease: a clinical approach.
Topics: Adolescent; Adult; Animals; Antiprotozoal Agents; Chagas Disease; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Latin America; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanosoma cruzi; Young Adult | 2010 |
Current and developing therapeutic agents in the treatment of Chagas disease.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Time Factors; Treatment Outcome; Trypanocidal Agents | 2010 |
Chagas disease: Present status of pathogenic mechanisms and chemotherapy.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Current status of Chagas disease chemotherapy.
Topics: Adult; Animals; Chagas Disease; Child; Clinical Trials as Topic; Drug Administration Schedule; Humans; Latin America; Mice; Myocarditis; Nifurtimox; Nitroimidazoles; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Antitrypanosomal therapy for chronic Chagas' disease.
Topics: Adult; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
First century of Chagas' disease: an overview on novel approaches to nifurtimox and benzonidazole delivery systems.
Topics: Animals; Chagas Disease; Drug Delivery Systems; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
American trypanosomiasis (Chagas disease).
Topics: Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African | 2012 |
Immunosuppression and Chagas disease: a management challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi | 2013 |
Chemotherapy of Chagas' disease: status and new developments.
Topics: Animals; Chagas Disease; Drug Design; Enzyme Inhibitors; Humans; Nifurtimox; Nitroimidazoles; Phosphoenolpyruvate Carboxykinase (ATP); Reducing Agents; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Humans; Imidazoles; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2005 |
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Topics: Acute-Phase Reaction; Animals; Chagas Disease; Ergosterol; Host-Parasite Interactions; Humans; Immunologic Factors; Mammals; Nifurtimox; Nitric Oxide; Nitroimidazoles; Purines; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis).
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2006 |
An overview of Chagas disease treatment.
Topics: Chagas Disease; Health Services Accessibility; Humans; International Cooperation; Nifurtimox; Nitroimidazoles; Pan American Health Organization; Trypanocidal Agents | 2007 |
Chagas disease: clinical overview and implications for nursing.
Topics: Acute Disease; Animals; Canada; Chagas Disease; Chronic Disease; Emigration and Immigration; Hispanic or Latino; Humans; Immunologic Tests; Incidence; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Nurse's Role; Prevalence; Primary Prevention; Risk Factors; South America; Travel; Triatoma; Trypanocidal Agents; United States | 2007 |
The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi.
Topics: Animals; Anti-Bacterial Agents; Azoles; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Chagas disease. American trypanosomiasis.
Topics: Animals; Chagas Disease; Heart; Humans; Immunocompromised Host; Interferon-gamma; Laboratory Infection; Mice; Nifurtimox; Nitroimidazoles; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi; United States | 1993 |
Reactivation of Chagas' disease in patients with AIDS: report of three new cases and review of the literature.
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Chagas Disease; Fatal Outcome; Female; Humans; Male; Middle Aged; Nitroimidazoles; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
[Human American trypanosomiasis 90 years after its discovery by Carlos Chagas. II--Clinical aspects, physiopathology, diagnosis and treatment].
Topics: Brain Diseases; Chagas Cardiomyopathy; Chagas Disease; Child; Child, Preschool; Diagnosis, Differential; Disease Vectors; Double-Blind Method; Follow-Up Studies; Gastrointestinal Diseases; Humans; Immunization; Immunologic Deficiency Syndromes; Longitudinal Studies; Myocarditis; Nitroimidazoles; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Trypanocidal Agents; Vaccines | 1999 |
[Treatment of Trypanosoma cruzi infection in the indeterminate phase: experience and current guidelines in Argentina].
Topics: Adult; Argentina; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Contributions of toxicology to the problem of Chagas' disease (American Trypanosomiasis)--a year 2000 update.
Topics: Animals; Chagas Disease; Gentian Violet; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Toxicology; Trypanocidal Agents | 2000 |
Clinical and epidemiological aspects of Chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Electrocardiography; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents | 2001 |
A critical review on Chagas disease chemotherapy.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2002 |
Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease).
Topics: Chagas Disease; Humans; Latin America; Nifurtimox; Nitrofurans; Nitroimidazoles | 1988 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
36 trial(s) available for benzonidazole and Chagas Disease
| Article | Year |
|---|---|
Tolerance of benznidazole in treatment of Chagas' disease in adults.
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2010 |
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial.
Topics: Adult; Aftercare; Argentina; Brazil; Case-Control Studies; Chagas Disease; Chronic Disease; Colombia; Double-Blind Method; Female; Humans; Male; Neglected Diseases; Nitroimidazoles; Parasite Load; Safety; Spain; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Short-course Benznidazole treatment to reduce Trypanosoma cruzi parasitic load in women of reproductive age (BETTY): a non-inferiority randomized controlled trial study protocol.
Topics: Argentina; Chagas Disease; Female; Humans; Nitroimidazoles; Parasite Load; Postpartum Period; Pregnancy; Randomized Controlled Trials as Topic; Real-Time Polymerase Chain Reaction; Retrospective Studies; Trypanosoma cruzi | 2020 |
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.
Topics: Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nitroimidazoles; Parasite Load; Treatment Outcome; Triazoles; Young Adult | 2021 |
What to expect and when: benznidazole toxicity in chronic Chagas' disease treatment.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Young Adult | 2018 |
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2018 |
Distinct Treatment Outcomes of Antiparasitic Therapy in
Topics: Adolescent; Chagas Disease; Chemokines; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; T-Lymphocytes; Trypanosoma cruzi | 2018 |
Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment.
Topics: Adolescent; Adult; Area Under Curve; Calibration; Chagas Disease; Chromatography, Liquid; Dried Blood Spot Testing; Drug Stability; Female; Humans; Male; Middle Aged; Nitroimidazoles; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.
Topics: Adolescent; Bacteria; Bolivia; Chagas Disease; Child; Child, Preschool; Feces; Female; Humans; Male; Microbiota; Mouth Mucosa; Nitroimidazoles; Rural Population; Skin | 2019 |
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial.
Topics: Adult; Aged; Asymptomatic Diseases; Chagas Disease; Colombia; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nifurtimox; Nitroimidazoles; Randomized Controlled Trials as Topic; Therapeutic Equivalency; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
Improved completion rates and characterization of drug reactions with an intensive Chagas disease treatment program in rural Bolivia.
Topics: Adolescent; Adult; Antiprotozoal Agents; Bolivia; Chagas Disease; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Medication Adherence; Middle Aged; Nitroimidazoles; Prospective Studies; Rural Population; Treatment Outcome; Young Adult | 2013 |
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults.
Topics: Adult; Chagas Disease; Child; Child, Preschool; Female; Humans; Linear Models; Male; Nitroimidazoles; Trypanocidal Agents | 2014 |
Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease.
Topics: Adult; Breast Feeding; Chagas Disease; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Milk, Human; Nitroimidazoles; Prospective Studies; Young Adult | 2015 |
Population pharmacokinetics of benznidazole in adult patients with Chagas disease.
Topics: Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2015 |
Changes in the immune response after treatment with benznidazole versus no treatment in patients with chronic indeterminate Chagas disease.
Topics: Adult; Aged; Biomarkers; Chagas Disease; Chronic Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice.
Topics: Administration, Oral; Adolescent; Adult; Animals; Chagas Disease; Chromatography, High Pressure Liquid; Female; Humans; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2017 |
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.
Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.
Topics: Adult; CD8-Positive T-Lymphocytes; Chagas Disease; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Middle Aged; Nitroimidazoles; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Antibody drop in newborns congenitally infected by Trypanosoma cruzi treated with benznidazole.
Topics: Antibodies, Protozoan; Chagas Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Nitroimidazoles; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study.
Topics: Adult; Allopurinol; Antiprotozoal Agents; B-Lymphocytes; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Pilot Projects; T-Lymphocytes; Treatment Outcome; Trypanosoma cruzi | 2013 |
Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.
Topics: Bolivia; Chagas Disease; Guideline Adherence; Humans; Infant, Newborn; Medication Adherence; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
[Treatment of Chagas disease with benznidazole and thioctic acid].
Topics: Administration, Oral; Adolescent; Adult; Animals; Antioxidants; Chagas Disease; Drug Therapy, Combination; Epidemiologic Research Design; Female; Humans; Male; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up.
Topics: Adolescent; Adolescent Health Services; Adult; Animals; Antigens, Protozoan; Chagas Disease; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Randomized Controlled Trials as Topic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
[Integral treatment of congenital Chagas disease: the Bolivian experience ].
Topics: Chagas Disease; Clinical Protocols; Comprehensive Health Care; Family; Follow-Up Studies; Humans; Infant; Infant, Newborn; Nitroimidazoles; Patient Compliance; Prospective Studies; Treatment Outcome; Trypanocidal Agents | 2005 |
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prognosis; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile.
Topics: Adolescent; Animals; Case-Control Studies; Chagas Disease; Child; Cytokines; Female; Gene Expression; Humans; Immunity, Innate; Longitudinal Studies; Male; Nitroimidazoles; Trypanosoma cruzi | 2006 |
[Use of thioctic acid for prevention of the adverse effects induced by benznidazole in patients with chronic Chagas' infection].
Topics: Chagas Disease; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Male; Nitroimidazoles; Thioctic Acid | 1983 |
Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection.
Topics: Animals; Antibodies, Protozoan; Brazil; Chagas Disease; Child; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Hemagglutination Tests; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.
Topics: Chagas Disease; Child; Double-Blind Method; Humans; Nitroimidazoles; Trypanocidal Agents | 1998 |
Soluble platelet selectin (sP-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease during therapy with benznidazole in children with indeterminate form of Chagas' disease.
Topics: Chagas Disease; Child; Double-Blind Method; Humans; Nitroimidazoles; P-Selectin; Regression Analysis; Trypanocidal Agents; Vascular Cell Adhesion Molecule-1 | 1999 |
Therapeutic efficacy of allopurinol in patients with chronic Chagas' disease.
Topics: Adult; Allopurinol; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1990 |
[Peripheral polyneuropathy induced by benzonidazole in the treatment of Chagas' disease].
Topics: Adult; Chagas Disease; Clinical Trials as Topic; Electromyography; Female; Humans; Male; Middle Aged; Nitroimidazoles; Peripheral Nerves; Polyneuropathies; Trypanocidal Agents | 1986 |
[Treatment of Chagas' disease].
Topics: Animals; Cats; Chagas Disease; Clinical Trials as Topic; Cricetinae; Dogs; Guinea Pigs; Humans; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Rats; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
[Allopurinol in the treatment of chronic Chagas' disease].
Topics: Allopurinol; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1985 |
585 other study(ies) available for benzonidazole and Chagas Disease
| Article | Year |
|---|---|
Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.
Topics: Alkaloids; Animals; Benzodioxoles; Cells, Cultured; Chagas Disease; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Inhibitory Concentration 50; Parasitic Sensitivity Tests; Piperidines; Polyunsaturated Alkamides; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Inhibitory Concentration 50; Lignans; Membrane Glycoproteins; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.
Topics: Acetamides; Amino Acids; Animals; Chagas Disease; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Chemical; Pyrophosphatases; Trypanocidal Agents; Trypanosoma cruzi; Uracil | 2006 |
2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.
Topics: Acute Disease; Animals; Benzimidazoles; Cell Line; Chagas Disease; Cyclic N-Oxides; Leishmania; Macrophages; Mice; Mice, Inbred BALB C; Models, Molecular; Oxidation-Reduction; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.
Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Impact of dual infections on chemotherapeutic efficacy in BALB/c mice infected with major genotypes of Trypanosoma cruzi.
Topics: Acute Disease; Alleles; Animals; Chagas Disease; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Mice; Mice, Inbred BALB C; Microsatellite Repeats; Nitroimidazoles; Reverse Transcriptase Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
Topics: Animals; Antibodies, Protozoan; Benzoxazoles; Cell Line; Chagas Disease; Cysteine Endopeptidases; Female; Glutathione; Humans; Macrophages; Mice; Models, Molecular; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxygen Consumption; Protozoan Proteins; Stereoisomerism; Structure-Activity Relationship; Sulfones; Trypanocidal Agents; Trypanosoma cruzi; Vinyl Compounds | 2007 |
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: chemical and biological studies.
Topics: Alkaloids; Animals; Benzodioxoles; Chagas Disease; Macrophages; Mice; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Benzoxazoles; Chagas Disease; Disease Models, Animal; Female; Mice; Parasitemia; Treatment Outcome; Trypanosoma cruzi | 2008 |
Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.
Topics: Animals; Chagas Disease; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Nitroimidazoles; Spectrophotometry, Ultraviolet; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chagas Disease; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Nitroimidazoles; Quinolones; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.
Topics: Animals; Benzimidazoles; Cell Line; Cell Survival; Chagas Disease; Glucose; Leishmania braziliensis; Leishmaniasis; Macrophages; Mice; Mitochondria; Oxidoreductases; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.
Topics: Animals; Cell Survival; Chagas Disease; Cysteine Endopeptidases; Hydrazones; Mice; Mice, Inbred BALB C; Models, Molecular; Oxadiazoles; Parasitic Sensitivity Tests; Protein Binding; Protozoan Proteins; Spleen; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
Topics: Amidines; Animals; Cells, Cultured; Chagas Disease; Electrocardiography; Female; Furans; Male; Mice; Mice, Inbred C3H; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Structure; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Hydroxymethylnitrofurazone is active in a murine model of Chagas' disease.
Topics: Animals; Chagas Disease; Female; Liver; Mice; Molecular Structure; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Polymerase Chain Reaction; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Molecular Structure; Phosphoric Diester Hydrolases; Protozoan Proteins; Trypanosoma cruzi | 2010 |
In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Female; Histocytochemistry; Humans; Imidazoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Microscopy, Electron, Transmission; Phthalazines; Pyrazoles; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Structure-Activity Relationship; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2011 |
Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues.
Topics: Animals; Blood Cells; Chagas Disease; Inhibitory Concentration 50; Life Cycle Stages; Mice; Naphthoquinones; Pyrans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Delphinium; Flavonoids; Mice; Mitochondria; Molecular Structure; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2011 |
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
Topics: Amines; Animals; Cells, Cultured; Chagas Disease; Leishmania donovani; Mice; Nitro Compounds; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2011 |
Phosphonium lipocations as antiparasitic agents.
Topics: Animals; Antiparasitic Agents; Cations; Chagas Disease; Chlorocebus aethiops; Humans; Inhibitory Concentration 50; Lipids; Models, Biological; Organophosphorus Compounds; Plasmodium falciparum; Trypanosoma cruzi; Ubiquinone; Vero Cells | 2012 |
Identification of benzoylisoquinolines as potential anti-Chagas agents.
Topics: Chagas Disease; Dose-Response Relationship, Drug; Isoquinolines; Molecular Structure; Parasitic Sensitivity Tests; Principal Component Analysis; Stereoisomerism; Structure-Activity Relationship; Trypanosoma cruzi | 2012 |
In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease.
Topics: Animals; Cell Survival; Chagas Disease; Chlorocebus aethiops; Enzyme Inhibitors; Female; Humans; Liver; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Polyamines; Pyrazoles; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2012 |
Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.
Topics: Animals; Cell Line; Chagas Disease; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Inhibitory Concentration 50; Male; Mice; Nuclear Magnetic Resonance, Biomolecular; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection.
