benzoic acid has been researched along with Seizures in 5 studies
Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.
aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with nonketotic hyperglycinemia generally have intractable seizures that are poorly responsive to anticonvulsant medication." | 7.67 | The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia. ( Kulovich, S; Nyhan, WL; Qiao, CN; Wolff, JA; Yu, AL, 1986) |
| "These outcomes suggest that benzoate and dextromethorphan are not uniformly effective in nonketotic hyperglycinemia, but for some patients they improve arousal, decrease or eliminate seizures, and allow for some developmental progress." | 3.70 | Long-term use of high-dose benzoate and dextromethorphan for the treatment of nonketotic hyperglycinemia. ( Bellus, GA; Hamosh, A; Johnston, MV; Maher, JF; Rasmussen, SA, 1998) |
| "Therapy with benzoic acid in a case of classic neonatal non-ketotic hyperglycinaemia (NKH) was successful in stopping seizures but not in promoting mental development." | 3.69 | Response to sodium benzoate treatment in non-ketotic hyperglycinaemia. ( Hobusch, D; Krüger, G; Radke, M; Stolpe, HJ; Tittelbach-Helmrich, W; Uhlemann, M; Walther, F, 1994) |
| "Patients with nonketotic hyperglycinemia generally have intractable seizures that are poorly responsive to anticonvulsant medication." | 3.67 | The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia. ( Kulovich, S; Nyhan, WL; Qiao, CN; Wolff, JA; Yu, AL, 1986) |
| "Choline treatment did not change brain choline content, and was not associated with clinical or radiological improvement." | 1.30 | One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. ( Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mizuno, N | 1 |
| Fukumoto-Hato, M | 1 |
| Matsumoto-Yoshino, M | 1 |
| Morita, E | 1 |
| Walther, F | 1 |
| Radke, M | 1 |
| Krüger, G | 1 |
| Hobusch, D | 1 |
| Uhlemann, M | 1 |
| Tittelbach-Helmrich, W | 1 |
| Stolpe, HJ | 1 |
| Hamosh, A | 1 |
| Maher, JF | 1 |
| Bellus, GA | 1 |
| Rasmussen, SA | 1 |
| Johnston, MV | 1 |
| Van Hove, JL | 1 |
| Lazeyras, F | 1 |
| Zeisel, SH | 1 |
| Bottiglieri, T | 1 |
| Hyland, K | 1 |
| Charles, HC | 1 |
| Gray, L | 1 |
| Jaeken, J | 1 |
| Kahler, SG | 1 |
| Wolff, JA | 1 |
| Kulovich, S | 1 |
| Yu, AL | 1 |
| Qiao, CN | 1 |
| Nyhan, WL | 1 |
5 other studies available for benzoic acid and Seizures
| Article | Year |
|---|---|
Stability, bactericidal activity, vitamin B6 activity and gastrointestinal absorption of benzoic acid esters of pyridoxine.
Topics: Absorption; Animals; Anti-Bacterial Agents; Bacillus subtilis; Benzoates; Benzoic Acid; Digestive Sy | 1981 |
Response to sodium benzoate treatment in non-ketotic hyperglycinaemia.
Topics: Benzoates; Benzoic Acid; Dose-Response Relationship, Drug; Female; Glycine; Humans; Infant, Newborn; | 1994 |
Long-term use of high-dose benzoate and dextromethorphan for the treatment of nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoates; Benzoic Acid; Child; Child, Preschool; Dextromethor | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; | 1998 |
The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoates; Benzoic Acid; Female; Glycine; Humans; Infant, Newb | 1986 |