Topics: Animals; Cell Death; Chagas Disease; Chlorocebus aethiops; Enzyme-Linked Immunosorbent Assay; Female; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Molecular Structure; Parasitemia; Phthalazines; Structure-Activity Relationship; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2012 |
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Topics: Animals; Cell Proliferation; Chagas Disease; Computer Simulation; Cysteine Endopeptidases; Female; Imines; Mice; Mice, Inbred BALB C; Models, Molecular; Protein Binding; Protozoan Proteins; Spleen; Stereoisomerism; Structure-Activity Relationship; Thiazolidines; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chagas Disease; Cloning, Molecular; Humans; Molecular Sequence Data; Phylogeny; Protozoan Proteins; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi.
Topics: Acetylgalactosamine; Animals; Cell Line; Cells, Cultured; Chagas Disease; Diketopiperazines; Glycoproteins; Glycosylation; Humans; Mice; Mice, Inbred C57BL; Mucins; Neuraminidase; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Topics: Administration, Oral; Animals; Chagas Disease; Drug Design; Humans; Mice; Piperazine; Piperazines; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Aromatic glycosyl disulfide derivatives: evaluation of their inhibitory activities against Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Benzene Derivatives; Chagas Disease; Chlorocebus aethiops; Disulfides; Glycosides; HeLa Cells; Humans; Trypanosoma cruzi; Vero Cells | 2013 |
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inbred Strains; Models, Chemical; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma cruzi | 2013 |
Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates.
Topics: Chagas Disease; Dose-Response Relationship, Drug; Drug Design; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiosemicarbazones; Trypanosoma cruzi | 2013 |
Selective activity of 2,4-diaryl-1,2,3,4-tetrahydroquinolines on Trypanosoma cruzi epimastigotes and amastigotes expressing β-galactosidase.
Topics: Animals; beta-Galactosidase; Cell Line; Chagas Disease; Fibroblasts; Gene Expression; Humans; Mice; Nitroimidazoles; Quinolines; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Preparation and antitrypanosomal activity of secochiliolide acid derivatives.
Topics: Asteraceae; Chagas Disease; Diterpenes; Humans; Propionates; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Synthesis, physicochemical properties of allopurinol derivatives and their biological activity against Trypanosoma cruzi.
Topics: Allopurinol; Animals; Chagas Disease; Chemistry, Physical; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Molecular Structure; Parasitic Sensitivity Tests; Solubility; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2013 |
Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Line, Tumor; Chagas Disease; Drug Design; Humans; Hydroxamic Acids; Isoenzymes; Isoxazoles; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Peptide Hydrolases; Protease Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Fibroblasts; Humans; Leishmania mexicana; Leishmaniasis, Cutaneous; Macrophages; Mice; Models, Molecular; Trypanosoma cruzi | 2014 |
Synthesis and biological evaluation of N,N'-squaramides with high in vivo efficacy and low toxicity: toward a low-cost drug against Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Cyclobutanes; Diamines; Female; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2014 |
New perspectives on the synthesis and antichagasic activity of 3-alkoxy-1-alkyl-5-nitroindazoles.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Humans; Indazoles; Vero Cells | 2014 |
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Topics: Animals; Cell Line; Cells, Cultured; Chagas Disease; Cysteine Proteases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Mice; Mice, Inbred BALB C; Molecular Conformation; Spleen; Structure-Activity Relationship; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
In vitro antiparasitic activity of new thiosemicarbazones in strains of Trypanosoma cruzi.
Topics: Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Humans; In Vitro Techniques; Molecular Structure; Monocytes; Platelet Activation; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
Topics: Amides; Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Leishmania donovani; Leishmaniasis, Visceral; Molecular Structure; Monocytes; Platelet Activation; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Crystallography, X-Ray; Humans; Mice; Microsomes, Liver; Models, Molecular; Piperazines; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.
Topics: Abietanes; Animals; Antiprotozoal Agents; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells | 2015 |
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Topics: Amides; Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Methanol; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
Designing and exploring active N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients.
Topics: Antiprotozoal Agents; Cells, Cultured; Chagas Disease; Dose-Response Relationship, Drug; Drug Design; Fibroblasts; Humans; Hydrazines; Hydrazones; Models, Molecular; Molecular Structure; Nitrofurans; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi | 2015 |
Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents.
Topics: 3T3 Cells; Animals; Chagas Disease; Diterpenes; Humans; Mice; Quinones; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease.
Topics: Acute Disease; Animals; Chagas Disease; Chemistry Techniques, Synthetic; Drug Design; Male; Mice; Mice, Inbred BALB C; Organoselenium Compounds; Semicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi.
Topics: Aphidicolin; Chagas Disease; Humans; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.
Topics: Abietanes; Amides; Chagas Disease; Humans; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis; Macrophages; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi.
Topics: Alkaloids; Anthraquinones; Antiparasitic Agents; Antiprotozoal Agents; Chagas Disease; Chalcones; Flavanones; Humans; Leishmania mexicana; Leishmaniasis, Cutaneous; Moraceae; Plant Extracts; Plants; Rubiaceae; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Zanthoxylum | 2016 |
Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.
Topics: Animals; Chagas Disease; Indazoles; Structure-Activity Relationship; Trichomonas; Trypanosoma cruzi | 2016 |
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma | 2016 |
Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity.
Topics: Alkylation; Animals; Cell Line; Chagas Disease; Humans; Imidazoles; Male; Mice; Mice, Inbred BALB C; Sonication; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Topics: Animals; Cells, Cultured; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Mannich Bases; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols.
Topics: Animals; Cells, Cultured; Chagas Disease; Humans; Models, Molecular; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Pyridines; Pyrroles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death.
Topics: Apoptosis; Chagas Disease; Cysteine Endopeptidases; Drug Design; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Design; Female; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds.
Topics: Cell Line; Chagas Disease; Drug Design; Humans; Models, Molecular; Nitrofurans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
Topics: Antiprotozoal Agents; Chagas Disease; Dose-Response Relationship, Drug; Humans; Macrophages; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiosemicarbazones; Trypanosoma | 2018 |
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Mice; Molecular Docking Simulation; Parasitemia; Pyrazolones; Structure-Activity Relationship; Survival Rate; Thiazepines; Trypanosoma cruzi | 2018 |
Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents.
Topics: Animals; Cell Survival; Cells, Cultured; Chagas Disease; Dose-Response Relationship, Drug; Mice; Molecular Structure; Pyridines; Structure-Activity Relationship; Sulfonamides | 2018 |
Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase.
Topics: Amination; Chagas Disease; Drug Design; Glycoproteins; Humans; Molecular Docking Simulation; Neuraminidase; Propionates; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2018 |
Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening.
Topics: Chagas Disease; Drug Discovery; Drug Evaluation, Preclinical; Humans; Quantitative Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
New polyamine drugs as more effective antichagas agents than benznidazole in both the acute and chronic phases.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Design; Fluorenes; Humans; Microbodies; Nitroimidazoles; Polyamines; Solubility; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity.
Topics: Animals; Benzimidazoles; Chagas Disease; Chlorocebus aethiops; Drug Design; Molecular Docking Simulation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Cyclobutanes; DNA; Female; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; RNA; Splenomegaly; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation.
Topics: Animals; Cells, Cultured; Chagas Disease; Chlorocebus aethiops; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Injections, Intraperitoneal; Mannich Bases; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease.
Topics: Animals; Cells, Cultured; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazolines; Molecular Structure; Parasitic Sensitivity Tests; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Discovery of Pyrrolo[2,3-
Topics: Administration, Oral; Animals; Chagas Disease; Crystallography, X-Ray; Disease Models, Animal; Male; Mice; Molecular Conformation; Nucleosides; Pyridines; Pyrroles; Structure-Activity Relationship; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Chronic Disease; Clofazimine; Combined Modality Therapy; Dihydropyridines; Female; Humans; Mice; Mice, Inbred C3H; Nitroimidazoles; Trypanocidal Agents; Vero Cells | 2019 |
Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Humans; Piperidines; Structure-Activity Relationship; Trypanosoma cruzi | 2020 |
Hit-to-lead optimization of novel 2-alkylaminomethylquinoline derivatives as anti-chagas agents.
Topics: Animals; Cell Survival; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Female; Inflammation; Mice; Mice, Inbred C3H; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2020 |
Discovery and Optimization of a Compound Series Active against
Topics: Animals; Cell Line; Chagas Disease; Drug Discovery; Female; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Proof of Concept Study; Quinazolinones; Rats; Small Molecule Libraries; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: Synthesis, in vitro and in vivo studies.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Pyrazoles; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Revisiting Pyrazolo[3,4-
Topics: Animals; Chagas Disease; Drug Design; Drug Stability; Humans; Leishmania infantum; Male; Mice; Microsomes, Liver; Molecular Structure; Nucleosides; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease.
Topics: Benzimidazoles; Cell Line; Cell Proliferation; Chagas Disease; Drug Design; Humans; Imidazoles; Life Cycle Stages; Mannich Bases; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Topics: Aldehydes; Cathepsin L; Chagas Disease; COVID-19 Drug Treatment; Cysteine Endopeptidases; Cysteine Proteases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Kinetics; Models, Molecular; Molecular Structure; Protozoan Proteins; SARS-CoV-2; Structure-Activity Relationship; Trypanosoma cruzi | 2021 |
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Topics: Animals; Chagas Disease; Leishmania; Mice; Nucleosides; Purines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.
Topics: Chagas Disease; Humans; Piperazines; Trypanosoma cruzi | 2022 |
Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.
Topics: Chagas Disease; Humans; Peptides; Trypanocidal Agents; Trypanosoma cruzi; Venoms | 2022 |
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Nitroreductases; Trypanosoma cruzi; Tuberculosis | 2022 |
Chemiluminescent Microparticle Immunoassay for the Diagnosis of Congenital Chagas Disease: A Prospective Study in Spain.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Female; Fetal Blood; Fluorescent Antibody Technique, Indirect; Humans; Immunoassay; Infant; Infant, Newborn; Luminescent Measurements; Male; Nitroimidazoles; Prospective Studies; Sensitivity and Specificity; Spain; Trypanocidal Agents; Young Adult | 2021 |
Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.
Topics: Adolescent; Antibodies, Protozoan; Chagas Disease; Chronic Disease; Cohort Studies; Female; Humans; Immunoglobulin G; Immunologic Tests; Male; Molecular Diagnostic Techniques; Nifurtimox; Nitroimidazoles; Pilot Projects; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Association of HLA-B∗35 and moderate or severe cutaneous reactions secondary to benznidazole treatment in chronic chagas disease.
Topics: Adult; Chagas Disease; Female; HLA-B Antigens; Humans; Hypersensitivity, Delayed; Male; Middle Aged; Nitroimidazoles; Skin | 2022 |
Prodrugs as new therapies against Chagas disease: in vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole.
Topics: Amino Acid Isomerases; Animals; Chagas Disease; Esters; Humans; Mice; Nitroimidazoles; Parasites; Prodrugs; Trypanosoma cruzi | 2022 |
4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Chagas Disease; Disease Models, Animal; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection.
Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Persistent Infection; Trypanocidal Agents; Trypanosoma cruzi; Vaccines | 2022 |
Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease.
Topics: Chagas Disease; Child; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents | 2022 |
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart Diseases; Heart Function Tests; Humans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanosoma cruzi | 2022 |
Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas' disease.
Topics: Adult; Antioxidants; Ascorbic Acid; Biomarkers; Chagas Disease; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Oxidative Stress | 2022 |
Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs.
Topics: Animals; Chagas Disease; Dogs; Itraconazole; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy.
Topics: Administration, Oral; Biological Availability; Caco-2 Cells; Chagas Disease; Humans; Nanoparticles; Nitroimidazoles; Particle Size; Solubility | 2022 |
Traditional use of benznidazole with weekly clinical follow-up indicate to be an important approach for the etiologic treatment of Chagas disease.
Topics: Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Miltefosine and Benznidazole Combination Improve Anti-
Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.
Topics: Animals; Chagas Disease; Disulfiram; Drug Resistance; Humans; Mice; Nitroimidazoles; Transaminases; Trypanocidal Agents | 2022 |
Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in
Topics: Amiodarone; Chagas Disease; Cytoskeleton; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.
Topics: Adjuvants, Immunologic; Animals; Chagas Disease; Dogs; Fibrosis; Humans; Inflammation; Mice; Mice, Inbred BALB C; Nitroimidazoles; Perforin; Protozoan Vaccines; Recombinant Proteins; Toll-Like Receptor 4; Trypanosoma cruzi; Vaccines, Combined; Vaccines, DNA | 2022 |
Severe drug-induced liver injury (DILI) associated with benznidazole therapy for Chagas' disease.
Topics: Chagas Cardiomyopathy; Chagas Disease; Chemical and Drug Induced Liver Injury; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi.
Topics: Chagas Disease; Dinoprost; Humans; Nifurtimox; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi; Vitamin K 3 | 2022 |
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi
Topics: Animals; Chagas Disease; Chloroquine; Drug Repositioning; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure.
Topics: Animals; Chagas Disease; Dogs; Humans; Mammals; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study.
Topics: Adult; Cardiology; Chagas Cardiomyopathy; Chagas Disease; Child; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Anti-Trypanosoma cruzi antibody profiling in patients with Chagas disease treated with benznidazole assessed by genome phage display.
Topics: Bacteriophages; Chagas Disease; Epitopes; Humans; Immunoglobulin G; Nitroimidazoles; Trypanosoma cruzi | 2023 |
Effect of B-NIPOx in Experimental
Topics: Animals; Chagas Disease; Isoenzymes; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole.
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Chloroquine; Excipients; Lignin; Trypanosoma cruzi | 2023 |
Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole.
Topics: Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Prospective Studies; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Major benznidazole metabolites in patients treated for Chagas disease: Mass spectrometry-based identification, structural analysis and detoxification pathways.
Topics: Chagas Disease; Chromatography, High Pressure Liquid; Humans; Ions; Mass Spectrometry; Nitroimidazoles | 2023 |
A functional assay using human whole blood and flow cytometry analysis to evaluate cytotoxicity and immunomodulatory effect of anti-Trypanosoma cruzi drugs.
Topics: Chagas Disease; Cytokines; Flow Cytometry; Humans; Interleukin-10; Interleukin-8; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease.
Topics: Animals; Chagas Disease; Female; Heart; Mice; Persistent Infection; Recombinant Proteins; Trypanosoma cruzi; Vaccines | 2023 |
Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Mice; MicroRNAs; Nitroimidazoles; Pentoxifylline; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Trypanosoma cruzi: Does the intake of nanoencapsulated benznidazole control acute infections?
Topics: Animals; Chagas Disease; Female; Mice; Nanocapsules; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Candimine from Hippeastrum escoipense (Amaryllidaceae): Anti-Trypanosoma cruzi activity and synergistic effect with benznidazole.
Topics: Alkaloids; Amaryllidaceae; Animals; Chagas Disease; Chromatography, Liquid; Humans; Mammals; Tandem Mass Spectrometry; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates.
Topics: Animals; Chagas Disease; Clinical Protocols; Dogs; Humans; Mammals; Mice; Nitroimidazoles; Primates; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Benzonidazole treatment has a beneficial effect on cells infected with the Colombian strain of Trypanosoma cruzi.
Topics: Chagas Disease; Colombia; Humans; Leukocytes, Mononuclear; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations.
Topics: Chagas Disease; Gene Expression Profiling; Humans; Nitroimidazoles; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation.
Topics: Adult; Chagas Disease; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents | 2023 |
Repurposing of rabeprazole as an anti-
Topics: Chagas Disease; Drug Repositioning; Humans; Rabeprazole; Triose-Phosphate Isomerase; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
DIAGNOSIS AND TREATMENT OF A NATURAL INFECTION WITH
Topics: Alabama; Animals; Cercopithecus; Chagas Disease; Humans; Male; Trypanosoma cruzi | 2023 |
Chagas disease is related to structural changes of the gut microbiota in adults with chronic infection (TRIPOBIOME Study).
Topics: Adult; Chagas Disease; Cross-Sectional Studies; Gastrointestinal Microbiome; Humans; Middle Aged; Persistent Infection; Prospective Studies | 2023 |
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
Topics: Antiprotozoal Agents; Chagas Disease; Cycloaddition Reaction; Humans; Isoxazoles; Nitroimidazoles; Structure-Activity Relationship; Trypanosoma cruzi | 2023 |
Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells.
Topics: Adipocytes; Adipose Tissue; Cell Differentiation; Chagas Disease; Humans; Interleukin-6; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Progression; Heart; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Persistent Biofluid Small-Molecule Alterations Induced by
Topics: Animals; Chagas Disease; Humans; Mice; Parasites; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
Topics: Animals; Chagas Disease; DNA Damage; Mammals; Mice; Nitroimidazoles; Parasites; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Activity of the sesquiterpene lactone goyazensolide against
Topics: Animals; Bridged-Ring Compounds; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Furans; Mice; Nitroimidazoles; Sesquiterpenes; Sesterterpenes; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
An evaluation of benznidazole as a Chagas disease therapeutic.
Topics: Adult; Chagas Disease; Child; Female; Humans; Nitroimidazoles; Prognosis; Trypanocidal Agents | 2019 |
Longitudinal follow up of serological response in children treated for Chagas disease.
Topics: Adolescent; Antibodies, Protozoan; Antibody Formation; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Nitroimidazoles; Prospective Studies; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2019 |
Mapping benznidazole resistance in trypanosomatids and exploring evolutionary histories of nitroreductases and ABCG transporter protein sequences.
Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily G; ATP-Binding Cassette Transporters; Chagas Disease; Drug Resistance; Geography; Humans; Membrane Transport Proteins; Nitroimidazoles; Nitroreductases; Phylogeny; Trypanocidal Agents; Trypanosoma | 2019 |
IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia.
Topics: Adolescent; Biomarkers; Bolivia; Chagas Disease; Child; Child, Preschool; Cytokines; Female; Follow-Up Studies; Humans; Interleukin-17; Male; Nitroimidazoles; Polymerase Chain Reaction; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Immunological exhaustion and functional profile of CD8
Topics: Biomarkers; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Costimulatory and Inhibitory T-Cell Receptors; Cytokines; Humans; Nitroimidazoles; Programmed Cell Death 1 Receptor; Signaling Lymphocytic Activation Molecule Family; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy.
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Cell Line; Chagas Disease; Cytokines; Female; Immunologic Factors; Inflammation; Lactones; Mice; Myocarditis; Nitroimidazoles; Parasitemia; Rats; Sesquiterpenes; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: a prospective cohort study in two Spanish referral centres.
Topics: Adult; Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Referral and Consultation; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; Drug Tolerance; Humans; Nifurtimox; Nitroimidazoles; Switzerland; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Differential phenotypic and functional profile of epitope-specific cytotoxic CD8
Topics: Adult; Biomarkers; CD8-Positive T-Lymphocytes; Chagas Disease; Cytokines; Epitopes; Female; Humans; Leukocytes, Mononuclear; Male; Nitroimidazoles; Phenotype; Trypanosoma cruzi | 2020 |
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis.
Topics: Aspirin; Cells, Cultured; Chagas Disease; Gene Expression; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Nitroimidazoles; Receptor, Notch1; Simvastatin; Trypanosoma cruzi | 2020 |
Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.
Topics: Acute Disease; Animals; Blood; Chagas Disease; Chronic Disease; Colon; Cyclophosphamide; Female; Heart; Immunosuppression Therapy; Mice; Neglected Diseases; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Benznidazole self-emulsifying delivery system: A novel alternative dosage form for Chagas disease treatment.
Topics: Animals; Caco-2 Cells; Cell Survival; Chagas Disease; Dosage Forms; Dose-Response Relationship, Drug; Drug Delivery Systems; Emulsifying Agents; Female; Hep G2 Cells; Humans; Mice; Nitroimidazoles; Rats; Trypanocidal Agents | 2020 |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil.
Topics: Adult; Brazil; Chagas Disease; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Fluorescent Antibody Technique, Indirect; Hemagglutination Tests; Hospitals, Public; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Severity of Illness Index; Socioeconomic Factors; Trypanocidal Agents | 2020 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Usefulness of real-time PCR during follow-up of patients treated with Benznidazole for chronic Chagas disease: Experience in two referral centers in Barcelona.
Topics: Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Retrospective Studies; Spain; Trypanocidal Agents | 2020 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocardiography; Male; Mice; Naphthoquinones; Nitroimidazoles; Parasitemia; Time Factors; Trypanocidal Agents | 2020 |
The Clinical and Parasitologic Follow-up of Trypanosoma cruzi-infected Children in a Nonendemic Country.
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Nitroimidazoles; Prospective Studies; Spain; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Congenital Chagas Disease in the United States: The Effect of Commercially Priced Benznidazole on Costs and Benefits of Maternal Screening.
Topics: Chagas Disease; Cost Savings; Cost-Benefit Analysis; Female; Humans; Infectious Disease Transmission, Vertical; Mass Screening; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; United States | 2020 |
State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Gastrointestinal Tract; Heart; Host-Parasite Interactions; Humans; Nifurtimox; Nitroimidazoles; Prognosis; Treatment Outcome; Trypanosoma cruzi | 2020 |
Pregnancy and Chagas Disease: Benznidazole's Impact on Pregnancy and Newborns: A Report of Four Cases.
Topics: Adolescent; Adult; Bolivia; Chagas Disease; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Efficacy of continuous versus intermittent administration of nanoformulated benznidazole during the chronic phase of Trypanosoma cruzi Nicaragua infection in mice.
Topics: Animals; Chagas Disease; Humans; Mice; Mice, Inbred C57BL; Nicaragua; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Population pharmacokinetics and biodistribution of benznidazole in mice.
Topics: Animals; Chagas Disease; Humans; Mice; Nitroimidazoles; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase.
Topics: Animals; Aspirin; Chagas Disease; Drug Combinations; Humans; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Chagas Disease; Chronic Disease; Disease Models, Animal; Excipients; Female; Heart; Mice; Myocardium; Nitroimidazoles; Parasitemia; Poloxamer; Quadriceps Muscle; Random Allocation; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?
Topics: Animals; Antiprotozoal Agents; Chagas Cardiomyopathy; Chagas Disease; Drug Therapy, Combination; Female; Mice; Myocarditis; Nitroimidazoles; Phenothiazines; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations; Female; Glycogen; Hepatitis; Mice; Muscle, Skeletal; Myositis; NADH, NADPH Oxidoreductases; Nitroimidazoles; Parasite Load; Parasitemia; Peroxidase; Thioridazine; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Identification of Inhibitors to
Topics: Animals; Cell Line; Chagas Disease; Drug Synergism; Epithelial Cells; Group III Histone Deacetylases; Inhibitory Concentration 50; Macaca mulatta; Molecular Docking Simulation; Nitroimidazoles; Phylogeny; Recombinant Proteins; Sirtuins; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant
Topics: Animals; Cell Line; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Humans; Indazoles; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Access to Chagas disease treatment in the United States after the regulatory approval of benznidazole.
Topics: Age Factors; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Drug Costs; Drugs, Investigational; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States; United States Food and Drug Administration | 2020 |
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.
Topics: Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Pilot Projects; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Benznidazole for the treatment of Chagas disease.
Topics: Adult; Chagas Disease; Disease Progression; Female; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Trypanocidal Agents | 2021 |
"We have already heard that the treatment doesn't do anything, so why should we take it?": A mixed method perspective on Chagas disease knowledge, attitudes, prevention, and treatment behaviour in the Bolivian Chaco.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Bolivia; Chagas Disease; Cross-Sectional Studies; Family Characteristics; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Middle Aged; Nitroimidazoles; Patient Acceptance of Health Care; Socioeconomic Factors; Surveys and Questionnaires; Young Adult | 2020 |
A novel Trypanosoma cruzi secreted antigen as a potential biomarker of Chagas disease.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Biomarkers; Chagas Disease; Humans; Macaca mulatta; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Effect of capsaicin on the protozoan parasite Trypanosoma cruzi.
Topics: Arginine Kinase; Capsaicin; Chagas Disease; Enzyme Activation; Inhibitory Concentration 50; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Evaluation of the anti-Trypanosoma cruzi activity in vitro and in vivo of silibinin and silibinin in association to benznidazole.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Female; Heart; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Silybin; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2021 |
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Female; Mice; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Benznidazole: Hero or villain of cellular immune response in chronic Chagas disease patients?
Topics: Antigen Presentation; B7-1 Antigen; Cells, Cultured; Chagas Disease; Chronic Disease; HLA-DR Antigens; Humans; Immunity, Cellular; Leukocytes, Mononuclear; Lymphocyte Activation; Macrophage Activation; Nitroimidazoles; Phagocytosis; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers.
Topics: Acute Disease; Animals; CD8-Positive T-Lymphocytes; Chagas Disease; Female; Mice; Mice, Inbred C57BL; Nitroimidazoles; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems.
Topics: Anacardium; Chagas Disease; Computer Simulation; Drug Delivery Systems; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microwaves; Molecular Structure; Nanoparticles; Nitroimidazoles; Particle Size; Phthalic Acids; Plant Gums; Spectroscopy, Fourier Transform Infrared; Trypanocidal Agents | 2021 |
Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the nervous tissue.
Topics: Animals; Chagas Disease; Chronic Disease; Cognition; Cognitive Dysfunction; Female; Mice, Inbred C57BL; Nitroimidazoles; Oxidative Stress; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
The ubiquinone synthesis pathway is a promising drug target for Chagas disease.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Delivery Systems; HeLa Cells; Humans; Mammals; Nitroimidazoles; Signal Transduction; Trypanocidal Agents; Trypanosoma cruzi; Ubiquinone | 2021 |
A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; Chagas Disease; Female; Granzymes; Humans; Interferon-gamma; Male; Middle Aged; Nitroimidazoles; Perforin; Spain; Trypanosoma cruzi; Young Adult | 2021 |
Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Female; Interleukin-17; Mice; Mice, Inbred BALB C; Nitroimidazoles; Protozoan Vaccines; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Oils, Volatile; Parasite Load; Plant Oils; Syzygium; Trypanosoma cruzi; Zingiber officinale | 2021 |
Pharmacogenomic Profile and Adverse Drug Reactions in a Prospective Therapeutic Cohort of Chagas Disease Patients Treated with Benznidazole.
Topics: Brazil; Chagas Disease; Female; Gene Regulatory Networks; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Nitroimidazoles; Polymorphism, Single Nucleotide; Prospective Studies; Risk; Signal Transduction; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Levels of anti-B13 antibodies over time in a cohort of chronic infected by Trypanosoma cruzi. Its relationship with specific treatment and clinical status.
Topics: Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Argentina; Chagas Disease; Chronic Disease; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nifurtimox; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2021 |
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Mice; Nanoparticle Drug Delivery System; Nitroimidazoles; Phagocytes; Polyethylene Glycols; Sulfides; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier.
Topics: Area Under Curve; Biological Availability; Chagas Disease; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Drug Liberation; Excipients; Humans; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kinetics; Metal-Organic Frameworks; Microscopy, Electron, Scanning; Nitroimidazoles; Solubility; Trypanosoma cruzi; X-Ray Diffraction; Zeolites | 2021 |
IgG Subclass Analysis in Patients with Chagas Disease 4 Years After Benznidazole Treatment.
Topics: Chagas Disease; Humans; Immunoglobulin G; Nitroimidazoles; Parasitemia | 2021 |
Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.
Topics: Animals; Chagas Disease; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Intrinsic and Chemotherapeutic Stressors Modulate ABCC-Like Transport in
Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Chagas Disease; Drug Resistance; Glutathione; Nitroimidazoles; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones | 2021 |
Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon.
Topics: Abdominal Wall; Animals; Brazil; Chagas Disease; Esophagus; Heart; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Stomach; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole.
Topics: Acute Disease; Animals; Antioxidants; Cerebral Cortex; Chagas Disease; Female; Gene Expression; Immunosuppressive Agents; Mice; Nitroimidazoles; Oxidative Stress; Receptors, Purinergic; Resveratrol | 2021 |
Benznidazole in Chagas disease study: do the data justify progression to phase 3?
Topics: Chagas Disease; Humans; Nitroimidazoles | 2021 |
Benznidazole in Chagas disease study: do the data justify progression to phase 3? - Authors' reply.
Topics: Chagas Disease; Humans; Nitroimidazoles | 2021 |
Predictors of development of cardiac and digestive disorders among patients with indeterminate chronic Chagas Disease.
Topics: Adult; Antiprotozoal Agents; Brazil; Chagas Disease; Chronic Disease; Digestive System Diseases; Female; Heart Diseases; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Trypanosoma cruzi | 2021 |
HIV and Chagas Disease: An Evaluation of the Use of Real-Time Quantitative Polymerase Chain Reaction to Measure Levels of Trypanosoma cruzi Parasitemia in HIV Patients in Cochabamba, Bolivia.
Topics: Adult; Antibodies, Protozoan; Bolivia; CD4 Lymphocyte Count; Chagas Disease; Coinfection; Cross-Sectional Studies; Female; HIV Infections; Humans; Latent Infection; Male; Microscopy; Middle Aged; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Viral Load | 2021 |
Interdisciplinary approach at the primary healthcare level for Bolivian immigrants with Chagas disease in the city of São Paulo.
Topics: Adolescent; Adult; Bolivia; Brazil; Chagas Disease; Child; Cross-Sectional Studies; Emigrants and Immigrants; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mass Screening; Middle Aged; Nitroimidazoles; Patient Care Team; Primary Health Care; Serologic Tests; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2017 |
[Treatment and follow up of Chagas Disease in immunocompromised hosts].
Topics: Chagas Disease; Follow-Up Studies; HIV Infections; Humans; Immunocompetence; Immunocompromised Host; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents | 2017 |
[Estimating demand for anti-Chagas drugs: a contribution for access in Latin America].
Topics: Adolescent; Adult; Chagas Disease; Child; Child, Preschool; Humans; Infant; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2017 |
Effects of (1
Topics: Chagas Disease; Drug Combinations; Drug Synergism; Fluconazole; Humans; Ketoconazole; Nitroimidazoles; Pentanones; Trypanosoma cruzi | 2017 |
Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease.
Topics: Adult; Bolivia; Chagas Disease; Cohort Studies; Female; Humans; Logistic Models; Male; Middle Aged; Nitroimidazoles; Patient Compliance; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole.
Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles | 2017 |
The immunomodulatory effects of the Enalapril in combination with Benznidazole during acute and chronic phases of the experimental infection with Trypanosoma cruzi.
Topics: Animals; Animals, Laboratory; Chagas Disease; Enalapril; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.
Topics: Adolescent; Adult; Chagas Disease; Cohort Studies; Disease Transmission, Infectious; Female; Humans; Infectious Disease Transmission, Vertical; Middle Aged; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanosoma cruzi; Young Adult | 2017 |
Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.
Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Chagas Disease; Drug Therapy, Combination; Metronidazole; Mice; Molecular Structure; Myocytes, Cardiac; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi.
Topics: Alcohol Dehydrogenase; Aldo-Keto Reductases; Animals; Chagas Disease; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Immunity, Innate; Nitroimidazoles; Protozoan Proteins; Receptors, Neurotensin; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Access to benznidazole for Chagas disease in the United States-Cautious optimism?
Topics: Centers for Disease Control and Prevention, U.S.; Chagas Disease; Drug Costs; Drugs, Investigational; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.
Topics: Antiprotozoal Agents; Chagas Disease; Cysteine Endopeptidases; High-Throughput Screening Assays; Host-Parasite Interactions; Humans; Kinetoplastida; Molecular Docking Simulation; Molecular Structure; Nifurtimox; Nitroimidazoles; Protein Domains; Protozoan Proteins; Trypanosoma cruzi | 2017 |
Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach.
Topics: Alcohols; Animals; Chagas Disease; Chemistry, Pharmaceutical; Child; Chlorocebus aethiops; Contraindications; Dosage Forms; Humans; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Polyethylene Glycols; Propylene Glycol; Solubility; Solvents; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells; Water | 2017 |
Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Risk Factors; Trypanocidal Agents; Young Adult | 2017 |
Benznidazole Nanoformulates: A Chance to Improve Therapeutics for Chagas Disease.
Topics: Chagas Disease; Chemical Phenomena; Cyclodextrins; Drug Carriers; Fibroblasts; Hep G2 Cells; Humans; Liposomes; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Diastole; Fenofibrate; Fibrosis; Humans; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; PPAR alpha; Stroke Volume; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Ventricular Dysfunction; Ventricular Function | 2017 |
[Rodolfo Viotti: clinical investigator in Chagas disease (1959-2017)].
Topics: Argentina; Chagas Disease; History, 20th Century; History, 21st Century; Humans; Nitroimidazoles; Research Personnel; Trypanocidal Agents | 2017 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Spanish group defeats Shkreli in Chagas voucher race.
Topics: Chagas Disease; Drug Industry; Drug Utilization Review; Humans; Neglected Diseases; Nitroimidazoles; Spain; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease.
Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents | 2017 |
FDA Gives First-Ever Approval of Drug To Treat Chagas' Disease.
Topics: Chagas Disease; Drug Approval; Humans; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
Timeline of events.
Topics: Antiprotozoal Agents; Biomedical Research; Chagas Disease; Cooperative Behavior; Cultural Diversity; Female; Hemorrhagic Fever, Ebola; Humans; Male; Nitroimidazoles; Nobel Prize; Patents as Topic; Research Support as Topic; Sex Factors; Social Discrimination; Social Justice; United States | 2017 |
Comment on: Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease.
Topics: Chagas Disease; Cohort Studies; Humans; Nitroimidazoles | 2018 |
Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease.
Topics: Animals; Antibodies, Protozoan; Cell Line; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Drug Carriers; Female; Heart; Inflammation; Mice; Mice, Inbred C3H; Nanoparticles; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Efficacy of essential oil of Syzygium aromaticum alone and in combination with benznidazole on murine oral infection with Trypanosoma cruzi IV.
Topics: Animals; Chagas Disease; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Insect Vectors; Male; Mice; Nitroimidazoles; Oils, Volatile; Parasitemia; Plant Oils; Rhodnius; Syzygium; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease-authors' response.
Topics: Chagas Disease; Cohort Studies; Humans; Nitroimidazoles | 2018 |
The long road towards a safe and effective treatment of chronic Chagas disease.
Topics: Adult; Chagas Disease; Humans; Nitroimidazoles | 2018 |
Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Drug Combinations; Drug Synergism; Drugs, Investigational; Immunoglobulin G; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Triose-Phosphate Isomerase; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
A novel antibody surrogate biomarker to monitor parasite persistence in Trypanosoma cruzi-infected patients.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Biomarkers; Brazil; Chagas Disease; DNA, Protozoan; Humans; Immunoassay; Nitroimidazoles; Parasite Load; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi | 2018 |
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Chagas disease knocks on our door: a cross-sectional study among Latin American immigrants in Milan, Italy.
Topics: Adolescent; Adult; Bolivia; Chagas Disease; Child; Cross-Sectional Studies; Data Accuracy; Drug Tolerance; El Salvador; Emigrants and Immigrants; Enzyme-Linked Immunosorbent Assay; Female; Hispanic or Latino; Humans; Immunoassay; Italy; Latin America; Male; Middle Aged; Nitroimidazoles; Prevalence; Risk Factors; Surveys and Questionnaires; Trypanosoma cruzi | 2018 |
Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease.
Topics: Cell Survival; Cells, Cultured; Chagas Disease; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Nitroimidazoles; Trypanosoma cruzi | 2018 |
Severe immune thrombocytopaenia in a patient taking benznidazole for chronic Chagas disease.
Topics: Adult; Chagas Disease; Chronic Disease; Female; Humans; Immunosuppressive Agents; Nitroimidazoles; Thrombocytopenia | 2018 |
Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi.
Topics: Animals; Calcium Carbonate; Cell Death; Cell Line; Chagas Disease; Drug Delivery Systems; Epithelial Cells; Membrane Potential, Mitochondrial; Nanocapsules; Nitroimidazoles; Trypanosoma cruzi | 2018 |
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions.
Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds | 2018 |
Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes.
Topics: Adhesiveness; Administration, Oral; Animals; Capsules; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Gelatin; Hydrophobic and Hydrophilic Interactions; Kinetics; Male; Mice, Inbred BALB C; Nitroimidazoles; Particle Size; Polyelectrolytes; Polymethacrylic Acids; Rheology; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach.
Topics: Animals; Chagas Disease; Clomipramine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Inhibitory Concentration 50; Male; Mice; Multivariate Analysis; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Principal Component Analysis; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Male; Mice; Nifurtimox; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release.
Topics: Adhesiveness; Administration, Oral; Alginates; Capsules; Chagas Disease; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Liberation; Gelatin; Glucuronic Acid; Hexuronic Acids; Kinetics; Models, Chemical; Nitroimidazoles; Polyelectrolytes; Solubility; Solvents; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; Cytokines; Female; Humans; Interleukin-2; Leukocytes, Mononuclear; Male; Nitroimidazoles; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2018 |
Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail.
Topics: Adult; Chagas Disease; Chronic Disease; Cohort Studies; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Prospective Studies; Retreatment; Trypanosoma cruzi | 2018 |
Chronic Chagas disease: therapeutic protocols and efficacy endpoints.
Topics: Adult; Chagas Disease; Humans; Nitroimidazoles | 2018 |
Repurposing Strategy of Atorvastatin against Trypanosoma cruzi:
Topics: Animals; Atorvastatin; Cell Line; Chagas Disease; Drug Repositioning; Drug Synergism; Drug Therapy, Combination; Heart; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Benefits of Ascorbic Acid in Association with Low-Dose Benznidazole in Treatment of Chagas Disease.
Topics: Animals; Antioxidants; Ascorbic Acid; Chagas Disease; Drug Therapy, Combination; Inflammation; Lipid Peroxidation; Male; Mice; Nitroimidazoles; Oxidation-Reduction; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
In vitro and in vivo trypanocidal activities of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-cromen-2-one, a new synthetic coumarin of low cytotoxicity against mammalian cells.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Coumarins; Female; Mice; Nitroimidazoles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance.
Topics: Administration, Oral; Chagas Disease; Drug Carriers; Drug Liberation; Humans; Nitroimidazoles; Poloxamer; Solubility; Trypanocidal Agents; Trypanosoma cruzi; X-Ray Diffraction | 2018 |
Characteristics of Patients for Whom Benznidazole Was Released Through the CDC-Sponsored Investigational New Drug Program for Treatment of Chagas Disease - United States, 2011-2018.
Topics: Adolescent; Adult; Aged; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Child; Child, Preschool; Drugs, Investigational; Emigrants and Immigrants; Female; Humans; Infant; Infant, Newborn; Latin America; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; United States; Young Adult | 2018 |
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
Topics: Animals; Ascorbic Acid; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Mice, Inbred C3H; Nitroimidazoles; Parasite Load; Parasitemia; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Experimental combination therapy using low doses of benznidazole and allopurinol in mouse models of Trypanosoma cruzi chronic infection.
Topics: Allopurinol; Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitroimidazoles; Random Allocation; Specific Pathogen-Free Organisms; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.
Topics: Animals; Chagas Disease; Disease Models, Animal; Inflammation; Kidney; Liver; Male; Mice; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 2018 |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Carvedilol; Catalase; Chagas Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mice, Inbred C57BL; Myocardium; Nitroimidazoles; Oxidative Stress; Parasitemia; Protein Carbonylation; Reference Values; Reproducibility of Results; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study.
Topics: Aftercare; Brazil; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; National Institutes of Health (U.S.); Nitroimidazoles; Parasitemia; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi; United States | 2018 |
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Flow Cytometry; Indoles; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement.
Topics: Brain; Chagas Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Nitroimidazoles | 2019 |
In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex.
Topics: Animals; Chagas Disease; Coordination Complexes; Copper; Female; Hydrazines; Hydrogen Bonding; Ligands; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Nitroimidazoles; Pyridines; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions.
Topics: Animals; Cell Line; Chagas Disease; Chemistry, Pharmaceutical; Chlorocebus aethiops; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Emulsions; Humans; Inhibitory Concentration 50; Liquid Crystals; Nanostructures; Nitroimidazoles; Phase Transition; Solubility; Solvents; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Chagas disease: An underrecognized diagnosis.
Topics: Acute-Phase Reaction; Cardiomyopathies; Chagas Disease; Chronic Disease; Diagnosis, Differential; Female; Humans; Male; Megacolon; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2018 |
Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease.
Topics: Chagas Disease; Chronic Disease; Cross-Sectional Studies; Cytokines; Echocardiography; Female; Heart; Humans; Interleukin-17; Male; Middle Aged; Mitral Valve; Myocardium; Nitroimidazoles | 2019 |
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Protozoan Proteins; Sterol 14-Demethylase; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development.
Topics: Chagas Disease; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Protozoan Vaccines; Trypanocidal Agents; Trypanosoma cruzi; Vaccination | 2019 |
Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Drug Repositioning; Drug Therapy, Combination; Fibroblasts; Imatinib Mesylate; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Humans; Nitroimidazoles; Prognosis; Thrombin; Thrombophilia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Trypanosoma cruzi-Specific T-Cell Responses to Monitor Treatment Efficacy in Chronic Chagas Disease.
Topics: Cells, Cultured; Chagas Disease; Chronic Disease; Humans; Immunity, Cellular; Immunoenzyme Techniques; Leukocytes, Mononuclear; Nitroimidazoles; Prognosis; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil.
Topics: Adolescent; Adult; Brazil; Chagas Cardiomyopathy; Chagas Disease; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?
Topics: Adult; Chagas Disease; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents | 2019 |
Insights into Chagas treatment based on the potential of bacteriocin AS-48.
Topics: Animals; Bacteriocins; Chagas Disease; Enterococcus faecalis; Mitochondria; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi.
Topics: Allopurinol; Animals; Cell Line; Chagas Disease; Humans; Mice; Mortality; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanosoma cruzi | 2019 |
Developments on treatment of Chagas disease - from discovery to current times.
Topics: Chagas Disease; Drug Repositioning; Humans; Molecular Structure; Nifurtimox; Nitroimidazoles; Prognosis; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Impact of levamisole in co-administration with benznidazole on experimental Chagas disease.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Levamisole; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis.
Topics: Acute Disease; Chagas Disease; Fatal Outcome; Food Parasitology; Humans; Infant; Male; Nitroimidazoles; Prognosis; Trypanocidal Agents | 2019 |
Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients.
Topics: Cardiomyopathies; Chagas Disease; Chronic Disease; Cost-Benefit Analysis; Disease Progression; Humans; Nitroimidazoles; Trypanosoma cruzi; Vaccination; Vaccines | 2019 |
Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis.
Topics: Animals; Antioxidants; Cardiotonic Agents; Catalase; Chagas Cardiomyopathy; Chagas Disease; Cytokines; Disease Models, Animal; Heart; Inflammation; Interleukin-10; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Recognition for Chagas disease.
Topics: Chagas Disease; Humans; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Benznidazole, itraconazole and their combination in the treatment of acute experimental chagas disease in dogs.
Topics: Acute Disease; Animals; Chagas Disease; DNA, Protozoan; Dogs; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Heart; Humans; Itraconazole; Male; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Trypanocidal Agents | 2019 |
Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi.
Topics: Animals; Anti-Bacterial Agents; Chagas Disease; Doxycycline; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Phenothiazinium Dyes Are Active against
Topics: Animals; Cell Line; Cell Proliferation; Chagas Disease; Coloring Agents; Humans; Methylene Blue; Nifurtimox; Nitroimidazoles; Phenothiazines; Tolonium Chloride; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Chagas Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Heart; Male; Myocarditis; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Running; Trypanosoma cruzi | 2019 |
Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.
Topics: Animals; Chagas Disease; DNA, Protozoan; Drug Resistance; Exons; Genetic Variation; Genotype; Humans; Insect Vectors; Mexico; Microsatellite Repeats; Nifurtimox; Nitroimidazoles; Opossums; Phylogeny; Polymerase Chain Reaction; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Female; Intestines; Kidney; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua.
Topics: Allopurinol; Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Mice; Nicaragua; Nitroimidazoles; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2013 |
Benznidazole prevents endothelial damage in an experimental model of Chagas disease.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Use of an enzyme-linked immunosorbent assay that utilizes the Tc13Tul antigen of Trypanosoma cruzi to monitor patients after treatment with benznidazole.
Topics: Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Infant; Nitroimidazoles; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi | 2013 |
Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment.
Topics: Adolescent; Adult; Chagas Disease; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2013 |
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2013 |
The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Skin Diseases; Steroids; Treatment Outcome; Young Adult | 2013 |
Clinical follow-up of responses to treatment with benznidazol in Amazon: a cohort study of acute Chagas disease.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibodies, Protozoan; Brazil; Chagas Cardiomyopathy; Chagas Disease; Child; Child, Preschool; Disease Progression; Follow-Up Studies; Humans; Immunoglobulin G; Middle Aged; Nitroimidazoles; Topography, Medical; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
Evaluation of the ELISA-F29 test as an early marker of therapeutic efficacy in adults with chronic Chagas disease.
Topics: Adolescent; Adult; Antibodies, Protozoan; Antigens, Protozoan; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Donor-derived Trypanosoma cruzi infection in solid organ recipients in the United States, 2001-2011.
Topics: Adult; Aged; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Organ Transplantation; Polymerase Chain Reaction; Tissue Donors; Trypanosoma cruzi; United States | 2013 |
Achievements and challenges upon the implementation of a program for national control of congenital Chagas in Bolivia: results 2004-2009.
Topics: Antiprotozoal Agents; Bolivia; Chagas Disease; Communicable Disease Control; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic | 2013 |
Benznidazole treatment in chronic children infected with Trypanosoma cruzi: serological and molecular follow-up of patients and identification of Discrete Typing Units.
Topics: Adolescent; Antibodies, Protozoan; Antiprotozoal Agents; Argentina; Chagas Disease; Child; Child, Preschool; Chronic Disease; DNA, Kinetoplast; DNA, Protozoan; Female; Follow-Up Studies; Genotype; Humans; Male; Nitroimidazoles; Nucleic Acid Hybridization; Rural Population; Treatment Outcome; Trypanosoma cruzi | 2013 |
Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.
Topics: Animals; Autophagy; Cell Membrane; Chagas Disease; Lactones; Liver; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Parasitic Sensitivity Tests; Sesquiterpenes; Survival Analysis; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Vacuoles | 2013 |
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
Topics: Animals; Biomarkers; CD8-Positive T-Lymphocytes; Chagas Disease; DNA; Drug Resistance; Drug Therapy, Combination; Immunophenotyping; Mice; Mice, Inbred C57BL; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Benznidazole treatment of chagasic encephalitis in pregnant woman with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiretroviral Therapy, Highly Active; Chagas Disease; Coinfection; Encephalitis; Female; Humans; Infant, Newborn; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention.
Topics: Adolescent; Adult; Case-Control Studies; Chagas Disease; Child; Disease Progression; Female; Humans; Male; Nitroimidazoles; Polymerase Chain Reaction; Prognosis; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
Development of UV/HPLC methods for quantitative analysis of benznidazole in human plasma and urine for application in pediatric clinical studies.
Topics: Chagas Disease; Child; Chromatography, High Pressure Liquid; Freeze Drying; Humans; Nitroimidazoles; Specimen Handling; Trypanocidal Agents | 2013 |
Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.
Topics: Chagas Disease; Crystallography, X-Ray; Humans; Models, Molecular; Nitroimidazoles; Spectrophotometry, Infrared; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
A study of photostability and compatibility of the anti-chagas drug Benznidazole with pharmaceutics excipients.
Topics: Chagas Disease; Chemistry, Pharmaceutical; Drug Stability; Excipients; Nitroimidazoles; Photolysis; Trypanocidal Agents | 2015 |
Reversible cysteine protease inhibitors show promise for a Chagas disease cure.
Topics: Administration, Oral; Animals; Area Under Curve; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Life Cycle Stages; Male; Mice; Nitroimidazoles; Parasitemia; Protozoan Proteins; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi.
Topics: Animals; Cell Survival; Chagas Disease; DNA Glycosylases; DNA Repair; DNA Repair Enzymes; DNA, Protozoan; Drug Resistance; Guanine; Nitroimidazoles; Protozoan Proteins; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Mother-to-child transmission of congenital Chagas disease, Japan.
Topics: Adolescent; Chagas Disease; Humans; Infectious Disease Transmission, Vertical; Japan; Male; Neglected Diseases; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Sesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Lactones; Mice; Nanocapsules; Nitroimidazoles; Sesquiterpenes; Trypanosoma cruzi | 2014 |
[Paediatric Chagas in a non-endemic area].
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Emigrants and Immigrants; Humans; Infant; Infant, Newborn; Nitroimidazoles; Spain; Trypanocidal Agents | 2014 |
In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.
Topics: Amidines; Animals; Cell Culture Techniques; Chagas Disease; Dose-Response Relationship, Drug; Heart; Humans; Nitroimidazoles; Parasitic Sensitivity Tests; Pentamidine; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.
Topics: Amidines; Animals; Cell Survival; Chagas Disease; Galactosidases; Male; Mice; Nitroimidazoles; No-Observed-Adverse-Effect Level; Parasitemia; Primary Cell Culture; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Advancing the treatment for Chagas' disease.
Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents | 2014 |
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
A flagellated protozoa in the urine: other than Trichomonas.
Topics: Adult; Chagas Disease; Female; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Urine | 2014 |
Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Chagas Disease; Diagnosis, Differential; Female; Humans; Meningoencephalitis; Middle Aged; Nitroimidazoles; Toxoplasmosis, Cerebral; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Development of novel benznidazole formulations: physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease.
Topics: Animals; Calorimetry, Differential Scanning; Cellulose; Chagas Disease; Chemistry, Pharmaceutical; Crystallization; Deoxycholic Acid; Drug Carriers; Female; Mice; Microscopy, Electron, Scanning; Nitroimidazoles; Parasitemia; Powder Diffraction; Trypanocidal Agents; X-Ray Diffraction | 2014 |
Cerebral trypanosomiasis in a renal transplant recipient.
Topics: Adult; Brain Diseases; Central Nervous System Protozoal Infections; Chagas Disease; Humans; Kidney Transplantation; Male; Nitroimidazoles; Tomography, X-Ray Computed; Trypanocidal Agents | 2014 |
A clinical adverse drug reaction prediction model for patients with chagas disease treated with benznidazole.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Biomarkers; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Educational Status; Female; Humans; Logistic Models; Male; Nitroimidazoles; Racial Groups; Sex Factors; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2014 |
The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country.
Topics: Adult; Chagas Disease; Cytokines; Diseases in Twins; Female; HSP70 Heat-Shock Proteins; Humans; Immunity, Innate; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Spain; Trypanocidal Agents; Twins, Dizygotic | 2014 |
Short report: Increasing access to treatment for Chagas disease: the case of Morelos, Mexico.
Topics: Chagas Disease; Health Services Accessibility; Humans; Mexico; Nitroimidazoles; Trypanocidal Agents | 2014 |
Ruthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Female; Heart; Humans; Inflammation; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Ruthenium; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Development of a LC-MS/MS methodology for the monitoring of the antichagasic drug benznidazole in human urine.
Topics: Chagas Disease; Child; Chromatography, Liquid; Humans; Liquid-Liquid Extraction; Nitroimidazoles; Tandem Mass Spectrometry; Trypanocidal Agents | 2015 |
Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.
Topics: Animals; Cell Death; Cell Line, Tumor; Chagas Disease; Chemical and Drug Induced Liver Injury; DNA Damage; Female; Hep G2 Cells; Humans; Liver; Male; Mice; Mitochondria; Nifurtimox; Nitrofurazone; Nitroimidazoles; Parasites; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Arthritis and benznidazole: more closely related than we thought.
Topics: Adult; Arthritis; Chagas Disease; Cohort Studies; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2015 |
First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up.
Topics: Adolescent; Adult; Aged; Arecaceae; Chagas Disease; Child; Family; Female; French Guiana; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Plant Extracts; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Profile of Trypanosoma cruzi infection in a tropical medicine reference center, Northern Italy.
Topics: Adolescent; Adult; Aged; Chagas Disease; Child; Echocardiography; Electrocardiography; Female; Humans; Italy; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Retrospective Studies; Tropical Medicine; United States | 2014 |
Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.
Topics: Animals; Antiprotozoal Agents; Aptamers, Nucleotide; Base Sequence; Biomarkers; Chagas Disease; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nitroimidazoles; RNA | 2015 |
Novel solid dispersions of benznidazole: preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system.
Topics: Animals; Cells, Cultured; Cellulose; Chagas Disease; Cholagogues and Choleretics; Deoxycholic Acid; Drug Compounding; Drug Delivery Systems; Drug Liberation; Female; Fibroblasts; Freeze Drying; Humans; Inhibitory Concentration 50; Lethal Dose 50; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Tolerance of benznidazole in a United States Chagas Disease clinic.
Topics: Adolescent; Adult; Aged; Angioedema; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Nitroimidazoles; Peripheral Nervous System Diseases; Retrospective Studies; Trypanocidal Agents; United States; Young Adult | 2015 |
Etiological treatment of Chagas disease patients with benznidazole lead to a sustained pro-inflammatory profile counterbalanced by modulatory events.
Topics: Adolescent; Adult; Chagas Disease; Controlled Before-After Studies; Cytokines; Female; Host-Pathogen Interactions; Humans; Immunomodulation; Inflammation Mediators; Male; Middle Aged; Neutrophils; Nitroimidazoles; Receptors, IgG; Toll-Like Receptor 4; Trypanocidal Agents; Young Adult | 2015 |
Development of an ionic-liquid-based dispersive liquid-liquid microextraction method for the determination of antichagasic drugs in human breast milk: Optimization by central composite design.
Topics: Chagas Disease; Chromatography, High Pressure Liquid; Humans; Imidazoles; Ionic Liquids; Liquid Phase Microextraction; Milk, Human; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Ultraviolet Rays | 2015 |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
Topics: Animals; Antibodies, Protozoan; Area Under Curve; Brazil; Chagas Disease; Child; Disease Models, Animal; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Flow Cytometry; Humans; Inflammation; Mice; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Primary Cell Culture; Remission Induction; Statistics, Nonparametric; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients.
Topics: Administration, Oral; Chagas Disease; Child; Drug Compounding; Drug Stability; Drug Storage; Humans; Nitroimidazoles; Pediatrics; Spectrophotometry, Ultraviolet; Suspensions; Tablets; Taste | 2015 |
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Esters; Isoenzymes; Male; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Trypanosoma cruzi infection and benznidazole therapy independently stimulate oxidative status and structural pathological remodeling of the liver tissue in mice.
Topics: Animals; Chagas Disease; Liver; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Impact of benznidazole on infection course in mice experimentally infected with Trypanosoma cruzi I, II, and IV.
Topics: Animals; Chagas Disease; DNA, Protozoan; Male; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin.
Topics: Cell Adhesion Molecules; Cells, Cultured; Chagas Disease; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoxins; NF-kappa B; Nitroimidazoles; Signal Transduction; Simvastatin; Trypanocidal Agents | 2015 |
Access to care for Chagas disease in the United States: a health systems analysis.
Topics: Blood Donors; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Clinical Competence; Delivery of Health Care; Drugs, Investigational; Health Services Accessibility; Humans; Nifurtimox; Nitroimidazoles; Referral and Consultation; Systems Analysis; Trypanocidal Agents; United States | 2015 |
Prevention of congenital Chagas through treatment of girls and women of childbearing age.
Topics: Adolescent; Adult; Chagas Disease; Child; Cohort Studies; Female; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Primary Prevention; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Immunosuppression and Chagas disease; experience from a non-endemic country.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunocompromised Host; Infant; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Spain; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2015 |
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Female; Immunoglobulin G; Itraconazole; Mice; Myocardium; Nitroimidazoles; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi.
Topics: Administration, Oral; Animals; Antibodies, Protozoan; Chagas Disease; Drug Administration Schedule; Drug Therapy, Combination; Immunoglobulin G; Injections, Intraperitoneal; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Parasite Load; Suramin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2015 |
In vivo and in vitro auranofin activity against Trypanosoma cruzi: Possible new uses for an old drug.
Topics: Animals; Antirheumatic Agents; Auranofin; Cell Line; Chagas Disease; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Lethal Dose 50; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Random Allocation; Specific Pathogen-Free Organisms; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Toxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers.
Topics: Adult; Chagas Disease; Chronic Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Risk Factors; Treatment Outcome | 2015 |
An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.
Topics: Animals; Chagas Disease; Cyclophosphamide; Immunocompromised Host; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Molecular Structure; Nitroimidazoles; Parasitemia; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Evaluation of cytokine profile and HLA association in benznidazole related cutaneous reactions in patients with Chagas disease.
Topics: Adult; Alleles; Chagas Disease; Cytokines; Drug Eruptions; Female; Genes, MHC Class I; Genes, MHC Class II; HLA-B Antigens; Humans; Hypersensitivity, Delayed; Interleukin-10; Interleukin-5; Male; Nitroimidazoles; Prospective Studies; Skin; Th2 Cells; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
A flow cytometer-based method to simultaneously assess activity and selectivity of compounds against the intracellular forms of Trypanosoma cruzi.
Topics: Chagas Disease; Drug Discovery; Flow Cytometry; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
Topics: Administration, Oral; Animals; Chagas Disease; Dimethyl Sulfoxide; Disease Models, Animal; Diterpenes; Heart; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Salvia; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Perspectives in Chagas disease treatment.
Topics: Animals; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Death, Sudden, Cardiac; Defibrillators, Implantable; Disease Management; Heart Failure; Humans; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Thromboembolism; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Gene Expression; Imidazoles; Immunosuppressive Agents; Male; Mice; Nitroimidazoles; Oxadiazoles; Parasitemia; Sex Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
[Postpartum treatment without interrupting breastfeeding in a patient with Chagas disease].
Topics: Breast Feeding; Chagas Disease; Female; Humans; Nitroimidazoles; Postpartum Period; Trypanocidal Agents; Young Adult | 2015 |
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients.
Topics: Adult; Chagas Disease; Chronic Disease; DNA, Kinetoplast; DNA, Satellite; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Liver; Male; Middle Aged; Nitroimidazoles; Pilot Projects; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Acute Chagas outbreaks: molecular and biological features of Trypanosoma cruzi isolates, and clinical aspects of acute cases in Santander, Colombia.
Topics: Acute Disease; Animals; Base Sequence; Chagas Disease; Colombia; Disease Outbreaks; DNA, Protozoan; Exons; Female; Genetic Variation; Genotype; Humans; Male; Molecular Sequence Data; Nifurtimox; Nitroimidazoles; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
Topics: Adolescent; Adult; Antiprotozoal Agents; Biomarkers; Chagas Disease; Chronic Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Thrombophilia; Treatment Outcome; Young Adult | 2016 |
Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations.
Topics: Antifungal Agents; Chagas Disease; Chemistry, Pharmaceutical; Drug Combinations; Humans; Itraconazole; Limit of Detection; Nitroimidazoles; Quality Control; Spectrophotometry; Trypanocidal Agents | 2016 |
Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country.
Topics: Adult; Chagas Disease; Dermatitis, Exfoliative; Drug Eruptions; Edema; Female; Humans; Male; Nitroimidazoles; Stevens-Johnson Syndrome; Trypanocidal Agents | 2016 |
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.
Topics: Amides; Amidines; Animals; Chagas Disease; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Parasitic Sensitivity Tests; Structure-Activity Relationship; Survival Analysis; Terphenyl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Chagas Disease; DNA, Protozoan; Nitroimidazoles; Nitroreductases; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
Topics: Animals; Cells, Cultured; Chagas Cardiomyopathy; Chagas Disease; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Humans; Immunologic Factors; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2016 |
Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study.
Topics: Adult; Animals; Antiprotozoal Agents; Biological Availability; Chagas Disease; Child; Delayed-Action Preparations; Humans; Male; Nitroimidazoles; Rabbits; Solubility; Tablets; Trypanosoma cruzi | 2016 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glutathione; Humans; Imidazoles; Nitroimidazoles; Polyamines; Spermidine; Thiophenes; Trypanosoma cruzi; User-Computer Interface | 2016 |
The BENEFIT Trial: Where Do We Go from Here?
Topics: Antiprotozoal Agents; Chagas Disease; Clinical Trials as Topic; Drug Evaluation; Humans; Nitroimidazoles; Trypanosoma cruzi; World Health Organization | 2016 |
Evaluation of Parasiticide Treatment with Benznidazol in the Electrocardiographic, Clinical, and Serological Evolution of Chagas Disease.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Protozoan; Brazil; Chagas Disease; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Treatment Outcome; Trypanocidal Agents | 2016 |
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole.
Topics: Adult; Chagas Disease; Chemistry, Pharmaceutical; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2016 |
Curcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease.
Topics: Acute Disease; Animals; Chagas Disease; Curcumin; Cytokines; Female; Liver; Mice; Myocardium; Nitroimidazoles; Parasitemia; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Chagas Disease; Female; Humans; Immunosuppressive Agents; Meningoencephalitis; Nitroimidazoles; Secondary Prevention; Survival Rate; Time Factors; Trypanocidal Agents; Ultrasonography | 2015 |
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Synergism; Heart; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses.
Topics: Adult; Antibodies, Protozoan; B-Lymphocytes; Chagas Disease; Drug Monitoring; Enzyme-Linked Immunospot Assay; Follow-Up Studies; Humans; Interferon-gamma; Middle Aged; Nitroimidazoles; Prognosis; T-Lymphocytes; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2016 |
Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease.
Topics: Animals; Chagas Disease; Female; Flow Cytometry; Heart Diseases; Immunohistochemistry; Mice; Mice, Inbred C57BL; Nitroimidazoles; Pentoxifylline; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina.
Topics: Adult; Antibodies, Protozoan; Antigens, Protozoan; Argentina; Chagas Disease; Chronic Disease; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Time Factors; Trypanocidal Agents; Young Adult | 2016 |
Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Carriers; Female; Life Cycle Stages; Mice; Mice, Inbred C3H; Myocytes, Cardiac; Nanoparticles; Nitroimidazoles; Parasitemia; Particle Size; Poloxamer; Primary Cell Culture; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.
Topics: Animals; Autophagy; Cell Membrane; Chagas Disease; Endoplasmic Reticulum; Flow Cytometry; Indazoles; Membrane Potential, Mitochondrial; Mice; Microscopy, Electron, Transmission; Mitochondria; Nitroimidazoles; Nuclear Envelope; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Animals; Chagas Disease; Chronic Disease; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Humans; Lactones; Mice; Nanocapsules; Nitroimidazoles; Polyethylene Glycols; Sesquiterpenes; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
[The third and new face of Chagas disease].
Topics: Adult; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Humans; Neglected Diseases; Nitroimidazoles; Treatment Failure | 2016 |
Vouching for access.
Topics: Chagas Disease; Cholera; Cholera Vaccines; Drug Approval; Drug Costs; Health Policy; Health Services Accessibility; Humans; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2016 |
Diagnosis and Treatment of Congenital Chagas Disease in a Premature Infant.
Topics: Chagas Disease; Diagnosis, Differential; Humans; Infant, Newborn; Infant, Premature; Male; Nitroimidazoles; Trypanocidal Agents | 2016 |
Success of benznidazole chemotherapy in chronic Trypanosoma cruzi-infected patients with a sustained negative PCR result.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Female; Follow-Up Studies; Humans; Immunoassay; Male; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.
Topics: Animals; Chagas Disease; Electrophoresis, Gel, Two-Dimensional; Mice; Naphthoquinones; Nifurtimox; Nitroimidazoles; Proteomics; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Chronic Heart Disease after Treatment of Oral Acute Chagas Disease.
Topics: Acute Disease; Adolescent; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Electrocardiography; Humans; Male; Nitroimidazoles; Recurrence; Trypanocidal Agents | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; Macrophages; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Parasitemia; Pentamidine; Putrescine; Random Allocation; Spermidine; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Chagas Disease; Humans; Macrophages; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nitroimidazoles; Trypanocidal Agents; Up-Regulation | 2016 |
Detection of Trypanosoma cruzi and Treatment Monitoring by PCR from Dried Blood Spot Samples in Children.
Topics: Adolescent; Argentina; Chagas Disease; Child; Child, Preschool; Dried Blood Spot Testing; Feasibility Studies; Female; Humans; Male; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Rural Population; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis.
Topics: Animals; Antioxidants; Chagas Disease; Disease Models, Animal; Down-Regulation; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitroimidazoles; Oxidative Stress; Sepsis; Toll-Like Receptor 4; Trypanocidal Agents | 2017 |
Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis.
Topics: Algorithms; Animals; Chagas Disease; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Immunoblotting; Lasers; Motion; Nitroimidazoles; Photometry; Reagent Kits, Diagnostic; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dogs; Immunoglobulin G; Male; Mice; Myocarditis; Nitroimidazoles; Trypanosoma cruzi | 2017 |
New Imidazole-Based Compounds Active Against Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Crystallography, X-Ray; Humans; Imidazoles; Mice; Models, Molecular; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Long-term comparative pharmacovigilance of orally transmitted Chagas disease: first report.
Topics: Chagas Disease; Cross-Sectional Studies; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Pharmacovigilance; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Need to screen for Chagas disease and Strongyloides infestation in non-endemic countries prior to treatment with biologics.
Topics: Angioedema; Animals; Antibodies, Helminth; Antibodies, Protozoan; Antiprotozoal Agents; Antirheumatic Agents; Arthritis, Psoriatic; Bolivia; Chagas Disease; Disease Susceptibility; Drug Substitution; Endemic Diseases; Etanercept; Humans; Ivermectin; Nitroimidazoles; Patient Selection; Spain; Strongyloidiasis | 2017 |
Treatment of Infected Women of Childbearing Age Prevents Congenital Trypanosoma cruzi Infection by Eliminating the Parasitemia Detected by PCR.
Topics: Adult; Antibiotic Prophylaxis; Chagas Disease; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Parasitic; Prospective Studies; Trypanocidal Agents | 2017 |
A New Epoch in Antitrypanosomal Treatment for Chagas Disease.
Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles | 2017 |
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Nitroimidazoles; Parasitemia; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole.
Topics: Animals; Chagas Disease; DNA, Protozoan; Female; Genotype; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Hemoglobins; Iron; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Siderophores; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease.
Topics: Adult; Aged; Animals; Antigens, Protozoan; B-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Chi-Square Distribution; Cohort Studies; Cytokines; Female; Flow Cytometry; Humans; Immunophenotyping; Leukocytes, Mononuclear; Male; Middle Aged; Nitroimidazoles; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.
Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: Genetic diversity influences the profile of immunoglobulins during experimental infection.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Female; Genetic Variation; Genotype; Immunoglobulin G; Mice; Nitroimidazoles; Phylogeny; Random Allocation; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks.
Topics: Administration, Oral; Chagas Disease; Chitosan; Drug Carriers; Drug Compounding; Drug Design; Humans; Microscopy, Electron, Scanning; Molecular Structure; Neural Networks, Computer; Nitroimidazoles; Particle Size; Solubility; Surface Properties; Trypanocidal Agents | 2009 |
[Part VI. Antiparasitic treatment for Chagas disease].
Topics: Allopurinol; Animals; Chagas Disease; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: Biological characterization of lineages I and II supports the predominance of lineage I in Colombia.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Colombia; Host-Parasite Interactions; Insect Vectors; Nitroimidazoles; Panstrongylus; Polymerase Chain Reaction; Rhodnius; Triatoma; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2009 |
Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture.
Topics: Animals; Bacteremia; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Inflammation; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2008 |
Tumour-like chagasic encephalitis in AIDS patients: an atypical presentation in one of them and outcome in a small series of cases.
Topics: Adult; AIDS-Related Opportunistic Infections; Chagas Disease; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitroimidazoles; Tomography, X-Ray Computed; Treatment Outcome; Trypanocidal Agents | 2008 |
[Chagas disease].
Topics: Animals; Chagas Disease; Emigration and Immigration; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up.
Topics: Adult; Animals; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; DNA, Kinetoplast; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole.
Topics: Adult; Aged; Brazil; Chagas Disease; Disease Outbreaks; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Time Factors; Trypanocidal Agents; Urban Population; Young Adult | 2009 |
Reduction of parasite levels in blood improves pregnancy outcome during experimental Trypanosoma cruzi infection.
Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; Chagas Disease; Female; Gene Expression Regulation; Hyaluronan Receptors; Immunoglobulin G; Interferon-gamma; Lectins, C-Type; Mice; Nitroimidazoles; Parasitemia; Placenta; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Spleen; Time Factors; Trypanosoma cruzi | 2009 |
Chagas disease: the forgotten American neuroinfection.
Topics: Americas; Central Nervous System Diseases; Chagas Disease; History, 20th Century; History, 21st Century; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières.
Topics: Adolescent; Animals; Bolivia; Chagas Disease; Child; Child, Preschool; Developing Countries; Education; Female; Follow-Up Studies; Guatemala; Honduras; Humans; Infant; Insect Control; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Antioxidant therapy attenuates oxidative insult caused by benzonidazole in chronic Chagas' heart disease.
Topics: Antioxidants; Ascorbic Acid; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Vitamin E | 2010 |
Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery.
Topics: Adolescent; Animals; Chagas Disease; DNA, Protozoan; Female; Humans; Infant, Newborn; Molecular Sequence Data; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Sequence Analysis, DNA; Triplets; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Trypanosoma cruzi: Immunological predictors of benznidazole efficacy during experimental infection.
Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Hyaluronan Receptors; Immunoglobulin G; Immunophenotyping; Lectins, C-Type; Male; Mice; Mice, Inbred C3H; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Spleen; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.
Topics: Animals; Chagas Disease; Cyclophosphamide; Female; Genetic Variation; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Secondary Prevention; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
New advances in the management of a long-neglected disease.
Topics: Adult; Animals; Bolivia; CD8-Positive T-Lymphocytes; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Interferon-gamma; Interleukin-2; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Pregnancy; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies.
Topics: Chagas Disease; Crystallography, X-Ray; DNA, Protozoan; HeLa Cells; Humans; Indazoles; Nitroimidazoles; Oxidation-Reduction; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras.
Topics: Age Distribution; Animals; Antibodies, Protozoan; Chagas Disease; Child; Child, Preschool; Chronic Disease; Epidemiologic Methods; Female; Honduras; Humans; Immunoglobulin G; Infant; Insect Control; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Drug Resistance; Drug Synergism; Female; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroimidazoles; Organometallic Compounds; Parasitemia; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
[Chagas disease and immunodeficiency: HIV infection and transplantation].
Topics: Anti-HIV Agents; Chagas Disease; France; HIV Infections; Humans; Meningoencephalitis; Nifurtimox; Nitroimidazoles; Transplantation; Trypanocidal Agents | 2009 |
Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment.
Topics: Adolescent; Adult; Antibodies, Protozoan; Brazil; Chagas Cardiomyopathy; Chagas Disease; Child; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains.
Topics: Acute Disease; Animals; Chagas Disease; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Interferon-gamma; Interleukin-2; Macrophages, Peritoneal; Male; Nitrites; Nitroimidazoles; Parasitemia; Rats; Rats, Wistar; Species Specificity; Survival Rate; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
[Chagas disease--varying treatment outcome].
Topics: Central America; Chagas Disease; Global Health; Humans; Nitroimidazoles; South America; Treatment Outcome; Trypanocidal Agents | 2010 |
New drugs for neglected infectious diseases: Chagas' disease.
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitric Oxide Donors; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Canova medication modifies parasitological parameters in mice infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Crotalid Venoms; Drug Therapy, Combination; Formularies, Homeopathic as Topic; Heart; Host-Pathogen Interactions; Intestines; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Plant Extracts; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
Acute Chagas' disease in postrenal transplant and treatment with benzonidazole.
Topics: Acute Disease; Adult; Chagas Disease; Fatal Outcome; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Male; Nitroimidazoles; Postoperative Complications; Renal Insufficiency; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease.
Topics: Animals; Cell Line; Chagas Disease; Female; Humans; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Palladium; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs.
Topics: Allopurinol; Animals; Cell Line; Cells, Cultured; Chagas Disease; Endemic Diseases; Inhibitory Concentration 50; Insect Vectors; Mice; Mice, Inbred C3H; Muscle Cells; Muscles; Nicaragua; Nitroimidazoles; Phylogeny; Rats; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.
Topics: Analysis of Variance; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Heart Function Tests; Hemodynamics; Lipid Peroxidation; Mitochondria, Heart; Nitroimidazoles; Oxidative Stress; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trypanosoma cruzi | 2010 |
Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-disease-endemic country.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Follow-Up Studies; Humans; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2010 |
Heart rate variability in chronic Chagas patients before and after treatment with benznidazole.
Topics: Adult; Aged; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Chagas Disease; Chronic Disease; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2010 |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
Topics: Acute Disease; Adolescent; Adult; Brazil; Chagas Disease; Child; Disease Outbreaks; Echocardiography, Doppler; Electrocardiography; Female; Humans; Male; Nitroimidazoles; Radiography, Thoracic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Chagas disease: pushing through the pipeline.
Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2010 |
Chagas disease 101.
Topics: Acute Disease; Animals; Carrier State; Chagas Disease; Chronic Disease; Clinical Trials as Topic; History, 16th Century; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; Humans; Insect Vectors; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Antitrypanosomal agents: treatment or threat?
Topics: Chagas Cardiomyopathy; Chagas Disease; Clinical Trials as Topic; Drug Administration Schedule; Drug Eruptions; Humans; Meta-Analysis as Topic; Nifurtimox; Nitroimidazoles; Polyneuropathies; Trypanocidal Agents; Trypanosoma cruzi; United States | 2010 |
A preformulation study of a new medicine for Chagas disease treatment: physicochemical characterization, thermal stability, and compatibility of benznidazole.
Topics: Chagas Disease; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Excipients; Hot Temperature; Humans; Nitroimidazoles; Transition Temperature | 2010 |
Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-γ and interleukin-18 but increased concentrations of interleukin-10.
Topics: Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Infant, Newborn; Interferon-gamma; Interleukin-10; Interleukin-18; Male; Nifurtimox; Nitroimidazoles; Toxoplasmosis, Congenital; Trypanocidal Agents | 2010 |
[Human immunodeficiency virus and Chagas disease coinfection treated successfully with benznidazole and a raltegravir-based antiretroviral regimen: a case report].
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Chagas Disease; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Nitroimidazoles; Oligopeptides; Organophosphonates; Paraguay; Pyridines; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Spain; Tenofovir; Trypanocidal Agents; Zidovudine | 2011 |
Chagas disease in Latin American migrants: a Spanish challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Echocardiography; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Latin America; Male; Mass Screening; Nitroimidazoles; Polymerase Chain Reaction; Pregnancy; Prospective Studies; Spain; Transients and Migrants | 2011 |
A high-performance liquid chromatographic method for benznidazole quantitation in plasma of patients with Chagas disease.
Topics: Adult; Chagas Disease; Chromatography, High Pressure Liquid; Female; Humans; Male; Nitroimidazoles; Reproducibility of Results; Trypanocidal Agents | 2011 |
Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease.
Topics: Adult; Chagas Disease; Drug Resistance; Female; Humans; Lethal Dose 50; Male; Microsatellite Repeats; Middle Aged; Nitroimidazoles; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Adverse events after the use of benznidazole in infants and children with Chagas disease.
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Young Adult | 2011 |
Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.
Topics: Animals; Chagas Disease; Chemical Precipitation; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Excipients; Female; Hardness Tests; Hypromellose Derivatives; Methylcellulose; Mice; Nitroimidazoles; Polymers; Solubility; Solvents; Tablets; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage.
Topics: Animals; Antibodies, Protozoan; Cardiomyopathies; Chagas Disease; Chronic Disease; Female; Humans; Immunity, Humoral; Male; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Ribosomal Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2011 |
[Benzonidazole: one of the rare treatment for Chagas disease].
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2011 |
Development of effervescent tablets containing benzonidazole complexed with cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biological Availability; Chagas Disease; Hydrophobic and Hydrophilic Interactions; Nitroimidazoles; Solubility; Tablets; Technology, Pharmaceutical; Water | 2011 |
Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.
Topics: Adolescent; Adult; Aged; Antibodies, Protozoan; Antigens, Protozoan; Antiprotozoal Agents; Biomarkers; Chagas Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Recombinant Proteins; Treatment Outcome; Young Adult | 2011 |
Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.
Topics: Amidines; Animals; Antifungal Agents; Benzamidines; Chagas Disease; Drug Combinations; Furans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Hypercoagulability biomarkers in Trypanosoma cruzi -infected patients.
Topics: Adult; Biomarkers; Biomarkers, Pharmacological; Chagas Disease; Chronic Disease; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prothrombin; Risk; Thrombin; Thromboembolism; Thrombophilia; Trypanosoma cruzi | 2011 |
Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi.
Topics: Chagas Disease; Drug Resistance; Gene Expression; Humans; Multigene Family; Nitroimidazoles; Nitroreductases; Protozoan Proteins; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro.
Topics: Amides; Animals; Cell Survival; Cells, Cultured; Chagas Disease; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; Argentina; Chagas Disease; Chronic Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Trypanosoma cruzi | 2011 |
Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country.
Topics: Adult; Arthritis; Chagas Disease; Cohort Studies; Drug Eruptions; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Different forms of administration of biotherapy 7dH in mice experimentally infected by Trypanosoma cruzi produce different effects.
Topics: Animals; Chagas Disease; Disease Models, Animal; Homeopathy; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole.
Topics: Amphotericin B; Animals; Body Weight; Carbolines; Cell Count; Cell Line; Chagas Disease; Drug Combinations; Drug Resistance; Drug Synergism; Haplorhini; Heart; Humans; Ketoconazole; Life Cycle Stages; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.
Topics: Biotransformation; Chagas Disease; Chromatography, Liquid; DNA Damage; Glyoxal; Guanosine; Humans; Hydroxylamine; Imidazoles; Kinetics; Mass Spectrometry; NAD; Nitroimidazoles; Nitroreductases; Prodrugs; Protozoan Proteins; Spectrophotometry; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2012 |
Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children.
Topics: Adolescent; Autoantibodies; Case-Control Studies; Chagas Disease; Child; Female; Humans; Interferon-gamma; Male; Nitroimidazoles; Receptor, Muscarinic M2; Treatment Outcome; Trypanosoma cruzi | 2011 |
Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Topics: Animals; Biomarkers; Blood Proteins; Cardiac Myosins; Chagas Disease; Cyclic N-Oxides; Free Radical Scavengers; Gelsolin; Myosin Light Chains; Nitroimidazoles; Protein Carbonylation; Proteome; Rats; Rats, Sprague-Dawley; Trypanocidal Agents; Trypanosoma cruzi; Vimentin | 2012 |
Serological profiles and evaluation of parasitaemia by PCR and blood culture in individuals chronically infected by Trypanosoma cruzi treated with benzonidazole.
Topics: Adult; Age Factors; Antibodies, Protozoan; Chagas Disease; Chronic Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Retrospective Studies; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2012 |
Safety of benznidazole use in the treatment of chronic Chagas' disease.
Topics: Adolescent; Adult; Aged; Algorithms; Antiprotozoal Agents; Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Models, Statistical; Nitroimidazoles; Young Adult | 2012 |
Supply chain problems for Chagas disease treatment.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2012 |
Taiwaniaquinoid and abietane quinone derivatives with trypanocidal activity against T. cruzi and Leishmania spp.
Topics: Abietanes; Animals; Cell Line; Chagas Disease; Female; Fluorenes; Leishmania braziliensis; Leishmania infantum; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Quinones; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Erythrocytes; Humans; Inhibitory Concentration 50; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Preclinical monitoring of drug association in experimental chemotherapy of Chagas' disease by a new HPLC-UV method.
Topics: Animals; Chagas Disease; Chromatography, High Pressure Liquid; Female; Itraconazole; Mice; Nitroimidazoles; Trypanocidal Agents | 2012 |
Nifurtimox chemotherapy: collateral effects in treated Trypanosoma cruzi infected patients.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease.
Topics: Adult; Antigens, CD; Antigens, Protozoan; CD4-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; CTLA-4 Antigen; Gene Expression Regulation; Heart; Humans; Interferon-gamma; Leukocyte Immunoglobulin-like Receptor B1; Male; Middle Aged; Myocarditis; Nitroimidazoles; Receptors, Immunologic; Species Specificity; Trypanosoma cruzi | 2012 |
[A clinical and epidemiological study of the Trypanosoma cruzi infected population in the north metropolitan area of Barcelona].
Topics: Adult; Asymptomatic Infections; Chagas Cardiomyopathy; Chagas Disease; Emigrants and Immigrants; Female; Humans; Incidence; Male; Nitroimidazoles; Prospective Studies; Spain; Trypanocidal Agents | 2012 |
Blood leukocytes from benznidazole-treated indeterminate chagas disease patients display an overall type-1-modulated cytokine profile upon short-term in vitro stimulation with Trypanosoma cruzi antigens.
Topics: Adolescent; Adult; Antiprotozoal Agents; CD8-Positive T-Lymphocytes; Chagas Disease; Cross-Sectional Studies; Cytokines; Female; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Male; Middle Aged; Nitroimidazoles; Th1 Cells; Trypanosoma cruzi; Young Adult | 2012 |
Reactivation of Chagas' disease: cutaneous manifestations in two immunosuppressed patients.
Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Female; Heart Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Recurrence; Trypanocidal Agents | 2012 |
Posttherapeutic cure criteria in Chagas' disease: conventional serology followed by supplementary serological, parasitological, and molecular tests.
Topics: Adolescent; Adult; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Female; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Nitroimidazoles; Parasitology; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi; Young Adult | 2012 |
Congenital transmission of Chagas disease - Virginia, 2010.
Topics: Adult; Ascites; Bolivia; Chagas Disease; Female; Humans; Infant, Newborn; Male; Nitroimidazoles; Pericardial Effusion; Pleural Effusion; Pregnancy; Pregnancy Complications, Infectious; Serologic Tests; Trypanocidal Agents; Virginia | 2012 |
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
In vitro and in vivo studies of the trypanocidal activity of four terpenoid derivatives against Trypanosoma cruzi.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Chlorocebus aethiops; Female; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Parasite Load; Parasitic Sensitivity Tests; Plant Extracts; Terpenes; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2012 |
Reactivation of Chagas disease by immunosuppressive therapy in a patient with systemic lupus erythematosus: report of an exceptional case.
Topics: Adult; Azathioprine; Biopsy; Chagas Disease; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Nitroimidazoles; Skin; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain.
Topics: Chagas Disease; Developed Countries; Humans; Nitroimidazoles; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.
Topics: Animals; Antidepressive Agents, Second-Generation; Chagas Disease; Depression; Emotions; Exploratory Behavior; Female; Fluoxetine; Glial Fibrillary Acidic Protein; Hindlimb Suspension; Immunohistochemistry; Meningoencephalitis; Mice; Mice, Inbred C3H; Motor Activity; Nitroimidazoles; Pentoxifylline; Phenotype; Phosphodiesterase Inhibitors; Psychomotor Performance; Real-Time Polymerase Chain Reaction; Swimming; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2012 |
Congenital Chagas disease reported in United States.
Topics: Chagas Disease; Female; Humans; Infant, Newborn; Male; Mass Screening; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Trypanocidal Agents; Trypanosoma cruzi; United States | 2012 |
Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Female; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Vitamin B 12 | 2012 |
Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites.
Topics: Animals; Cardiomyopathies; Chagas Disease; Genotype; Heart; Inflammation; Mexico; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.
Topics: Adult; Chagas Disease; Chronic Disease; Drug Administration Schedule; Female; Humans; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Mice; Nitroimidazoles; Pharmaceutical Solutions; Polyethylene Glycols; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole.
Topics: Animals; Atrioventricular Block; Chagas Disease; Chronic Disease; Cicatrix; Collagen; Dogs; Drug Resistance; Electrocardiography; Fibrosis; Heart Atria; Myocardium; Nitroimidazoles; Prospective Studies; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Chronic Disease; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
In vivo susceptibility to benznidazole of Trypanosoma cruzi strains from the western Brazilian Amazon.
Topics: Animals; Brazil; Chagas Disease; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Humans; Male; Marsupialia; Mice; Mice, Inbred Strains; Nitroimidazoles; Polymerase Chain Reaction; Species Specificity; Triatominae; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Multicenter epidemiological and clinical study on imported Chagas diseases in Alicante, Spain.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Bolivia; Chagas Disease; Child; Child, Preschool; Emigration and Immigration; Female; Hospitals, General; Humans; Infant; Male; Middle Aged; Nitroimidazoles; Pregnancy; Spain; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2012 |
[Trypanosoma cruzi strains resistant to benznidazole occurring in Colombia].
Topics: Animals; Chagas Disease; Colombia; Drug Resistance; Ecology; Humans; Insect Vectors; Nitroimidazoles; Opossums; Panstrongylus; Rats; Rhodnius; Rodent Diseases; Species Specificity; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Dioxoles; Lignans; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Piper; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
A Practical Green Synthesis and Biological Evaluation of Benzimidazoles Against Two Neglected Tropical Diseases: Chagas and Leishmaniasis.
Topics: Amphotericin B; Antiprotozoal Agents; Benzimidazoles; Chagas Disease; Green Chemistry Technology; Heating; Leishmania mexicana; Leishmaniasis; Microwaves; Nifurtimox; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure.
Topics: Animals; Antigens, CD; Chagas Disease; Female; Gene Deletion; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroimidazoles; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Resistance; Exudates and Transudates; Inflammation; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitroimidazoles; omega-N-Methylarginine; Phosphorylcholine; Survival Analysis; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2002 |
The dog as model for chemotherapy of the Chagas' disease.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Dogs; Drug Resistance; Female; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Nitroimidazoles; Secondary Prevention; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes.
Topics: Animals; Chagas Disease; Female; Genotype; Itraconazole; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2003 |
Relationship between long-term resistance to Trypanosoma cruzi and latent infection, examined by antibody production and polymerase chain reaction in mice.
Topics: Animals; Animals, Newborn; Antibodies, Protozoan; Chagas Disease; DNA, Protozoan; Female; Immunization; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi; Vaccines, Attenuated; Virulence | 2002 |
[Interventional study in the natural evolution of Chagas disease. Evaluation of specific antiparasitic treatment. Retrospective-prospective study of antiparasitic therapy].
Topics: Adolescent; Adult; Aged; Allopurinol; Antiprotozoal Agents; Chagas Cardiomyopathy; Chagas Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Prospective Studies; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents | 2000 |
Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Disease; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; Immunoblotting; Leishmaniasis; Neuraminidase; Nitroimidazoles; Recombinant Proteins; Sensitivity and Specificity; Treatment Outcome; Trypanocidal Agents | 2003 |
Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Cloning, Molecular; Female; Genotype; Heart; Inflammation; Itraconazole; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Trypanosoma cruzi; Urogenital System | 2004 |
Chagas seropositive donors in kidney transplantation.
Topics: Chagas Disease; Female; Follow-Up Studies; Humans; Kidney; Kidney Transplantation; Male; Nitroimidazoles; Time Factors; Tissue Donors; Trypanocidal Agents | 2004 |
Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough.
Topics: Animals; Chagas Disease; Female; Injections, Intravenous; Liposomes; Liver; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Particle Size; Phospholipids; Rats; Rats, Wistar; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Monocytes; Nifurtimox; Nitroimidazoles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chagas Disease; DNA Primers; Dose-Response Relationship, Drug; Endotoxemia; Flow Cytometry; Inflammation; Interleukin-10; Interleukin-12; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroimidazoles; Peritoneal Lavage; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2004 |
Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Heart; Humans; Male; Mice; Mice, Inbred BALB C; Myocarditis; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
[Treatment of Chagas disease with benznidazole and thioctic acid].
Topics: Antioxidants; Chagas Disease; Drug Therapy, Combination; Humans; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents | 2005 |
Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes.
Topics: Animals; Apoptosis; Atrophy; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Death; Chagas Disease; Flow Cytometry; Fluorescent Antibody Technique; Male; Mice; Microscopy, Confocal; Nitroimidazoles; Phenotype; Thymus Gland; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Chagas disease in bone marrow transplantation: an approach to preemptive therapy.
Topics: Adolescent; Adult; Aged; Bone Marrow Transplantation; Chagas Disease; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Middle Aged; Nitroimidazoles; Parasitemia; Retrospective Studies; Trypanocidal Agents | 2005 |
The need of a neonatal preparation for Chagas disease.
Topics: Chagas Disease; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Nifurtimox; Nitroimidazoles; Patient Compliance; Trypanocidal Agents | 2005 |
Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis.
Topics: Alkaloids; Animals; Chagas Disease; Chlorocebus aethiops; Diterpenes; Inhibitory Concentration 50; Nitroimidazoles; Parasitic Sensitivity Tests; Plant Preparations; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2006 |
Chagas disease: hidden affliction and visible neglect.
Topics: Animals; Chagas Disease; Child; Diagnosis, Differential; Humans; Nifurtimox; Nitroimidazoles; Poverty; Risk Factors; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.
Topics: Acute Disease; Animals; B-Lymphocytes; Chagas Disease; Immunity, Cellular; Lymph Nodes; Lymphoid Tissue; Male; Mice; Nitroimidazoles; Parasitemia; Spleen; T-Lymphocytes; Thymus Gland; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Treatment of experimental chronic chagas disease with trifluralin.
Topics: Animals; Chagas Disease; Disease Models, Animal; Electrocardiography; Heart; Herbicides; Male; Mice; Mice, Inbred Strains; Myocarditis; Nitroimidazoles; Trifluralin; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Summaries for patients. Long-term outcomes of treating nonacute Chagas disease with benznidazole.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prognosis; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
The treatment of Chagas disease (South American trypanosomiasis).
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2006 |
Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.
Topics: Alkaloids; Animals; Carbolines; Chagas Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi; Zanthoxylum | 2007 |
Liver transplantation from deceased donors serologically positive for Chagas disease.
Topics: Adult; Antibodies, Protozoan; Cadaver; Chagas Disease; Female; Humans; Liver Transplantation; Male; Middle Aged; Nitroimidazoles; Tissue and Organ Procurement; Tissue Donors; Treatment Outcome; Trypanocidal Agents | 2007 |
Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Brazil; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Female; HIV Infections; Humans; Male; Meningoencephalitis; Middle Aged; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Xenodiagnosis | 2007 |
DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi.
Topics: Animals; Blood Cells; Chagas Disease; DNA Damage; Liver; Male; Mice; Mice, Inbred BALB C; Myocardium; Neoplasms; Nitric Oxide; Nitroimidazoles; Random Allocation; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Mice; Nitroimidazoles; Thioridazine; Trypanocidal Agents | 2007 |
Novel potential drug against T. cruzi and its interaction with surfactant micelles.
Topics: Animals; Chagas Disease; Erythrocytes; Hemolysis; Hydrazones; Micelles; Nitrofurans; Nitroimidazoles; Scattering, Small Angle; Sheep; Solubility; Surface-Active Agents; Trypanocidal Agents; Trypanosoma cruzi; X-Ray Diffraction | 2007 |
In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Congenital Trypanosoma cruzi infection in a non-endemic area.
Topics: Adult; Animals; Chagas Disease; Child, Preschool; Female; Humans; Immunosuppressive Agents; Infectious Disease Transmission, Vertical; Male; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome | 2007 |
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Homeodomain Proteins; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Severe invalidating pain syndrome associated with benznidazole therapy for Chagas' disease.
Topics: Adult; Arthralgia; Chagas Disease; Female; Humans; Nitroimidazoles; Somatoform Disorders; Trypanocidal Agents | 2008 |
Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole.
Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Female; Humans; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Serial Passage; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern.
Topics: Adolescent; Antigens, CD; Antiprotozoal Agents; B-Lymphocytes; Biomarkers; Chagas Disease; Child; Cytokines; Flow Cytometry; Humans; Killer Cells, Natural; Longitudinal Studies; Lymphocyte Activation; Monocytes; Nitroimidazoles; T-Lymphocytes | 2008 |
Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes.
Topics: Animal Structures; Animals; Antibodies, Protozoan; Blood; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Serologic Tests; Treatment Outcome; Trypanosoma cruzi | 2008 |
Chagas disease, France.
Topics: Adult; Animals; Chagas Disease; Female; France; French Guiana; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
Topics: Animals; Bromodeoxyuridine; CD8-Positive T-Lymphocytes; Chagas Disease; Immunologic Memory; Immunophenotyping; Mice; Nitroimidazoles; Receptors, Chemokine; Treatment Outcome; Trypanosoma cruzi | 2008 |
Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole.
Topics: Animals; Chagas Disease; Crotalid Venoms; DNA, Protozoan; Materia Medica; Mice; Nitroimidazoles; Plant Extracts; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Difference of effective antitrypanosomal dosages of benznidazole in mice and man. Chemotherapeutic and pharmacokinetic results.
Topics: Adult; Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Middle Aged; Nitroimidazoles; Trypanocidal Agents | 1980 |
Ketoconazole and other potent antimycotic azoles exhibit pronounced activity against Trypanosoma cruzi, Plasmodium berghei and Entamoeba histolytica in vivo.
Topics: Amebiasis; Animals; Antifungal Agents; Chagas Disease; Entamoeba histolytica; Entamoebiasis; Ketoconazole; Malaria; Mice; Nitroimidazoles; Plasmodium berghei; Trypanosoma cruzi | 1984 |
Chronic Chagas' disease in the mouse. IV. Effect of trypanocidal drugs.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Female; Intestinal Diseases, Parasitic; Mice; Mice, Inbred Strains; Myositis; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1983 |
Administration of benznidazole, a chemotherapeutic agent against Chagas disease, to pregnant rats. Covalent binding of reactive metabolites to fetal and maternal proteins.
Topics: Animals; Chagas Disease; Female; Fetus; Mutagens; Nitroimidazoles; Placenta; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Solubility; Tissue Distribution | 1984 |
[Benznidazole and chronic Chagas disease].
Topics: Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 1984 |
[Thioctic acid in the prevention of the toxic effects of benznidazole].
Topics: Chagas Disease; Humans; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents | 1984 |
Multiple-dose kinetics of the trypanosomicide benznidazole in man.
Topics: Adult; Chagas Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nitroimidazoles | 1980 |
The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.
Topics: Animals; Biphenyl Compounds; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
[Treatment of Chagas disease].
Topics: Amphotericin B; Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1981 |
Effect of specific chemotherapy on the levels of lytic antibodies in Chagas's disease.
Topics: Animals; Antibodies; Chagas Disease; Complement System Proteins; Humans; Male; Mice; Mice, Inbred Strains; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
A nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
Topics: Animals; Chagas Disease; Drug Administration Schedule; Male; Mice; Mice, Inbred Strains; Nitrofurazone; Nitroimidazoles; Thiadiazoles; Trypanocidal Agents | 1982 |
[Etiological treatment of Chagas' disease].
Topics: Animals; Chagas Disease; Humans; Mice; Nifurtimox; Nitrofurans; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 1982 |
[Chagas disease and pregnancy. Review apropos of a clinical case. Treatment].
Topics: Adult; Chagas Disease; Female; Humans; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious | 1981 |
Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice.
Topics: Animals; Carcinogens; Cell Division; Chagas Disease; Female; Liver; Lymph Nodes; Lymphoma; Mice; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1994 |
Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation.
Topics: Animals; Antibodies, Protozoan; Base Sequence; Chagas Disease; DNA, Kinetoplast; Humans; Molecular Sequence Data; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanosoma cruzi | 1995 |
Chagasic meningoencephalitis with detection of Trypanosoma cruzi in the cerebrospinal fluid of an immunodepressed patient.
Topics: Adult; Animals; Cerebrospinal Fluid; Chagas Disease; Humans; Immunocompromised Host; Immunosuppression Therapy; Kidney Transplantation; Male; Meningoencephalitis; Nitroimidazoles; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Chronic Disease; Female; Glycoproteins; Humans; Immune Sera; Infant, Newborn; Neuraminidase; Neutralization Tests; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Effects of immunosuppression and benzonidazole on Trypanosoma cruzi parasitism during experimental acute Chagas' disease.
Topics: Animals; Chagas Disease; Cyclosporine; Heart; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Prednisone; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Use of Trypanosoma cruzi purified glycoprotein (GP57/51) or trypomastigote-shed antigens to assess cure for human Chagas' disease.
Topics: Acute Disease; Adsorption; Adult; Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Chagas Disease; Child; Chronic Disease; Cross Reactions; Cysteine Endopeptidases; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Follow-Up Studies; Glycoproteins; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up.
Topics: Adult; Aged; Animals; Antibodies, Protozoan; Chagas Disease; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Serologic Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Successful treatment of Trypanosoma cruzi encephalitis in a patient with hemophilia and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Chagas Disease; Drug Therapy, Combination; Encephalitis; Fluconazole; Hemophilia A; Humans; Itraconazole; Ketoconazole; Male; Nitroimidazoles; Transfusion Reaction; Trypanocidal Agents | 1993 |
Long-term follow-up after heart transplantation in Chagas' disease.
Topics: Actuarial Analysis; Adrenal Cortex Hormones; Adult; Azathioprine; Chagas Cardiomyopathy; Chagas Disease; Cyclosporine; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Male; Necrosis; Nitroimidazoles; Retrospective Studies; Survival Analysis; Time Factors; Treatment Outcome; Trypanocidal Agents | 1993 |
Chelating agent inhibition of Trypanosoma cruzi epimastigotes in vitro.
Topics: Animals; Carbamates; Cell Division; Chagas Disease; Chelating Agents; Disulfides; Dose-Response Relationship, Drug; Ethylenediamines; Metals; Molecular Structure; Nitroimidazoles; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi | 1995 |
Should benznidazole be used in chronic Chagas' disease?
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; Neoplasms; Nitroimidazoles; Trypanocidal Agents | 1997 |
Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera from parasite-free, serologically cured chagasic patients.
Topics: Adult; Animals; Antibodies, Protozoan; Argentina; Brazil; Chagas Disease; Child; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Longitudinal Studies; Neuraminidase; Nitroimidazoles; Paraguay; Pregnancy; Pregnancy Complications, Parasitic; Reference Values; Time Factors; Trypanosoma cruzi | 1997 |
In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole.
Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nitroimidazoles; Parasitemia; Parasitology; Phenotype; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Recipients and donors of bone marrow transplants suffering from Chagas' disease: management and preemptive therapy of parasitemia.
Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Chronic Disease; Female; Humans; Immunosuppression Therapy; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nitroimidazoles; Parasitemia; Recurrence; Transplantation, Autologous; Transplantation, Homologous; Trypanocidal Agents | 1998 |
Trypanosoma cruzi: impact of clonal evolution of the parasite on its biological and medical properties.
Topics: Animals; Biological Evolution; Chagas Disease; Chlorocebus aethiops; Cluster Analysis; Discriminant Analysis; DNA, Protozoan; Electrophoresis, Cellulose Acetate; Genetic Variation; Genotype; Humans; Isoenzymes; Monte Carlo Method; Nifurtimox; Nitroimidazoles; Phylogeny; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1998 |
Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brazil; Chagas Disease; DNA, Protozoan; DNA, Ribosomal; Drug Resistance; Exons; Genes, Protozoan; Genetic Variation; Glucose-6-Phosphate Isomerase; Humans; Hypoxanthine Phosphoribosyltransferase; Isoenzymes; Nifurtimox; Nitroimidazoles; Polymorphism, Genetic; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Treatment of congenital Chagas' disease diagnosed and followed up by the polymerase chain reaction.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Immunoglobulin M; Incidence; Infant, Newborn; Infectious Disease Transmission, Vertical; Nitroimidazoles; Paraguay; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi.
Topics: Acute Disease; Animals; Chagas Disease; Drug Resistance; Interferon-gamma; Interleukin-12; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents | 1998 |
[Treatment of chronic Chagas' disease. Is the etiological treatment effective?].
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents | 1998 |
Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages.
Topics: Animals; Cell Line; Chagas Disease; Cytokines; Down-Regulation; Gene Expression Regulation, Enzymologic; Immunosuppressive Agents; Interleukin-10; Interleukin-6; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroimidazoles; Transcriptional Activation; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 1999 |
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population.
Topics: Animals; Chagas Disease; Cytokines; Drug Resistance; Interleukin-12; Macrophages; Male; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Phagocytosis; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 1999 |
Criteria of Chagas disease cure.
Topics: Adolescent; Adult; Animals; Antibodies, Protozoan; Chagas Disease; Humans; Middle Aged; Nitroimidazoles; Serologic Tests; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Etiological treatment for infection by Trypanosoma cruzi.
Topics: AIDS-Related Opportunistic Infections; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Topics: Acute Disease; Administration, Oral; Alkaloids; Animals; Benzylisoquinolines; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents | 2000 |
Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north-western Argentina.
Topics: Adult; Animals; Argentina; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutination Tests; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents | 2000 |
A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease.
Topics: Animals; Anti-Infective Agents; Antifungal Agents; Chagas Disease; Drug Combinations; Drug Synergism; Female; Ketoconazole; Mice; Nitroimidazoles; Ofloxacin; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Enzymatic markers of heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy.
Topics: Animals; Biomarkers; Chagas Disease; Creatine Kinase; Isoenzymes; Mice; Myocarditis; Myocardium; Nitroimidazoles; Trypanocidal Agents | 2000 |
Reactivation of chronic Chagas' disease following allogeneic bone marrow transplantation and successful pre-emptive therapy with benznidazole.
Topics: Adult; Animals; Bone Marrow Transplantation; Chagas Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Nitroimidazoles; Postoperative Complications; Recurrence; Transplantation, Homologous; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Chagas' disease.
Topics: Adolescent; Adult; Chagas Cardiomyopathy; Chagas Disease; Child; Chronic Disease; Humans; Nitroimidazoles; Risk Factors; Trypanocidal Agents | 2001 |
Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cells, Cultured; Chagas Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Heart; Interferon-gamma; Macrophages, Peritoneal; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Rats; Rats, Inbred Strains; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Chagas Disease; Drug Resistance; Gene Amplification; Glycoproteins; Humans; Karyotyping; Mice; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Polymorphism, Restriction Fragment Length; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.
Topics: Animals; Chagas Disease; Dogs; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Mice; Nitroimidazoles; Parasitemia; Parasitology; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
Topics: Animals; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Phytotherapy; Plant Extracts; Quinolines; Rutaceae; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.
Topics: Acute Disease; Animals; Chagas Disease; Disease Susceptibility; Immunoenzyme Techniques; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Necrosis; Nitroimidazoles; Parasitemia; Spleen; Survival Rate; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2001 |
The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.
Topics: Animals; Chagas Disease; Cholesterol; Cholesterol Esters; Fatty Acids; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitroimidazoles; Trifluralin; Triglycerides; Trypanocidal Agents | 2002 |
Evaluation of the mutagenic potential of the antichagasic drug Rochagan in healthy and chagasic rodents.
Topics: Acute Disease; Animals; Bone Marrow; Bone Marrow Cells; Chagas Disease; Chromosome Aberrations; Chromosomes; Chronic Disease; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB C; Micronucleus Tests; Nitroimidazoles; Rats; Rats, Inbred Strains; Time Factors; Trypanocidal Agents | 1991 |
Shift of excretory-secretory immunogens of Trypanosoma cruzi during human Chagas' disease.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Chronic Disease; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Nitroimidazoles; Rabbits; Trypanocidal Agents; Trypanosoma cruzi | 1991 |
Experimental chemotherapy of Trypanosoma cruzi infection: persistence of parasite antigens and positive serology in parasitologically cured mice.
Topics: Animals; Antigens, Protozoan; Chagas Disease; Mice; Microscopy, Immunoelectron; Nifurtimox; Nitroimidazoles; Spleen; Trypanocidal Agents | 1991 |
Lack of sensitivity of sister-chromatid exchange for lymphocyte chromosomal damage detection caused by antichagasic treatment.
Topics: Chagas Disease; Child; Child, Preschool; Chromosomes; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes; Male; Nifurtimox; Nitroimidazoles; Sister Chromatid Exchange; Trypanocidal Agents | 1991 |
Chagas' disease: lymphoma growth in rabbits treated with Benznidazole.
Topics: Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Female; Hypersensitivity, Delayed; Immunity, Cellular; Intradermal Tests; Liver; Lymphoma, Non-Hodgkin; Male; Molecular Structure; Myocardium; Nitroimidazoles; Rabbits; Trypanocidal Agents; Trypanosoma cruzi | 1990 |
Trypanocidal nitroarene treatment of experimental Trypanosoma cruzi infection does not prevent progression of chronic-phase heart lesions in rabbits.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Nifurtimox; Nitroimidazoles; Rabbits; Trypanocidal Agents | 1990 |
Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
Topics: Animals; Chagas Disease; Ferredoxins; Microsomes, Liver; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Rats; Subcellular Fractions; Thiadiazoles; Trypanosoma cruzi | 1989 |
[Chagas' disease in patients with renal transplantation].
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Immune Tolerance; Kidney Transplantation; Male; Nifurtimox; Nitroimidazoles; Serologic Tests; Transfusion Reaction; Trypanocidal Agents | 1989 |
Trypanosoma cruzi: zymodemes associated with acute and chronic Chagas' disease in central Brazil.
Topics: Adolescent; Adult; Brazil; Chagas Disease; Child; Child, Preschool; Drug Resistance; Female; Humans; Isoenzymes; Male; Middle Aged; Nitroimidazoles; Seasons; Trypanocidal Agents; Trypanosoma cruzi | 1986 |
[Tolerance to benzonidazole during the etiological treatment of Chagas' disease].
Topics: Adult; Animals; Body Weight; Chagas Cardiomyopathy; Chagas Disease; Drug Tolerance; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanosoma cruzi | 1987 |
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1987 |
Assessment of cytogenetic damage in chagasic children treated with benznidazole.
Topics: Cell Nucleus; Chagas Disease; Child; Child, Preschool; Chromosome Aberrations; DNA Damage; Female; Humans; Infant; Lymphocytes; Male; Mutagens; Nitroimidazoles; Trypanocidal Agents | 1988 |
[Chagas' disease: clastogenic effect of nifurtimox and benznidazole in children].
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Chromosome Banding; Chromosome Fragility; Humans; Infant; Metaphase; Micronucleus Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1988 |
Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Species Specificity; Trypanocidal Agents | 1985 |